Tag: M.W=100-150

I found the field of Chemistry very interesting. Saw the article A carboxylate-assisted amination/unactivated C(sp(2))-H arylation reaction via a palladium/norbornene cooperative catalysis published in 2020. SDS of cas: 177-11-7, Reprint Addresses Liang, YM (corresponding author), Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

This report describes a carboxylate-assisted palladium-catalysed Catellani reaction, which is compatible with ortho-amination and unactivated C(sp(2))-H arylation. This method was used to synthesize a series of 1-amino substituted dihydrophenanthridines, phenanthridines and 6H-benzo[c]chromenes. Based on kinetic isotope experiments, the kinetic curve proves that pivalic acid accelerates the reaction rate of unactivated C(sp(2))-H activation, and thus this rate can keep up with the five membered aryl-norbornene-palladacycle (ANP) intermediate.

SDS of cas: 177-11-7. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact An, Y; Zhang, BS; Zhang, Z; Liu, C; Gou, XY; Ding, YN; Liang, YM or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article A Simple Protocol for the Stereoselective Construction of Enaminyl Sulfonyl Fluorides WOS:000538848600052 published article about CATALYZED FLUOROSULFONYLVINYLATION; ARYLETHENESULFONYL FLUORIDES; ETHENESULFONYL FLUORIDE; LEAVING GROUPS; DUAL WARHEAD; HYDROAMINATION; INHIBITORS; CHEMISTRY; MACROLIDES; RESISTANCE in [Leng, Jing; Fang, Wan-Yin; Zhao, Chuang; Qin, Hua-Li] Wuhan Univ Technol, State Key Lab Silicate Mat Architectures, Wuhan 430070, Peoples R China; [Leng, Jing; Fang, Wan-Yin; Zhao, Chuang; Qin, Hua-Li] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Wuhan 430070, Peoples R China; [Tang, Wenjian] Anhui Med Univ, Sch Pharm, Hefei 230032, Peoples R China in 2020, Cited 52. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. COA of Formula: C7H13NO2

A clickable connective hub 1-bromo-2-triazole-thane-1-sulfonyl fluoride BTESF (1) was developed and successfully applied for the fluorosulfonylvinylation of a host of primary and secondary cyclic or acyclic amines including amino acids and pharmaceuticals. Further antimicrobial experiments revealed that vinyl sulfonyl fluoride functionalized norfloxacin (3ak), ciprofloxacin (3am), and lomefloxacin (3an) exhibited 4-fold improved antimicrobial activity against Gram-positive bacteria compared to their parent drugs.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Leng, J; Tang, WJ; Fang, WY; Zhao, C; Qin, HL or concate me.. COA of Formula: C7H13NO2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

In 2020 J ORG CHEM published article about C-H FUNCTIONALIZATION; ALLYLIC ALKYLATIONS; ARYLATION; PD/NORBORNENE; TERMINATION; BOND in [Chen, Yanhui; Lv, Weiwei; Ba, Dan; Wen, Si; Cheng, Guolin] Huaqiao Univ, Coll Mat Sci & Engn, Xiamen 361021, Peoples R China in 2020, Cited 48. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane

We report a highly chemoselective palladium-catalyzed Catellani-type amination of aryl iodides terminated by the Heck reaction using allylic esters as terminating reagents. 2-Aminocinnamyl esters were formed exclusively via beta-H elimination rather than beta-OAc elimination without the assistance of a silver salt. This protocol represents a useful extension of Catellani-type transformations.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Chen, YH; Lv, WW; Ba, D; Wen, S; Cheng, GL or concate me.. Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Authors Flood, DT; Zhang, XJ; Fu, X; Zhao, ZX; Asai, S; Sanchez, BB; Sturgell, EJ; Vantourout, JC; Richardson, P; Flanagan, ME; Piotrowski, DW; Kolmel, DK; Wan, JQ; Tsai, MH; Chen, JSS; Baran, PS; Dawson, PE in WILEY-V C H VERLAG GMBH published article about ENCODED CHEMICAL LIBRARIES; MEDICINAL CHEMISTRY; HYDROGEN-PEROXIDE; DNA; DESIGN; SULFONAMIDES; DRUGS; INHIBITOR; DISCOVERY; SULFONES in [Flood, Dillon T.; Zhang, Xuejing; Fu, Xiang; Zhao, Zhenxiang; Vantourout, Julien C.; Baran, Phil S.; Dawson, Philip E.] Scripps Res, Dept Chem, 10550 N Torrey Pines Rd, La Jolla, CA 92037 USA; [Zhang, Xuejing; Fu, Xiang] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China; [Asai, Shota] Iwate Univ, Dept Chem & Biol Sci, Fac Engn, 4-3-5 Ueda, Morioka, Iwate 0208551, Japan; [Sanchez, Brittany B.; Sturgell, Emily J.; Chen, Jason S.] Scripps Res Inst, Automated Synth Facil, 10550 N Torrey Pines Rd, La Jolla, CA 92037 USA; [Richardson, Paul] Pfizer, Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA; [Flanagan, Mark E.; Piotrowski, David W.; Kolmel, Dominik K.] Pfizer, Med Chem, Eastern Point Rd, Groton, CT 06340 USA; [Wan, Jinqiao; Tsai, Mei-Hsuan] HitGen Inc, Bldg 6,8 Huigu 1st East Rd Tianfu Int Bio Town, Chengdu 610200, Sichuan, Peoples R China in 2020, Cited 49. Safety of 1,4-Dioxa-8-azaspiro[4.5]decane. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

DNA encoded libraries (DEL) have shown promise as a valuable technology for democratizing the hit discovery process. Although DEL provides relatively inexpensive access to libraries of unprecedented size, their production has been hampered by the idiosyncratic needs of the encoding DNA tag relegating DEL compatible chemistry to dilute aqueous environments. Recently reversible adsorption to solid support (RASS) has been demonstrated as a promising method to expand DEL reactivity using standard organic synthesis protocols. Here we demonstrate a suite of on-DNA chemistries to incorporate medicinally relevant and C-S, C-P and N-S linkages into DELs, which are underrepresented in the canonical methods.

Safety of 1,4-Dioxa-8-azaspiro[4.5]decane. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Flood, DT; Zhang, XJ; Fu, X; Zhao, ZX; Asai, S; Sanchez, BB; Sturgell, EJ; Vantourout, JC; Richardson, P; Flanagan, ME; Piotrowski, DW; Kolmel, DK; Wan, JQ; Tsai, MH; Chen, JSS; Baran, PS; Dawson, PE or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Recently I am researching about CARBONYLATION REACTIONS; ORGANIC ELECTROSYNTHESIS; AMINES; CARBON; HYDROCARBONS; 2-YNAMIDES; EVOLUTION; CATALYSTS; GREEN, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21520102003, 21702152]; 973 ProgramNational Basic Research Program of China [2012CB725302]; CAS Interdisciplinary Innovation Team; Hubei Province Natural Science Foundation of ChinaNatural Science Foundation of Hubei Province [2017CFA010]. Published in NATURE PUBLISHING GROUP in LONDON ,Authors: Zeng, L; Li, HR; Hu, JC; Zhang, DC; Hu, JY; Peng, P; Wang, SC; Shi, RY; Peng, JQ; Pao, CW; Chen, EL; Lee, JF; Zhang, H; Chen, YH; Lei, AW. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane. Recommanded Product: 177-11-7

Oxidative carbonylation using CO/O-2 is an attractive strategy to construct carbonyl compounds, but the explosive limit of the gas mixture hampers its application. Now, this safety issue is overcome in the aminocarbonylation of alkynes by replacing the external oxidant O-2 by electrochemistry facilitating a mild and safe reaction. Palladium-catalysed oxidative carbonylation using oxygen as the oxidant is an economical approach; however, the gas mixture of CO and air has an explosive limit of 12.5-74.0% that could hamper extensive application of this process. Herein we report an electrochemical aminocarbonylation of alkynes under atmospheric pressure in an undivided cell without an external oxidant. The transformation has a broad substrate scope (83 examples) that involves primary amines and ammonium salts. Furthermore, mechanistic studies through cyclic voltammetry, in situ infrared and quick-scanning X-ray absorption fine structure spectroscopy reveal the reasons for this protocol proceeding smoothly under electrochemical conditions.

Recommanded Product: 177-11-7. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Zeng, L; Li, HR; Hu, JC; Zhang, DC; Hu, JY; Peng, P; Wang, SC; Shi, RY; Peng, JQ; Pao, CW; Chen, EL; Lee, JF; Zhang, H; Chen, YH; Lei, AW or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Rhodium-Catalyzed Asymmetric Hydroamination of Allyl Amines WOS:000456350300004 published article about ANTI-MARKOVNIKOV HYDROAMINATION; INTERMOLECULAR HYDROAMINATION; ALKENES; DISCOVERY; ALDEHYDES in [Vanable, Evan P.; Kennemur, Jennifer L.; Hull, Kami L.] Univ Illinois, Dept Chem, 600 S Mathews, Urbana, IL 61801 USA; [Joyce, Leo A.; Ruck, Rebecca T.; Schultz, Danielle M.] Merck & Co Inc, Dept Proc Res & Dev, Rahway, NJ 07065 USA; [Kennemur, Jennifer L.] Max Planck Inst Kohlenforsch, Kaiser Wilhelm Pl 1, D-45470 Mulheim, Germany; [Hull, Kami L.] Univ Texas Austin, 105 E 24th St, Austin, TX 78712 USA in 2019, Cited 36. SDS of cas: 177-11-7. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

A Rh-catalyzed enantioselective hydroamination of allylamines using a chiral BIPHEP-type ligand is reported. Enantioenriched 1,2-diamines are formed in good yields and with excellent enantioselectivities. A diverse array of nucleophiles and amine directing groups are demonstrated, including deprotectable motifs. Finally, the methodology was demonstrated toward the rapid synthesis of 2-methyl-moclobemide.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Vanable, EP; Kennemur, JL; Joyce, LA; Ruck, RT; Schultz, DM; Hull, KL or concate me.. SDS of cas: 177-11-7

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Electrochemical Nonacidic N-Nitrosation/N-Nitration of Secondary Amines through a Biradical Coupling Reaction WOS:000546649400001 published article about METAL; NITROSAMINES; AMINATION; NITRO in [Zhao, Ji-Ping; Ding, Lu-jia; Wang, Peng-Cheng; Liu, Ying; Huang, Min-Jun; Zhou, Xin-Li; Lu, Ming] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Jiangsu, Peoples R China in 2020, Cited 54. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Category: piperidines

An acid-free N-nitrosation/nitration of the N-H bonds in secondary amines with Fe(NO3)(3)center dot 9H(2)O as the nitroso/nitro source through an electrocatalyzed radical coupling reaction was developed. Cyclic aliphatic amines and N-heteroaromatic compounds were N-nitrosated and N-nitrated, respectively, under mild conditions. Control and competition experiments, as well as kinetic studies, demonstrate that N-nitrosation and N-nitration involve two different radical reaction pathways involving N+ and N-center dot radicals. Moreover, the electrocatalysis method enables the preferential activation of the N-H bond over the electrode and thus provides high selectivity for specific N atoms. Finally, this strategy exhibits a broad scope and provides a green and straightforward approach to generate useful N-nitroso/nitro compounds in good yields.

Category: piperidines. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Zhao, JP; Ding, LJ; Wang, PC; Liu, Y; Huang, MJ; Zhou, XL; Lu, M or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane. Authors Sahoo, T; Sarkar, S; Ghosh, SC in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Sahoo, Tapan; Sarkar, Souvik; Ghosh, Subhash Chandra] Cent Salt & Marine Chem Res Inst CSIR CSMCRI, Nat Prod & Green Chem Div, GB Marg, Bhavnagar 364002, Gujarat, India; [Sahoo, Tapan; Ghosh, Subhash Chandra] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India in 2021, Cited 50. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

A simple and facile copper(II) mediated protocol for C-8 amination of 1-naphthylamide derivatives is reported here. Picolinamide and its derivatives were used as a bidentate directing group for the C-8 amination reaction. Various substituted naphthylamide derivatives with numerous cyclic and acyclic amines proceed in good yields under mild conditions. Air was used solely as an oxidant. (C) 2021 Elsevier Ltd. All rights reserved.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Sahoo, T; Sarkar, S; Ghosh, SC or concate me.. Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Recently I am researching about CATALYTIC HYDRATION; CHEMISTRY; PURIFICATION, Saw an article supported by the Croucher Foundation; DARPA Make-It program [ARO W911NF-16-2-0023]. Formula: C7H13NO2. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Fu, WC; Jamison, TF. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

A modular continuous flow synthesis of imatinib and analogues is reported. Structural y diverse imatinib analogues are rapidly generated using three readily available building blocks via a flow hydration/chemoselective C-N coupling sequence. The newly developed continuous flow hydration and amidation modules each exhibit a broad scope with good to excellent yields. Overall, the method described does not require solvent switches, in-line purifications, or packed-bed apparatuses due to the judicious manipulation of flow setups and solvent mixtures.

Formula: C7H13NO2. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Fu, WC; Jamison, TF or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Name: 1,4-Dioxa-8-azaspiro[4.5]decane. Recently I am researching about PREVALENCE, Saw an article supported by the Australian Institute of Criminology/Criminology Research Grant [34/15-16]. Published in JMIR PUBLICATIONS, INC in TORONTO ,Authors: Karystianis, G; Adily, A; Schofield, PW; Greenberg, D; Jorm, L; Nenadic, G; Butler, T. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

Background: The police attend numerous domestic violence events each year, recording details of these events as both structured (coded) data and unstructured free-text narratives. Abuse types (including physical, psychological, emotional, and financial) conducted by persons of interest (POIs) along with any injuries sustained by victims are typically recorded in long descriptive narratives. Objective: We aimed to determine if an automated text mining method could identify abuse types and any injuries sustained by domestic violence victims in narratives contained in a large police dataset from the New South Wales Police Force. Methods: We used a training set of 200 recorded domestic violence events to design a knowledge-driven approach based on syntactical patterns in the text and then applied this approach to a large set of police reports. Results: Testing our approach on an evaluation set of 100 domestic violence events provided precision values of 90.2% and 85.0% for abuse type and victim injuries, respectively. In a set of 492,393 domestic violence reports, we found 71.32% (351,178) of events with mentions of the abuse type(s) and more than one-third (177,117 events; 35.97%) contained victim injuries. Emotional/verbal abuse (33.46%; 117,488) was the most common abuse type, followed by punching (86,322 events; 24.58%) and property damage (22.27%; 78,203 events). Bruising was the most common form of injury sustained (51,455 events; 29.03%), with cut/abrasion (28.93%; 51,284 events) and red marks/signs (23.71%; 42,038 events) ranking second and third, respectively. Conclusions: The results suggest that text mining can automatically extract information from police-recorded domestic violence events that can support further public health research into domestic violence, such as examining the relationship of abuse types with victim injuries and of gender and abuse types with risk escalation for victims of domestic violence. Potential also exists for this extracted information to be linked to information on the mental health status.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Karystianis, G; Adily, A; Schofield, PW; Greenberg, D; Jorm, L; Nenadic, G; Butler, T or concate me.. Name: 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem