Tag: M.W=100-150

Authors Kathiravan, S; Suriyanarayanan, S; Nicholls, IA in AMER CHEMICAL SOC published article about ORGANIC ELECTROSYNTHESIS; AMIDATION; HALIDES; ARENES; FUNCTIONALIZATION; COMPATIBILITY; OXYGENATION; ALKYLAMINES; ACTIVATION; BENZAMIDES in [Kathiravan, Subban; Nicholls, Ian A.] Linnaeus Univ, Dept Chem & Biomed Sci, Bioorgan & Biophys Chem Lab, SE-39182 Kalmar, Sweden; Linnaeus Univ, Ctr Biomat Chem, SE-39182 Kalmar, Sweden in 2019, Cited 69. Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

Metal-catalyzed cross-coupling reactions are among the most important transformations in organic synthesis. However, the use of C-H activation for sp(2) C-N bond formation remains one of the major challenges in the field of cross-coupling chemistry. Described herein is the first example of the synergistic combination of copper catalysis and electrocatalysis for aryl C-H amination under mild reaction conditions in an atom-and step-economical manner with the liberation of H-2 as the sole and benign byproduct.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Kathiravan, S; Suriyanarayanan, S; Nicholls, IA or concate me.. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Recently I am researching about C-H FUNCTIONALIZATION; ELECTROPHILIC AMINATION; MULTICOMPONENT REACTIONS; INSERTION REACTION; FACILE ACCESS; OXIMES; CYCLOADDITION; ISONITRILES; CYCLIZATION; ARYL, Saw an article supported by the NSFCNational Natural Science Foundation of China (NSFC) [21772231]; Natural Science Foundation of ChongqingNatural Science Foundation of Chongqing [cstc2016jcy-jA0008]; Army Medical University [2016PY04]. Product Details of 177-11-7. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Yang, Z; Jiang, K; Chen, YC; Wei, Y. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

A copper-catalyzed protocol has been realized for the rapid assembly of dihydroquinolinones from readily accessible isocyanides and O-benzoyl hydroxylamines. The reactions (10 mol % of CuOAc, 10 mol % of dppe, 3 equiv of PhONa, 30 degrees C) deliver various structurally interesting dihydroquinolinones in moderate to good yields (up to 76%). The reactions may proceed in a cascade manner involving isocyanide insertion into the N-O bond, Mumm-type rearrangement, and intramolecular nucleophilic substitution.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Yang, Z; Jiang, K; Chen, YC; Wei, Y or concate me.. Recommanded Product: 177-11-7

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Formula: C7H13NO2. In 2019 ANGEW CHEM INT EDIT published article about TRANSITION-METAL-FREE; C-H AMINATION; NUCLEOPHILIC-SUBSTITUTION; REDUCTIVE ELIMINATION; CATALYZED AMINATION; COUPLING REACTIONS; CARBOXYLIC-ACIDS; CROSS-COUPLINGS; DIRECTING-GROUP; ARYL CHLORIDES in [Drapeau, Martin Pichette; Bahri, Janet; Lichte, Dominik; Goossen, Lukas J.] Ruhr Univ Bochum, Fak Chem & Biochem, ZEMOS, Univ Str 150, D-44801 Bochum, Germany in 2019, Cited 80. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

In the presence of a bimetallic Pd/Cu system with 1,10-phenanthroline as the ligand and either air or N-methylmorpholine N-oxide as the oxidant, electron-deficient benzoic acids undergo oxidative decarboxylative coupling with unprotected amines. This operationally simple aniline synthesis is widely applicable with respect to the amine and gives good yields, even on multigram scale. The orthogonality of this reaction to other Pd-catalyzed cross-couplings allows the concise synthesis of multisubstituted arenes by sequential C-C, C-Cl, and C-N functionalizations. Mechanistic investigations suggest the intermediacy of a hypervalent Pd species.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Drapeau, MP; Bahri, J; Lichte, D; Goossen, LJ or concate me.. Category: piperidines

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Anti-Markovnikov Hydroamination of Racemic Allylic Alcohols to Access Chiral gamma-Amino Alcohols WOS:000573540200001 published article about CATALYZED ASYMMETRIC HYDROGENATION; METHODOLOGY COOPERATIVE CATALYSIS; COMPLEX RUPHOX-RU; C-H AMINATION; BORROWING HYDROGEN; ENANTIOSELECTIVE SYNTHESIS; DIASTEREOSELECTIVE SYNTHESIS; SECONDARY ALCOHOLS; N-ALKYLATION; KETONES in [Xu, Ruirui; Wang, Kun; Liu, Haoying; Tang, Weijun; Sun, Huaming; Xue, Dong; Wang, Chao] Shaanxi Normal Univ, Sch Chem & Chem Engn, Minist Educ, Key Lab Appl Surface & Colloid Chem, Xian 710062, Peoples R China; [Xiao, Jianliang] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England in 2020, Cited 129. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

A ruthenium-catalyzed formal anti-Markovnikov hydroamination of allylic alcohols for the synthesis of chiral gamma-amino alcohols is presented. Proceeding via an asymmetric hydrogen-borrowing process, the catalysis allows racemic secondary allylic alcohols to react with various amines, affording enantiomerically enriched chiral gamma-amino alcohols with broad substrate scope and excellent enantioselectivities (68 examples, up to >99 %ee).

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Xu, RR; Wang, K; Liu, HY; Tang, WJ; Sun, HM; Xue, D; Xiao, JL; Wang, C or concate me.. Recommanded Product: 177-11-7

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

SDS of cas: 177-11-7. Recently I am researching about NUCLEOPHILIC CYCLOPROPANATION; ASYMMETRIC CYCLOPROPANATION; 3+2 ANNULATION; AMINO-ACIDS; C-C; BIS(IODOZINCIO)METHANE; AMINOCYCLOPROPANES; CYCLOADDITION; 1,4-ADDITION; HOMOENOLATE, Saw an article supported by the NSERCNatural Sciences and Engineering Research Council of Canada (NSERC); Canada Foundation for InnovationCanada Foundation for InnovationCGIAR [19119]; Ontario Research Fund; University of TorontoUniversity of Toronto. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: West, MS; Mills, LR; McDonald, TR; Lee, JB; Ensan, D; Rousseaux, SAL. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

Cyclopropylamines are prevalent in pharmaceuticals and agrochemicals. Herein, we report the synthesis of trans-2-substituted cyclopropylamines in high diastereoselectivity from readily available alpha-chloroaldehydes. The reaction proceeds via trapping of an electrophilic zinc homoenolate with an amine followed by ring closure to generate the cyclopropylamine. We have also observed that cyclopropylamine cis/trans-isomerization occurs in the presence of zinc halide salts and that this process can be turned off by the addition of a polar aprotic cosolvent.

SDS of cas: 177-11-7. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact West, MS; Mills, LR; McDonald, TR; Lee, JB; Ensan, D; Rousseaux, SAL or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

SDS of cas: 177-11-7. Yang, Z; Jiang, K; Chen, YC; Wei, Y in [Yang, Zhen; Jiang, Kun; Chen, Ying-Chun; Wei, Ye] Army Med Univ, Coll Pharm, Chongqing 400038, Peoples R China; [Wei, Ye] Southwest Univ, Sch Chem & Chem Engn, Chongqing 400715, Peoples R China published Copper-Catalyzed Dihydroquinolinone Synthesis from isocyanides and O-Benzoyl Hydroxylamines in 2019, Cited 57. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

A copper-catalyzed protocol has been realized for the rapid assembly of dihydroquinolinones from readily accessible isocyanides and O-benzoyl hydroxylamines. The reactions (10 mol % of CuOAc, 10 mol % of dppe, 3 equiv of PhONa, 30 degrees C) deliver various structurally interesting dihydroquinolinones in moderate to good yields (up to 76%). The reactions may proceed in a cascade manner involving isocyanide insertion into the N-O bond, Mumm-type rearrangement, and intramolecular nucleophilic substitution.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Yang, Z; Jiang, K; Chen, YC; Wei, Y or concate me.. Formula: C7H13NO2

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Category: piperidines. I found the field of Biochemistry & Molecular Biology; Pharmacology & Pharmacy very interesting. Saw the article Derivatisation of parthenolide to address chemoresistant chronic lymphocytic leukaemia published in 2019, Reprint Addresses Fossey, JS (corresponding author), Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England.; Agathanggelou, A (corresponding author), Univ Birmingham, Inst Canc & Genom Sci, Birmingham B15 2TT, W Midlands, England.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane.

Parthenolide is a natural product that exhibits anti-leukaemic activity, however, its clinical use is limited by its poor bioavailability. It may be extracted from feverfew and protocols for growing, extracting and derivatising it are reported. A novel parthenolide derivative with good bioavailability and pharmacological properties was identified through a screening cascade based on in vitro anti-leukaemic activity and calculated drug-likeness properties, in vitro and in vivo pharmacokinetics studies and hERG liability testing. In vitro studies showed the most promising derivative to have comparable anti-leukaemic activity to DMAPT, a previously described parthenolide derivative. The newly identified compound was shown to have pro-oxidant activity and in silico molecular docking studies indicate a prodrug mode of action. A synthesis scheme is presented for the production of amine 7 used in the generation of 5f.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Li, XJ; Payne, DT; Ampolu, B; Bland, N; Brown, JT; Dutton, MJ; Fitton, CA; Gulliver, A; Hale, L; Hamza, D; Jones, G; Lane, R; Leach, AG; Male, L; Merisor, EG; Morton, MJ; Quy, AS; Roberts, R; Scarll, R; Schulz-Utermoehl, T; Stankovic, T; Stevenson, B; Fossey, JS; Agathanggelou, A or concate me.. Recommanded Product: 177-11-7

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

I found the field of Chemistry very interesting. Saw the article Expanding Reactivity in DNA-Encoded Library Synthesis via Reversible Binding of DNA to an Inert Quaternary Ammonium Support published in 2019. COA of Formula: C7H13NO2, Reprint Addresses Baran, PS; Dawson, PE (corresponding author), Scripps Res, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

DNA Encoded Libraries have proven immensely powerful tools for lead identification. The ability to screen billions of compounds at once has spurred increasing interest in DEL development and utilization. Although DEL provides access to libraries of unprecedented size and diversity, the idiosyncratic and hydrophilic nature of the DNA tag severely limits the scope of applicable chemistries. It is known that biomacromolecules can be reversibly, noncovalently adsorbed and eluted from solid supports, and this phenomenon has been utilized to perform synthetic modification of biomolecules in a strategy we have described as reversible adsorption to solid support (RASS). Herein, we present the adaptation of RASS for a DEL setting, which allows reactions to be performed in organic solvents at near anhydrous conditions opening previously inaccessible chemical reactivities to DEL. The RASS approach enabled the rapid development of C(sp(2))-C(sp(3)) decarboxylative cross couplings with broad substrate scope, an electrochemical amination (the first electrochemical synthetic transformation performed in a DEL context), and improved reductive amination conditions. The utility of these reactions was demonstrated through a DEL-rehearsal in which all newly developed chemistries were orchestrated to afford a compound rich in diverse skeletal linkages. We believe that RASS will offer expedient access to new DEL reactivities, expanded chemical space, and ultimately more drug-like libraries.

COA of Formula: C7H13NO2. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Flood, DT; Asai, S; Zhang, XJ; Wang, J; Yoon, L; Adams, ZC; Dillingham, BC; Sanchez, BB; Vantourout, JC; Flanagan, ME; Piotrowsld, DW; Richardson, P; Green, SA; Shenvi, RA; Chen, JS; Baran, PS; Dawson, PE or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Phosphorus-nitrogen compounds: Part 46. The reactions of N3P3Cl6 with bidentate and monodentate ligands: The syntheses, structural characterizations, antimicrobial and cytotoxic activities, and DNA interactions of (N/N)spirocyclotriphosphazenes with 4-chlorobenzyl pendant arm WOS:000481728800018 published article about CHIRAL CONFIGURATIONS; BIOLOGICAL-ACTIVITIES; MOLECULAR DOCKING; PHOSPHAZENES; BINDING; ASSAY in [Asmafiliz, Nuran; Berberoglu, Ipek; Ozgur, Mehtap; Kilic, Zeynel] Ankara Univ, Dept Chem, TR-06100 Ankara, Turkey; [Kayalak, Hande; Acik, Leyla] Gazi Univ, Dept Biol, TR-06500 Ankara, Turkey; [Turk, Mustafa] Kirikkale Univ, Dept Bioengn, TR-71450 Kirikkale, Turkey; [Hokelek, Tuncer] Hacettepe Univ, Dept Phys, TR-06800 Ankara, Turkey in 2019, Cited 59. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Category: piperidines

In the present study, the partly and fully-substituted monospiro (4-6, 4a-6d), cis-dispiro (7-9), trans-dispiro (10-15) cyclotriphosphazenes were synthesized for the investigations of their chemical, stereogenic and biological properties. The cis/trans phosphazenes (7-12) have two stereogenic P centers. They are expected to be in meso and racemic forms. In addition, the structures of four compounds were evaluated using X-ray crystal-lographic data. Compound 13 was found to be a single enantiomer (RR) in the solid state, as also proved with its CD spectrum. The antibacterial and antifungal activities of the phosphazenes were elucidated for against Gram-positive (G+) and Gram-negative (G-) bacteria, and yeast strains, respectively. Of the compounds, 14 exhibits strong antimicrobial activity against most of the tested organisms, especially B. cereus and E. hirae. MBC and MFC values of compounds on different bacterial and fungal species ranged from < 9.8 mu M to 2500 mu M. Furthermore, the cytotoxic activities of 6, 4c, 10 and 14 were investigated against L929 fibroblast and DLD-1 cells, and 14 was the most cytotoxic compound against DLD-1. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Asmafiliz, N; Berberoglu, I; Ozgur, M; Kilic, Z; Kayalak, H; Acik, L; Turk, M; Hokelek, T or concate me.. Category: piperidines

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

COA of Formula: C7H13NO2. In 2021 ORG BIOMOL CHEM published article about N-ACYL KETIMINES; ASYMMETRIC-SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; 1,3-DISUBSTITUTED ISOINDOLINES; STEREOSELECTIVE-SYNTHESIS; CATALYZED ARYLATION; MICHAEL REACTIONS; DIRECTING GROUP; 3+2 ANNULATION; ACTIVATION in [Li, Xue-Hong; Gong, Jun-Fang; Song, Mao-Ping] Zhengzhou Univ, Green Catalysis Ctr, Coll Chem, Zhengzhou 450001, Peoples R China in 2021, Cited 104. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

A new method for the direct and stereoselective synthesis of 3-substituted isoindolinones via Rh(iii)-catalyzed chiral N-sulfinyl amide directed asymmetric [4 + 1] annulation of benzamides with acrylic esters has been developed. The reaction proceeded through an oxidative C-H olefination and a subsequent cyclization by intramolecular aza-Michael addition, producing a series of diastereoisomeric chiral isoindolinones (20 examples) in generally good yields with a dr value up to 5.5 : 1. The absolute configurations of the newly formed C-stereocenters in the major and minor diastereomers of the catalysis product have been determined by X-ray crystal diffraction analysis to be S and R, respectively. The separation of the major diastereoisomers from the catalysis products and subsequent removal of the N-sulfinyl chiral auxiliary afforded enantiomerically pure (S)-isoindolinones. The application of the obtained (S)-isoindolinones in the synthesis of several biologically active isoindolinones such as (S)-PD172938, (S)-pazinaclone and (S)-pagoclone is presented.

COA of Formula: C7H13NO2. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Li, XH; Gong, JF; Song, MP or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem