Tag: M.W=100-150

An article Step-wise and one-pot synthesis of highly substituted conjugated trienes from 2-oxobenzo [h]chromenes/2H-pyran-2-ones WOS:000639414200001 published article about STEREOSELECTIVE-SYNTHESIS in [Elagamy, Amr; Pratap, Ramendra] Univ Delhi, Dept Chem, North Campus, Delhi 110007, India; [Althagafi, Ismail] Umm Al Qura Univ, Fac Sci, Chem Dept, Mecca 21955, Saudi Arabia in 2021, Cited 36. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. COA of Formula: C7H13NO2

A mild and efficient route for the synthesis of conjugated trienes via nitroethane-mediated ring contraction of 2-oxobenzo[h]chromenes/2H-pyran-2-ones followed by decarboxylative rearrangement of the obtained spirobutenolides and butenolides is described. The (E)-isomer of trienes was obtained by step-wise and one-pot approaches from 2-oxobenzo[h]chromenes. Butenolides 4a-l as new substrates have been developed for the construction of trienes. The mixture of the (E)- and (Z)-isomers of spirobutenolides undergoes decarboxylative rearrangement in the presence of sodium ethoxide as a base to yield the (E)-isomer of trienes, while the (E)-isomer of butenolides reacts to give a mixture of (2E,4E)- and (2E,4Z)-isomers of trienes in an almost steady ratio of 45 : 55 or 1 : 1.2. The structure and geometry of the obtained butenolides and trienes were confirmed by single-crystal X-ray analysis.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Elagamy, A; Althagafi, I; Pratap, R or concate me.. COA of Formula: C7H13NO2

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An article Modular Continuous Flow Synthesis of Imatinib and Analogues WOS:000480371600070 published article about CATALYTIC HYDRATION; CHEMISTRY; PURIFICATION in [Fu, Wai Chung; Jamison, Timothy F.] MIT, Dept Chem, 77 Massachusetts Ave, Cambridge, MA 02139 USA in 2019, Cited 33. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. SDS of cas: 177-11-7

A modular continuous flow synthesis of imatinib and analogues is reported. Structural y diverse imatinib analogues are rapidly generated using three readily available building blocks via a flow hydration/chemoselective C-N coupling sequence. The newly developed continuous flow hydration and amidation modules each exhibit a broad scope with good to excellent yields. Overall, the method described does not require solvent switches, in-line purifications, or packed-bed apparatuses due to the judicious manipulation of flow setups and solvent mixtures.

SDS of cas: 177-11-7. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Fu, WC; Jamison, TF or concate me.

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Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Preparation of Chiral Allenes through Pd-Catalyzed Intermolecular Hydroamination of Conjugated Enynes: Enantioselective Synthesis Enabled by Catalyst Design WOS:000470034500024 published article about CARBONYL PROPARGYLATION; ASYMMETRIC AMINATION; DIENES; 1,3-ENYNES; 1,3-DIENES; ALDEHYDE; ALCOHOL; HYDROBORATION; ADDITIONS; KETONES in [Adamson, Nathan J.; Jeddi, Haleh; Malcolmson, Steven J.] Duke Univ, Dept Chem, Durham, NC 27708 USA in 2019, Cited 68. Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

In this study, we establish that conjugated enynes undergo selective 1,4-hydroamination under Pd catalysis to deliver chiral allenes with pendant allylic amines. Several primary and secondary aliphatic and aryl-substituted amines couple with a wide range of mono- and disubstituted enynes in a nonenantioselective reaction where DPEphos serves as the ligand for Pd. Benzophenone imine acts as an ammonia surrogate to afford primary amines in a two-step/one-pot process. Examination of chiral catalysts revealed a high degree of reversibility in the C-N bond formation that negatively impacted enantioselectivity. Consequently, an electron-poor ferrocenyl-PHOX ligand was developed to enable efficient and enantioselective enyne hydroamination.

Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Adamson, NJ; Jeddi, H; Malcolmson, SJ or concate me.

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Piperidine – Wikipedia,
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SDS of cas: 177-11-7. Kathiravan, S; Suriyanarayanan, S; Nicholls, IA in [Kathiravan, Subban; Nicholls, Ian A.] Linnaeus Univ, Dept Chem & Biomed Sci, Bioorgan & Biophys Chem Lab, SE-39182 Kalmar, Sweden; Linnaeus Univ, Ctr Biomat Chem, SE-39182 Kalmar, Sweden published Electrooxidative Amination of sp(2) C-H Bonds: Coupling of Amines with Aryl Amides via Copper Catalysis in 2019, Cited 69. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

Metal-catalyzed cross-coupling reactions are among the most important transformations in organic synthesis. However, the use of C-H activation for sp(2) C-N bond formation remains one of the major challenges in the field of cross-coupling chemistry. Described herein is the first example of the synergistic combination of copper catalysis and electrocatalysis for aryl C-H amination under mild reaction conditions in an atom-and step-economical manner with the liberation of H-2 as the sole and benign byproduct.

SDS of cas: 177-11-7. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Kathiravan, S; Suriyanarayanan, S; Nicholls, IA or concate me.

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Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Product Details of 177-11-7. Recently I am researching about C-H ARYLATION; TETRASUBSTITUTED HELICAL ALKENES; PALLADIUM-CATALYZED ANNULATION; REGIOSELECTIVE SYNTHESIS; FUNCTIONALIZATION; ACTIVATION; ROUTE; PD/NORBORNENE; AMIDATION, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [NSF 21472073, 21772075, 21532001]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Zhang, BS; Li, YK; Zhang, Z; An, Y; Wen, YH; Gou, XY; Quan, SQ; Wang, XG; Liang, YM. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

Highly functionalized 4-aminoindoles were synthesized via the three-component cross-coupling of o-iodoaniline, N-benzoyloxyamines, and norbornadiene. The Catellani and retro-Diels-Alder strategy was used in this domino process. o-Iodoaniline, with electron-donating and sterically hindered protecting groups, made the reaction selective toward o-C-H amination. On the basis of density functional theory calculations, the intramolecular Buchwald coupling of this reaction underwent a dearomatization and a 1,3-palladium migration process. The reasons for the control of the chemical selectivity by the protecting groups are given. Moreover, synthetic applications toward 4-piperazinylindole and a GOT1 inhibitor were realized.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Zhang, BS; Li, YK; Zhang, Z; An, Y; Wen, YH; Gou, XY; Quan, SQ; Wang, XG; Liang, YM or concate me.. Product Details of 177-11-7

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Piperidine – Wikipedia,
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In 2020 ADV SYNTH CATAL published article about COUPLING REACTIONS; ACTIVATED ALKENES; N-ARYLACRYLAMIDES; PHOTOREDOX; RADICALS; NITROGEN; OLEFINS; BOND; AMINATION; FUNCTIONALIZATION in [Wang, Yu-Zhao; Lin, Wu-Jie; Zou, Jian-Yu; Yu, Wei; Liu, Xue-Yuan] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China in 2020, Cited 68. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Safety of 1,4-Dioxa-8-azaspiro[4.5]decane

The cascade amination/cyclization ofN-arylacrylamides with alkyl amines under visible-light photoredox catalysis is realized via intermediacy of aminium radicals. The aminium radicals are generated by a two-step sequence which involves N-chlorination of alkyl amines and subsequent reductive N-Cl cleavage. This method provides a convenient access to aminated oxindoles.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Wang, YZ; Lin, WJ; Zou, JY; Yu, W; Liu, XY or concate me.. Safety of 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

COA of Formula: C7H13NO2. I found the field of Chemistry very interesting. Saw the article Preparation of Chiral Allenes through Pd-Catalyzed Intermolecular Hydroamination of Conjugated Enynes: Enantioselective Synthesis Enabled by Catalyst Design published in 2019, Reprint Addresses Malcolmson, SJ (corresponding author), Duke Univ, Dept Chem, Durham, NC 27708 USA.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane.

In this study, we establish that conjugated enynes undergo selective 1,4-hydroamination under Pd catalysis to deliver chiral allenes with pendant allylic amines. Several primary and secondary aliphatic and aryl-substituted amines couple with a wide range of mono- and disubstituted enynes in a nonenantioselective reaction where DPEphos serves as the ligand for Pd. Benzophenone imine acts as an ammonia surrogate to afford primary amines in a two-step/one-pot process. Examination of chiral catalysts revealed a high degree of reversibility in the C-N bond formation that negatively impacted enantioselectivity. Consequently, an electron-poor ferrocenyl-PHOX ligand was developed to enable efficient and enantioselective enyne hydroamination.

COA of Formula: C7H13NO2. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Adamson, NJ; Jeddi, H; Malcolmson, SJ or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane. I found the field of Chemistry very interesting. Saw the article Ni/NHC-catalyzed cross-coupling of methyl sulfinates and amines for direct access to sulfinamides published in 2019, Reprint Addresses Chen, JZ (corresponding author), Zhejiang Univ, Coll Pharmaceut Sci, 866 Yuhangtang Rd, Hangzhou, Zhejiang, Peoples R China.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane.

It was reported to develop a simple and convenient method for the Ni/NHC-catalyzed cross-coupling of methyl sulfinates and amines without an acid/base to afford secondary or tertiary sulfinamides in moderate to good yields. The method can provide the desired products with broad substrate scope, good chemoselectivity and good functional group compatibility. The presented approach may enrich the Nil NHC catalyst system and promote the applications of methyl sulfinates in the organic sulfur chemistry. (C) 2019 Elsevier Ltd. All rights reserved.

Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Li, GJ; Pan, YL; Liu, YL; Xu, HF; Chen, JZ or concate me.

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Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Metal-Free Cyclocarboamination of ortho-Formyl Phenylacetylenes with Secondary Amines: Access to 1,3-Diamino-1H-Indenes and 3-Amino-1-Indanones WOS:000457795500026 published article about CATALYZED HYDROAMINATION; INTERNAL ALKYNES; H BONDS; CARBOAMINATION; ALKENES; GENERATION; ACID; HETEROCYCLES; CYCLIZATION; INSERTION in [Cui, Jian-Fang; Tang, Rishi; Yang, Bin; Lai, Nathanael Chun-Him; Jiang, Jia-Jun; Deng, Jie-Ren; Wong, Man-Kin] Hong Kong Polytech Univ, State Key Lab Chem Biol & Drug Discovery, Dept Appl Biol & Chem Technol, Hong Kong, Peoples R China; [Cui, Jian-Fang] Southern Univ Sci & Technol, Dept Chem, Shenzhen, Peoples R China in 2019, Cited 62. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Formula: C7H13NO2

This work first discloses a new strategy for amine activation to give reactive amine anion by in situ generated iminium cation-amine anion pair through decomposition of sterically hindered aminals. Utilizing this strategy, a highly regio- and chemoselective cyclocarboamination of ortho-formyl phenylacetylenes with secondary amines has been realized under metal-free mild reaction conditions. The cyclocarboamination with notably tunable product profiles depends on the separation and purification procedure, a diverse range of 1, 3-diamino-1H-indenes (essentially reactive enamines) and 3-amino-1-indanones were obtained, respectively. Moreover, using iodine as an electrophile to couple with various ortho-formyl phenylacetylenes and secondary amines, a series of 3-amino-2-iodo-1-indanones were efficiently achieved with four bonds (C=O, C-C, C-N and C-I) formation in an one-pot three-component reaction. These results demonstrated an unprecedented methodology for the construction of highly functionalized 1H-indene and 1-indanone compounds.

Formula: C7H13NO2. About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Cui, JF; Tang, RS; Yang, B; Lai, NCH; Jiang, JJ; Deng, JR; Wong, MK or concate me.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Name: 1,4-Dioxa-8-azaspiro[4.5]decane. In 2020 ORG LETT published article about BINAPHTHOL DERIVATIVES; C(SP(3))-H BONDS; ARENES; HYDROXYLATION; C(SP(2))-H; FUNCTIONALIZATION; MECHANISM; MILD in [Cheng, Tai-Jin; Xu, Hui; Dai, Hui-Xiong] Chinese Acad Sci, Shanghai Inst Mat Med, Key Lab Receptor Res, Shanghai 201203, Peoples R China; [Dai, Hui-Xiong] Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China; [Cheng, Tai-Jin; Dai, Hui-Xiong] Univ Chinese Acad Sci, Beijing 100049, Peoples R China; [Wu, Peng; Lin, Hai-Xia] Shanghai Univ, Innovat Drug Res Ctr, Dept Chem, Shanghai 200444, Peoples R China; [Huang, Wei] Nanchang Univ, Sch Pharm, Nanchang 330006, Jiangxi, Peoples R China in 2020, Cited 56. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

A copper-catalyzed oxalamide-directed ortho-C-H amination of anilines has been developed by using 1 atm of air as the sole oxidant. The protocol shows excellent functional group tolerance, and some heterocyclic amines including indole, benzothiophene, benzothiazole, quinoline, isoquinoline, and quinoxaline could be compatible in the reaction. The late-stage diversification of medicinal drugs demonstrates the synthetic utility of this protocol.

About 1,4-Dioxa-8-azaspiro[4.5]decane, If you have any questions, you can contact Wu, P; Huang, W; Cheng, TJ; Lin, HX; Xu, H; Dai, HX or concate me.. Name: 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem