Tag: M.W=100-150

I found the field of Chemistry very interesting. Saw the article Mono- and dispirocyclotriphosphazenes containing 4-bromobenzyl pendant arm(s): Synthesis, spectroscopy, crystallography and biological activity studies published in 2020. COA of Formula: C7H13NO2, Reprint Addresses Asmafiliz, N (corresponding author), Ankara Univ, Dept Chem, TR-06100 Ankara, Turkey.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

The N/N donor-type bromobenzyldiamines (1-3) were successively prepared by reduction of Schiff bases formed as a result of condensation reactions of 4-bromobenzaldehyde with aliphatic diamines. The Cl exchange reactions of hexachlorocyclotriphosphazene (HCCP; trimer; N3P3Cl6; 4) with the bidentate ligands (1-3) produced the new monospiro- (5-7) and dispirocyclotriphosphazenes (8-13) containing 4-bromo-benzyl pendant arm(s). The tetrachloro phosphazenes (5-7) were reacted with pyrrolidine, tetra-1,4-dioxa-8-azaspiro [4.5]decane (DASD) and piperidine to give the tetraamino substituted mono-spirophosphazenes (5a-7c). The spectral analyses of all the phosphazenes were made using appropriate spectroscopic methods; such as FTIR, H-1, C-13, P-31 NMR and ESI-MS. The molecular and crystal structures of 5, 6, 7 and 12 were also determined by X-ray crystallography. On the other hand, the antimicrobial activities of the phosphazenes were evaluated against G (-) and G (+) bacteria and fungi. Some of the tetraaminophosphazenes were found to be very active against several bacteria and fungi. Besides, the interactions of the cyclotriphosphazenes with plasmid DNA were investigated using agarose gel electrophoresis. (C) 2020 Elsevier B.V. All rights reserved.

COA of Formula: C7H13NO2. Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Recently I am researching about PALLADIUM-CATALYZED SYNTHESIS; SULFUR-DIOXIDE SURROGATE; ONE-POT; SULFONYL FLUORIDES; BORONIC ACIDS; DABSO; BORYLATION; RONGALITE; REAGENTS; HALIDES, Saw an article supported by the MPI fur Kohlenforschung. SDS of cas: 177-11-7. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Alvarez, EM; Plutschack, MB; Berger, F; Ritter, T. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

Aryl sulfinates are precursors to a diverse number of sulfonyl-derived arenes, which are common motifs in pharmaceuticals and agrochemicals. Here, we report a site-selective two-step C-H sulfination sequence via aryl sulfonium salts to access aryl sulfonamides. Combined with site-selective aromatic thianthrenation, an operationally simple one-pot palladium-catalyzed protocol introduces the sulfonyl group using sodium hydroxymethylsulfinate (Rongalite) as a source of SO22-. The hydroxymethyl sulfone intermediate generated from the catalytic process can be employed as a synthetic handle to deliver a variety of sulfonyl-containing compounds.

Welcome to talk about 177-11-7, If you have any questions, you can contact Alvarez, EM; Plutschack, MB; Berger, F; Ritter, T or send Email.. SDS of cas: 177-11-7

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article A Broad-Spectrum Catalytic Amidation of Sulfonyl Fluorides and Fluorosulfates** WOS:000615932400001 published article about SUFEX CLICK CHEMISTRY; NUCLEOPHILIC-SUBSTITUTION; N-ALKYLATION; SULFONAMIDES; ARYL; DISCOVERY; AMINES; ARYLATION; PEPTIDES; REAGENTS in [Wei, Mingjie; Liang, Dacheng; Luo, Wenjun; Ma, Guojian; Liu, Zeyuan; Li, Le] Sun Yat Sen Univ, Sch Chem, PCFM Lab, Guangzhou 510275, Peoples R China; [Wei, Mingjie; Liang, Dacheng; Luo, Wenjun; Ma, Guojian; Liu, Zeyuan; Li, Le] Sun Yat Sen Univ, Sch Chem, GDHPRC Lab, Guangzhou 510275, Peoples R China; [Cao, Xiaohui] Guangdong Pharmaceut Univ, Sch Pharm, Guangzhou 510006, Peoples R China in 2021, Cited 144. HPLC of Formula: C7H13NO2. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

A broad-spectrum, catalytic method has been developed for the synthesis of sulfonamides and sulfamates. With the activation by the combination of a catalytic amount of 1-hydroxybenzotriazole (HOBt) and silicon additives, amidations of sulfonyl fluorides and fluorosulfates proceeded smoothly and excellent yields were generally obtained (87-99 %). Noticeably, this protocol is particularly efficient for sterically hindered substrates. Catalyst loading is generally low and only 0.02 mol % of catalyst is required for the multidecagram-scale synthesis of an amantadine derivative. In addition, the potential of this method in medicinal chemistry has been demonstrated by the synthesis of the marketed drug Fedratinib via a key intermediate sulfonyl fluoride 13. Since a large number of amines are commercially available, this route provides a facile entry to access Fedratinib analogues for biological screening.

HPLC of Formula: C7H13NO2. Welcome to talk about 177-11-7, If you have any questions, you can contact Wei, MJ; Liang, DC; Cao, XH; Luo, WJ; Ma, GJ; Liu, ZY; Li, L or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Authors Chen, YH; Lv, WW; Ba, D; Wen, S; Cheng, GL in AMER CHEMICAL SOC published article about C-H FUNCTIONALIZATION; ALLYLIC ALKYLATIONS; ARYLATION; PD/NORBORNENE; TERMINATION; BOND in [Chen, Yanhui; Lv, Weiwei; Ba, Dan; Wen, Si; Cheng, Guolin] Huaqiao Univ, Coll Mat Sci & Engn, Xiamen 361021, Peoples R China in 2020, Cited 48. Product Details of 177-11-7. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

We report a highly chemoselective palladium-catalyzed Catellani-type amination of aryl iodides terminated by the Heck reaction using allylic esters as terminating reagents. 2-Aminocinnamyl esters were formed exclusively via beta-H elimination rather than beta-OAc elimination without the assistance of a silver salt. This protocol represents a useful extension of Catellani-type transformations.

Welcome to talk about 177-11-7, If you have any questions, you can contact Chen, YH; Lv, WW; Ba, D; Wen, S; Cheng, GL or send Email.. Product Details of 177-11-7

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

HPLC of Formula: C7H13NO2. In 2019 J ORG CHEM published article about C-H FUNCTIONALIZATION; ELECTROPHILIC AMINATION; MULTICOMPONENT REACTIONS; INSERTION REACTION; FACILE ACCESS; OXIMES; CYCLOADDITION; ISONITRILES; CYCLIZATION; ARYL in [Yang, Zhen; Jiang, Kun; Chen, Ying-Chun; Wei, Ye] Army Med Univ, Coll Pharm, Chongqing 400038, Peoples R China; [Wei, Ye] Southwest Univ, Sch Chem & Chem Engn, Chongqing 400715, Peoples R China in 2019, Cited 57. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

A copper-catalyzed protocol has been realized for the rapid assembly of dihydroquinolinones from readily accessible isocyanides and O-benzoyl hydroxylamines. The reactions (10 mol % of CuOAc, 10 mol % of dppe, 3 equiv of PhONa, 30 degrees C) deliver various structurally interesting dihydroquinolinones in moderate to good yields (up to 76%). The reactions may proceed in a cascade manner involving isocyanide insertion into the N-O bond, Mumm-type rearrangement, and intramolecular nucleophilic substitution.

HPLC of Formula: C7H13NO2. Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Category: piperidines. Authors Sahoo, T; Sarkar, S; Ghosh, SC in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Sahoo, Tapan; Sarkar, Souvik; Ghosh, Subhash Chandra] Cent Salt & Marine Chem Res Inst CSIR CSMCRI, Nat Prod & Green Chem Div, GB Marg, Bhavnagar 364002, Gujarat, India; [Sahoo, Tapan; Ghosh, Subhash Chandra] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India in 2021, Cited 50. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

A simple and facile copper(II) mediated protocol for C-8 amination of 1-naphthylamide derivatives is reported here. Picolinamide and its derivatives were used as a bidentate directing group for the C-8 amination reaction. Various substituted naphthylamide derivatives with numerous cyclic and acyclic amines proceed in good yields under mild conditions. Air was used solely as an oxidant. (C) 2021 Elsevier Ltd. All rights reserved.

Category: piperidines. Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

In 2020 CHEM COMMUN published article about C-H FUNCTIONALIZATION; ARYL IODIDES; BOND FUNCTIONALIZATIONS; ARYLATION; PD/NORBORNENE; AMINATION; ALKYLATION; ANILINES; PD; MECHANISM in [Zhang, Bo-Sheng] Northwest Normal Univ, Coll Chem & Chem Engn, Lanzhou 730070, Gansu, Peoples R China; [Zhang, Bo-Sheng; Gou, Xue-Ya; Zhang, Zhe; An, Yang; Wang, Xin-Gang; Liang, Yong-Min] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China; [Li, Yuke] Chinese Univ Hong Kong, Dept Chem, Shatin, Hong Kong, Peoples R China; [Li, Yuke] Chinese Univ Hong Kong, Ctr Sci Modeling & Computat, Shatin, Hong Kong, Peoples R China in 2020, Cited 47. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane

This report described the first DMAP and PivOH-promotedortho-C-H amination andipso-allenization reaction of iodobenzenes realized by Pd/norbornene cooperative catalysis. Based on control experiments and DFT calculations, we speculated that the three ligands have different functions and mechanism paths in the reaction.

Welcome to talk about 177-11-7, If you have any questions, you can contact Zhang, BS; Li, YK; Gou, XY; Zhang, Z; An, Y; Wang, XG; Liang, YM or send Email.. Application In Synthesis of 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

COA of Formula: C7H13NO2. Authors Shelkovnikov, VV; Orlova, NA; Kargapolova, IY; Erin, KD; Maksimov, AM; Chernonosov, AA in MAIK NAUKA/INTERPERIODICA/SPRINGER published article about in [Shelkovnikov, V. V.; Orlova, N. A.; Kargapolova, I. Yu.; Maksimov, A. M.] Russian Acad Sci, Siberian Branch, Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk, Russia; [Shelkovnikov, V. V.] Novosibirsk State Tech Univ, Novosibirsk, Russia; [Erin, K. D.] Tomsk Polytech Univ, Tomsk, Russia; [Chernonosov, A. A.] Russian Acad Sci, Siberian Branch, Inst Chem Biol & Fundamental Med, Novosibirsk, Russia in 2019, Cited 14. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

A series of new formyl derivatives of polyfluorinated triphenyl-4,5-dihydro-1H-pyrazoles containing various amine residues in the fluorinated benzene ring have been synthesized and used as donor building blocks in the synthesis of donor-acceptor dyes as potential chromophores for nonlinear electro-optics. Effects of substituents in the donor and acceptor moieties of the obtained chromophores on their spectral characteristics have been studied.

COA of Formula: C7H13NO2. Welcome to talk about 177-11-7, If you have any questions, you can contact Shelkovnikov, VV; Orlova, NA; Kargapolova, IY; Erin, KD; Maksimov, AM; Chernonosov, AA or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article RASS-Enabled S/P-C and S-N Bond Formation for DEL Synthesis WOS:000527854000010 published article about ENCODED CHEMICAL LIBRARIES; MEDICINAL CHEMISTRY; HYDROGEN-PEROXIDE; DNA; DESIGN; SULFONAMIDES; DRUGS; INHIBITOR; DISCOVERY; SULFONES in [Flood, Dillon T.; Zhang, Xuejing; Fu, Xiang; Zhao, Zhenxiang; Vantourout, Julien C.; Baran, Phil S.; Dawson, Philip E.] Scripps Res, Dept Chem, 10550 N Torrey Pines Rd, La Jolla, CA 92037 USA; [Zhang, Xuejing; Fu, Xiang] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Peoples R China; [Asai, Shota] Iwate Univ, Dept Chem & Biol Sci, Fac Engn, 4-3-5 Ueda, Morioka, Iwate 0208551, Japan; [Sanchez, Brittany B.; Sturgell, Emily J.; Chen, Jason S.] Scripps Res Inst, Automated Synth Facil, 10550 N Torrey Pines Rd, La Jolla, CA 92037 USA; [Richardson, Paul] Pfizer, Med Chem, 10770 Sci Ctr Dr, San Diego, CA 92121 USA; [Flanagan, Mark E.; Piotrowski, David W.; Kolmel, Dominik K.] Pfizer, Med Chem, Eastern Point Rd, Groton, CT 06340 USA; [Wan, Jinqiao; Tsai, Mei-Hsuan] HitGen Inc, Bldg 6,8 Huigu 1st East Rd Tianfu Int Bio Town, Chengdu 610200, Sichuan, Peoples R China in 2020, Cited 49. Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

DNA encoded libraries (DEL) have shown promise as a valuable technology for democratizing the hit discovery process. Although DEL provides relatively inexpensive access to libraries of unprecedented size, their production has been hampered by the idiosyncratic needs of the encoding DNA tag relegating DEL compatible chemistry to dilute aqueous environments. Recently reversible adsorption to solid support (RASS) has been demonstrated as a promising method to expand DEL reactivity using standard organic synthesis protocols. Here we demonstrate a suite of on-DNA chemistries to incorporate medicinally relevant and C-S, C-P and N-S linkages into DELs, which are underrepresented in the canonical methods.

Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane. Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Category: piperidines. Cui, JF; Tang, RS; Yang, B; Lai, NCH; Jiang, JJ; Deng, JR; Wong, MK in [Cui, Jian-Fang; Tang, Rishi; Yang, Bin; Lai, Nathanael Chun-Him; Jiang, Jia-Jun; Deng, Jie-Ren; Wong, Man-Kin] Hong Kong Polytech Univ, State Key Lab Chem Biol & Drug Discovery, Dept Appl Biol & Chem Technol, Hong Kong, Peoples R China; [Cui, Jian-Fang] Southern Univ Sci & Technol, Dept Chem, Shenzhen, Peoples R China published Metal-Free Cyclocarboamination of ortho-Formyl Phenylacetylenes with Secondary Amines: Access to 1,3-Diamino-1H-Indenes and 3-Amino-1-Indanones in 2019, Cited 62. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

This work first discloses a new strategy for amine activation to give reactive amine anion by in situ generated iminium cation-amine anion pair through decomposition of sterically hindered aminals. Utilizing this strategy, a highly regio- and chemoselective cyclocarboamination of ortho-formyl phenylacetylenes with secondary amines has been realized under metal-free mild reaction conditions. The cyclocarboamination with notably tunable product profiles depends on the separation and purification procedure, a diverse range of 1, 3-diamino-1H-indenes (essentially reactive enamines) and 3-amino-1-indanones were obtained, respectively. Moreover, using iodine as an electrophile to couple with various ortho-formyl phenylacetylenes and secondary amines, a series of 3-amino-2-iodo-1-indanones were efficiently achieved with four bonds (C=O, C-C, C-N and C-I) formation in an one-pot three-component reaction. These results demonstrated an unprecedented methodology for the construction of highly functionalized 1H-indene and 1-indanone compounds.

Welcome to talk about 177-11-7, If you have any questions, you can contact Cui, JF; Tang, RS; Yang, B; Lai, NCH; Jiang, JJ; Deng, JR; Wong, MK or send Email.. Category: piperidines

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem