Tag: M.W=100-150

In 2019 INORG CHIM ACTA published article about CHIRAL CONFIGURATIONS; BIOLOGICAL-ACTIVITIES; MOLECULAR DOCKING; PHOSPHAZENES; BINDING; ASSAY in [Asmafiliz, Nuran; Berberoglu, Ipek; Ozgur, Mehtap; Kilic, Zeynel] Ankara Univ, Dept Chem, TR-06100 Ankara, Turkey; [Kayalak, Hande; Acik, Leyla] Gazi Univ, Dept Biol, TR-06500 Ankara, Turkey; [Turk, Mustafa] Kirikkale Univ, Dept Bioengn, TR-71450 Kirikkale, Turkey; [Hokelek, Tuncer] Hacettepe Univ, Dept Phys, TR-06800 Ankara, Turkey in 2019, Cited 59. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Formula: C7H13NO2

In the present study, the partly and fully-substituted monospiro (4-6, 4a-6d), cis-dispiro (7-9), trans-dispiro (10-15) cyclotriphosphazenes were synthesized for the investigations of their chemical, stereogenic and biological properties. The cis/trans phosphazenes (7-12) have two stereogenic P centers. They are expected to be in meso and racemic forms. In addition, the structures of four compounds were evaluated using X-ray crystal-lographic data. Compound 13 was found to be a single enantiomer (RR) in the solid state, as also proved with its CD spectrum. The antibacterial and antifungal activities of the phosphazenes were elucidated for against Gram-positive (G+) and Gram-negative (G-) bacteria, and yeast strains, respectively. Of the compounds, 14 exhibits strong antimicrobial activity against most of the tested organisms, especially B. cereus and E. hirae. MBC and MFC values of compounds on different bacterial and fungal species ranged from < 9.8 mu M to 2500 mu M. Furthermore, the cytotoxic activities of 6, 4c, 10 and 14 were investigated against L929 fibroblast and DLD-1 cells, and 14 was the most cytotoxic compound against DLD-1. Formula: C7H13NO2. Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Recently I am researching about SULFONYL FLUORIDES; CLICK CHEMISTRY; TOSYLATES; CHLORIDES; REAGENT, Saw an article supported by the National Institute of General Medical Sciences of the National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of General Medical Sciences (NIGMS) [R15GM134457]. Computed Properties of C7H13NO2. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Mahapatra, S; Woroch, CP; Butler, TW; Carneiro, SN; Kwan, SC; Khasnavis, SR; Gu, J; Dutra, JK; Vetelino, BC; Bellenger, J; Ende, CWA; Ball, ND. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

A method to activate sulfamoyl fluorides, fluorosulfates, and sulfonyl fluorides with calcium triflimide and DABCO for SuFEx with amines is described. The reaction was applied to a diverse set of sulfamides, sulfamates, and sulfonamides at room temperature under mild conditions. Additionally, we highlight this transformation to parallel medicinal chemistry to generate a broad array of nitrogen-based S(VI) compounds.

Computed Properties of C7H13NO2. Welcome to talk about 177-11-7, If you have any questions, you can contact Mahapatra, S; Woroch, CP; Butler, TW; Carneiro, SN; Kwan, SC; Khasnavis, SR; Gu, J; Dutra, JK; Vetelino, BC; Bellenger, J; Ende, CWA; Ball, ND or send Email.

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Piperidine – Wikipedia,
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An article Electrochemical Iodoamination of Indoles Using Unactivated Amines WOS:000598141000008 published article about C-H FUNCTIONALIZATION; PHOTOCATALYTIC OXIDATION; REGIOSELECTIVE AMINATION; IMIDYL RADICALS; IODINE; ELECTROSYNTHESIS; GENERATION; AMIDATION; CHEMISTRY; ARENES in [Lei, Ning; Shen, Yanling; Li, Yujun; Tao, Pan; Yang, Liquan; Su, Zhishan; Zheng, Ke] Sichuan Univ, Coll Chem, Key Lab Green Chem & Technol, Minist Educ, Chengdu 610064, Peoples R China in 2020, Cited 72. Product Details of 177-11-7. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

An environmentally friendly electrochemical approach for iodoamination of various indole derivatives with a series of unactivated amines, amino acid derivatives, and benzotriazoles (more than 80 examples) has been developed. This strategy was further applied in late-stage functionalization of natural products and pharmaceuticals and gram-scale synthesis and radiosynthesis of I-13(1)-labeled compounds. Fundamental insights into the mechanism of the reaction based on control experiments, density functional theory calculation, and cyclic voltammetry are provided.

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Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Selective Synthesis of 1-Dialkylamino-2-alkylbicyclo-[1.1.1]pentanes WOS:000592988800072 published article about TRANSFORMATIONS; PHOTOCONVERSION; PHOTOCHEMISTRY; REACTIVITY; PHOTOLYSIS in [Ma, Xiaoshen; Han, Yongxin; Bennett, David J.] Merck & Co Inc, Dept Discovery Chem, Boston, MA 02115 USA in 2020, Cited 44. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7. Category: piperidines

Compared to the abundance of methodologies accessing 1-substituted and 1,3-disubstuted bicyclo[1.1.1] pentanes (BCPs), the synthetic accessibility of BCPs with substitutions at the methylene position has been limited. Herein, we report a selective synthesis of 1-dialkylamino-2-alkylbicyclo[1.1.1]pentanes from prefunctionalized starting materials. We also achieved further functionalizations of these 1,2-disubstituted BCPs and developed a synthesis of these compounds with minimum necessity of chromatographic purifications starting from 1,3-dichloroacetone. Finally, we also detailed the synthesis of a 1,2,3-trisubstituted BCP analogue.

Welcome to talk about 177-11-7, If you have any questions, you can contact Ma, XS; Han, YX; Bennett, DJ or send Email.. Category: piperidines

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Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Recently I am researching about BUCHWALD-HARTWIG AMINATION; C-N; ARYL CHLORIDES; REDUCTIVE AMINATION; ROOM-TEMPERATURE; AROMATIC AMINATION; ARYLATION; EFFICIENT; AMINES; MONOARYLATION, Saw an article supported by the Hong Kong Polytechnic University Start-up Fund [1-BE0Z]; Shenzhen Strategic New Industry Development Research Fund of Shenzhen Science, Technology and Innovation Commission (SZSTI) [JCYJ20180306173843318]. Name: 1,4-Dioxa-8-azaspiro[4.5]decane. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Chen, ZC; Chen, XM; So, CM. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

The first general palladium-catalyzed amination of aryl phosphates is described. The combination of MorDalPhos with [Pd(pi-cinnamyl)Cl](2) enables the amination of electron-rich, electron-neutral, and electron-poor aryl phosphates with a board range of aromatic, aliphatic, and heterocyclic amines. Common functional groups such as ether, keto, ester, and nitrile show an excellent compatibility in this reaction condition. The solvent-free amination reactions are also successful in both solid coupling partners. The gram-scale cross-coupling is achieved by this catalytic system.

Welcome to talk about 177-11-7, If you have any questions, you can contact Chen, ZC; Chen, XM; So, CM or send Email.. Name: 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Authors Mahapatra, S; Woroch, CP; Butler, TW; Carneiro, SN; Kwan, SC; Khasnavis, SR; Gu, J; Dutra, JK; Vetelino, BC; Bellenger, J; Ende, CWA; Ball, ND in AMER CHEMICAL SOC published article about SULFONYL FLUORIDES; CLICK CHEMISTRY; TOSYLATES; CHLORIDES; REAGENT in [Woroch, Cristian P.; Carneiro, Sabrina N.; Kwan, Sabrina C.; Khasnavis, Samuel R.; Gu, Junha; Ball, Nicholas D.] Pomona Coll, Dept Chem, Claremont, CA 91711 USA; [Mahapatra, Subham; Butler, Todd W.; Dutra, Jason K.; Vetelino, Beth C.; Bellenger, Justin; Ende, Christopher W. am] Pfizer Worldwide Res & Dev, Groton, CT 06340 USA in 2020, Cited 35. Product Details of 177-11-7. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

A method to activate sulfamoyl fluorides, fluorosulfates, and sulfonyl fluorides with calcium triflimide and DABCO for SuFEx with amines is described. The reaction was applied to a diverse set of sulfamides, sulfamates, and sulfonamides at room temperature under mild conditions. Additionally, we highlight this transformation to parallel medicinal chemistry to generate a broad array of nitrogen-based S(VI) compounds.

Product Details of 177-11-7. Welcome to talk about 177-11-7, If you have any questions, you can contact Mahapatra, S; Woroch, CP; Butler, TW; Carneiro, SN; Kwan, SC; Khasnavis, SR; Gu, J; Dutra, JK; Vetelino, BC; Bellenger, J; Ende, CWA; Ball, ND or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Automated Analysis of Domestic Violence Police Reports to Explore Abuse Types and Victim Injuries: Text Mining Study WOS:000461283900001 published article about PREVALENCE in [Karystianis, George; Adily, Armita; Butler, Tony] Univ New South Wales, Kirby Inst, Fac Med, Level 6,Wallace Wurth Bldg,High St, Sydney, NSW 2052, Australia; [Schofield, Peter W.] Hunter New England Hlth, Neuropsychiat Serv, Newcastle, NSW, Australia; [Greenberg, David] Univ New South Wales, Sch Psychiat, Sydney, NSW, Australia; [Jorm, Louisa] Univ New South Wales, Ctr Big Data Res Hlth, Sydney, NSW, Australia; [Nenadic, Goran] Univ Manchester, Sch Comp Sci, Manchester, Lancs, England in 2019, Cited 36. Product Details of 177-11-7. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

Background: The police attend numerous domestic violence events each year, recording details of these events as both structured (coded) data and unstructured free-text narratives. Abuse types (including physical, psychological, emotional, and financial) conducted by persons of interest (POIs) along with any injuries sustained by victims are typically recorded in long descriptive narratives. Objective: We aimed to determine if an automated text mining method could identify abuse types and any injuries sustained by domestic violence victims in narratives contained in a large police dataset from the New South Wales Police Force. Methods: We used a training set of 200 recorded domestic violence events to design a knowledge-driven approach based on syntactical patterns in the text and then applied this approach to a large set of police reports. Results: Testing our approach on an evaluation set of 100 domestic violence events provided precision values of 90.2% and 85.0% for abuse type and victim injuries, respectively. In a set of 492,393 domestic violence reports, we found 71.32% (351,178) of events with mentions of the abuse type(s) and more than one-third (177,117 events; 35.97%) contained victim injuries. Emotional/verbal abuse (33.46%; 117,488) was the most common abuse type, followed by punching (86,322 events; 24.58%) and property damage (22.27%; 78,203 events). Bruising was the most common form of injury sustained (51,455 events; 29.03%), with cut/abrasion (28.93%; 51,284 events) and red marks/signs (23.71%; 42,038 events) ranking second and third, respectively. Conclusions: The results suggest that text mining can automatically extract information from police-recorded domestic violence events that can support further public health research into domestic violence, such as examining the relationship of abuse types with victim injuries and of gender and abuse types with risk escalation for victims of domestic violence. Potential also exists for this extracted information to be linked to information on the mental health status.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Recently I am researching about DNA INTERACTIONS; STEREOGENIC PROPERTIES; STRUCTURAL CHARACTERIZATIONS; ANTIMICROBIAL ACTIVITIES; ELECTROCHEMICAL INVESTIGATIONS; CYCLOTRIPHOSPHAZENE CORE; CHIRAL CONFIGURATIONS; DENDRIMERS; CYCLOPHOSPHAZENES; CHEMISTRY, Saw an article supported by the Scientific and Technical Research Council of TurkeyTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [215Z496]; Hacettepe University Scientific Research Project UnitHacettepe University [013 D04 602 004]; Turkish Academy of Sciences (TUBA)Turkish Academy of Sciences. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Binici, A; Okumus, A; Elmas, G; Kilic, Z; Ramazanoglu, N; Acik, L; Simsek, H; Tunali, BC; Turk, M; Guzel, R; Hokelek, T. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane. Product Details of 177-11-7

The reaction of N4P4Cl8 (1) with one equimolar amount of the sodium salt of an N/O donor-type bidentate ligand (2) afforded two kinds of derivatives, namely, mono-ferrocenyl-2-cis-4-dichloro-ansa- (2,4-ansa; 3) and mono-ferrocenyl-spiro- (spiro; 4) hexachlorocyclotetraphosphazenes. The reaction yield (35%) of 4 was significantly larger than that of 3 (14%). The 2,4-ansa compound (3) was reacted with excess secondary amines to produce 2-cis-4-dichloro-ansa-cyclotetraphosphazenes (3a-3d). On the other hand, the spiro compound (4) gave fully substituted mono-ferrocenyl-spiro-cyclotetraphosphazenes (4a-4d) with excess monoamines as well. The tetrameric phosphazene derivatives were characterized by ESI-MS and/or HRMS, FTIR, HSQC, HMBC, H-1, C-13, and P-31 NMR spectroscopy and X-ray crystallography (for 4). It is observed that the 2,4-ansa and spiro-cyclotetraphosphazenes have different thermal stabilities. Additionally, the CVs of the new mono-ferrocenyl pendant-armed cyclotetraphosphazenes revealed electrochemically reversible one-electron oxidation of the Fe-redox centre. The 2,4-ansa phosphazenes (3 and 3a-3d) have two different stereogenic P centers indicating that they are expected to be in racemic mixtures (RR’/SS’). The chiralities of 3a and 3c were investigated by chiral HPLC. The manuscript also deals with the antimicrobial activities against G(+)/G(-) bacteria and fungi, the interactions with plasmid DNA, the in vitro cytotoxic activities against L929 fibroblast and MCF7 breast cells, and the antituberculosis activities against Mycobacterium tuberculosis H37Rv of the cyclotetraphosphazenes.

Product Details of 177-11-7. Welcome to talk about 177-11-7, If you have any questions, you can contact Binici, A; Okumus, A; Elmas, G; Kilic, Z; Ramazanoglu, N; Acik, L; Simsek, H; Tunali, BC; Turk, M; Guzel, R; Hokelek, T or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Formula: C7H13NO2. Recently I am researching about PHOSPHORUS-NITROGEN COMPOUNDS; DNA INTERACTIONS; STRUCTURAL INVESTIGATIONS; CYTOTOXIC ACTIVITIES; PHOSPHAZENES; DERIVATIVES; SPIRO, Saw an article supported by the Ankara University, Scientific Research Unit (Turkey) [16H0430017]; Turkish Academy of Sciences (TUBA)Turkish Academy of Sciences. Published in ELSEVIER in AMSTERDAM ,Authors: Kuzey, NG; Ozgur, M; Cemaloglu, R; Asmafiliz, N; Kilic, Z; Acik, L; Aydin, B; Hokelek, T. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

The N/N donor-type bromobenzyldiamines (1-3) were successively prepared by reduction of Schiff bases formed as a result of condensation reactions of 4-bromobenzaldehyde with aliphatic diamines. The Cl exchange reactions of hexachlorocyclotriphosphazene (HCCP; trimer; N3P3Cl6; 4) with the bidentate ligands (1-3) produced the new monospiro- (5-7) and dispirocyclotriphosphazenes (8-13) containing 4-bromo-benzyl pendant arm(s). The tetrachloro phosphazenes (5-7) were reacted with pyrrolidine, tetra-1,4-dioxa-8-azaspiro [4.5]decane (DASD) and piperidine to give the tetraamino substituted mono-spirophosphazenes (5a-7c). The spectral analyses of all the phosphazenes were made using appropriate spectroscopic methods; such as FTIR, H-1, C-13, P-31 NMR and ESI-MS. The molecular and crystal structures of 5, 6, 7 and 12 were also determined by X-ray crystallography. On the other hand, the antimicrobial activities of the phosphazenes were evaluated against G (-) and G (+) bacteria and fungi. Some of the tetraaminophosphazenes were found to be very active against several bacteria and fungi. Besides, the interactions of the cyclotriphosphazenes with plasmid DNA were investigated using agarose gel electrophoresis. (C) 2020 Elsevier B.V. All rights reserved.

Formula: C7H13NO2. Welcome to talk about 177-11-7, If you have any questions, you can contact Kuzey, NG; Ozgur, M; Cemaloglu, R; Asmafiliz, N; Kilic, Z; Acik, L; Aydin, B; Hokelek, T or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane. Authors Wu, J; Zheng, CM; Li, BY; Hawkins, JM; Scott, SL in ROYAL SOC CHEMISTRY published article about in [Wu, Jing; Zheng, Chunming; Scott, Susannah L.] Univ Calif Santa Barbara, Dept Chem Engn, Santa Barbara, CA 93106 USA; [Li, Bryan] Pfizer Global Res & Dev, Chem R&D La Jolla Lab, San Diego, CA 92121 USA; [Hawkins, Joel M.] Pfizer Global Res & Dev, Groton, CT 06371 USA; [Scott, Susannah L.] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA in 2021, Cited 64. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

N-Boc deprotection (deBoc) is a common reaction in pharmaceutical research and development, as well as pharma manufacturing. Use of a catalyst lowers the required reaction temperature, and heterogeneous catalysts allow the reaction to be conducted in a continuous flow reactor with a low-boiling solvent, facilitating product separation and enhancing efficiency and productivity relative to a batch process. In this study, we explore the use of simple solid Bronsted acid catalysts to achieve continuous N-Boc deprotection of amines, without additional workup steps. Using THF as the solvent, H-BEA zeolite affords high yields of a variety of aromatic and aliphatic amines, often in residence times of less than a minute at 140 degrees C. The same catalyst/solvent combination is ineffective in batch conditions, due to the much lower temperature of refluxing THF. Boc-protected p-chloroaniline was deprotected with a throughput of 18 mmol p-chloroaniline per h per g(cat), sustained over 9 h. The active sites of the zeolite do not appear to be directly associated with the Al framework substitution in the micropores, since partially ion-exchanged Na/H-BEA shows activity similar to H-BEA. The strong Bronsted acid sites (framework [Si(OH)Al]), are likely poisoned by the amine product. Moderate Bronsted acid sites associated with silanol defects near Al on or near the external surface (and not susceptible to Na+-exchange) are presumably the active sites, since they are not poisoned even by more basic aliphatic amines.

Recommanded Product: 1,4-Dioxa-8-azaspiro[4.5]decane. Welcome to talk about 177-11-7, If you have any questions, you can contact Wu, J; Zheng, CM; Li, BY; Hawkins, JM; Scott, SL or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem