Tag: M.W=100-150

Safety of 1,4-Dioxa-8-azaspiro[4.5]decane. In 2019 ACS CATAL published article about H BOND FUNCTIONALIZATION; ASYMMETRIC DEAROMATIZATION; OXIDATIVE DEAROMATIZATION; AEROBIC FUNCTIONALIZATION; UNIFIED SYNTHESIS; ALPHA-AMINATION; NAPHTHOLS; HYDROAMINATION; REARRANGEMENT; AMINOBORATION in [Yao, Zhi-Li; Shao, Nan-Qi; Wang, Dong-Hui] Chinese Acad Sci, Shanghai Inst Organ Chem, CAS Key Lab Synthet & Self Assembly Chem Organ Fu, Univ Chinese Acad Sci,Ctr Excellence Mol Synth, 345 Lingling Rd, Shanghai 200032, Peoples R China; [Wang, Lei; Guo, Yin-Long] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Univ Chinese Acad Sci,Ctr Excellence Mol Synth, 345 Lingling Rd, Shanghai 200032, Peoples R China in 2019, Cited 82. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

A Cu-catalyzed dearomative amination of simple phenols with O-benzoylhydroxylamines (R’RN-OBz) to synthesize alpha-aminocyclohexa-2,4-dienones is reported. This intermolecular transformation occurs exclusively at the position ortho to the hydroxyl group, providing a convenient method to synthesize the desired products in high yields. The reaction proceeds under mild conditions and tolerates a wide range of functional groups. Mechanistic studies indicate that this transformation proceeds via either (1) a single-electron transfer process involving attack of an N-centered radical onto the phenol or (2) a two-electron pathway involving addition of phenol to an electrophilic Cu-III-amino complex via an inner-sphere process.

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Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Computed Properties of C7H13NO2. Authors De Angelis, L; Crawford, AM; Su, YL; Wherritt, D; Arman, H; Doyle, MP in AMER CHEMICAL SOC published article about in [De Angelis, Luca; Crawford, Alexandra M.; Su, Yong-Liang; Wherritt, Daniel; Arman, Hadi; Doyle, Michael P.] Univ Texas San Antonio, Dept Chem, San Antonio, TX 78249 USA in 2021, Cited 23. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

The formation of nitrile oxides with diazocarbonyl compounds by nitrosyl transfer from tert-butyl nitrite under mild conditions and without the use of a catalyst or an additive is reported. This transformation is broadly applicable to the synthesis of furoxans by dimerization and isoxazoles and isoxazolines by cycloaddition. This methodology is also applied for the millimole-scale synthesis of two biologically active compounds. The formation of the nitrile oxide from a diazoacetamide is stable and confirmed experimentally.

Computed Properties of C7H13NO2. Welcome to talk about 177-11-7, If you have any questions, you can contact De Angelis, L; Crawford, AM; Su, YL; Wherritt, D; Arman, H; Doyle, MP or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

I found the field of Chemistry very interesting. Saw the article SuFEx Activation with Ca(NTf2)(2) : A Unified Strategy to Access Sulfamides, Sulfamates, and Sulfonamides from S(VI) Fluorides published in 2020. Recommanded Product: 177-11-7, Reprint Addresses Ball, ND (corresponding author), Pomona Coll, Dept Chem, Claremont, CA 91711 USA.; Ende, CWA (corresponding author), Pfizer Worldwide Res & Dev, Groton, CT 06340 USA.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

A method to activate sulfamoyl fluorides, fluorosulfates, and sulfonyl fluorides with calcium triflimide and DABCO for SuFEx with amines is described. The reaction was applied to a diverse set of sulfamides, sulfamates, and sulfonamides at room temperature under mild conditions. Additionally, we highlight this transformation to parallel medicinal chemistry to generate a broad array of nitrogen-based S(VI) compounds.

Recommanded Product: 177-11-7. Welcome to talk about 177-11-7, If you have any questions, you can contact Mahapatra, S; Woroch, CP; Butler, TW; Carneiro, SN; Kwan, SC; Khasnavis, SR; Gu, J; Dutra, JK; Vetelino, BC; Bellenger, J; Ende, CWA; Ball, ND or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Mono- and dispirocyclotriphosphazenes containing 4-bromobenzyl pendant arm(s): Synthesis, spectroscopy, crystallography and biological activity studies WOS:000573639200004 published article about PHOSPHORUS-NITROGEN COMPOUNDS; DNA INTERACTIONS; STRUCTURAL INVESTIGATIONS; CYTOTOXIC ACTIVITIES; PHOSPHAZENES; DERIVATIVES; SPIRO in [Kuzey, Nur Guven; Ozgur, Mehtap; Cemaloglu, Resit; Asmafiliz, Nuran; Kilic, Zeynel] Ankara Univ, Dept Chem, TR-06100 Ankara, Turkey; [Acik, Leyla; Aydin, Betul] Gazi Univ, Dept Biol, TR-06500 Ankara, Turkey; [Hokelek, Tuncer] Hacettepe Univ, Dept Phys, TR-06800 Ankara, Turkey in 2020, Cited 40. Computed Properties of C7H13NO2. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

The N/N donor-type bromobenzyldiamines (1-3) were successively prepared by reduction of Schiff bases formed as a result of condensation reactions of 4-bromobenzaldehyde with aliphatic diamines. The Cl exchange reactions of hexachlorocyclotriphosphazene (HCCP; trimer; N3P3Cl6; 4) with the bidentate ligands (1-3) produced the new monospiro- (5-7) and dispirocyclotriphosphazenes (8-13) containing 4-bromo-benzyl pendant arm(s). The tetrachloro phosphazenes (5-7) were reacted with pyrrolidine, tetra-1,4-dioxa-8-azaspiro [4.5]decane (DASD) and piperidine to give the tetraamino substituted mono-spirophosphazenes (5a-7c). The spectral analyses of all the phosphazenes were made using appropriate spectroscopic methods; such as FTIR, H-1, C-13, P-31 NMR and ESI-MS. The molecular and crystal structures of 5, 6, 7 and 12 were also determined by X-ray crystallography. On the other hand, the antimicrobial activities of the phosphazenes were evaluated against G (-) and G (+) bacteria and fungi. Some of the tetraaminophosphazenes were found to be very active against several bacteria and fungi. Besides, the interactions of the cyclotriphosphazenes with plasmid DNA were investigated using agarose gel electrophoresis. (C) 2020 Elsevier B.V. All rights reserved.

Computed Properties of C7H13NO2. Welcome to talk about 177-11-7, If you have any questions, you can contact Kuzey, NG; Ozgur, M; Cemaloglu, R; Asmafiliz, N; Kilic, Z; Acik, L; Aydin, B; Hokelek, T or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Yao, ZL; Wang, L; Shao, NQ; Guo, YL; Wang, DH in [Yao, Zhi-Li; Shao, Nan-Qi; Wang, Dong-Hui] Chinese Acad Sci, Shanghai Inst Organ Chem, CAS Key Lab Synthet & Self Assembly Chem Organ Fu, Univ Chinese Acad Sci,Ctr Excellence Mol Synth, 345 Lingling Rd, Shanghai 200032, Peoples R China; [Wang, Lei; Guo, Yin-Long] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Univ Chinese Acad Sci,Ctr Excellence Mol Synth, 345 Lingling Rd, Shanghai 200032, Peoples R China published Copper-Catalyzed ortho-Selective Dearomative C-N Coupling of Simple Phenols with O-Benzoylhydroxylamines in 2019, Cited 82. Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

A Cu-catalyzed dearomative amination of simple phenols with O-benzoylhydroxylamines (R’RN-OBz) to synthesize alpha-aminocyclohexa-2,4-dienones is reported. This intermolecular transformation occurs exclusively at the position ortho to the hydroxyl group, providing a convenient method to synthesize the desired products in high yields. The reaction proceeds under mild conditions and tolerates a wide range of functional groups. Mechanistic studies indicate that this transformation proceeds via either (1) a single-electron transfer process involving attack of an N-centered radical onto the phenol or (2) a two-electron pathway involving addition of phenol to an electrophilic Cu-III-amino complex via an inner-sphere process.

Welcome to talk about 177-11-7, If you have any questions, you can contact Yao, ZL; Wang, L; Shao, NQ; Guo, YL; Wang, DH or send Email.. Quality Control of 1,4-Dioxa-8-azaspiro[4.5]decane

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

I found the field of Chemistry very interesting. Saw the article Anti-Markovnikov Hydroamination of Racemic Allylic Alcohols to Access Chiral gamma-Amino Alcohols published in 2020. HPLC of Formula: C7H13NO2, Reprint Addresses Wang, C (corresponding author), Shaanxi Normal Univ, Sch Chem & Chem Engn, Minist Educ, Key Lab Appl Surface & Colloid Chem, Xian 710062, Peoples R China.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane

A ruthenium-catalyzed formal anti-Markovnikov hydroamination of allylic alcohols for the synthesis of chiral gamma-amino alcohols is presented. Proceeding via an asymmetric hydrogen-borrowing process, the catalysis allows racemic secondary allylic alcohols to react with various amines, affording enantiomerically enriched chiral gamma-amino alcohols with broad substrate scope and excellent enantioselectivities (68 examples, up to >99 %ee).

HPLC of Formula: C7H13NO2. Welcome to talk about 177-11-7, If you have any questions, you can contact Xu, RR; Wang, K; Liu, HY; Tang, WJ; Sun, HM; Xue, D; Xiao, JL; Wang, C or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Cao, Q; Nicholson, WI; Jones, AC; Browne, DL in [Cao, Qun; Nicholson, William I.; Jones, Andrew C.; Browne, Duncan L.] Cardiff Univ, Sch Chem, Main Bldg,Pk Pl, Cardiff CF10 3EQ, S Glam, Wales published Robust Buchwald-Hartwig amination enabled by ball-milling in 2019, Cited 35. Formula: C7H13NO2. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7.

An operationally simple mechanochemical method for the Pd catalysed Buchwald-Hartwig amination of arylhalides with secondary amines has been developed using a Pd PEPPSI catalyst system. The system is demonstrated on 30 substrates and applied in the context of a target synthesis. Furthermore, the performance of the reaction under aerobic conditions has been probed under traditional solution and mechanochemical conditions, the observations are discussed herein.

Formula: C7H13NO2. Welcome to talk about 177-11-7, If you have any questions, you can contact Cao, Q; Nicholson, WI; Jones, AC; Browne, DL or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

An article Copper-Catalyzed Coupling of Sulfonamides with Alkylamines: Synthesis of (E)-N-Sulfonylformamidines WOS:000516665800029 published article about ONE-POT SYNTHESIS; N-SULFONYLFORMAMIDINES; SULFONYL AMIDINES; TERTIARY-AMINES; METAL-FREE; INHIBITORS; DESIGN; ROUTE; INTERCEPTION; FORMAMIDINES in [Gou, Quan; Cao, Tuanwu; Tan, Xiaoping; Shi, Wenbing; Ran, Man] Yangtze Normal Univ, Chongqing, Peoples R China; [Liu, Zining; Cheng, Feixiang] Qujing Normal Univ, Qujing, Peoples R China; [Qn, Jun] Yunnan Univ, Kunming, Yunnan, Peoples R China in 2020, Cited 43. Category: piperidines. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

Herein, we describe an efficient copper-catalyzed coupling of sulfonamides with alkylamines to synthesize (E)-N-sulfonylformamidines. The reaction is accomplished under mild conditions without the use of a corrosive acid or base as an additive. It tolerates a broad scope of substrates and generates the products with exclusive (E)-stereoselectivity.

Welcome to talk about 177-11-7, If you have any questions, you can contact Gou, Q; Liu, ZN; Cao, TW; Tan, XP; Shi, WB; Ran, M; Cheng, FX; Qn, J or send Email.. Category: piperidines

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Authors Prinsloo, IF; Zuma, NH; Aucamp, J; N’Da, DD in WILEY published article about FEBRIFUGINE; INHIBITORS; CHEMISTRY; UPDATE in [Prinsloo, Izak F.] North West Univ, Sch Pharm, Pharmaceut Chem, Potchefstroom, South Africa; [Zuma, Nonkululeko H.; Aucamp, Janine; N’Da, David D.] North West Univ, Ctr Excellence Pharmaceut Sci, ZA-2520 Potchefstroom, South Africa in 2021, Cited 32. Product Details of 177-11-7. The Name is 1,4-Dioxa-8-azaspiro[4.5]decane. Through research, I have a further understanding and discovery of 177-11-7

Currently available drugs being used to treat leishmaniasis have several shortcomings, including high toxicity, drug administration that requires hospitalization, and the emergence of parasite resistance against clinically used drugs. As a result, there is a dire need for the development of new antileishmanial drugs that are safe, affordable, and efficient. In this study, two new series of synthesized quinazolinone derivatives were investigated as potential future antileishmanial agents, by assessing their activities against theLeishmania(L.)donovaniandL. majorspecies. The cytotoxicity profiles of these derivatives were assessed in vitro on Vero cells. The compounds were found to be safer and without any toxic activities against mammalian cells, compared to the reference drug, halofuginone, a clinical derivative of febrifugine. However, they had demonstrated poor antileishmanial growth inhibition efficacies. The two compounds that had been found the most active were the mono quinazolinone2dand the bisquinazolinone5bwith growth inhibitory efficacies of 35% and 29% for theL. majorandL. donovani9515 promastigotes, respectively. These outcomes had suggested structural redesign,inter aliathe inclusion of polar groups on the quinazolinone ring, to potentially generate novel quinazolinone derivatives, endowed with effective antileishmanial potential.

Product Details of 177-11-7. Bye, fridends, I hope you can learn more about C7H13NO2, If you have any questions, you can browse other blog as well. See you lster.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem

Formula: C7H13NO2. I found the field of Chemistry very interesting. Saw the article Expanding Reactivity in DNA-Encoded Library Synthesis via Reversible Binding of DNA to an Inert Quaternary Ammonium Support published in 2019, Reprint Addresses Baran, PS; Dawson, PE (corresponding author), Scripps Res, Dept Chem, 10550 North Torrey Pines Rd, La Jolla, CA 92037 USA.. The CAS is 177-11-7. Through research, I have a further understanding and discovery of 1,4-Dioxa-8-azaspiro[4.5]decane.

DNA Encoded Libraries have proven immensely powerful tools for lead identification. The ability to screen billions of compounds at once has spurred increasing interest in DEL development and utilization. Although DEL provides access to libraries of unprecedented size and diversity, the idiosyncratic and hydrophilic nature of the DNA tag severely limits the scope of applicable chemistries. It is known that biomacromolecules can be reversibly, noncovalently adsorbed and eluted from solid supports, and this phenomenon has been utilized to perform synthetic modification of biomolecules in a strategy we have described as reversible adsorption to solid support (RASS). Herein, we present the adaptation of RASS for a DEL setting, which allows reactions to be performed in organic solvents at near anhydrous conditions opening previously inaccessible chemical reactivities to DEL. The RASS approach enabled the rapid development of C(sp(2))-C(sp(3)) decarboxylative cross couplings with broad substrate scope, an electrochemical amination (the first electrochemical synthetic transformation performed in a DEL context), and improved reductive amination conditions. The utility of these reactions was demonstrated through a DEL-rehearsal in which all newly developed chemistries were orchestrated to afford a compound rich in diverse skeletal linkages. We believe that RASS will offer expedient access to new DEL reactivities, expanded chemical space, and ultimately more drug-like libraries.

Formula: C7H13NO2. Welcome to talk about 177-11-7, If you have any questions, you can contact Flood, DT; Asai, S; Zhang, XJ; Wang, J; Yoon, L; Adams, ZC; Dillingham, BC; Sanchez, BB; Vantourout, JC; Flanagan, ME; Piotrowsld, DW; Richardson, P; Green, SA; Shenvi, RA; Chen, JS; Baran, PS; Dawson, PE or send Email.

Reference：
Piperidine – Wikipedia,
Piperidine | C5H7510N – PubChem