Tag: M.W:0-100

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Ye, Suhui, once mentioned the application of 41661-47-6, Name is Piperidin-4-one, molecular formula is C5H9NO, molecular weight is 99.1311, MDL number is MFCD00955709, category is piperidines. Now introduce a scientific discovery about this category, Name: Piperidin-4-one.

New Insights into the Biosynthesis Pathway of Polyketide Alkaloid Argimycins P in Streptomyces argillaceus

Argimycins P are a recently identified family of polyketide alkaloids encoded by the cryptic gene cluster arp of Streptomyces argillaceus. These compounds contain either a piperideine ring, or a piperidine ring which may be fused to a five membered ring, and a polyene side chain, which is bound in some cases to an N-acetylcysteine moiety. The arp cluster consists of 11 genes coding for structural proteins, two for regulatory proteins and one for a hypothetical protein. Herein, we have characterized the post-piperideine ring biosynthesis steps of argimycins P through the generation of mutants in arp genes, the identification and characterization of compounds accumulated by those mutants, and cross-feeding experiments between mutants. Based in these results, a biosynthesis pathway is proposed assigning roles to every arp gene product. The regulation of the arp cluster is also addressed by inactivating/overexpressing the positive SARP-like arpRI and the negative TetR-like arpRII transcriptional regulators and determining the effect on argimycins P production, and through gene expression analyses (reverse transcription PCR and quantitative real-time PCR) of arp genes in regulatory mutants in comparison to the wild type strain. These findings will contribute to deepen the knowledge on the biosynthesis of piperidine-containing polyketides and provide tools that can be used to generate new analogs by genetic engineering and/or biocatalysis.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Related Products of 41661-47-6, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 41661-47-6, Name is Piperidin-4-one, SMILES is O=C1CCNCC1, belongs to piperidines compound. In a article, author is Mohamadpour, Farzaneh, introduce new discover of the category.

Green and Convenient One-Pot Access to Polyfunctionalized Piperidine Scaffolds via Glutamic acid Catalyzed Knoevenagel- Intramolecular [4+2] aza-Deils-Alder Imin-Based Multi-Component Reaction Under Ambient temperature

A catalytic methodology is reported that enables the green, operationally simple and convenient synthesis of corresponding polyfunctionalized piperidine scaffolds via one-pot Knoevenagel- intramolecular [4+2] aza-Diels-Alder imin-based multi-component reaction of between beta-ketoesters, aromatic aldehydes and various amines, including some relevant drugs and pharmacologically active derivatives in the presence of biologically active alpha-amino acid, glutamic acid as a green and biodegradable catalyst. Remarkable E factors, green, readily and inexpensive catalyst, short reaction times, high to excellent yields, mild reaction conditions, high atom-economy and easy isolation procedures are key features of this methodology.

Related Products of 41661-47-6, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 41661-47-6.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry, like all the natural sciences, Recommanded Product: 41661-47-6, begins with the direct observation of nature¡ª in this case, of matter.41661-47-6, Name is Piperidin-4-one, SMILES is O=C1CCNCC1, belongs to piperidines compound. In a document, author is Chaudhari, Prashant P., introduce the new discover.

CLEAN SYNTHESIS AND ANTIMICROBIAL INTERPRETATION OF AZO (DIPYRANO) AND BIS-CHALCONES DERIVATIVES FROM N-PHENYL PYRROLIDINE-2,5-DIONE AND N-PHENYL PIPERIDINE-2,6-DIONE

The solvent-free synthesis ofAzo (Dipyrano) derivatives was carried out with the help ofPbO nanoparticles. They have been employed as an efficient catalyst (yields 81-91%) at room temperature using green chemistry and clean approach. PbO nanoparticles were established to be highly efficient, renewable and eco-friendly heterogeneous catalyst. PbO nanoparticles were prepared by hydro-thermal method. In the same mannera simple eco-friendly microwave instigated solvent free synthesis of bis-chalcones was carried out by the reaction of1-(3chlorophenyl) ethan-1-one with different substituted N-phenylpyrrolidine-2,5-dione orN-phenyl piperidine-2,6-dione in presence of neutral corundum(yields 85-90%). All the derivatives were characterized and interpreted for antimicrobial potencies.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 41661-47-6. Recommanded Product: 41661-47-6.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Application In Synthesis of Piperidin-4-one, 41661-47-6, Name is Piperidin-4-one, SMILES is O=C1CCNCC1, belongs to piperidines compound. In a document, author is Volkova, M. A., introduce the new discover.

Solvation of Piperidine in Nonaqueous Solvents

The enthalpies of solvation of piperidine (Ppd) in methanol (MeOH), ethanol (EtOH), N,N-dimethylformamide (DMF), and dimethylsulfoxide (DMSO) are calculated by means of quantum-chemical modeling. The enthalpies of solvation of Ppd in EtOH and DMF are determined calorimetrically. The energies of Ppd solvation in aprotic solvents is found to be generally governed by universal types of interactions between amine and solvent molecules. The energy contributions from both universal and specific types of interactions to the overall enthalpy of Ppd solvation are determined in amphoteric MeOH and EtOH.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 41661-47-6. Application In Synthesis of Piperidin-4-one.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

41661-47-6, Name is Piperidin-4-one, molecular formula is C5H9NO, belongs to piperidines compound, is a common compound. In a patnet, author is Li, Yanping, once mentioned the new application about 41661-47-6, Category: piperidines.

Identification of the metabolites of piperine via hepatocyte incubation and liquid chromatography combined with diode-array detection and high-resolution mass spectrometry

Rationale Piperine, an alkaloid isolated from Piper nigrum L., has been demonstrated to have many pharmacological effects and several health benefits. The aim of this work was to study the metabolic profiles of piperine in mouse, rat, dog and human hepatocytes. Methods The biotransformation was carried out by incubating piperine with hepatocytes at 37 degrees C. After incubation for 2 h, the samples were pretreated and analyzed using liquid chromatography combined with diode-array detection and high-resolution mass spectrometry (LC/DAD-HRMS). The structures of the metabolites were assigned through a comparison of their accurate masses and product ions with those of the parent compound. Results A total of 20 metabolites were detected, and the structures were proposed. Piperine was metabolized through the following pathways: (a) oxidation to form a catechol derivative, which further underwent methylation, glucuronidation, glutathione (GSH) conjugation, and hydroxylation followed by opening of the piperidine ring; (b) hydroxylation to form a carbinolamine intermediate followed by opening of the piperidine ring and the formation of alcohol and acid derivatives; and (c) hydroxylation to form stable hydroxylated metabolites. In mouse, the formation of the catechol derivative (M12) and hydroxylation (M11) were the major metabolic pathways; in rat, the formation of the catechol derivative (M12) and glucuronidation (M9) were the main pathways; and in dog and human, the formation of the catechol derivative (M12) was the predominant pathway. No human-specific metabolite was observed. Conclusions This study provided some new information on the metabolic profiles of piperine, which should be of great importance in the study of the pharmacology and toxicity of this compound.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 41661-47-6. The above is the message from the blog manager. Category: piperidines.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Formula: C4H6N2O, 108-26-9, Name is 3-Methyl-1H-pyrazol-5(4H)-one, molecular formula is C4H6N2O, belongs to piperidines compound. In a document, author is Virjamo, Virpi, introduce the new discover.

1,6-Dehydropinidine Is an Abundant Compound in Picea abies (Pinaceae) Sprouts and 1,6-Dehydropinidine Fraction Shows Antibacterial Activity against Streptococcus equi Subsp. equi

Knowledge about the defensive chemistry of coniferous trees has increased in recent years regarding a number of alkaloid compounds; in addition to phenolics and terpenes. Here, we show that Norway spruce (Picea abies (L.) H. Karst.), an important boreal zone tree species; accumulates 1,6-dehydropinidine (2-methyl-6-(2-propenyl)-1,6-piperideine) in its needles and bark. We reanalyzed previously published GC-MS data to obtain a full picture of 1,6-dehydropinidine in P. abies. 1,6-dehydropinidine appeared to especially accumulate in developing spring shoots. We used solid-phase partitioning to collect the alkaloid fraction of the sprouts and thin-layer chromatography to purify 1,6-dehydropinidine. The antibacterial properties of the 1,6-dehydropinidine fraction were tested using a broth microdilution method; with Streptococcus equi subsp. equi as a model organism. Based on our results 1,6-dehydropinidine is common in alkaloid extractions from P. abies (0.4 +/- 0.03 mg g(-1) dw in mature needles) and it is especially abundant in young spruce shoots (2.7 +/- 0.5 mg g(-1) dw). Moreover; 1,6-dehydropinidine extracted from P. abies sprouts showed mild antibacterial potential against Streptococcus equi subsp. equi (MIC 55 mu g mL(-1)). The antibacterial activity of a plant compound thought of as an intermediate rather than an end-product of biosynthesis calls for more detailed studies regarding the biological function of these coniferous alkaloids

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 108-26-9. Formula: C4H6N2O.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 41661-47-6, Name is Piperidin-4-one, molecular formula is C5H9NO. In an article, author is Di Martino, Simona,once mentioned of 41661-47-6, Formula: C5H9NO.

Lead Optimization of Benzoxazolone Carboxamides as Orally Bioavailable and CNS Penetrant Acid Ceramidase Inhibitors

Sphingolipids (SphLs) are a diverse class of molecules that are regulated by a complex network of enzymatic pathways. A disturbance in these pathways leads to lipid accumulation and initiation of several SphL-related disorders. Acid ceramidase is one of the key enzymes that regulate the metabolism of ceramides and glycosphingolipids, which are important members of the SphL family. Herein, we describe the lead optimization studies of benzoxazolone carboxamides resulting in piperidine 22m, where we demonstrated target engagement in two animal models of neuropathic lysosomal storage diseases (LSDs), Gaucher’s and Krabbe’s diseases. After daily intraperitoneal administration at 90 mg kg(-1), 22m significantly reduced the brain levels of the toxic lipids glucosylsphingosine (GluSph) in 4L;C* mice and galactosylsphingosine (GalSph) in Twitcher mice. We believe that 22m is a lead molecule that can be further developed for the correction of severe neurological LSDs where GluSph or GalSph play a significant role in disease pathogenesis.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Application of 108-26-9, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 108-26-9, Name is 3-Methyl-1H-pyrazol-5(4H)-one, SMILES is O=C1CC(C)=NN1, belongs to piperidines compound. In a article, author is Al-Ghorbani, Mohammed M. Abdullah, introduce new discover of the category.

Synthesis and Biological Evaluations of Some New Oxadiazole-piperidine Hybrid Derivatives as Antioxidant Agents

A series of some new 1,3,4-oxadiazole-2-thiol derivatives (6a-h) containing cyclic secondary amine such as piperidine ring was expeditiously synthesized by alkylation of 1,3,4-oxadiazol-2-thiol derivatives with chloroethyl piperidine hydrochloride. The 1,3,4-oxadiazole-2-thiols were effectively synthesized by cyclization reaction of acid hydrazide derivatives with carbon disulfide. The target compounds 6a-h were preliminarily screened for in vitro antioxidant activities using various in vitro antioxidant assays including 2,2′-diphenyl-1-picrylhydrazyl, nitric oxide, and hydrogen peroxide methods. The results showed that the compounds exhibited promising antioxidant property in the three methods at 50, 75, and 100 mu M. Among the tested compounds, the compounds 6a and 6b having chloro substituent in the benzene ring displayed greater radical scavenging activity. [GRAPHICS]

Application of 108-26-9, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 108-26-9 is helpful to your research.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 108-26-9, Name is 3-Methyl-1H-pyrazol-5(4H)-one, molecular formula is C4H6N2O. In an article, author is Pinheiro, Danilo da Silva,once mentioned of 108-26-9, Name: 3-Methyl-1H-pyrazol-5(4H)-one.

Microreactor Technology as a Tool for the Synthesis of a Glitazone Drug Intermediate

One of the bottlenecks in the pharmaceutical industry is drug production scale-up, which can be performed by microreactor technology. Such an approach was applied to the synthesis of (Z)-5-(4-hydroxybenzylidene)thiazolidine-2,4-dione, a bioactive aromatic heterocyclic compound belonging to the class of glitazones. n-Propanol was the best solvent and piperidine the best catalyst for the batch reaction, which was completed in only 5.5h. In the microreactor, the productivity was almost independent of solvent. The microreactor behaved as a plug-flow reactor and operated at a steady state for ten hours without efficiency loss. The results suggest that microreactors may replace batch reactors in scaling up drug production.

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Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem

 

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 41661-47-6, Name is Piperidin-4-one, molecular formula is C5H9NO, belongs to piperidines compound. In a document, author is Choi, Na Rae, introduce the new discover, Category: piperidines.

Winter-time particulate nitrosamines and nitramines in the atmosphere at seoul, South Korea

Nitrosamines and nitramines are groups of chemical compounds containing nitroso (N-NO) and nitro (N-NO2) functional groups, respectively. They exert detrimental effects on our health. Simultaneous analysis of 7 nitrosamines and 3 nitramines present in atmospheric particulate matter with an aerodynamic diameter less than or equal to the nominal value of 2.5 mu m (PM2.5) at Seoul in the winter of 2018 was undertaken using gas chromatography/tandem mass spectrometry (GC/MS-MS). The daily average concentrations of nitrosamines and nitramines during the sampling period were 9.75. 17.77 ng/m(3) (0.06-54.72 ng/m(3)) and 0.68. 0.56 ng/m(3) (0.08-2.40 ng/m(3)), respectively. The concentrations of nitramines in the atmosphere were reported in this study for the first time and could not be compared. Among the nitrosamines, nitrosodi-methylamine (NDMA) concentrations observed in this study were high and comparable to that observed at the area with emission sources (Zonguldak, Turkey) and higher than that in an urban area (North Kensington, UK). Concentrations of other nitrosamines such as nitrosodi-ethylamine (NDEA), nitrosodi-butylamine (NDBA), nitroso-piperidine (NPIP), nitroso-pyrrolidine (NPYR), and nitrosodi-propylamine (NDPA) were similar to or lower than those noted in urban areas in the previous studies. In order to determine the relative importance of primary emissions and secondary reactions, statistical analyses such as correlation and multivariance analysis were carried out. Multivariance analysis results showed that secondary reaction might affect to the formation of the nitrosamines and nitramines in the atmosphere more than the primary emission. Furthermore, the high correlations of the nitrosamines and nitramines with HONO and NO supported the possibility of the high contribution of the secondary reactions producing the nitrosamines and nitramines.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 41661-47-6. Category: piperidines.

Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem