Tag: M.W:0-100

675-20-7, Piperidin-2-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

The preparation was carried out in an inert atmosphere (argon). Ethyl 6-(4-iodophenyl)-l-(4- methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate (536 mg; 1.04 mmol) was dissolved in 5 ml of cyclopentyl methyl ether in a 10 ml sealable pressure container. Piperidin-2-one (128 mg; 1.30 mmol), Cul (10 mg; 0.052 mmol), K3PO4 (440 mg; 2,1 mmol) and N,N’-dimethylethylenediamine (37 mg; 0.42 mmol) were added. A stirrer was inserted in the container and it was closed under an inert atmosphere. Being stirred by a magnetic stirrer the mixture was heated up in an oil bath to 110 C for 6 h. After cooling the reaction mixture was diluted with a solvent, the solid salts were isolated by filtration and thoroughly washed on the filter. The filtrate was concentrated and the crude product was obtained in the yield of 84%.

675-20-7, 675-20-7 Piperidin-2-one 12665, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; ZENTIVA, K.S.; HEJTMANKOVA, Ludmila; JIRMAN, Josef; WO2014/75648; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.675-20-7,Piperidin-2-one,as a common compound, the synthetic route is as follows.

10300] To a solution of compound 1 (31.00 g, 312.72 mmol) in CH3CN (500 mE) was added TEA (63.29 g, 625.44 mmol), 13oc20 (88.73 g, 406.54 mmol), DMAP (1.91 g, 15.64 mmol) in portions under N2. The mixture was stirred at 18 C. for 16 hours. TLC showed the reaction was completed. The mixture was concentrated in reduced pressure at 35 C. The residue was purified by silica gel chromatography (PE/EA30/1 to 5/1) to afford compound 2 (41.90 g, 210.29 mmol, 67.25% yield) as yellow oil. LCMS:200 [M+1]., 675-20-7

675-20-7 Piperidin-2-one 12665, apiperidines compound, is more and more widely used in various fields.

Reference£º
Patent; Novira Therapeutics, Inc.; Hartman, George D.; Kuduk, Scott; (85 pag.)US2016/272599; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem