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Compounds of general formula (I) in which:A represents a hydrogen atom, a hydroxyl, a C1-3 alkoxy group, a hydroxy(C1-6 alkyl) group, a (C1-3 alkoxy)(C1-3 alkyl) group, a thiol, (C1-6 alkyl)sulfanyl or a halogen;B and D represent, independently of one another, a hydrogen atom, a C1-6 alkyl group, a fluoro(C1-6 alkyl) group or a perfluoro(C1-2 alkyl) group or B and D together from an oxo;R1 represents a phenyl, a naphthyl or a heteroaryl comprising 4 or 5 carbon atoms;R2 and R3 represent, independently of one another, a hydrogen atom, a halogen or a C1-6 alkyl group,R4 represents a hydrogen atom, a hydroxyl or a halogen, andR5 and R6 represent, independently of one another, a hydrogen atom, a C1-6 alkyl group, a C2-6 alkenyl group, a C3-6 cycloalkyl group, a C3-6 cycloalkenyl group, a fluoro(C1-6 alkyl) group or a perfluoro(C1-2 alkyl) group or R5 and R6 together form a C2-6 alkylene chain or a C3-6 alkenylene chain, to give, with the nitrogen to which they are attached, a heterocycle, this heterocycle optionally being substituted by a C1-4 alkyl group; and their salts.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H507N – PubChem

 

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The invention also discloses a 2 – synthesis method thereof, and an application of the compound as an antibacterial agent, in the phthisis-caused by the bacterium, in particular to the, mycobacterium-induced infectious disease (especially (Tuberculosis,TB), mycobacterium- induced mycobacterium, tuberculosis), and (I) the invention, specifically relates to a pharmaceutical composition containing the compound of the present invention or, a R pharmaceutical composition comprising the compound of the present invention. 1 , R2 , R3 , R4 , R5 As described Y in the present invention. as described in the specification, the present invention is directed, to the preparation of novel compounds, having an anti-mycobacterial activity as potential, new drug (s) for the treatment (TB) or preventative treatment of infectious diseases, consisting of M. tuberculosis, in particular phthisis- caused by tubercular mycobacteria, while being useful in overcoming the problems associated with drug resistance. (by machine translation)

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Piperidine – Wikipedia,
Piperidine | C5H170N – PubChem

 

17-Sep News Some scientific research about 41661-47-6

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The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to treat subjects with Sjogren’s syndrome, or diffuse intrinsic pontine glioma (DIPG).

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H127N – PubChem

 

Sep 2021 News Extracurricular laboratory:new discovery of 41661-47-6

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The invention relates to new piperidino-dihydrothienopyrimidines of formula 1, as well as pharmacologically acceptable salts thereof, wherein X is SO or SO2 , but preferably SO, and wherein R1, R2, R3 and R4 may have the meanings given in claim 1, as well as pharmaceutical compositions which contain these compounds. These new piperidino-dihydrothienopyrimidines are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin or eyes, diseases of the peripheral or central nervous system or cancers.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H154N – PubChem

 

13/9/2021 News Archives for Chemistry Experiments of 41661-47-6

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N-monosubstituted 4-aminopiperidine is prepared by a process comprising, in a single stage, continuously passing a 4-oxopiperidine and a primary amine over a metal hydrogenation catalyst under a hydrogen partial pressure of 1-500 bar at a LHSV of up to 1 hr-1.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H253N – PubChem

 

13-Sep-2021 News Discovery of 41661-47-6

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A series of novel five- and six-membered ring urea derivatives have been described as potent and selective NK1 receptor antagonists. Several compounds in this series exhibited good oral activity and brain penetration. Syntheses of these compounds are also described herein.

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Piperidine – Wikipedia,
Piperidine | C5H393N – PubChem

 

9-Sep-2021 News Simple exploration of C5H9NO

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The use of tert-butyl(3-cyano-4,6-dimethylpyridin-2-yl)carbonate as a chemoselective tert-butoxycarbonylation reagent for aromatic and aliphatic amines has been demonstrated. To gain insight into this reaction, in situ React IR technology was used to confirm the effectivity and chemoselectivity of this novel Boc reagent. The reaction was carried out chemoselectively in high yield under mild, environment-friendly conditions and was completed quickly within 1 hour. Simultaneously, the Boc carrier was easily recyclable, and has great application prospects for industrial production.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H78N – PubChem

 

Sep 2021 News The important role of 41661-47-6

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Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 41661-47-6, molcular formula is C5H9NO, introducing its new discovery. Application In Synthesis of 4-Piperidinone

1,3-Dimethyl-2,6-diphenylpiperidin-4-one N(4?)-cyclohexylsemicarbazone (DDPCS) has been synthesized and characterized by IR, 1H NMR and 13C NMR spectral analysis. IR and NMR spectra of compound DDPCS have been simulated by computational method using DFT-B3LYP with the 6?31 G basis set. Single crystal X-ray diffraction analysis has been performed and it evidences the configuration about C=N double bond is ?E ?and the chair conformation of the heterocyclic ring. The N?H????O intermolecular hydrogen bonding in the crystal structure forms an eight membered pseudo ring with the R2 2 (8), Etter’s graph set. The computational, spectral and X-ray structural results exemplifies the chair conformation of the heterocyclic ring with the equatorial orientation of bulky groups. The calculated vibrational frequencies of the normal modes accorded well with the experimental values. Hirshfeld surface analysis was also carried out and discussed in detail. The synthesized compound was screened for its in vitro antimicrobial activity.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H463N – PubChem

 

07/9/2021 News The Absolute Best Science Experiment for 41661-47-6

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Compounds of formula (I): or pharmaceutically acceptable salts thereof, are GPCR agonists and are useful as for the treatment of obesity and diabetes.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H331N – PubChem

 

6-Sep-2021 News Extracurricular laboratory:new discovery of 41661-47-6

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The structural similarity between an MmpL3 inhibitor BM212, and a cannabinoid receptor modulator rimonabant, prompted us to investigate the anti-tubercular activity of rimonabant and its analogues. Further optimization, particularly through incorporation of silicon into the scaffold, resulted in new compounds with significant improvement in anti-tubercular activity against Mycobacterium tuberculosis (H37Rv). The sila analogue 18a was found to be the most potent antimycobacterial compound (MIC, 31 ng/mL) from this series with an excellent selectivity index.

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Reference:
Piperidine – Wikipedia,
Piperidine | C5H92N – PubChem