Ionic liquids as stationary phase solvents for methylated cyclodextrins in gas chromatography was written by Berthod, A.;He, L.;Armstrong, D. W.. And the article was included in Chromatographia in 2001.Product Details of 1722-95-8 This article mentions the following:
Room temperature ionic liquids (RTIL) are molten salts with m.ps. well below room temperature 1-Butyl-3-methylimidazolium chloride is a typical example of such RTIL. It was used as a solvent to dissolve permethylated-尾-cyclodextrin (BPM) and dimethylated-尾-cyclodextrin (BDM) to prepare stationary phases for capillary columns in gas chromatog. for chiral separation The RTIL containing columns were compared to com. columns containing the same chiral selectors. A set of 64 chiral compounds separated by the com. BPM column was tested on the RTIL BPM column. Only 21 were enantioresolved. Similarly, a set of 80 compounds separated by the com. BDM column was passed on the RTIL BDM column with only 16 pos. separations Probably the imidazolium ion pair could make an inclusion complex with the cyclodextrin cavity, blocking it for chiral recognition. All the chiral compounds recognized by the RTIL columns had their asym. carbon that was part of a ring structure. The retention factors of the derivatized solutes were lower on the RTIL columns than those obtained on the com. equivalent column. The peak efficiencies obtained with the RTIL capillary were significantly higher than that obtained with the com. column. These observations may contribute to the knowledge of the mechanism of cyclodextrin-based GC enantioselective separations In the experiment, the researchers used many compounds, for example, (R)-2-Methylpiperidine (cas: 1722-95-8Product Details of 1722-95-8).
(R)-2-Methylpiperidine (cas: 1722-95-8) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Product Details of 1722-95-8
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem