Tag: 91419-48-6

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.91419-48-6,tert-Butyl 4-carbamoylpiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

91419-48-6, To a solution of tert-butyl 4-carbamoylpiperidine-1-carboxylate (160 mg, 0.7 mmol) in DCM (2 mL) was added a HCl in EtOAc solution (4 M, 2 mL) . The mixture was stirred at rt for 30 min and concentrated to give the title compound as a white solid (112 mg, 97) .1H NMR (400 MHz, CD3OD) : delta ppm 3.33-3.39 (m, 2H) , 2.95-3.24 (m, 2H) , 2.50-2.58 (m, 1H) , 1.95-1.99 (m, 2H) , 1.76-1.87 (m, 2H) and MS-ESI: m/z 129.20 [M+H-HCl] +.

As the paragraph descriping shows that 91419-48-6 is playing an increasingly important role.

Reference£º
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; LIU, Bing; YU, Tianzhu; ZHANG, Xiangyu; ZHANG, Shiguo; ZHANG, Jiancun; CHENG, Changchung; (426 pag.)WO2016/34134; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.91419-48-6,tert-Butyl 4-carbamoylpiperidine-1-carboxylate,as a common compound, the synthetic route is as follows.,91419-48-6

The amide (20 g, 76.3 mmol) was dissolved in 1,4-dioxane with heating and the clear solution placed in a 60 0C oil bath. Lawesson’s Reagent was added (15.43 g, 38.15 mmol) and the solution stirred for 2 hours. The solution was cooled to RT, poured into 8:1 water : saturated NaHCO3, followed by aqueous/EtOAc work-up and silica gel chromatography (EtOAc : hexanes (1:4)) to give the titled compound.

The synthetic route of 91419-48-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; MERCK & CO., INC.; WO2007/64553; (2007); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

91419-48-6, tert-Butyl 4-carbamoylpiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

4-CARBAMOYL-PIPERIDINE-L-CARBOXYLIC acid TERT-BUTYL ester (2) (45.4 g, 0.199 mol), Lawesson’s reagent (40.2 g, 0.099 mol, 0.5 equiv), 1,2-dimethoxyethane (DME) (500 mL) and chloroform (200 mL) were combined and stirred at room temperature. The course of the reaction was followed by tlc analysis (30% ethyl ACETATE/HEXANE) and on completion the reaction mixture was evaporated to dryness (glassy solid). The solid was dissolved in ethyl acetate and washed with half saturated potassium carbonate solution, dried (MGSO4), filtered and concentrated to yield the title compound as a colourless solid. The crude product was crystallised from ethyl acetate and hexane to give the title compound (3) (35 g, 0.14 mol, 72%).

As the paragraph descriping shows that 91419-48-6 is playing an increasingly important role.

Reference£º
Patent; METRIS THERAPEUTICS LIMITED; WO2004/58750; (2004); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

91419-48-6, tert-Butyl 4-carbamoylpiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

under room temperature, nitrogen protection, (27.36g, 0 . 12mol, 1eq), laurance reagent (24.26g, 0 . 06mol, 0 . 5eq), mixed, added into the 1,4-dioxane 250 ml, the mixing tabs 50 C, 4h. Quality monitoring, after the reaction is complete. The reaction system can be obtained direct turns on lathe does target product 51. 86g crude product (containing laurance reagent decay product), purity 50%. The crude product of viscosity is very high bombycinous oily liquid.

The synthetic route of 91419-48-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Beijing Agricultural High-tech R & D Center Deere music; Beijing Century Dade Environmental Protection Technology Co., Ltd.; Yang, Fangli; (17 pag.)CN105541830; (2016); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem