87120-72-7, tert-Butyl 4-aminopiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
87120-72-7, Method G:Example G-1 : [1 -(4-Acryloylamino-benzenesulfonyl)-piperidin-4-yl]-carbamic acid benzyl ester4-Benzyloxycarbonylamino-piperidine-1 -carboxylic acid tert-butyl ester[00456] Diisopropylethylamine (0.9ml, 5.5mmol) was added in one portion to a stirred solution of 4-amino-piperidine-1 -carboxylic acid tert-butyl ester (1 .0g, 5.0mmol) in THF (10ml) at room temperature. To this mixture was added benzyl chloroformate (0.78ml, 5.5mmol) drop wise and the mixture was stirred at room temperature under a nitrogen atmosphere for 18 hours. After this time the mixture was diluted with ethyl acetate (50ml) and washed with water (100ml), saturated NaHCO3 (100ml) and HCl (100ml, 2M). The organic layer was separated, dried (MgSO ), filtered and concentrated under vacuum. The resulting residue was purified by flash column chromatography (elution: 50% heptane, 50% ethyl acetate) to give the title compound (1 .2g, 73% yield) as a colourless oil. Tr = 2.08 min m/z (ES+) (M+ Na+) 357.
The synthetic route of 87120-72-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; CHDI, INC.; DOMINGUEZ, Celia; WITYAK, John; PRIME, Michael; COURTNEY, Stephen; YARNOLD, Christoper; BROOKFIELD, Frederick; MARSTON, Richard; MACDONALD, Douglas; WO2011/60321; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem