With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.622-26-4,2-(Piperidin-4-yl)ethanol,as a common compound, the synthetic route is as follows.
2-(Piperidin-4-yl)ethan-1-ol (3.00 g, 23.22 mmol) was dissolved in 30 mL dichloromethane. Di-tert-butyl dicarbonate (5.22 g, 23.92 mmol) was slowly added portionwise at 15 to 20 C. After that, the reaction mixture was stirred for 20 h at room temperature. The reaction mixture was slowly poured into 50 mL water after the reaction was complete as monitored by TLC. Then, the mixture was extracted with dichloromethane (50 mL¡Á2). The combined organic layer was dried over anhydrous sodium sulfate, filtered and the filtrate was concentrated under vacuum to give a residue. The residue was purified by column chromatography (Height: 250 mm, Diameter, 20 mm, 100-200 slica gel, petroleum/ethyl acetate=3:1, 1:1) to afford 2-(1-tert-butoxycarbonyl-4-piperidyl)ethanol (4.89 g, 91.83% yield) as a colorless liquid.
622-26-4 2-(Piperidin-4-yl)ethanol 73953, apiperidines compound, is more and more widely used in various.
Reference£º
Patent; MEDSHINE DISCOVERY INC.; DING, Charles Z.; SUN, Fei; WU, Lifang; DU, Jinhua; KATSU, Yasuhiro; HU, Guoping; LI, Jian; (46 pag.)US2018/148452; (2018); A1;,
Piperidine – Wikipedia
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