With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5570-78-5,1-Isopropylpiperidin-4-ol,as a common compound, the synthetic route is as follows.
General procedure: A solution of methyl 4-hydroxybenzoate derivatives 4a-4f (1 mmol), 1-substituted-4-piperidinol I-IV (1.3 mmol) and triphenylphosphine (1.5 mmol) in tetrahydrofuran (90 mL) was treated with diethyl azodicarboxylate (1.5 mmol) dropwise at 0 C. The mixture was left at 0 C for 15 min and stirred overnight at room temperature. After completion of the reaction, the reaction mixture was poured onto cold water, the resulting solution was extracted with dichloromethane, washed with brine, dried over Na2SO4, concentrated in vacuo and purified by flash chromatography. Thus the reaction of 4a-4f with various I, II, III and IV gave intermediates 5a-5i.
The synthetic route of 5570-78-5 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Nirogi, Ramakrishna; Shinde, Anil; Tiriveedhi, Vinaykumar; Kota, Laxman; Saraf, Sangram Keshari; Badange, Rajesh Kumar; Mohammed, Abdul Rasheed; Subramanian, Ramkumar; Muddana, Nageshwararao; Bhyrapuneni, Gopinadh; Abraham, Renny; European Journal of Medicinal Chemistry; vol. 108; (2016); p. 655 – 662;,
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