With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.55695-51-7,(4-Chlorophenyl)(piperidin-4-yl)methanone hydrochloride,as a common compound, the synthetic route is as follows.
To a stirred suspension of (4-chlorophenyl) (4-piperidyl) methanone hydrochloride [(100MG,] 0.41mmol) in DCM [(5ML)] was added triethylamine (104mg, 1. [03MMOL)] and 2- [BROMO-L- (2-THIENYL)-L-ETHANONE] (76mg, 0. [37MMOL).] The reaction was stirred at room temperature for 1 hour. The crude reaction mixture was transferred to a separating funnel and washed with 2M hydrochloric acid. The organic layer was separated and washed with water then evaporated to yield an impure solid. This material was partitioned between DCM and saturated sodium hydrogencarbonate solution. The organic layer was separated and washed with brine then dried [(MGS04),] filtered and evaporated to give a solid. This solid was dissolved in ether and treated with hydrochloric acid in ether. The resulting solid was filtered off to yield the product as a solid (24mg, 17%). NMR (DMSO-d6): 2.00 [(M,] 4H), 3.20 [(M,] 2H), 3.50 [(M,] 1H), 3.60 [(M,] 2H), 5.00 (s, 2H), 7.35 (s, 1H), 7.60 (d, 2H), 8.05 (d, 2H), 8.10 (s, 1H), 8.20 (d, [1H),] 10.20 (br s, 1H) ; m/z: 348.
The synthetic route of 55695-51-7 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/11410; (2004); A1;,
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