Tag: 538.1173

Interplay between spherical confinement and particle shape on the self-assembly of rounded cubes was written by Wang, Da;Hermes, Michiel;Kotni, Ramakrishna;Wu, Yaoting;Tasios, Nikos;Liu, Yang;de Nijs, Bart;van der Wee, Ernest B.;Murray, Christopher B.;Dijkstra, Marjolein;van Blaaderen, Alfons. And the article was included in Nature Communications in 2018.Quality Control of 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride This article mentions the following:

Self-assembly of nanoparticles (NPs) inside drying emulsion droplets provides a general strategy for hierarchical structuring of matter at different length scales. The local orientation of neighboring crystalline NPs can be crucial to optimize for instance the optical and electronic properties of the self-assembled superstructures. By integrating experiments and computer simulations, we demonstrate that the orientational correlations of cubic NPs inside drying emulsion droplets are significantly determined by their flat faces. We analyze the rich interplay of positional and orientational order as the particle shape changes from a sharp cube to a rounded cube. Sharp cubes strongly align to form simple-cubic superstructures whereas rounded cubes assemble into icosahedral clusters with addnl. strong local orientational correlations. This demonstrates that the interplay between packing, confinement and shape can be utilized to develop new materials with novel properties. In the experiment, the researchers used many compounds, for example, 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8Quality Control of 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Quality Control of 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Antiallergical effect of new combined nazal aerodisperse system in the conditions of experimental allergic rhinitis was written by Pozdnyakov, D. I.;Khadzieva, Z. D.;Pozdnyakova, A. E.;Zagorskaya, N. S.. And the article was included in Biomedical and Pharmacology Journal in 2019.Quality Control of 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride This article mentions the following:

To assess the severity of the anti-allergic effect of the combined nasal spray in the conditions of exptl. allergic rhinitis. The experiment was performed on Balb / c male mice, which reproduced ovalbumin-induced allergic rhinitis. The test-spray composition of fexofenadine hydrochloride + ammonium glycyrrhizinate in doses of 2.5 μg; 5 μg and 7.5 μg / nostril and compartion drugs: beclomethasone (<<Nasobec>>, IVAX Pharmaceuticals) and levocabastine (<<Tyzine Allergy>>, Johnson & Johnson) in doses of 3.5 μg / nostril and 5 μg / nostril resp., were administered intranasally after 14-day immunization of animals. On the 17th day of the experiment, the severity of nasal symptoms (sneezing and nasal grooming), the change in the concentration of histamine, IFN-α, IL-6, IgE, and TNF-α and markers of oxidative stress (superoxide dismutase activity and concentration of malonic dialdehyde) were determined The use of levocabastine and beclomethasone contributed to the reduction of allergic symptoms, with the most pronounced pharmacol. effect observed with the administration of beclomethasone. The administration of the 5 μg of test-spray reduced nasal symptoms in mice and also contributed to a decrease in the concentration of histamine, IFN-α, IL-6, IgE, and TNF-α, as well as the restoration of pro / antioxidant balance. At the same time, the test aerodisperse system at a dose of 5 μg was comparable to beclomethasone and exceeded levocabastine in terms of pharmacol. action. The high effectiveness of the test-spray, comparable to itranasal glucocorticoids, makes this compound a promising drug corrector of allergic rhinitis. In the experiment, the researchers used many compounds, for example, 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8Quality Control of 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising α-glucosidase inhibitors. The former are analogs of DNJ with an improved α-glucosidase inhibitory profile than that of DNJ. Boisson et al.Quality Control of 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Design and preparation of controlled floating gastroretentive delivery systems for enhanced fexofenadine hydrochloride oral bioavailability was written by Saab, May;Samy, Wael;Issa, Mohamed;El-Maradny, Hoda. And the article was included in Tropical Journal of Pharmaceutical Research in 2018.Computed Properties of C32H40ClNO4 This article mentions the following:

To design and prepare effervescent floating gastroretentive tablets for controlled fexofenadine hydrochloride (HCl) release and enhanced oral bioavailability. Various tablet formulations of the drug were prepared by direct compression. A systematic approach in the design of the formulations was adopted, where, first, formulations consisting of single polymers with a high polymer : sodium bicarbonate ratio were investigated for its physicochem. properties (in-vitro floating behavior, drug release profile, etc). Next, improvement of tablets′ properties was achieved by decreasing polymer : sodium bicarbonate ratio. The formulations were evaluated in vitro and in vivo in albino rabbits Results: The formulation consisting of hydroxypropyl methylcellulose K15M/hydroxypropyl methylcellulose K100LV at 1 : 2 ratio (F8) showed good floating properties (14 s floating lag time) with nearly zero order controlled drug release for 24 h (R2= 0.9876). In-vivo bioavailability studies of F8 in albino rabbits showed a significant increase in area under the curve (AUC, 134 %, p < 0.05) and hence an improvement in its oral bioavailability, compared to a com. conventional product. The good quality of the effervescent floating gastroretentive tablets of fexofenadine HCl develoral bioavailabilityoped is an indication that the approach used is suitable for the formulation of the drug for controlled drug release and enhanced oral bioavailabiliy. In the experiment, the researchers used many compounds, for example, 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8Computed Properties of C32H40ClNO4).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Computed Properties of C32H40ClNO4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Formulation and evaluation of mouth dissolving tablet of fexofenadine hydrocloride was written by Talsaniya, Mahendra B.;Dabhi, Mahesh R.;Sheth, Navin R.;Dudhrejiya, Ashvin V.. And the article was included in Pharma Science Monitor in 2017.Reference of 153439-40-8 This article mentions the following:

The purpose of current study was to enhance the solubility and dissolution rate of fexofenadine HCl by co-grinding with different diluents. Simplex lattice design was utilized in the present study. The amount of diluent- X1 (D-mannitol), X2 (lactose), X3 (MCC) were selected as independent variables. Average particle size (Y1), saturation solubility (Y2) and the amount of drug release in 5 min (Y3) were taken as the responses. In each diluent mixture, appropriate amount of fexofenadine HCl mixed. These mixtures were co-ground by ball mill for two different time intervals (3hrs and 6hrs). Prepared phys. mixtures and various co-ground mixtures were evaluated for different densities, flow property, average particle size, drug content, saturation solubility, in vitro dissolution study. From the results co-ground mixture ABII (D-mannitol, lactose and drug co ground for 6 h) was found to be optimized. FTIR and DSC study shows that there was no any interaction between drug and excipients. Contour plot, overlay contour and response surface plot of the variables were prepared by statistic-7. Mouth Dissolving Tablet of optimized co-ground mixture was prepared by direct compression method using sucralose as sweetener and crospovidone as superdisintegrant. Prepared MDTs were evaluated for different pre-compression parameters and different post-compression parameters. All evaluation parameters were passed by prepared MDTs. There was enhancement of solubility of fexofenadine HCl and dissolution rate thus the MDTs shown faster release. In the experiment, the researchers used many compounds, for example, 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8Reference of 153439-40-8).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising α-glucosidase inhibitors. The former are analogs of DNJ with an improved α-glucosidase inhibitory profile than that of DNJ. Boisson et al.Reference of 153439-40-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Interplay between spherical confinement and particle shape on the self-assembly of rounded cubes was written by Wang, Da;Hermes, Michiel;Kotni, Ramakrishna;Wu, Yaoting;Tasios, Nikos;Liu, Yang;de Nijs, Bart;van der Wee, Ernest B.;Murray, Christopher B.;Dijkstra, Marjolein;van Blaaderen, Alfons. And the article was included in Nature Communications in 2018.Quality Control of 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride This article mentions the following:

Self-assembly of nanoparticles (NPs) inside drying emulsion droplets provides a general strategy for hierarchical structuring of matter at different length scales. The local orientation of neighboring crystalline NPs can be crucial to optimize for instance the optical and electronic properties of the self-assembled superstructures. By integrating experiments and computer simulations, we demonstrate that the orientational correlations of cubic NPs inside drying emulsion droplets are significantly determined by their flat faces. We analyze the rich interplay of positional and orientational order as the particle shape changes from a sharp cube to a rounded cube. Sharp cubes strongly align to form simple-cubic superstructures whereas rounded cubes assemble into icosahedral clusters with addnl. strong local orientational correlations. This demonstrates that the interplay between packing, confinement and shape can be utilized to develop new materials with novel properties. In the experiment, the researchers used many compounds, for example, 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8Quality Control of 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Quality Control of 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Antiallergical effect of new combined nazal aerodisperse system in the conditions of experimental allergic rhinitis was written by Pozdnyakov, D. I.;Khadzieva, Z. D.;Pozdnyakova, A. E.;Zagorskaya, N. S.. And the article was included in Biomedical and Pharmacology Journal in 2019.Quality Control of 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride This article mentions the following:

To assess the severity of the anti-allergic effect of the combined nasal spray in the conditions of exptl. allergic rhinitis. The experiment was performed on Balb / c male mice, which reproduced ovalbumin-induced allergic rhinitis. The test-spray composition of fexofenadine hydrochloride + ammonium glycyrrhizinate in doses of 2.5 μg; 5 μg and 7.5 μg / nostril and compartion drugs: beclomethasone (<<Nasobec>>, IVAX Pharmaceuticals) and levocabastine (<<Tyzine Allergy>>, Johnson & Johnson) in doses of 3.5 μg / nostril and 5 μg / nostril resp., were administered intranasally after 14-day immunization of animals. On the 17th day of the experiment, the severity of nasal symptoms (sneezing and nasal grooming), the change in the concentration of histamine, IFN-α, IL-6, IgE, and TNF-α and markers of oxidative stress (superoxide dismutase activity and concentration of malonic dialdehyde) were determined The use of levocabastine and beclomethasone contributed to the reduction of allergic symptoms, with the most pronounced pharmacol. effect observed with the administration of beclomethasone. The administration of the 5 μg of test-spray reduced nasal symptoms in mice and also contributed to a decrease in the concentration of histamine, IFN-α, IL-6, IgE, and TNF-α, as well as the restoration of pro / antioxidant balance. At the same time, the test aerodisperse system at a dose of 5 μg was comparable to beclomethasone and exceeded levocabastine in terms of pharmacol. action. The high effectiveness of the test-spray, comparable to itranasal glucocorticoids, makes this compound a promising drug corrector of allergic rhinitis. In the experiment, the researchers used many compounds, for example, 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8Quality Control of 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising α-glucosidase inhibitors. The former are analogs of DNJ with an improved α-glucosidase inhibitory profile than that of DNJ. Boisson et al.Quality Control of 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Design and preparation of controlled floating gastroretentive delivery systems for enhanced fexofenadine hydrochloride oral bioavailability was written by Saab, May;Samy, Wael;Issa, Mohamed;El-Maradny, Hoda. And the article was included in Tropical Journal of Pharmaceutical Research in 2018.Computed Properties of C32H40ClNO4 This article mentions the following:

To design and prepare effervescent floating gastroretentive tablets for controlled fexofenadine hydrochloride (HCl) release and enhanced oral bioavailability. Various tablet formulations of the drug were prepared by direct compression. A systematic approach in the design of the formulations was adopted, where, first, formulations consisting of single polymers with a high polymer : sodium bicarbonate ratio were investigated for its physicochem. properties (in-vitro floating behavior, drug release profile, etc). Next, improvement of tablets′ properties was achieved by decreasing polymer : sodium bicarbonate ratio. The formulations were evaluated in vitro and in vivo in albino rabbits Results: The formulation consisting of hydroxypropyl methylcellulose K15M/hydroxypropyl methylcellulose K100LV at 1 : 2 ratio (F8) showed good floating properties (14 s floating lag time) with nearly zero order controlled drug release for 24 h (R2= 0.9876). In-vivo bioavailability studies of F8 in albino rabbits showed a significant increase in area under the curve (AUC, 134 %, p < 0.05) and hence an improvement in its oral bioavailability, compared to a com. conventional product. The good quality of the effervescent floating gastroretentive tablets of fexofenadine HCl develoral bioavailabilityoped is an indication that the approach used is suitable for the formulation of the drug for controlled drug release and enhanced oral bioavailabiliy. In the experiment, the researchers used many compounds, for example, 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8Computed Properties of C32H40ClNO4).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Computed Properties of C32H40ClNO4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Formulation and evaluation of mouth dissolving tablet of fexofenadine hydrocloride was written by Talsaniya, Mahendra B.;Dabhi, Mahesh R.;Sheth, Navin R.;Dudhrejiya, Ashvin V.. And the article was included in Pharma Science Monitor in 2017.Reference of 153439-40-8 This article mentions the following:

The purpose of current study was to enhance the solubility and dissolution rate of fexofenadine HCl by co-grinding with different diluents. Simplex lattice design was utilized in the present study. The amount of diluent- X1 (D-mannitol), X2 (lactose), X3 (MCC) were selected as independent variables. Average particle size (Y1), saturation solubility (Y2) and the amount of drug release in 5 min (Y3) were taken as the responses. In each diluent mixture, appropriate amount of fexofenadine HCl mixed. These mixtures were co-ground by ball mill for two different time intervals (3hrs and 6hrs). Prepared phys. mixtures and various co-ground mixtures were evaluated for different densities, flow property, average particle size, drug content, saturation solubility, in vitro dissolution study. From the results co-ground mixture ABII (D-mannitol, lactose and drug co ground for 6 h) was found to be optimized. FTIR and DSC study shows that there was no any interaction between drug and excipients. Contour plot, overlay contour and response surface plot of the variables were prepared by statistic-7. Mouth Dissolving Tablet of optimized co-ground mixture was prepared by direct compression method using sucralose as sweetener and crospovidone as superdisintegrant. Prepared MDTs were evaluated for different pre-compression parameters and different post-compression parameters. All evaluation parameters were passed by prepared MDTs. There was enhancement of solubility of fexofenadine HCl and dissolution rate thus the MDTs shown faster release. In the experiment, the researchers used many compounds, for example, 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8Reference of 153439-40-8).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid hydrochloride (cas: 153439-40-8) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising α-glucosidase inhibitors. The former are analogs of DNJ with an improved α-glucosidase inhibitory profile than that of DNJ. Boisson et al.Reference of 153439-40-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem