Tag: 52763-21-0

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.52763-21-0,Ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride,as a common compound, the synthetic route is as follows.

A solution of NaOMe in MeOH (23.6 g, 25% in MeOH, 0.109 mol) is added to a stirred solution of formamidine (4.02 g, 38.6 mmol) in MeOH (50 ml) at rt. The mixture is stirred for 15 min. Ethyl-3-oxo-N-benzylpiperidine-4-carboxylate hydrochloride (9.58 g, 32.2 mmol) is added and the mixture is stirred at rt overnight. Acetic acid (2.33 g, 38.5 mmol) is added and the solvent is removed in vacuo. Water (100 ml) is added to the residue and the solution is extracted with DCM (2 x 100 ml). The combined extracts are washed with brine (40 ml) and dried (Na2SO4), and the solvent is evaporated to provide the title compound as a yellow solid, which is used in the next step without further purification.

52763-21-0 Ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride 2723880, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; NEUROGEN CORPORATION; WO2007/146122; (2007); A2;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

52763-21-0, Ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

B. 7-Benzyl-5,6, 7, 8-tetrahydro-2- (morpholinomethyl) pyrido [3, 4-d] pyrimidin-4 (4aH)-one [00252] Ethyl N-benzyl-3-oxo-4-piperidinecarboxylate hydrochloride (2.98 g, 10 mmol) and 2-Morpholinoethane-1, 1-diamine (~ 20 mmol) were dissolved in the solution of sodium methoxide in methanol (12 mL, 25% wt) and stirred at 100 C in a sealed tube for 4 h. Solvent was removed in vacuo, residue was dissolved in water (100 mL) and was extracted by CHC13 and i- PrOH (3: 1,5 x 80 mL), dried over sodium sulfate. Solvent was removed in vacuo, brown solid residue was directly gone to next step.

52763-21-0 Ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride 2723880, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; RENOVIS, INC.; WO2005/66171; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem