Tag: 500-600

Comparative analysis of montelukast, levocetirizine, cetirizine & fexofenadine was written by Mansoor, Namia;Nadig, Ramya;Munoth, Rohan;Reddy, Vasavi;Kamdi, Yadini. And the article was included in World Journal of Pharmacy and Pharmaceutical Sciences in 2021.Formula: C32H39NO4 The following contents are mentioned in the article:

This article is an examination of the Comparative Anal. of Fexofenadine, Levocetirizine, Cetirizine and Montelukast. The scientific development and subsequent continues to influence researchers all over the globe today. This article examines the research done and published by researchers and scientists. Consideration of current trends and data in scientific queries and demonstrates further aspects of Comparative Anal. of Fexofenadine, Levocetirizine, Cetirizine and Montelukast. Addnl., this article explores options for therapeutic functions of the antihistamines while diving into allergenic issues as well. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Formula: C32H39NO4).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Formula: C32H39NO4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Impact of green tea intake on the pharmacokinetics of celiprolol in healthy subjects was written by Sonoda, Junichiro;Ogata, Kenji;Yoshikawa, Naoki;Sato, Keizo;Ikeda, Ryuji;Shimodozono, Yoshihiro. And the article was included in International Journal of Clinical Pharmacology and Therapeutics in 2021.Formula: C32H39NO4 The following contents are mentioned in the article:

To assess the effect of green tea intake on the pharmacokinetics of the β-blocker celiprolol. In an open-label crossover study, 3 healthy subjects were given water or a green tea beverage daily for 3 days. On day 4, each subject received a single oral dose of 200 mg celiprolol with water or green tea. Serum and urinary concentrations of celiprolol were measured for up to 24 h. Green tea intake decreased the area under the serum concentration-time curve and urinary excretion of celiprolol by 98.6 and 98.0%, resp. Green tea intake might have a neg. impact on the clin. effectiveness of celiprolol. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Formula: C32H39NO4).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Formula: C32H39NO4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Repeated idiopathic anaphylaxis caused by povidone was written by Bruusgaard-Mouritsen, Maria Anna;Mortz, Charlotte;Winther, Lone;Garvey, Lene Heise. And the article was included in Annals of Allergy, Asthma, & Immunology in 2021.Formula: C32H39NO4 The following contents are mentioned in the article:

Povidone, also known as polyvinylpyrrolidone (PVP) and E1201, is a synthetic, hydrophilic polymer used as an excipient in cosmetics, pharmaceutical products and food. It is used as a lubricant and antiseptic in eye drops and contact lenses and is found in the disinfectant povidone iodine (Betadine, Alcon Nordic, Copenhagen,Denmark). Allergy to povidone is rare but has been reported with increasing frequency. In this case report we present a case of allergy to povidone of a 49-yr-old man and was referred for allergy investigation in Jan. 2019 after repeated allergic reactions over a 10-yr period, diagnosed after repeated allergic reactions, over several years, to chem. unrelated drugs and idiopathic exposures. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Formula: C32H39NO4).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Formula: C32H39NO4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Effect of Nitric Oxide on the Functioning of the P-Glycoprotein Transporter was written by Abalenikhina, Yu. V.;Sudakova, E. A.;Slepnev, A. A.;Shchul′kin, A. V.;Yakusheva, E. N.. And the article was included in Bulletin of Experimental Biology and Medicine in 2022.Product Details of 83799-24-0 The following contents are mentioned in the article:

We studied the effect of nitric oxide (NO) on the functioning of P-glycoprotein transporter (Pgp) in Caco-2 cells. NO donor S-nitrosoglutathione (GSNO) was used in concentrations of 1, 10, 50, 100, and 500 μM; the duration of exposure was 24 h. The content of Pgp was analyzed by the Western blotting, activity of the transport protein was analyzed by the transport of its substrate fexofenadine. It was shown that GSNO in concentrations of 10 and 50 μM increased the content and activity of Pgp. Increasing the GSNO concentration to 500 μM led to the development of nitrosative stress and a decrease in the content and activity of the transporter protein. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Product Details of 83799-24-0).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Product Details of 83799-24-0

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

UHPLC-ESI-QTOF-MS analysis on Canthium coromandelicum stem was written by A., Anto Arockia Raj;J., Vinnarasi. And the article was included in Research Journal of Chemistry and Environment in 2021.Safety of 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid The following contents are mentioned in the article:

A rapid ultra high-performance liquid chromatog. coupled with crossover triple quadrupole time of flight mass spectrometry (UHPLC- ESI -QTOF-MS/MS) method has been developed for the identification of debasement products. According to the distinctive fragmentation patterns, the presence of 79 compounds with retention time between 1.05 to 26.81 min was found. In Canthium coromandelicum stem, 22 amino acids, 10 fatty acids, 6 alkaloids, 6 steroids, 2 flavonoids, 2 terpenoids, 2 phenolic, 4 lipids, 3 anthraquinone glycosides, sugars, vitamins were distinguished. These outcomes demonstrated that the contemporary technique has been utilized for quality control of Canthium coromandelicum, exceptionally for recognizable proof, verification and portrayal in medication arrangements. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Safety of 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Safety of 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Acute generalized exanthematous pustulosis induced by pseudoephedrine in a combination tablet with fexofenadine was written by Kusutani, Nao;Nishida, Marina;Sowa-Osako, Junko;Maekawa, Naoki;Fukai, Kazuyoshi. And the article was included in International Journal of Dermatology in 2021.Related Products of 83799-24-0 The following contents are mentioned in the article:

Acute generalized exanthematous pustulosis (AGEP) is a type of severe drug adverse reaction characterized by the acute development of numerous nonfollicular sterile pustules on a background of edematous erythema. A 52-yr-old otherwise healthy woman presented with diffuse erythema that gradually worsened over 4 days after administration of the second dose of fexofenadine (FEX)/pseudoephedrine (PSE) (Dellegra) combination tablet. A skin punch biopsy from the thigh revealed multiple subcorneal pustules with mildly acanthotic and spongiotic epidermis. Skin tests for PSE itself could not be performed because it was unavailable in a suitable form. The provocation test was not planned for fear of possible severe reactions. Here we report the first case of AGEP caused by FEX/PSE combination tablet. The patient was advised to avoid not only FEX/PSE medication but also PSE-containing OTC cold remedies and Kampo formulas. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Related Products of 83799-24-0).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Related Products of 83799-24-0

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Urticaria 12 days after COVID-19 mRNA booster vaccination was written by Wolfson, Anna R.;Freeman, Esther E.;Blumenthal, Kimberly G.. And the article was included in JAMA, the Journal of the American Medical Association in 2022.Name: 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid The following contents are mentioned in the article:

A healthy 27-yr-old woman received a COVID-19 mRNA booster vaccine (Moderna) on Dec. 7, 2021. She had not experienced adverse effects after the first 2 vaccine doses on Jan. 17 and Feb. 5, 2021. Twelve days after the booster vaccination, she developed pruritic wheals on her face and bilateral, transient eyelid swelling. The patient’s urticaria did not resolve with standard-dose fexofenadine (180 mg daily) or with 4 times the standard dose, so montelukast(10 mg nightly) and an addition almidday dose of 360 mg fexofenadine was added. Two weeks after receiving omalizumab,her dermatographism resolved. Fexofenadine was decreased to 180 mg twice daily and continued omalizumab monthly for a total of 3 doses. She was counseled to increase her dose of non-sedating antihistamines starting 3 days prior to another COVID-19 mRNA vaccination. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Name: 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Name: 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Potential COVID-19 Therapies from Computational Repurposing of Drugs and Natural Products against the SARS-CoV-2 Helicase was written by Piplani, Sakshi;Singh, Puneet;Winkler, David A.;Petrovsky, Nikolai. And the article was included in International Journal of Molecular Sciences in 2022.Recommanded Product: 83799-24-0 The following contents are mentioned in the article:

Repurposing of existing drugs is a rapid way to find potential new treatments for SARS-CoV-2. Here, we applied a virtual screening approach using Autodock Vina and mol. dynamic simulation in tandem to screen and calculate binding energies of repurposed drugs against the SARS-CoV-2 helicase protein (non-structural protein nsp13). Amongst the top hits from our study were antivirals, antihistamines, and antipsychotics, plus a range of other drugs. Approx. 30% of our top 87 hits had published evidence indicating in vivo or in vitro SARS-CoV-2 activity. Top hits not previously reported to have SARS-CoV-2 activity included the antiviral agents, cabotegravir and RSV-604; the NK1 antagonist, aprepitant; the trypanocidal drug, aminoquinuride; the analgesic, antrafenine; the anticancer intercalator, epirubicin; the antihistamine, fexofenadine; and the anticoagulant, dicoumarol. These hits from our in silico SARS-CoV-2 helicase screen warrant further testing as potential COVID-19 treatments. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0Recommanded Product: 83799-24-0).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising α-glucosidase inhibitors. The former are analogs of DNJ with an improved α-glucosidase inhibitory profile than that of DNJ. Boisson et al.Recommanded Product: 83799-24-0

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Effects of membrane transport activity and cell metabolism on the unbound drug concentrations in the skeletal muscle and liver of drugs: A microdialysis study in rats was written by Wang, Shuyao;Chen, Chun;Guan, Chi;Qiu, Liping;Zhang, Lei;Zhang, Shaofeng;Zhou, Hongyu;Du, Hongwen;Li, Chen;Wu, Yaqiong;Chang, Hang;Wang, Tao. And the article was included in Pharmacology Research & Perspectives in 2021.COA of Formula: C32H39NO4 The following contents are mentioned in the article:

The unbound concentrations of 14 com. drugs, including five non-efflux/uptake transporter substrates-Class I, five efflux transporter substrates-class II and four influx transporter substrates-Class III, were simultaneously measured in rat liver, muscle, and blood via microanal. Kpuu,liver and Kpuu,muscle were calculated to evaluate the membrane transport activity and cell metabolism on the unbound drug concentrations in the skeletal muscle and liver. For Class I compounds, represented by antipyrine, unbound concentrations among liver, muscle and blood are sym. distributed when compound hepatic clearance is low. And when compound hepatic clearance is high, unbound concentrations among liver, muscle and blood are asym. distributed, such as Propranolol. For Class II and III compounds, overall, the unbound concentrations among liver, muscle, and blood are asym. distributed due to a combination of hepatic metabolism and efflux and/or influx transporter activity. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0COA of Formula: C32H39NO4).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.COA of Formula: C32H39NO4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Effect of dietary-aged maize on growth performance, nutrient utilization, and serum metabolites in broilers was written by Tang, Defu;Du, Baolong;Yan, Ruxia;Chen, Zhigang;Nian, Fang. And the article was included in Animal Biotechnology.COA of Formula: C32H39NO4 The following contents are mentioned in the article:

In China, most maize used for animal diets is stored for long periods. We examined the effects of dietary aged maize on growth performance, nutrients utilization, and serum metabolites in broilers. A total of 270 healthy 1-day-old male Cobb broilers were assigned randomly into three treatments groups and fed maize stored for different times (24 days, M0; 18 mo, M18; 36 mo, M36). Growth performance was examined at 21 and 42 days of age. Nutrient digestibility was studied on days 18-21 and 38-41. At day 42, blood samples were collected for serum metabolite anal. Dietary aged maize significantly affected the feed to gain ratio, total starch digestibility, and apparent metabolizable energy (p < 0.05). Compared with the M0 group, 39 and 144 differential metabolites were observed in the M18 and M36 groups, resp., whereas 56 differential metabolites were identified between the M18 and M36 groups. Pathway anal. indicated that the main altered pathways were clustered into lipid metabolism in M18, and lipid and glucose metabolism in M0 and M36, resp. In conclusion, neg. effects were observed for both new harvested maize and maize stored for 36 mo; maize stored for 18 mo may improve broiler performance. This study involved multiple reactions and reactants, such as 2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0COA of Formula: C32H39NO4).

2-(4-(1-Hydroxy-4-(4-(hydroxydiphenylmethyl)piperidin-1-yl)butyl)phenyl)-2-methylpropanoic acid (cas: 83799-24-0) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.COA of Formula: C32H39NO4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem