Association between sexual activity-related death and non-prescription use of phosphodiesterase type 5 inhibitors was written by Nagasawa, Sayaka;Saka, Kanju;Yamagishi, Yoshikazu;Yajima, Daisuke;Chiba, Fumiko;Yamaguchi, Rutsuko;Torimitsu, Suguru;Iwase, Hirotaro. And the article was included in Legal Medicine in 2021.Related Products of 224785-90-4 This article mentions the following:
In recent years, there has been an increase in the use of phosphodiesterase type 5 inhibitors (PDE5i) that are purchased from abroad without a doctor’s diagnosis via the Internet or other means. We report six cases in which nonprescription use of PDE5i may have led to death. Among the four deceased individuals who were believed to have experienced sudden cardiac death, three (cases 1-3) had a history of cardiovascular disease, which is a contraindication, and the remaining case (case 4) involved combined use of multiple PDE5i. Sildenafil (0.063μg/mL, 0.087μg/mL) was detected in two of the four cases of sudden cardiac death. Tadalafil (0.096μg/mL) was detected in one of the remaining two cases, and tadalafil (0.197μg/mL) and vardenafil (0.011μg/mL) were detected in the other case. Sildenafil (0.032μg/mL), tadalafil (0.062μg/mL), and ethanol were detected in a traffic accident case with a history of contraindications. In a case of asphyxiation by vomit aspiration, autopsy showed 90% stenosis in the anterior descending branch of the coronary artery, and sildenafil (0.063μg/mL) was detected. To the best of our knowledge, this is the first report of postmortem blood levels of tadalafil and vardenafil likely contributing to the cause of death. Despite all the warnings about the dangers of using PDE5 inhibitors, cases of PDE5i contributing to death are still identified during autopsies. Therefore, raising public awareness of the risks of the risks associated with the imported drug use by individuals is necessary. In the experiment, the researchers used many compounds, for example, 2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4Related Products of 224785-90-4).
2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one (cas: 224785-90-4) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Intermediate for a wide range of pharmaceuticals, polymers, dyes, corrosion inhibitors, rubber accelerators and surfactants.Related Products of 224785-90-4
Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics