Tag: 446.6292

Development of predictive retention-activity relationship models of antipsychotic drugs by micellar liquid chromatography was written by Martin-Biosca, Y.;Molero-Monfort, M.;Sagrado, S.;Villanueva-Camanas, R. M.;Medina-Hernandez, M. J.. And the article was included in Biomedical Chromatography in 1999.Name: N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide This article mentions the following:

The predictive and interpretative capability of quant. chromatog. retention-biol. activity models is supported by the fact that in adequate exptl. conditions the solute partitioning into the chromatog. system can emulate the solute partitioning into lipid bilayers of biol. membranes, which is the basis of drug and metabolite uptake, passive transport across membranes and bioaccumulation. The use of micellar solutions of Brij35 as mobile phases in reversed liquid chromatog. has proven to be valid in predicting some biol. activities of different kinds of drugs. In this paper, the correlations between the logarithm of capacity factors and pharmacokinetic, preclin. pharmacol. and therapeutic efficacy parameters of phenothiazines are studied. Parabolic quant. retention-activity relationship models with predictive and interpretative ability have been obtained. In the experiment, the researchers used many compounds, for example, N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4Name: N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide).

N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4) belongs to piperazine derivatives. Piperazine is a fairly basic compound and is an amine solvent. Piperazine is an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms, which is a condition primarily seen in children. Piperazine hydrate and piperazine citrate are the main anthelminthic piperazines.Name: N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Automated determination of phenothiazine drugs by spectrophotometry with palladium(II) chloride was written by Sawada, Minoru;Motoyama, Ichiro;Yamada, Sachiko;Kanaya, Yoshikiyo. And the article was included in Bunseki Kagaku in 1986.COA of Formula: C22H30N4O2S2 This article mentions the following:

An automated assay for phenothiazine drugs using a PdCl₂ solution was established by application of a continuous flow anal. A sample was dissolved in a mixture of 0.625M H₂SO₄ and DMF (2:3) to make about 3 × 10^-3M solution A standard solution was prepared in the same way. A 4.2 × 10^-3M PdCl₂ stock solution was prepared by dissolving PdCl₂ in 0.625M H₂S₄ and diluted with DMF (4:1) before use. Using an automatic analyzer, the sample solution was diluted with a mixture of 0.625M H₂SO₄ and DMF (4:1) to one-seventh of the concentration, and the diluted sample solution was added to a 6-fold volume of the PdCl₂ solution The absorbance of this mixture was determined at 490 nm. The accuracy was 99-100% except pharmaceutical preparations containing excess chloride and the reproducibility was 0.1-0.3%. It was possible to assay up to 30 samples per day which are 2- to 3-fold more than those handled manually. The continuous variation methods showed that the Pd complex was a 1:1 of Pd-phenothiazine. The absorption at about 490 nm resulting from the Pd complex was affected by substituents at 2- and 10-positions of a phenothiazine ring. In the experiment, the researchers used many compounds, for example, N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4COA of Formula: C22H30N4O2S2).

N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Piperazine and its salts did not induce point mutations in a bacterial test. A series of mutagenicity studies in cells, both in vitro and in vivo, has been completed and showed no evidence of mutagenic effect.COA of Formula: C22H30N4O2S2

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

An integrative approach using real-world data to identify alternative therapeutic uses of existing drugs was written by Lin, Pei-Ying;Chang, Yu-Jung;Chen, Yu-Chen;Lin, Chin-Hung;Erkekoglu, Pinar;Chao, Ming-Wei;Tseng, Chia-Yi. And the article was included in PLoS One in 2018.Reference of 316-81-4 This article mentions the following:

Here we report a novel multi-methodol. approach to identify opportunities for drug repositioning. We performed analyses of real-world data (RWD) acquired from the FAERS and the claims database maintained by the JMDC. These analyses were followed by cross-validation through bioinformatics analyses of gene expression data. Inverse associations revealed using DPA and SSA were used to detect potential drug-repositioning signals. To evaluate the validity of the approach, we conducted a feasibility study to identify marketed drugs with the potential for treating inflammatory bowel disease (IBD). Primary analyses of the FAERS and JMDC claims databases identified psycholeptics such as haloperidol, diazepam, and hydroxyzine as candidates that may improve the treatment of IBD. To further investigate the mechanistic relevance between hit compounds and disease pathol., we conducted bioinformatics analyses of the associations of the gene expression profiles of these compounds with disease. We identified common biol. features among genes differentially expressed with or without compound treatment as well as disease-perturbation data available from open sources, which strengthened the mechanistic rationale of our initial findings. Integrative anal. of RWD such as those available from adverse-event databases, claims databases, and transcriptome analyses represent an effective approach that adds value to efficiently identifying potential novel therapeutic opportunities. In the experiment, the researchers used many compounds, for example, N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4Reference of 316-81-4).

N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Reference of 316-81-4

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Simple and simultaneous determination for 12 phenothiazines in human serum by reversed-phase high-performance liquid chromatography was written by Tanaka, Einosuke;Nakamura, Takako;Terada, Masaru;Shinozuka, Tatsuo;Hashimoto, Chikako;Kurihara, Katsuyoshi;Honda, Katsuya. And the article was included in Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences in 2007.Application In Synthesis of N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide This article mentions the following:

A high-performance liquid chromatog. method has been developed for the simultaneous anal. of the 12 phenothiazines (chlorpromazine, fluphenazine, levomepromazine, perazine, perphenazine, prochlorperazine, profenamine, promethazine, propericiazine, thioproperazine, thioridazine and trifluoperazine) in human serum using HPLC/UV. The separation was achieved using a C₁₈ reversed-phase column (250 mm × 4.6 mm I.D., particle size 5 μm, Inersil ODS-SP). The mobile phase, consisting of acetonitrile-methanol-30 mM NaH₂PO₄ (pH 5.6) (300:200:500, volume/volume/v), was delivered at a flow rate of 0.9 mL/min and UV detection was carried out at 250 nm. The recoveries of the 12 phenothiazines spiked into serum samples were 87.6-99.8%. Regression equations for the 12 phenothiazines showed excellent linearity, with detection limits of 3.2-5.5 ng/mL for serum. The inter-day and intra-day coefficients of variation for serum samples were commonly below 8.8%. The selectivity, accuracy and precision of this method are satisfactory for clin. and forensic purposes. This sensitive and selective method offers the opportunity for simultaneous screening and quantification of almost all phenothiazines available in Japan for the purposes of clin. and forensic applications. In the experiment, the researchers used many compounds, for example, N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4Application In Synthesis of N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide).

N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4) belongs to piperazine derivatives. Piperazine belongs to the family of medicines called anthelmintics. Piperazine is formed as a co-product in the ammoniation of 1,2-dichloroethane or ethanolamine. These are the only routes to the chemical used commercially.Application In Synthesis of N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

Extractive-spectrophotometric determination of phenothiazine derivatives as compounds with picramic acid was written by Puzanowska-Tarasiewicz, Helena;Regulska, Ewa;Kleszczewska, Ewa. And the article was included in Acta Poloniae Pharmaceutica in 1990.Product Details of 316-81-4 This article mentions the following:

Promazine, chlorpromazine, and thioproperazine were extracted from. aqueous solutions with a CHCl₃ solution of picramic acid as 1:1 associates The drugs were determined in the extracts by spectrophotometry at 500 nm in concentrations of 8-80, 25-250, and 16-160 μg/mL concentrations, resp. The average error did not exceed 1.12%. In the experiment, the researchers used many compounds, for example, N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4Product Details of 316-81-4).

N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4) belongs to piperazine derivatives. Industrial applications of piperazine include the manufacture of plastics, resins, pesticides and brake fluids. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Product Details of 316-81-4

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics

MALDI-TOF mass spectrometric determination of 11 phenothiazines with heavy side chains in urine was written by Minakata, Kayoko;Yamagishi, Itaru;Nozawa, Hideki;Gonmori, Kunio;Hasegawa, Koutaro;Wurita, Amin;Suzuki, Masako;Watanabe, Kanako;Suzuki, Osamu. And the article was included in Forensic Toxicology in 2013.SDS of cas: 316-81-4 This article mentions the following:

A rapid screening method was developed for the determination of phenothiazines by matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS). In this method, α-cyano-4-hydroxy cinnamic acid (CHCA) was used as the matrix to assist the ionization of phenothiazines. The identification of 11 phenothiazines with heavy side chains was achieved by observing their protonated mol. ions [M+H]⁺ at m/z 340-447. Quantification was achieved by using triflupromazine at m/z 353 as the internal standard (IS). The relative ionization efficiencies of 11 phenothiazines and IS on MALDI-TOF-MS were different from those achieved by ESI-MS, but the product ion spectra from MALDI-MS-MS were quite similar to those from ESI-MS-MS except in the case of flupentixol. The limit of detection was 0.3 ng/mL with a quantification range of 1-50 ng/mL urine in the best case; the limit of detection was 5 ng/mL with a quantification range of 10-100 ng/mL urine in the worst case for 10 phenothiazines except thiethylperazine. The present method provides a simple and high-throughput method for the screening of these phenothiazines using only 20 μl of urine. To our knowledge, this study is the first trial to analyze phenothiazines by MALDI-TOF-MS (-MS). In the experiment, the researchers used many compounds, for example, N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4SDS of cas: 316-81-4).

N,N-Dimethyl-10-(3-(4-methylpiperazin-1-yl)propyl)-10H-phenothiazine-2-sulfonamide (cas: 316-81-4) belongs to piperazine derivatives. Piperazine causes primary dermal irritation and skin burns at high concentrations. Piperazine also causes eye irritation in humans. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. SDS of cas: 316-81-4

Referemce:
Piperazine – Wikipedia,
Piperazines – an overview | ScienceDirect Topics