Tag: 387827-19-2

387827-19-2, tert-Butyl 4-(3-aminophenyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Cooled at 0C, the solution of 4-(3-aminophenyl)piperidine-1-carboxylic acid tert-butyl ester in THF (6 mL) was slowly added Et3N (260 mul, 1.86 mmol) and propionyl chloride (59 mul, 0.68 mmol). The reaction mixture was stirred at room temperature for 3 hours. Dichloromethane was added and the reaction mixture was washed with brine. Dehydrated by Na2SO4. Filtered and concentrated to give a residue. The residue was purified by flash chromatography (silica gel, gradient from hexane to ethyl acetate). The desired product was obtained as a white solid (186 mg, 90% yield)., 387827-19-2

As the paragraph descriping shows that 387827-19-2 is playing an increasingly important role.

Reference£º
Patent; LABORATORIOS DEL DR. ESTEVE, S. A.; CUEVAS CORDOBES, FELIX; ALMANSA ROSALES, CARMEN; GARCIA LOPEZ, MONICA; (299 pag.)TW2016/27300; (2016); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.387827-19-2,tert-Butyl 4-(3-aminophenyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

A dried flask, under argon atmosphere, was charged w[th Pd2(dba)3 (21 mg, 0.023mmo), 1,1Bs(diphenyphosphino)ferrocene (38 mg, 0.068 mmo), NaOtBu (44 mg,0455 mmo), tertbuty (126 mg, 0.455mmo) and 2bromo54uoropyridine (80 mg, 0.455 mmo). Degassed dry touene (4mL) was added and the mxture was heated at 80 C for 4.5 h, The reaction mixturewas cooed at rt, dichoromethane was added and fiftered through a pad of Ceite, Purification by flash chromatography, siNca ge, gradient hexane to ethy acetate afforded the desired product (127 mg, 75% yied). 1H-NMR (500MHz, CDC3) oe ppm:8.09 (m, 1H), 7.29 (m, 2H), 7.17 (m, 1H), 7.14 (m, 1H), 6.91 (m, 1H), 6.84 (m, 1H),6.53 (bs, 1H), 4.26 (m, 2H), 2.82 (m, 2H), 2.65 (m, 1H), 1.85 (m, 2H), 1.64 (m, 2H),1.45 (s, 9H).

The synthetic route of 387827-19-2 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; LABORATORIOS DEL DR. ESTEVE, S.A.; CUEVAS CORDOBES, Felix; ALMANSA-ROSALES, Carmen; GARCIA LOPEZ, Monica; WO2015/91939; (2015); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem