Tag: 374.3878

Song, Heng et al. published their research in Organic Letters in 2020 | CAS: 1872262-73-1

1-(tert-Butyl) 4-(1,3-dioxoisoindolin-2-yl) piperidine-1,4-dicarboxylate (cas: 1872262-73-1) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Synthetic Route of C19H22N2O6

Decarboxylative and Deaminative Alkylation of Difluoroenoxysilanes via Photoredox Catalysis: A General Method for Site-Selective Synthesis of Difluoroalkylated Alkanes was written by Song, Heng;Cheng, Ran;Min, Qiao-Qiao;Zhang, Xingang. And the article was included in Organic Letters in 2020.Synthetic Route of C19H22N2O6 This article mentions the following:

A general method for site-selective difluoroalkylation of alkyl carboxylic redox esters with difluoroenoxysilanes through photoredox-catalyzed decarboxylative reaction has been developed. The reaction can also be extended to aliphatic amine derived pyridinium salts. This method has the advantages of high efficiency, mild reaction conditions, and broad substrate scope, including primary, secondary, and sterically hindered tertiaryl alkyl substrates, providing a general and practical route for applications in organic synthesis and pharmaceutical studies. In the experiment, the researchers used many compounds, for example, 1-(tert-Butyl) 4-(1,3-dioxoisoindolin-2-yl) piperidine-1,4-dicarboxylate (cas: 1872262-73-1Synthetic Route of C19H22N2O6).

1-(tert-Butyl) 4-(1,3-dioxoisoindolin-2-yl) piperidine-1,4-dicarboxylate (cas: 1872262-73-1) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Synthetic Route of C19H22N2O6

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Cai, Yi-Ping et al. published their research in Journal of Organic Chemistry in 2021 | CAS: 1872262-73-1

1-(tert-Butyl) 4-(1,3-dioxoisoindolin-2-yl) piperidine-1,4-dicarboxylate (cas: 1872262-73-1) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Category: piperidines

Visible-Light-Mediated Alkylation of Thiophenols via Electron Donor-Acceptor Complexes Formed between Two Reactants was written by Cai, Yi-Ping;Nie, Fang-Yuan;Song, Qin-Hua. And the article was included in Journal of Organic Chemistry in 2021.Category: piperidines This article mentions the following:

A metal-free, photocatalyst-free, photochem. system was developed for the direct alkylation of thiophenols ArSH (Ar = 4-chlorophenyl, naphthalen-2-yl, pyridin-4-yl, 1,3-benzothiazol-2-yl, etc.) via electron donor-acceptor (EDA) complexes (KEDA = 145 M-1) associated between two reactants, N-hydroxyphthalimide esters I [R = 3-oxobutyl, cyclohexyl, 1-[4-(2-methylpropyl)phenyl]ethyl, 1-[(tert-butoxy)carbonyl]piperidin-4-yl, etc.] as acceptors and thiophenol anions as donors, in the presence of a tertiary amine to give corresponding aryl alkyl sulfides RS(Ar). The EDA complexes in the reaction system have broad range of visible light absorption (400-650 nm) and can trigger the reaction effectively under sunlight. In the experiment, the researchers used many compounds, for example, 1-(tert-Butyl) 4-(1,3-dioxoisoindolin-2-yl) piperidine-1,4-dicarboxylate (cas: 1872262-73-1Category: piperidines).

1-(tert-Butyl) 4-(1,3-dioxoisoindolin-2-yl) piperidine-1,4-dicarboxylate (cas: 1872262-73-1) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Dong, Weizhe et al. published their research in Nature Chemistry in 2022 | CAS: 1872262-73-1

1-(tert-Butyl) 4-(1,3-dioxoisoindolin-2-yl) piperidine-1,4-dicarboxylate (cas: 1872262-73-1) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Computed Properties of C19H22N2O6

Exploiting the sp2 character of bicyclo[1.1.1]pentyl radicals in the transition-metal-free multi-component difunctionalization of [1.1.1]propellane was written by Dong, Weizhe;Yen-Pon, Expedite;Li, Longbo;Bhattacharjee, Ayan;Jolit, Anais;Molander, Gary A.. And the article was included in Nature Chemistry in 2022.Computed Properties of C19H22N2O6 This article mentions the following:

Strained bicyclic substructures are increasingly relevant in medicinal chem. discovery research because of their role as bioisosteres. Over the last decade, the successful use of bicyclo[1.1.1]pentane (BCP) as a para-disubstituted benzene replacement has made it a highly valuable pharmacophore. However, various challenges, including limited and lengthy access to useful BCP building blocks, are hampering early discovery research. Here authors report a single-step transition-metal-free multi-component approach to synthetically versatile BCP boronates. Radicals derived from commonly available carboxylic acids and organo halides perform additions onto [1.1.1]propellane to afford BCP radicals, which then engage in polarity-matched borylation. A wide array of alkyl-, aryl- and alkenyl-functionalized BCP boronates were easily prepared Late-stage functionalization performed on natural products and approved drugs proceeded with good efficiency to generate the corresponding BCP conjugates. Various photoredox transformations forging C-C and C-N bonds were demonstrated by taking advantage of BCP trifluoroborate salts derived from the BCP boronates. In the experiment, the researchers used many compounds, for example, 1-(tert-Butyl) 4-(1,3-dioxoisoindolin-2-yl) piperidine-1,4-dicarboxylate (cas: 1872262-73-1Computed Properties of C19H22N2O6).

1-(tert-Butyl) 4-(1,3-dioxoisoindolin-2-yl) piperidine-1,4-dicarboxylate (cas: 1872262-73-1) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Computed Properties of C19H22N2O6

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Cai, Yi-Ping et al. published their research in Journal of Organic Chemistry in 2021 | CAS: 1872262-73-1

1-(tert-Butyl) 4-(1,3-dioxoisoindolin-2-yl) piperidine-1,4-dicarboxylate (cas: 1872262-73-1) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Category: piperidines

Visible-Light-Mediated Alkylation of Thiophenols via Electron Donor-Acceptor Complexes Formed between Two Reactants was written by Cai, Yi-Ping;Nie, Fang-Yuan;Song, Qin-Hua. And the article was included in Journal of Organic Chemistry in 2021.Category: piperidines This article mentions the following:

A metal-free, photocatalyst-free, photochem. system was developed for the direct alkylation of thiophenols ArSH (Ar = 4-chlorophenyl, naphthalen-2-yl, pyridin-4-yl, 1,3-benzothiazol-2-yl, etc.) via electron donor-acceptor (EDA) complexes (KEDA = 145 M-1) associated between two reactants, N-hydroxyphthalimide esters I [R = 3-oxobutyl, cyclohexyl, 1-[4-(2-methylpropyl)phenyl]ethyl, 1-[(tert-butoxy)carbonyl]piperidin-4-yl, etc.] as acceptors and thiophenol anions as donors, in the presence of a tertiary amine to give corresponding aryl alkyl sulfides RS(Ar). The EDA complexes in the reaction system have broad range of visible light absorption (400-650 nm) and can trigger the reaction effectively under sunlight. In the experiment, the researchers used many compounds, for example, 1-(tert-Butyl) 4-(1,3-dioxoisoindolin-2-yl) piperidine-1,4-dicarboxylate (cas: 1872262-73-1Category: piperidines).

1-(tert-Butyl) 4-(1,3-dioxoisoindolin-2-yl) piperidine-1,4-dicarboxylate (cas: 1872262-73-1) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Dong, Weizhe et al. published their research in Nature Chemistry in 2022 | CAS: 1872262-73-1

1-(tert-Butyl) 4-(1,3-dioxoisoindolin-2-yl) piperidine-1,4-dicarboxylate (cas: 1872262-73-1) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Computed Properties of C19H22N2O6

Exploiting the sp2 character of bicyclo[1.1.1]pentyl radicals in the transition-metal-free multi-component difunctionalization of [1.1.1]propellane was written by Dong, Weizhe;Yen-Pon, Expedite;Li, Longbo;Bhattacharjee, Ayan;Jolit, Anais;Molander, Gary A.. And the article was included in Nature Chemistry in 2022.Computed Properties of C19H22N2O6 This article mentions the following:

Strained bicyclic substructures are increasingly relevant in medicinal chem. discovery research because of their role as bioisosteres. Over the last decade, the successful use of bicyclo[1.1.1]pentane (BCP) as a para-disubstituted benzene replacement has made it a highly valuable pharmacophore. However, various challenges, including limited and lengthy access to useful BCP building blocks, are hampering early discovery research. Here authors report a single-step transition-metal-free multi-component approach to synthetically versatile BCP boronates. Radicals derived from commonly available carboxylic acids and organo halides perform additions onto [1.1.1]propellane to afford BCP radicals, which then engage in polarity-matched borylation. A wide array of alkyl-, aryl- and alkenyl-functionalized BCP boronates were easily prepared Late-stage functionalization performed on natural products and approved drugs proceeded with good efficiency to generate the corresponding BCP conjugates. Various photoredox transformations forging C-C and C-N bonds were demonstrated by taking advantage of BCP trifluoroborate salts derived from the BCP boronates. In the experiment, the researchers used many compounds, for example, 1-(tert-Butyl) 4-(1,3-dioxoisoindolin-2-yl) piperidine-1,4-dicarboxylate (cas: 1872262-73-1Computed Properties of C19H22N2O6).

1-(tert-Butyl) 4-(1,3-dioxoisoindolin-2-yl) piperidine-1,4-dicarboxylate (cas: 1872262-73-1) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Computed Properties of C19H22N2O6

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Cai, Yi-Ping et al. published their research in Journal of Organic Chemistry in 2021 | CAS: 1872262-73-1

1-(tert-Butyl) 4-(1,3-dioxoisoindolin-2-yl) piperidine-1,4-dicarboxylate (cas: 1872262-73-1) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Category: piperidines

Visible-Light-Mediated Alkylation of Thiophenols via Electron Donor-Acceptor Complexes Formed between Two Reactants was written by Cai, Yi-Ping;Nie, Fang-Yuan;Song, Qin-Hua. And the article was included in Journal of Organic Chemistry in 2021.Category: piperidines This article mentions the following:

A metal-free, photocatalyst-free, photochem. system was developed for the direct alkylation of thiophenols ArSH (Ar = 4-chlorophenyl, naphthalen-2-yl, pyridin-4-yl, 1,3-benzothiazol-2-yl, etc.) via electron donor-acceptor (EDA) complexes (KEDA = 145 M-1) associated between two reactants, N-hydroxyphthalimide esters I [R = 3-oxobutyl, cyclohexyl, 1-[4-(2-methylpropyl)phenyl]ethyl, 1-[(tert-butoxy)carbonyl]piperidin-4-yl, etc.] as acceptors and thiophenol anions as donors, in the presence of a tertiary amine to give corresponding aryl alkyl sulfides RS(Ar). The EDA complexes in the reaction system have broad range of visible light absorption (400-650 nm) and can trigger the reaction effectively under sunlight. In the experiment, the researchers used many compounds, for example, 1-(tert-Butyl) 4-(1,3-dioxoisoindolin-2-yl) piperidine-1,4-dicarboxylate (cas: 1872262-73-1Category: piperidines).

1-(tert-Butyl) 4-(1,3-dioxoisoindolin-2-yl) piperidine-1,4-dicarboxylate (cas: 1872262-73-1) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Dong, Weizhe et al. published their research in Nature Chemistry in 2022 | CAS: 1872262-73-1

1-(tert-Butyl) 4-(1,3-dioxoisoindolin-2-yl) piperidine-1,4-dicarboxylate (cas: 1872262-73-1) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Computed Properties of C19H22N2O6

Exploiting the sp2 character of bicyclo[1.1.1]pentyl radicals in the transition-metal-free multi-component difunctionalization of [1.1.1]propellane was written by Dong, Weizhe;Yen-Pon, Expedite;Li, Longbo;Bhattacharjee, Ayan;Jolit, Anais;Molander, Gary A.. And the article was included in Nature Chemistry in 2022.Computed Properties of C19H22N2O6 This article mentions the following:

Strained bicyclic substructures are increasingly relevant in medicinal chem. discovery research because of their role as bioisosteres. Over the last decade, the successful use of bicyclo[1.1.1]pentane (BCP) as a para-disubstituted benzene replacement has made it a highly valuable pharmacophore. However, various challenges, including limited and lengthy access to useful BCP building blocks, are hampering early discovery research. Here authors report a single-step transition-metal-free multi-component approach to synthetically versatile BCP boronates. Radicals derived from commonly available carboxylic acids and organo halides perform additions onto [1.1.1]propellane to afford BCP radicals, which then engage in polarity-matched borylation. A wide array of alkyl-, aryl- and alkenyl-functionalized BCP boronates were easily prepared Late-stage functionalization performed on natural products and approved drugs proceeded with good efficiency to generate the corresponding BCP conjugates. Various photoredox transformations forging C-C and C-N bonds were demonstrated by taking advantage of BCP trifluoroborate salts derived from the BCP boronates. In the experiment, the researchers used many compounds, for example, 1-(tert-Butyl) 4-(1,3-dioxoisoindolin-2-yl) piperidine-1,4-dicarboxylate (cas: 1872262-73-1Computed Properties of C19H22N2O6).

1-(tert-Butyl) 4-(1,3-dioxoisoindolin-2-yl) piperidine-1,4-dicarboxylate (cas: 1872262-73-1) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Computed Properties of C19H22N2O6

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem