370.5745 | Heterocyclic Building Blocks-piperidine

Dilelio, Marina Cardoso et al. published their research in Dyes and Pigments in 2022 | CAS: 50-52-2

10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Application of 50-52-2

Synthesis and evaluation of photophysical and electrochemical properties of vinyl chalcogenide derivatives of phenothiazines was written by Dilelio, Marina Cardoso;Kaufman, Teodoro S.;Iglesias, Bernardo Almeida;Silveira, Claudio C.. And the article was included in Dyes and Pigments in 2022.Application of 50-52-2 This article mentions the following:

The Wittig-Horner mediated syntheses of phenothiazines carrying vinylsulfide and vinylselenide motifs attached to the aromatic ring(s) or connected to the central nitrogen atom of the heterocycle, and the subsequent study of their photophys. and electrochem. properties, are reported. These compounds were obtained as mixtures of geometric isomers, in good to excellent yields. To complete the study, a small set of vinylsulfoxide and vinylsulfone derivatives was also prepared from the corresponding oxidized phosphinoxides. The photophys. properties of the compounds were examined in solvents of varying polarity, in which they presented absorption maxima in the UV region, with molar absorptivity coefficients compatible with symmetry-allowed 蟺-蟺* electronic transitions. The heterocyclic derivatives were fluorescent. Compounds bearing vinylsulfide moieties associated to the nitrogen atom of the heterocycle displayed less intense fluorescence than the phenothiazine derivatives carrying vinylchalcogenides bonded to the aromatic ring; the latter also exhibited more red-shifted absorption spectra, and Stokes shifts in the range 6115-8170 cm^-1 with weak dependence of solvent polarity. The sulfoxide and sulfones displayed more red-shifted spectra than the corresponding sulfides. The cyclic voltammograms of all derivatives exhibited a common pattern of reversible or quasi-reversible processes in the anodic region, related to the phenothiazine unit. In the experiment, the researchers used many compounds, for example, 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2Application of 50-52-2).

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Rehman Umar, Abdul et al. published their research in Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) in 2022 | CAS: 50-52-2

10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.Quality Control of 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine

Ultra-trace level voltammetric sensor for MB in human plasma based on a carboxylic derivative of Calix[4]resorcinarene capped silver nanoparticles was written by Rehman Umar, Abdul;Hussain, Kashif;Aslam, Zara;Anwar Ul Haq, Muhammad;Muhammad, Haji;Sirajuddin;Raza Shah, Muhammad. And the article was included in Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) in 2022.Quality Control of 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine This article mentions the following:

This work was initiated by synthesizing a carboxylic derivative of Calix[4]resorcinarene through a three step protocol confirmed by proton NMR (¹H NMR) spectroscopy and Electrospray ionization mass spectroscopy (ESI-MS). As synthesized derivative, was used as reducing and capping material for the fabrication of small and stable silver nanoparticles (AgNPs) in aqueous medium under the combined influence of dilute alkali and heat at 90掳 C. These nanoparticles were referred as KM20-AgNPs. Techniques used for characterization of AgNPs include UV-Visible (UV-Vis) spectroscopy, Fourier transform infra-red (FTIR) spectroscopy, at. force microscopy (AFM), dynamic light scattering (DLS) and zeta potential analyzer (ZPA). The finally produced KM20-AgNPs were recognized as highly sensitive and extremely selective voltammetric sensor for low level detection of methylene blue drug in the linear working range of 1-30 nM with limit of detection (LOD) and limit of quantification (LOQ) as 0.16 nM and 0.53 nM resp. The developed sensor was successfully used for sensing of MB in human blood plasma. In the experiment, the researchers used many compounds, for example, 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2Quality Control of 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine).

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Liang, Xinyu et al. published their research in Chemistry – A European Journal in 2022 | CAS: 50-52-2

10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine derivatives bearing a masked aldehyde function in the 蔚-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Quality Control of 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine

The Aryl Sulfide Synthesis via Sulfide Transfer was written by Liang, Xinyu;Wen, Kaikai;Shi, Qinqin;Zhang, Bei-Bei;Pei, Shurui;Lin, Qijie;Ma, Bowei;Wang, Song;Zhang, Meng;Li, Xiang;Wang, Zhi-Xiang;Huang, Hui. And the article was included in Chemistry – A European Journal in 2022.Quality Control of 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine This article mentions the following:

Aryl sulfides are in great demands in drugs and materials sciences. To avoid using nucleophilic and noxious thiols, many efforts have been focused on exploring novel sulfide resources. Herein, a reductive Pd-catalyzed, Ni-mediated method to synthesize aryl sulfides via a sulfide transfer reaction is developed. The utility and scope of this reaction is exemplified by various aryl electrophiles and aryl sulfides. Mechanistic studies reveal two competing catalytic cycles of sulfide transfer and aryl transfer in this reaction, where the former one is favored over the later one because of the large energy barrier difference during the transmetalation. Moreover, two important chems. are late-stage functionalized by this method, exhibiting the potential applications in drugs and materials science. In the experiment, the researchers used many compounds, for example, 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2Quality Control of 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine).

10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine derivatives bearing a masked aldehyde function in the 蔚-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Quality Control of 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Dorgau, Birthe et al. published their research in Stem cells translational medicine in 2022 | CAS: 50-52-2

10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine derivatives bearing a masked aldehyde function in the 蔚-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Application of 50-52-2

Human Retinal Organoids Provide a Suitable Tool for Toxicological Investigations: A Comprehensive Validation Using Drugs and Compounds Affecting the Retina. was written by Dorgau, Birthe;Georgiou, Maria;Chaudhary, Alexander;Moya-Molina, Marina;Collin, Joseph;Queen, Rachel;Hilgen, Gerrit;Davey, Tracey;Hewitt, Philip;Schmitt, Michael;Kustermann, Stefan;Pognan, Francois;Steel, David H;Sernagor, Evelyne;Armstrong, Lyle;Lako, Majlinda. And the article was included in Stem cells translational medicine in 2022.Application of 50-52-2 This article mentions the following:

Retinal drug toxicity screening is essential for the development of safe treatment strategies for a large number of diseases. To this end, retinal organoids derived from human pluripotent stem cells (hPSCs) provide a suitable screening platform due to their similarity to the human retina and the ease of generation in large-scale formats. In this study, two hPSC cell lines were differentiated to retinal organoids, which comprised all key retinal cell types in multiple nuclear and synaptic layers. Single-cell RNA-Seq of retinal organoids indicated the maintenance of retinal ganglion cells and development of bipolar cells: both cell types segregated into several subtypes. Ketorolac, digoxin, thioridazine, sildenafil, ethanol, and methanol were selected as key compounds to screen on retinal organoids because of their well-known retinal toxicity profile described in the literature. Exposure of the hPSC-derived retinal organoids to digoxin, thioridazine, and sildenafil resulted in photoreceptor cell death, while digoxin and thioridazine additionally affected all other cell types, including M眉ller glia cells. All drug treatments caused activation of astrocytes, indicated by dendrites sprouting into neuroepithelium. The ability to respond to light was preserved in organoids although the number of responsive retinal ganglion cells decreased after drug exposure. These data indicate similar drug effects in organoids to those reported in in vivo models and/or in humans, thus providing the first robust experimental evidence of their suitability for toxicological studies. In the experiment, the researchers used many compounds, for example, 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2Application of 50-52-2).

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Krecisz, Pawel et al. published their research in Journal of Chromatographic Science in 2022 | CAS: 50-52-2

10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.COA of Formula: C21H26N2S2

Thin-layer chromatography gradient optimization strategy for wet load adsorption flash chromatography was written by Krecisz, Pawel;Czarnecka, Kamila;Szymanski, Pawel. And the article was included in Journal of Chromatographic Science in 2022.COA of Formula: C21H26N2S2 This article mentions the following:

Chromatog. is one of the most popular methods for the separation of compounds in modern pharmaceutical industry and science. Despite the extensive use of the reversed phase chromatog. in anal. and preparative applications, the normal phase adsorption chromatog. has a special place in purifying post-reaction mixtures or the separation of natural extracts, especially in wet load mode, because of simplicity and high velocity of preparation Complex mixtures, more difficult to sep., require gradient methods to obtain better results of separations These methods can be developed by external software, but the automatic methods are often not very accurate and the neg. impact of wet load application on separation quality is considerable in them. Therefore, we present the thin-layer chromatog. (TLC) gradient optimization strategy for wet load separations to obtain repeatable results of separations for different compounds without worrying about neg. impact of wet loading on separation quality. The strategy provides information about an elution model of desired compound, which is used to develop the gradient method. The strategy also allows to standardize the separation length, because gradient methods performed by the TLC gradient optimization strategy have a very similar duration time in column volumes The method can also be simply scaled because of using the column volume as a base unit in calculations In the experiment, the researchers used many compounds, for example, 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2COA of Formula: C21H26N2S2).

10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.COA of Formula: C21H26N2S2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Rehman Umar, Abdul et al. published their research in Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) in 2022 | CAS: 50-52-2

10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Quality Control of 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine

This work was initiated by synthesizing a carboxylic derivative of Calix[4]resorcinarene through a three step protocol confirmed by proton NMR (¹H NMR) spectroscopy and Electrospray ionization mass spectroscopy (ESI-MS). As synthesized derivative, was used as reducing and capping material for the fabrication of small and stable silver nanoparticles (AgNPs) in aqueous medium under the combined influence of dilute alkali and heat at 90° C. These nanoparticles were referred as KM20-AgNPs. Techniques used for characterization of AgNPs include UV-Visible (UV-Vis) spectroscopy, Fourier transform infra-red (FTIR) spectroscopy, at. force microscopy (AFM), dynamic light scattering (DLS) and zeta potential analyzer (ZPA). The finally produced KM20-AgNPs were recognized as highly sensitive and extremely selective voltammetric sensor for low level detection of methylene blue drug in the linear working range of 1-30 nM with limit of detection (LOD) and limit of quantification (LOQ) as 0.16 nM and 0.53 nM resp. The developed sensor was successfully used for sensing of MB in human blood plasma. In the experiment, the researchers used many compounds, for example, 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2Quality Control of 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine).

10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Quality Control of 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Liang, Xinyu et al. published their research in Chemistry – A European Journal in 2022 | CAS: 50-52-2

10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Quality Control of 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Dorgau, Birthe et al. published their research in Stem cells translational medicine in 2022 | CAS: 50-52-2

10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Application of 50-52-2

Retinal drug toxicity screening is essential for the development of safe treatment strategies for a large number of diseases. To this end, retinal organoids derived from human pluripotent stem cells (hPSCs) provide a suitable screening platform due to their similarity to the human retina and the ease of generation in large-scale formats. In this study, two hPSC cell lines were differentiated to retinal organoids, which comprised all key retinal cell types in multiple nuclear and synaptic layers. Single-cell RNA-Seq of retinal organoids indicated the maintenance of retinal ganglion cells and development of bipolar cells: both cell types segregated into several subtypes. Ketorolac, digoxin, thioridazine, sildenafil, ethanol, and methanol were selected as key compounds to screen on retinal organoids because of their well-known retinal toxicity profile described in the literature. Exposure of the hPSC-derived retinal organoids to digoxin, thioridazine, and sildenafil resulted in photoreceptor cell death, while digoxin and thioridazine additionally affected all other cell types, including Müller glia cells. All drug treatments caused activation of astrocytes, indicated by dendrites sprouting into neuroepithelium. The ability to respond to light was preserved in organoids although the number of responsive retinal ganglion cells decreased after drug exposure. These data indicate similar drug effects in organoids to those reported in in vivo models and/or in humans, thus providing the first robust experimental evidence of their suitability for toxicological studies. In the experiment, the researchers used many compounds, for example, 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2Application of 50-52-2).

10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Application of 50-52-2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Krecisz, Pawel et al. published their research in Journal of Chromatographic Science in 2022 | CAS: 50-52-2

10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.COA of Formula: C21H26N2S2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Grover, Shipra et al. published their research in ACS Infectious Diseases in 2021 | CAS: 50-52-2

10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Name: 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine

Two-Way Regulation of MmpL3 Expression Identifies and Validates Inhibitors of MmpL3 Function in Mycobacterium tuberculosis was written by Grover, Shipra;Engelhart, Curtis A.;Perez-Herran, Esther;Li, Wei;Abrahams, Katherine A.;Papavinasasundaram, Kadamba;Bean, James M.;Sassetti, Christopher M.;Mendoza-Losana, Alfonso;Besra, Gurdyal S.;Jackson, Mary;Schnappinger, Dirk. And the article was included in ACS Infectious Diseases in 2021.Name: 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine This article mentions the following:

MmpL3, an essential mycolate transporter in the inner membrane of Mycobacterium tuberculosis (Mtb), has been identified as a target of multiple, chem. diverse antitubercular drugs. However, several of these mols. seem to have secondary targets and inhibit bacterial growth by more than one mechanism. Here, we describe a cell-based assay that utilizes two-way regulation of MmpL3 expression to readily identify MmpL3-specific inhibitors. We successfully used this assay to identify a novel guanidine-based MmpL3 inhibitor from a library of 220 compounds that inhibit growth of Mtb by largely unknown mechanisms. We furthermore identified inhibitors of cytochrome bc₁-aa₃ oxidase as one class of off-target hits in whole-cell screens for MmpL3 inhibitors and report a novel sulfanylacetamide as a potential QcrB inhibitor. In the experiment, the researchers used many compounds, for example, 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine (cas: 50-52-2Name: 10-(2-(1-Methylpiperidin-2-yl)ethyl)-2-(methylthio)-10H-phenothiazine).

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

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