Tag: 309956-78-3

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.309956-78-3,(R)-tert-Butyl piperidin-3-ylcarbamate,as a common compound, the synthetic route is as follows.

In 100 mL of DMF, 4.53 g (10 mmol) of compound 5 and 2.41 g (12 mmol) of compound 6, 2.76 g (20 mmol) of K2CO3 were added, and the reaction was performed at 75 C for 16 hours.Monitor the progress of the reaction by TLC, cool to room temperature, filter, and add 500 mL of distilled water to the filtrate.A solid was precipitated, and the filtrate was cooled to 0 C, filtered, washed with water, and dried to obtain 8-[(3R) -3-tert-butoxycarbonylamino-1-piperidinyl] -7- (2-butynyl) -3, 7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl) methyl] -1H-purine-2,6-dione 5.21 g (9.1 mmol) in a yield of 91%.

As the paragraph descriping shows that 309956-78-3 is playing an increasingly important role.

Reference£º
Patent; Shenzhen The Second People Hospital; Chen Xuhong; Tan Hui; Yan Dewen; Li Haiyan; Liu Xueting; Ou Huiting; Cai Jinlin; (8 pag.)CN110590780; (2019); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

309956-78-3, (R)-tert-Butyl piperidin-3-ylcarbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE II 3-Methyl-7-(2-butyn-1-yl)-8-[(R)-3-(tert.-butyloxycarbonylamino)-piperidin-1-yl]-xanthine 11.00 g of (R)-3-tert.-butyloxycarbonylamino-piperidine are added to 15.00 g of 3-methyl-7-(2-butyn-1-yl)-8-bromo-xanthine and 16.00 g of potassium carbonate in 100 ml of dimethylsulphoxide and the thick, light beige suspension is stirred for four hours with a mechanical stirrer at approx. 114 C. Then another 900 mg of (R)-3-tert.-butyloxycarbonylamino-piperidine, dissolved in 10 ml of dimethylsulphoxide, are added to the reaction mixture and this is stirred for a further two hours at 114 C. After cooling to ambient temperature the reaction mixture is diluted with copious amounts of water. The precipitate formed is thoroughly triturated until no more clumps are left, and suction filtered. The light solid is again suspended with water, suction filtered, washed with water and diethyl ether and dried in the circulating air dryer at 60 C. Yield: 19.73 g (94% of theory) Rf value: 0.64 (silica gel, ethyl acetate) Mass spectrum (ESI+): m/z=417 [M+H]+

As the paragraph descriping shows that 309956-78-3 is playing an increasingly important role.

Reference£º
Patent; Boehringer Ingelheim International GmbH; US2005/143377; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

309956-78-3, (R)-tert-Butyl piperidin-3-ylcarbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 5b (460 mg, 0.96 mmol) was dissolved in N, N-dimethylformamide (12 ml) by a known method, and (R) -3-tert-butoxycarbonylaminopiperidine (193 mg, 0.96 mmol) ,Potassium carbonate (200mg, 1.44mmol)was added, The reaction solution was cooled to room temperature, poured into cold water, filtered, washed with water and dried to give 5c (417 mg, gray solid), and the reaction mixture was cooled to room temperature. , Yield: 72.6%.

309956-78-3 (R)-tert-Butyl piperidin-3-ylcarbamate 1514172, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; Chengdu YuanDong Biological Pharmaceutical Co., Ltd; WANG, YING; XIANG, YONGZHE; CENG, GUODONG; (21 pag.)CN103936738; (2016); B;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem