Tag: 300-400

Why Proline? Influence of Ring-Size on the Collagen Triple Helix was written by Egli, Jasmine;Schnitzer, Tobias;Dietschreit, Johannes C. B.;Ochsenfeld, Christian;Wennemers, Helma. And the article was included in Organic Letters in 2020.COA of Formula: C21H21NO4 The following contents are mentioned in the article:

The effect of four- and six-membered ring-size analogs (azetidine- and piperidine-2-carboxylic acid, H-Aze-OH and H-Pip-OH) of proline on the stability of the collagen triple helix was examined Computational and NMR spectroscopic studies with model compounds and thermal denaturation experiments with collagen peptides showed that the ring-size analogs destabilize the triple helix to a similar extent by either mismatching backbone dihedral angles ϕ and ψ (Pip) or by an unfavorable trans/cis amide bond ratio (Aze). This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5COA of Formula: C21H21NO4).

(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.COA of Formula: C21H21NO4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Design and synthesis of N’-phenylacylhydrazide safety-catch resin and its application in synthesis of p-nitroaniline chromogenic peptide substrates was written by Bai, Guo-liang;Yang, Xiao-xiao;Lin, Hao;Yang, Li-quan;Wang, De-xin. And the article was included in Huaxue Shiji in 2012.Recommanded Product: (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid The following contents are mentioned in the article:

N’-Phenylacylhydrazide safety-catch resin was synthesized by derivatizing com. available MBHA resin with N’-Boc-4-hydrazinobenzoic acid. N’-Protection form of 4-hydrazinobenzoic acid and initial amino functional resin type have been investigated to achieve higher derivation yield. Five serine protease peptidyl-pNA chromogenic substrates were synthesized with the safety-catch resin by Boc/Fmoc hybridized protocol with high yields and purity. Intermediates and product were characterized by HRMS and NMR. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Recommanded Product: (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid).

(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Recommanded Product: (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Design and synthesis of N’-phenylacylhydrazide safety-catch resin and its application in synthesis of p-nitroaniline chromogenic peptide substrates was written by Bai, Guo-liang;Yang, Xiao-xiao;Lin, Hao;Yang, Li-quan;Wang, De-xin. And the article was included in Huaxue Shiji in 2012.Category: piperidines The following contents are mentioned in the article:

N’-Phenylacylhydrazide safety-catch resin was synthesized by derivatizing com. available MBHA resin with N’-Boc-4-hydrazinobenzoic acid. N’-Protection form of 4-hydrazinobenzoic acid and initial amino functional resin type have been investigated to achieve higher derivation yield. Five serine protease peptidyl-pNA chromogenic substrates were synthesized with the safety-catch resin by Boc/Fmoc hybridized protocol with high yields and purity. Intermediates and product were characterized by HRMS and NMR. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Category: piperidines).

(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Heterocyclic core analogs of a direct thrombin inhibitor was written by Blizzard, Timothy A.;Singh, Sanjay;Patil, Basanagoud;Chidurala, Naresh;Komanduri, Venukrishnan;Debnath, Samarpita;Belyakov, Sergei;Crespo, Alejandro;Struck, Alice;Kurtz, Marc;Wiltsie, Judyann;Shen, Xun;Sonatore, Lisa;Arocho, Marta;Lewis, Dale;Ogletree, Martin;Biftu, Tesfaye. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2014.Computed Properties of C21H21NO4 The following contents are mentioned in the article:

Thrombin is a serine protease that plays a key role in blood clotting. Pyrrolidine I•TFA is a potent thrombin inhibitor discovered at Merck several years ago. Seven analogs of I•TFA in which the pyrrolidine core was replaced with various heterocycles were prepared and evaluated for activity against thrombin, clotting factors VIIa, IXa, Xa, and XIIa, and trypsin. The thiomorpholine analog II•TFA was the most active, essentially matching the thrombin inhibitory activity of I•TFA with slightly improved selectivity over trypsin. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Computed Properties of C21H21NO4).

(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Computed Properties of C21H21NO4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Heterocyclic core analogs of a direct thrombin inhibitor was written by Blizzard, Timothy A.;Singh, Sanjay;Patil, Basanagoud;Chidurala, Naresh;Komanduri, Venukrishnan;Debnath, Samarpita;Belyakov, Sergei;Crespo, Alejandro;Struck, Alice;Kurtz, Marc;Wiltsie, Judyann;Shen, Xun;Sonatore, Lisa;Arocho, Marta;Lewis, Dale;Ogletree, Martin;Biftu, Tesfaye. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2014.Reference of 86069-86-5 The following contents are mentioned in the article:

Thrombin is a serine protease that plays a key role in blood clotting. Pyrrolidine I•TFA is a potent thrombin inhibitor discovered at Merck several years ago. Seven analogs of I•TFA in which the pyrrolidine core was replaced with various heterocycles were prepared and evaluated for activity against thrombin, clotting factors VIIa, IXa, Xa, and XIIa, and trypsin. The thiomorpholine analog II•TFA was the most active, essentially matching the thrombin inhibitory activity of I•TFA with slightly improved selectivity over trypsin. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Reference of 86069-86-5).

(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Reference of 86069-86-5

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Synthesis and biological activity of endomorphin-2 analogs incorporating piperidine-2-, 3- or 4-carboxylic acids instead of proline in position 2 was written by Staniszewska, Renata;Fichna, Jakub;Gach, Katarzyna;Toth, Geza;Poels, Jeroen;Vanden Broeck, Jozef;Janecka, Anna. And the article was included in Chemical Biology & Drug Design in 2008.Name: (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid The following contents are mentioned in the article:

Novel endomorphin-2 (EM-2) analogs have been synthesized, incorporating unnatural amino acids with six-membered heterocyclic rings, such as piperidine-2-, 3- and 4-carboxylic acids (Pip, Nip and Inp, resp.) instead of Pro in position 2. [(R)-Nip²]EM-2 displayed an extremely high affinity for the μ-opioid receptor with IC₅₀ = 0.04 ± 0.01 nM in comparison with IC₅₀ = 0.69 ± 0.03 nM for EM-2. This analog was also very potent in the aequorin luminescence-based functional calcium assay and showed significantly enhanced stability in rat brain homogenate. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Name: (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid).

(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Name: (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Synthesis and biological activity of endomorphin-2 analogs incorporating piperidine-2-, 3- or 4-carboxylic acids instead of proline in position 2 was written by Staniszewska, Renata;Fichna, Jakub;Gach, Katarzyna;Toth, Geza;Poels, Jeroen;Vanden Broeck, Jozef;Janecka, Anna. And the article was included in Chemical Biology & Drug Design in 2008.Reference of 86069-86-5 The following contents are mentioned in the article:

Novel endomorphin-2 (EM-2) analogs have been synthesized, incorporating unnatural amino acids with six-membered heterocyclic rings, such as piperidine-2-, 3- and 4-carboxylic acids (Pip, Nip and Inp, resp.) instead of Pro in position 2. [(R)-Nip²]EM-2 displayed an extremely high affinity for the μ-opioid receptor with IC₅₀ = 0.04 ± 0.01 nM in comparison with IC₅₀ = 0.69 ± 0.03 nM for EM-2. This analog was also very potent in the aequorin luminescence-based functional calcium assay and showed significantly enhanced stability in rat brain homogenate. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Reference of 86069-86-5).

(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Reference of 86069-86-5

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Synthetic studies on homophymine B: solid phase synthesis of a cyclic fragment was written by Tokairin, Yoshinori;Takeda, Sho;Kikuchi, Mari;Konno, Hiroyuki. And the article was included in Tetrahedron Letters in 2015.SDS of cas: 86069-86-5 The following contents are mentioned in the article:

The synthesis of a cyclic fragment of homophymine B is described. Fmoc-derivatives (Fmoc = 9-fluorenylmethoxycarbonyl) of βMOT and AHDH, which were necessary unusual amino acids for a designed cyclic depsipeptide, were prepared The linear peptides were synthesized using Fmoc-based solid phase peptide synthesis. The designed cyclic depsipeptide was constructed via the macrolactamization between the Pip and D-Asp residues of the corresponding linear peptide with PyBOP/HOAt/DIPEA in DMF followed by global deprotection to give the cyclic fragment of homophymine B. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5SDS of cas: 86069-86-5).

(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.SDS of cas: 86069-86-5

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Synthetic studies on homophymine B: solid phase synthesis of a cyclic fragment was written by Tokairin, Yoshinori;Takeda, Sho;Kikuchi, Mari;Konno, Hiroyuki. And the article was included in Tetrahedron Letters in 2015.Synthetic Route of C21H21NO4 The following contents are mentioned in the article:

The synthesis of a cyclic fragment of homophymine B is described. Fmoc-derivatives (Fmoc = 9-fluorenylmethoxycarbonyl) of βMOT and AHDH, which were necessary unusual amino acids for a designed cyclic depsipeptide, were prepared The linear peptides were synthesized using Fmoc-based solid phase peptide synthesis. The designed cyclic depsipeptide was constructed via the macrolactamization between the Pip and D-Asp residues of the corresponding linear peptide with PyBOP/HOAt/DIPEA in DMF followed by global deprotection to give the cyclic fragment of homophymine B. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Synthetic Route of C21H21NO4).

(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising α-glucosidase inhibitors. The former are analogs of DNJ with an improved α-glucosidase inhibitory profile than that of DNJ. Boisson et al.Synthetic Route of C21H21NO4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Total synthesis and antifungal evaluation of cyclic aminohexapeptides was written by Klein, Larry L.;Li, Leping;Chen, Hui-Ju;Curty, Cynthia B.;DeGoey, David A.;Grampovnik, David J.;Leone, Christina L.;Thomas, Sheela A.;Yeung, Clinto M.;Funk, Kenneth W.;Kishore, Vimal;Lundell, Edwin O.;Wodka, Dariusz;Meulbroek, Jon A.;Alder, Jeffrey D.;Nilius, Angela M.;Lartey, Paul A.;Plattner, Jacob J.. And the article was included in Bioorganic & Medicinal Chemistry in 2000.Recommanded Product: (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid The following contents are mentioned in the article:

Naturally occurring hexapeptide echinocandin B (1) has shown potent antifungal activity via its inhibition of the synthesis of β-1,3 glucan, a key fungal cell wall component. Although this series of agents has been limited thus far based on their physicochem. characteristics, we have found that the synthesis of analogs bearing an aminoproline residue in the ‘northwest’ position imparts greatly improved water solubility (>5 mg/mL). The synthesis and structure-activity relationships (SAR) based on whole cell and upon in vivo activity of the series of compounds are reported. This study involved multiple reactions and reactants, such as (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5Recommanded Product: (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid).

(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (cas: 86069-86-5) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Recommanded Product: (S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem