Tag: 29608-05-7

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29608-05-7,4-(Piperidin-1-ylmethyl)aniline,as a common compound, the synthetic route is as follows.

Example 84 (Production of Compound 84) To 3-benzyloxybenzoic acid (800 mg) dissolved in THF (10 ml) were added oxalyl chloride (397 mul) and one drop of DMF, and the resulting mixture was stirred at room temperature for one hour. After the reaction mixture was evaporated to remove the solvent, to the residue dissolved in THF (15 ml) were added dropwise at room temperature 1-(4-aminobenzyl)piperidine (733 mg) and triethylamine (589 mul). This reaction mixture was stirred at room temperature for 17 hours, was then mixed with water (100 ml) and was extracted with ethyl acetate. The organic layer was washed with an aqueous saturated solution of sodium chloride, was dried with anhydrous sodium sulfate and was then evaporated under reduced pressure to remove the solvent. The resulting residue was recrystallized from ethyl acetate/hexane to obtain 3-benzyloxy-4′-(piperidinomethyl)benzanilide (compound 84) (1.06 g) as colorless crystals., 29608-05-7

The synthetic route of 29608-05-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Takeda Chemical Industries, Ltd.; US6627651; (2003); B1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29608-05-7,4-(Piperidin-1-ylmethyl)aniline,as a common compound, the synthetic route is as follows.

WORKING EXAMPLE 71 (Production of Compound 71) In THF (10 ml) was dissolved 3-(2-methylphenyl)cinnamic acid (0.48 g), and to the solution were added oxalyl chloride (0.35 ml) and a drop of DMF. The mixture was stirred at room temperature for 1 hour and concentrated under reduced pressure. The residue was dissolved in THF (20 ml), and to the solution were added 1-(4-aminobenzyl)piperidine (0.38 g) and triethylamine (0.34 ml) at room temperature. The reaction mixture was stirred at room temperature for 2 hours, and to the mixture was added water (50 ml). The mixture was extracted with ethyl acetate. The organic layer was washed with saturated sodium chloride solution, dried with anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was washed with ethyl acetate-diisopropylether to give (E)-N-[4-(piperidinomethyl)phenyl]-3-(2-methyl-phenyl)-cinnamamide (Compound 71) (0.75 g) as pale yellow amorphous. Elemental Analysis for C28 H30 N2 O.0.5H2 O; Calcd: C, 80.16; H, 7.45; N, 6.68. Found: C, 80.15; H, 7.38; N, 6.64. 1 H NMR (200 MHz, CDCl3) delta: 1.45 (2H, m), 1.58 (4H, m), 2.27 (3H, s), 2.39 (2H, m), 3.47 (2H, s), 6.58 (1H, d, J=15.4 Hz), 7.24-7.35 (7H, m), 7.39-7.58 (6H, m), 7.80 (1H, d, J=15.6 Hz)., 29608-05-7

The synthetic route of 29608-05-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Takeda Chemical Industries, Ltd.; US6166006; (2000); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29608-05-7,4-(Piperidin-1-ylmethyl)aniline,as a common compound, the synthetic route is as follows.

Compound 1 (2.0 g, 5.9 mmol) was refluxed for 2 hours in SOCl2. The reaction was cooled to RT and concentrated. The residue was taken up in DCM and concentrated a second time. The residue was then taken up in THF (25 mL) and added dropwise to a solution containing Compound Ik (1.1 g, 5.9 mmol), THF (25 mL) and DIPEA (2.5 mL, 14.4 mmol) at 0 0C. After 30 mins, the reaction was diluted with DCM and washed successively with 10% NH4Cl, water and brine. The organic layer was dried (Na2SO4), then filtered and treated with excess 2M HCl in ether to precipitate Compound 3 as an HCl salt (1.45 g). MS 537, 539 (MH+).

29608-05-7 4-(Piperidin-1-ylmethyl)aniline 846150, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2006/118749; (2006); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem