Tag: 285.34

The efficacy of curcumin-piperine co-supplementation on clinical symptoms, duration, severity, and inflammatory factors in COVID-19 outpatients: a randomized double-blind, placebo-controlled trial was written by Askari, Gholamreza;Sahebkar, Amirhossein;Soleimani, Davood;Mahdavi, Atena;Rafiee, Sahar;Majeed, Muhammed;Khorvash, Farzin;Iraj, Bijan;Elyasi, Mahshid;Rouhani, Mohammad Hossein;Bagherniya, Mohammad. And the article was included in Trials in 2022.Recommanded Product: 94-62-2 This article mentions the following:

COVID-19 pandemic has made the disease a major global problem by creating a significant burden on health, economic, and social status. To date, there are no effective and approved medications for this disease. Curcumin as an anti-inflammatory agent can have a pos. effect on the control of COVID-19 complications. This study aimed to assess the efficacy of curcumin-piperine supplementation on clin. symptoms, duration, severity, and inflammatory factors in patients with COVID-19. Forty-six outpatients with COVID-19 disease were randomly allocated to receive two capsules of curcumin-piperine; each capsule contained 500 mg curcumin plus 5 mg piperine or placebo for 14 days. Mean changes in complete blood count, liver enzymes, blood glucose levels, lipid parameters, kidney function, and c-reactive protein (CRP) were not significantly different between the two groups. There was a significant improvement in health status, including dry cough, sputum cough, ague, sore throat, weakness, muscular pain, headache, and dyspnea at week 2 in both curcumin-piperine and placebo groups (P value < 0.05); however, the improvement in weakness was more in the curcumin-piperine group than with placebo group (P value 025). The present study results showed that curcumin-piperine co-supplementation in outpatients with COVID-19 could significantly reduce weakness. However, in this study, curcumin-piperine co-supplementation could not significantly affect the other indexes, including biochem. and clin. indexes. In the experiment, the researchers used many compounds, for example, (2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one (cas: 94-62-2Recommanded Product: 94-62-2).

(2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one (cas: 94-62-2) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Recommanded Product: 94-62-2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Cardioprotective effect of ethanol extracts of Sugemule-3 decoction on isoproterenol-induced heart failure in Wistar rats through regulation of mitochondrial dynamics was written by Zhen, Dong;Na, Ri-song;Wang, Yu;Bai, Xue;Fu, Dan-ni;Wei, Cheng-xi;Liu, Ming-jie;Yu, Li-jun. And the article was included in Journal of Ethnopharmacology in 2022.Category: piperidines This article mentions the following:

Sugemule-3 decoction (SD-3) is a commonly used prescription in Mongolian medicine which composed of the herbs Baidoukou (the fruit of Amomum compactum Soluble ex Maton), Baijusheng (the fruit of Lactuca sativa L.) and Biba (Piper longum L.). SD-3 has remarkable effect on the cardiovascular diseases, but its pharmacol. mechanism has not been elucidated. To evaluate the cardioprotective effects and the potential mechanisms of the ethanol extracts of SD-3 against isoproterenol (ISO)-induced heart failure (HF) in rats. The ethanol extracts of SD-3 were prepared and analyzed by LC-ESI-MS/MS. One hundred male Wistar rats were randomly divided into five groups: control, ISO (HF) and different doses of SD-3 (0.4, 0.2, 0.1 g/kg/d) groups. HF model rats were established by i.p. injecting of ISO. The left ventricular function was evaluated by echocardiog. Myocardial injury and fibrosis were examined by hematoxylin-eosin (HE) and Masson staining. Western-blot anal. was performed to determine the protein expression of apoptosis and mitochondrial dynamics in all the groups. Moreover, the structural changes in the mitochondria of cardiomyocytes were also observed by transmission electron microscopy. Fifteen compounds were detected in the ethanol extracts of SD-3, include piperine, piperanine, etc. Rats administered with ISO showed a significant decline in the left ventricular function. The cardiac histopathol. changes such as local necrosis, interstitial edema, and cardiac fibrosis were also observed in the ISO group. The treatment with SD-3 significantly inhibited these effects of ISO. ISO was found to increase the protein expression of Bax, cleaved-PARP and cleaved-caspase-3, -7 -9, destroy the balance between mitochondrial fusion and fission, and alter the mitochondrial morphol. The ethanol extracts of SD-3 could rebalance mitochondrial fusion and fission, and ameliorates the morphol. abnormalities induced by ISO in mitochondria. The current study demonstrated that ethanol extracts of SD-3 improved isoprenaline-induced cardiac hypertrophy and fibrosis through inhibiting cardiomyocyte apoptosis and regulating the mitochondrial dynamics. In the experiment, the researchers used many compounds, for example, (2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one (cas: 94-62-2Category: piperidines).

(2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one (cas: 94-62-2) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Biomarker selection and a prospective metabolite-based machine learning diagnostic for lyme disease was written by Kehoe, Eric R.;Fitzgerald, Bryna L.;Graham, Barbara;Islam, M. Nurul;Sharma, Kartikay;Wormser, Gary P.;Belisle, John T.;Kirby, Michael J.. And the article was included in Scientific Reports in 2022.Application of 94-62-2 This article mentions the following:

We provide a pipeline for data preprocessing, biomarker selection, and classification of liquid chromatog.-mass spectrometry (LCMS) serum samples to generate a prospective diagnostic test for Lyme disease. We utilize tools of machine learning (ML), e.g., sparse support vector machines (SSVM), iterative feature removal (IFR), and k-fold feature ranking to select several biomarkers and build a discriminant model for Lyme disease. We report a 98.13% test balanced success rate (BSR) of our model based on a sequestered test set of LCMS serum samples. The methodol. employed is general and can be readily adapted to other LCMS, or metabolomics, data sets. In the experiment, the researchers used many compounds, for example, (2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one (cas: 94-62-2Application of 94-62-2).

(2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one (cas: 94-62-2) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Application of 94-62-2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Various Physical Properties of Piperic Acid: A Potential Biomaterial for Future Electronics Applications was written by Gowsia, Ishrat;Mir, Feroz A.;Banday, Javid A.. And the article was included in Journal of Electronic Materials.SDS of cas: 94-62-2 This article mentions the following:

Alk. hydrolysis of piperine yields piperic acid, which has been studied for its structural, optical, and thermal properties. X-ray diffraction studies revealed an orthorhombic crystal structure for the compound Morphol. studies carried out by SEM revealed that the compound has a fibrous structure. Fourier-transform IR spectroscopy confirms its associated vibrational groups at expected positions. In its UV-visible spectrum, the compound displayed direct forbidden and indirect allowed transitions. The optical band gap (Eg) was calculated at around 3.42 eV, indicating that indirect allowed transitions are followed by the compound Photoluminescence studies show that, with excitation in the UV region, the compound emits in the violet and red regions of the visible spectrum. M.p., stability, and other important thermodn. parameters were obtained from thermal studies of the compound Various properties shown by the compound have also been compared with piperine (parent compound). Piperic acid shows a significant improvement in these properties in comparison with piperine. Both piperine and piperic acid were subjected to theor. calculations using d. function theory. These theor. calculations and exptl. results mostly correlate with each other. Further, as per the observed properties, a diode-like structure of piperic acid was prepared and characterized for elec. properties under various illumination conditions displaying good rectifying behavior. Variation of capacitance and loss of this device was also studied and is briefly explained. The studies carried out on piperic acid project it a suitable candidate for optoelectronic device operation. In the experiment, the researchers used many compounds, for example, (2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one (cas: 94-62-2SDS of cas: 94-62-2).

(2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one (cas: 94-62-2) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.SDS of cas: 94-62-2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Evaluation of Piperine as Natural Coformer for Eutectics Preparation of Drugs Used in the Treatment of Cardiovascular Diseases was written by Wilhelm-Romero, Krissia;Quiros-Fallas, Maria Isabel;Vega-Baudrit, Jose Roberto;Guillen-Giron, Teodolito;Vargas-Huertas, Felipe;Navarro-Hoyos, Mirtha;Araya-Sibaja, Andrea Mariela. And the article was included in AAPS PharmSciTech in 2022.SDS of cas: 94-62-2 This article mentions the following:

Piperine (PIP) was evaluated as a natural coformer in the preparation of multicomponent organic materials for enhancing solubility and dissolution rate of the poorly water-soluble drugs: curcumin (CUR), lovastatin (LOV), and irbesartan (IBS). A screening based on liquid assisted grinding technique was performed using 1:1 drug-PIP molar ratio mixtures, followed by differential scanning calorimetry (DSC) and powder X-ray diffraction (PXRD) anal. Three eutectic mixtures (EMs) composed of CUR-PIP, LOV-PIP, and IBS-PIP were obtained. Therefore, binary phase and Tamman′s diagrams were constructed for each system to obtain the exact eutectic composition, which was 0.41:0.59, 0.29:0.71, and 0.31:0.69 for CUR-PIP, LOV-PIP, and IBS-PIP, resp. Further, bulk materials of each system were prepared to characterize them through DSC, PXRD fully, Fourier transform IR spectroscopy (FT-IR), and solution-state NMR (NMR) spectroscopy. In addition, the contact angle, solubility, and dissolution rate of each system were evaluated. The preserved characteristic in the PXRD patterns and FT-IR spectra of the bulk material of each system confirmed the formation of EM mixture without mol. interaction in solid-state. The formation of EM resulted in improved aqueous solubility and dissolution rate associated with the increased wettability observed by the decrease in contact angle. In addition, solution NMR analyses of CUR-PIP, LOV-PIP, and IBS-PIP suggested no significant intermol. interactions in solution between the components of the EM. Hence, this study concludes that PIP could be an effective coformer to improve the solubility and dissolution rate of CUR, LOV, and IBS. In the experiment, the researchers used many compounds, for example, (2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one (cas: 94-62-2SDS of cas: 94-62-2).

(2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one (cas: 94-62-2) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.SDS of cas: 94-62-2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Application of ohmic heating for black pepper (Piper nigrum L.) oleoresin extraction compared with conventional heating was written by Induruwa Vidana Arachchige Don, Chaminda Sampath Induruwa;Jittanit, Weerachet;Lorjaroenphon, Yaowapa. And the article was included in Journal of Food Processing and Preservation in 2022.Safety of (2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one This article mentions the following:

The aims of this research were to investigate the possibility of applying ohmic heating for assisting in solvent extraction of black pepper oleoresin and to compare the yield and quality of oleoresin with that obtained from the conventional heating method. The elec. conductivities were measured of black pepper powder mixed with different solvents and the residues from each extraction stage. The extraction was conducted in two stages using a black pepper powder-to-solvent ratio of 1:10. The elec. conductivities of the black pepper powder and residue mixtures ranged from 0.01 to 0.17 S/m depending on the ethanol-to-distilled water ratio and extraction stage. Ohmic heating extraction significantly improved the oleoresin yield and piperine content compared to conventional heating. The microstructures of the powder and residues obtained after extraction indicated that ohmic heating caused pores and fractures in the cell walls of black pepper cells that facilitated solvent and oleoresin transfer. Novelty impact statement : This study revealed that the elec. conductivity is an indicator of the oleoresin content in the black pepper powder and raffinate. Moreover, ohmic heating has potential for the com. extraction of black pepper oleoresin and provided scientific evidence of yield and quality improvement. The application of ohmic heating-assisted extraction could broaden the technol. for extracting spice oleoresins in the food industry. In the experiment, the researchers used many compounds, for example, (2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one (cas: 94-62-2Safety of (2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one).

(2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one (cas: 94-62-2) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Safety of (2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Phytochemicals in Breast Cancer-Induced Osteoclastogenesis and Bone Resorption: Mechanism and Future Perspective was written by Pore, Subrata Kumar;Hahm, Eun-Ryeong. And the article was included in Current Pharmacology Reports in 2022.Electric Literature of C9H15NO5 This article mentions the following:

Most breast cancer patients develop bone metastasis and bone-related complications at the late stage of the disease irresp. of the subtypes. Breast cancer destroys bones by inducing osteoclastogenesis, a bone erosion process. Bisphosphonates and denosumab treatments are clin. approved but often with several limitations. Phytochems. have been shown to have anticancer properties against breast cancer especially as chemo-preventive agents. The highly promising phytochems. against breast cancer include cruciferous vegetable components (phenethyl isothiocyanate, benzyl isothiocyanate, and sulforaphane), food constituents (curcumin, piperine, and epigallocatechin gallate), and medicinal plant components (dihydroartemisinin, betulinic acid, silibinin, and plumbagin). A few of them, e.g., isothiocyanates from cruciferous vegetables are under clin. trials. These structurally diverse non-toxic phytochems. could also suppress breast cancer-induced osteoclastogenesis and bone destruction by regulating either breast cancer cells or osteoclast precursors. This review aims to discuss the mechanistic aspects and future perspective for clin. significance of these diverse phytochems. in breast cancer-induced osteoclastogenesis and osteolytic bone erosion. In the experiment, the researchers used many compounds, for example, (2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one (cas: 94-62-2Electric Literature of C9H15NO5).

(2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one (cas: 94-62-2) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Electric Literature of C9H15NO5

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

The efficacy of curcumin-piperine co-supplementation on clinical symptoms, duration, severity, and inflammatory factors in COVID-19 outpatients: a randomized double-blind, placebo-controlled trial was written by Askari, Gholamreza;Sahebkar, Amirhossein;Soleimani, Davood;Mahdavi, Atena;Rafiee, Sahar;Majeed, Muhammed;Khorvash, Farzin;Iraj, Bijan;Elyasi, Mahshid;Rouhani, Mohammad Hossein;Bagherniya, Mohammad. And the article was included in Trials in 2022.Recommanded Product: 94-62-2 This article mentions the following:

COVID-19 pandemic has made the disease a major global problem by creating a significant burden on health, economic, and social status. To date, there are no effective and approved medications for this disease. Curcumin as an anti-inflammatory agent can have a pos. effect on the control of COVID-19 complications. This study aimed to assess the efficacy of curcumin-piperine supplementation on clin. symptoms, duration, severity, and inflammatory factors in patients with COVID-19. Forty-six outpatients with COVID-19 disease were randomly allocated to receive two capsules of curcumin-piperine; each capsule contained 500 mg curcumin plus 5 mg piperine or placebo for 14 days. Mean changes in complete blood count, liver enzymes, blood glucose levels, lipid parameters, kidney function, and c-reactive protein (CRP) were not significantly different between the two groups. There was a significant improvement in health status, including dry cough, sputum cough, ague, sore throat, weakness, muscular pain, headache, and dyspnea at week 2 in both curcumin-piperine and placebo groups (P value < 0.05); however, the improvement in weakness was more in the curcumin-piperine group than with placebo group (P value 025). The present study results showed that curcumin-piperine co-supplementation in outpatients with COVID-19 could significantly reduce weakness. However, in this study, curcumin-piperine co-supplementation could not significantly affect the other indexes, including biochem. and clin. indexes. In the experiment, the researchers used many compounds, for example, (2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one (cas: 94-62-2Recommanded Product: 94-62-2).

(2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one (cas: 94-62-2) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Recommanded Product: 94-62-2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Cardioprotective effect of ethanol extracts of Sugemule-3 decoction on isoproterenol-induced heart failure in Wistar rats through regulation of mitochondrial dynamics was written by Zhen, Dong;Na, Ri-song;Wang, Yu;Bai, Xue;Fu, Dan-ni;Wei, Cheng-xi;Liu, Ming-jie;Yu, Li-jun. And the article was included in Journal of Ethnopharmacology in 2022.Category: piperidines This article mentions the following:

Sugemule-3 decoction (SD-3) is a commonly used prescription in Mongolian medicine which composed of the herbs Baidoukou (the fruit of Amomum compactum Soluble ex Maton), Baijusheng (the fruit of Lactuca sativa L.) and Biba (Piper longum L.). SD-3 has remarkable effect on the cardiovascular diseases, but its pharmacol. mechanism has not been elucidated. To evaluate the cardioprotective effects and the potential mechanisms of the ethanol extracts of SD-3 against isoproterenol (ISO)-induced heart failure (HF) in rats. The ethanol extracts of SD-3 were prepared and analyzed by LC-ESI-MS/MS. One hundred male Wistar rats were randomly divided into five groups: control, ISO (HF) and different doses of SD-3 (0.4, 0.2, 0.1 g/kg/d) groups. HF model rats were established by i.p. injecting of ISO. The left ventricular function was evaluated by echocardiog. Myocardial injury and fibrosis were examined by hematoxylin-eosin (HE) and Masson staining. Western-blot anal. was performed to determine the protein expression of apoptosis and mitochondrial dynamics in all the groups. Moreover, the structural changes in the mitochondria of cardiomyocytes were also observed by transmission electron microscopy. Fifteen compounds were detected in the ethanol extracts of SD-3, include piperine, piperanine, etc. Rats administered with ISO showed a significant decline in the left ventricular function. The cardiac histopathol. changes such as local necrosis, interstitial edema, and cardiac fibrosis were also observed in the ISO group. The treatment with SD-3 significantly inhibited these effects of ISO. ISO was found to increase the protein expression of Bax, cleaved-PARP and cleaved-caspase-3, -7 -9, destroy the balance between mitochondrial fusion and fission, and alter the mitochondrial morphol. The ethanol extracts of SD-3 could rebalance mitochondrial fusion and fission, and ameliorates the morphol. abnormalities induced by ISO in mitochondria. The current study demonstrated that ethanol extracts of SD-3 improved isoprenaline-induced cardiac hypertrophy and fibrosis through inhibiting cardiomyocyte apoptosis and regulating the mitochondrial dynamics. In the experiment, the researchers used many compounds, for example, (2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one (cas: 94-62-2Category: piperidines).

(2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one (cas: 94-62-2) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Biomarker selection and a prospective metabolite-based machine learning diagnostic for lyme disease was written by Kehoe, Eric R.;Fitzgerald, Bryna L.;Graham, Barbara;Islam, M. Nurul;Sharma, Kartikay;Wormser, Gary P.;Belisle, John T.;Kirby, Michael J.. And the article was included in Scientific Reports in 2022.Application of 94-62-2 This article mentions the following:

We provide a pipeline for data preprocessing, biomarker selection, and classification of liquid chromatog.-mass spectrometry (LCMS) serum samples to generate a prospective diagnostic test for Lyme disease. We utilize tools of machine learning (ML), e.g., sparse support vector machines (SSVM), iterative feature removal (IFR), and k-fold feature ranking to select several biomarkers and build a discriminant model for Lyme disease. We report a 98.13% test balanced success rate (BSR) of our model based on a sequestered test set of LCMS serum samples. The methodol. employed is general and can be readily adapted to other LCMS, or metabolomics, data sets. In the experiment, the researchers used many compounds, for example, (2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one (cas: 94-62-2Application of 94-62-2).

(2E,4E)-5-(Benzo[d][1,3]dioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one (cas: 94-62-2) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Application of 94-62-2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem