Tag: 257.3691

Dahlhaus, Helmut et al. published their research in MedChemComm in 2017 | CAS: 142355-83-7

4-(1-Boc-4-piperidyl)-1-butanol (cas: 142355-83-7) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Safety of 4-(1-Boc-4-piperidyl)-1-butanol

(Indolylalkyl)piperidine carbamates as inhibitors of fatty acid amide hydrolase (FAAH) was written by Dahlhaus, Helmut;Hanekamp, Walburga;Lehr, Matthias. And the article was included in MedChemComm in 2017.Safety of 4-(1-Boc-4-piperidyl)-1-butanol This article mentions the following:

A series of Ph 4-[(indol-1-yl)alkyl]piperidine carbamates was synthesized and tested for inhibition of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and for metabolic stability in rat liver S9 fractions and porcine blood plasma. Structure-activity relationship studies revealed that variation of the length of the alkyl spacer connecting the indole and the piperidine heterocycle, introduction of substituents into the indole ring, replacement of the piperidine by a piperazine scaffold as well as opening of the piperidine ring system affect activity significantly. The metabolic stability of this compound class proved to be significantly higher than that of corresponding Ph N-(indol-1-ylalkyl)carbamates. In the experiment, the researchers used many compounds, for example, 4-(1-Boc-4-piperidyl)-1-butanol (cas: 142355-83-7Safety of 4-(1-Boc-4-piperidyl)-1-butanol).

4-(1-Boc-4-piperidyl)-1-butanol (cas: 142355-83-7) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Safety of 4-(1-Boc-4-piperidyl)-1-butanol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Jue, Zhaofan et al. published their research in ChemSusChem in 2022 | CAS: 142355-83-7

4-(1-Boc-4-piperidyl)-1-butanol (cas: 142355-83-7) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Safety of 4-(1-Boc-4-piperidyl)-1-butanol

Visible Light-Induced Unactivated 未-C(sp3)-H Amination of Alcohols Catalyzed by Iron was written by Jue, Zhaofan;Huang, Yahao;Qian, Jiahui;Hu, Peng. And the article was included in ChemSusChem in 2022.Safety of 4-(1-Boc-4-piperidyl)-1-butanol This article mentions the following:

An iron-catalyzed remote C(sp3)-H amination of alcs. through 1,5-hydrogen atom transfer is developed. This protocol provides a method to generate 未-C(sp3)-N bonds from primary, secondary, and tertiary alcs. under mild conditions. A wide substrate scope and a good functional group tolerance are presented. Mechanistic studies show that a LMCT course of an Fe-OR species and a chlorine radical-induced hydrogen abstraction of an alc. are possible to generate the alkoxy radical intermediate. In the experiment, the researchers used many compounds, for example, 4-(1-Boc-4-piperidyl)-1-butanol (cas: 142355-83-7Safety of 4-(1-Boc-4-piperidyl)-1-butanol).

4-(1-Boc-4-piperidyl)-1-butanol (cas: 142355-83-7) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Safety of 4-(1-Boc-4-piperidyl)-1-butanol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Ha, Khanh et al. published their research in ACS Sensors in 2021 | CAS: 142355-83-7

4-(1-Boc-4-piperidyl)-1-butanol (cas: 142355-83-7) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.SDS of cas: 142355-83-7

In Vivo Platelet Detection Using a Glycoprotein IIb/IIIa-Targeted Near-Infrared Fluorescence Imaging Probe was written by Ha, Khanh;Zheng, Xiaoxin;Kessinger, Chase W.;Mauskapf, Adam;Li, Wenzhu;Kawamura, Yoichiro;Orii, Makoto;Hilderbrand, Scott A.;Jaffer, Farouc A.;McCarthy, Jason R.. And the article was included in ACS Sensors in 2021.SDS of cas: 142355-83-7 This article mentions the following:

Platelets play a prominent role in multiple diseases, in particular arterial and venous thrombosis and also in atherosclerosis and cancer. To advance the in vivo study of the biol. activity of this cell type from a basic exptl. focus to a clin. focus, new translatable platelet-specific mol. imaging agents are required. Herein, the development of a near-IR fluorescence probe based upon tirofiban, a clin. approved small-mol. glycoprotein IIb/IIIa inhibitor (GPIIb/IIIa) was reported. Through in vitro experiments with human platelets and in vivo ones in a murine model of deep-vein thrombosis, we demonstrate the avidity of the generated probe for activated platelets, with the added benefit of a short blood half-life, thereby enabling rapid in vivo visualization within the vasculature. In the experiment, the researchers used many compounds, for example, 4-(1-Boc-4-piperidyl)-1-butanol (cas: 142355-83-7SDS of cas: 142355-83-7).

4-(1-Boc-4-piperidyl)-1-butanol (cas: 142355-83-7) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.SDS of cas: 142355-83-7

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Jue, Zhaofan et al. published their research in ChemSusChem in 2022 | CAS: 142355-83-7

4-(1-Boc-4-piperidyl)-1-butanol (cas: 142355-83-7) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Safety of 4-(1-Boc-4-piperidyl)-1-butanol

Visible Light-Induced Unactivated δ-C(sp3)-H Amination of Alcohols Catalyzed by Iron was written by Jue, Zhaofan;Huang, Yahao;Qian, Jiahui;Hu, Peng. And the article was included in ChemSusChem in 2022.Safety of 4-(1-Boc-4-piperidyl)-1-butanol This article mentions the following:

An iron-catalyzed remote C(sp3)-H amination of alcs. through 1,5-hydrogen atom transfer is developed. This protocol provides a method to generate δ-C(sp3)-N bonds from primary, secondary, and tertiary alcs. under mild conditions. A wide substrate scope and a good functional group tolerance are presented. Mechanistic studies show that a LMCT course of an Fe-OR species and a chlorine radical-induced hydrogen abstraction of an alc. are possible to generate the alkoxy radical intermediate. In the experiment, the researchers used many compounds, for example, 4-(1-Boc-4-piperidyl)-1-butanol (cas: 142355-83-7Safety of 4-(1-Boc-4-piperidyl)-1-butanol).

4-(1-Boc-4-piperidyl)-1-butanol (cas: 142355-83-7) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Safety of 4-(1-Boc-4-piperidyl)-1-butanol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Ha, Khanh et al. published their research in ACS Sensors in 2021 | CAS: 142355-83-7

4-(1-Boc-4-piperidyl)-1-butanol (cas: 142355-83-7) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.SDS of cas: 142355-83-7

In Vivo Platelet Detection Using a Glycoprotein IIb/IIIa-Targeted Near-Infrared Fluorescence Imaging Probe was written by Ha, Khanh;Zheng, Xiaoxin;Kessinger, Chase W.;Mauskapf, Adam;Li, Wenzhu;Kawamura, Yoichiro;Orii, Makoto;Hilderbrand, Scott A.;Jaffer, Farouc A.;McCarthy, Jason R.. And the article was included in ACS Sensors in 2021.SDS of cas: 142355-83-7 This article mentions the following:

Platelets play a prominent role in multiple diseases, in particular arterial and venous thrombosis and also in atherosclerosis and cancer. To advance the in vivo study of the biol. activity of this cell type from a basic exptl. focus to a clin. focus, new translatable platelet-specific mol. imaging agents are required. Herein, the development of a near-IR fluorescence probe based upon tirofiban, a clin. approved small-mol. glycoprotein IIb/IIIa inhibitor (GPIIb/IIIa) was reported. Through in vitro experiments with human platelets and in vivo ones in a murine model of deep-vein thrombosis, we demonstrate the avidity of the generated probe for activated platelets, with the added benefit of a short blood half-life, thereby enabling rapid in vivo visualization within the vasculature. In the experiment, the researchers used many compounds, for example, 4-(1-Boc-4-piperidyl)-1-butanol (cas: 142355-83-7SDS of cas: 142355-83-7).

4-(1-Boc-4-piperidyl)-1-butanol (cas: 142355-83-7) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.SDS of cas: 142355-83-7

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Jue, Zhaofan et al. published their research in ChemSusChem in 2022 | CAS: 142355-83-7

4-(1-Boc-4-piperidyl)-1-butanol (cas: 142355-83-7) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Safety of 4-(1-Boc-4-piperidyl)-1-butanol

Visible Light-Induced Unactivated δ-C(sp3)-H Amination of Alcohols Catalyzed by Iron was written by Jue, Zhaofan;Huang, Yahao;Qian, Jiahui;Hu, Peng. And the article was included in ChemSusChem in 2022.Safety of 4-(1-Boc-4-piperidyl)-1-butanol This article mentions the following:

An iron-catalyzed remote C(sp3)-H amination of alcs. through 1,5-hydrogen atom transfer is developed. This protocol provides a method to generate δ-C(sp3)-N bonds from primary, secondary, and tertiary alcs. under mild conditions. A wide substrate scope and a good functional group tolerance are presented. Mechanistic studies show that a LMCT course of an Fe-OR species and a chlorine radical-induced hydrogen abstraction of an alc. are possible to generate the alkoxy radical intermediate. In the experiment, the researchers used many compounds, for example, 4-(1-Boc-4-piperidyl)-1-butanol (cas: 142355-83-7Safety of 4-(1-Boc-4-piperidyl)-1-butanol).

4-(1-Boc-4-piperidyl)-1-butanol (cas: 142355-83-7) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Safety of 4-(1-Boc-4-piperidyl)-1-butanol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Ha, Khanh et al. published their research in ACS Sensors in 2021 | CAS: 142355-83-7

4-(1-Boc-4-piperidyl)-1-butanol (cas: 142355-83-7) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.SDS of cas: 142355-83-7

In Vivo Platelet Detection Using a Glycoprotein IIb/IIIa-Targeted Near-Infrared Fluorescence Imaging Probe was written by Ha, Khanh;Zheng, Xiaoxin;Kessinger, Chase W.;Mauskapf, Adam;Li, Wenzhu;Kawamura, Yoichiro;Orii, Makoto;Hilderbrand, Scott A.;Jaffer, Farouc A.;McCarthy, Jason R.. And the article was included in ACS Sensors in 2021.SDS of cas: 142355-83-7 This article mentions the following:

Platelets play a prominent role in multiple diseases, in particular arterial and venous thrombosis and also in atherosclerosis and cancer. To advance the in vivo study of the biol. activity of this cell type from a basic exptl. focus to a clin. focus, new translatable platelet-specific mol. imaging agents are required. Herein, the development of a near-IR fluorescence probe based upon tirofiban, a clin. approved small-mol. glycoprotein IIb/IIIa inhibitor (GPIIb/IIIa) was reported. Through in vitro experiments with human platelets and in vivo ones in a murine model of deep-vein thrombosis, we demonstrate the avidity of the generated probe for activated platelets, with the added benefit of a short blood half-life, thereby enabling rapid in vivo visualization within the vasculature. In the experiment, the researchers used many compounds, for example, 4-(1-Boc-4-piperidyl)-1-butanol (cas: 142355-83-7SDS of cas: 142355-83-7).

4-(1-Boc-4-piperidyl)-1-butanol (cas: 142355-83-7) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.SDS of cas: 142355-83-7

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem