Tag: 247.2897

Three-Component Coupling of Aldehydes, 2-Aminopyridines, and Diazo Esters via Rhodium(III)-Catalyzed Imidoyl C-H Activation: Synthesis of Pyrido[1,2-a]pyrimidin-4-ones was written by Hoang, Gia L.;Zoll, Adam J.;Ellman, Jonathan A.. And the article was included in Organic Letters in 2019.Formula: C14H17NO3 This article mentions the following:

Imines formed in situ from 2-aminopyridines and aldehydes undergo Rh(III)-catalyzed imidoyl C-H activation and coupling with diazo esters to give pyrido[1,2-a]pyrimidin-4-ones. Aromatic and enolizable aliphatic aldehydes were both effective substrates, and a broad range of functional groups were incorporated at different sites on the heterocyclic products. In addition, methoxy and dimethylamino functionalities could be directly installed on the pyrimidine ring by employing tri-Me orthoformate or N,N-dimethylformamide di-Me acetal in place of the aldehyde, resp. In the experiment, the researchers used many compounds, for example, Benzyl 4-formylpiperidine-1-carboxylate (cas: 138163-08-3Formula: C14H17NO3).

Benzyl 4-formylpiperidine-1-carboxylate (cas: 138163-08-3) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Formula: C14H17NO3

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA₂) was written by Woolford, Alison J.-A.;Day, Philip J.;Beneton, Veronique;Berdini, Valerio;Coyle, Joseph E.;Dudit, Yann;Grondin, Pascal;Huet, Pascal;Lee, Lydia Y. W.;Manas, Eric S.;McMenamin, Rachel L.;Murray, Christopher W.;Page, Lee W.;Patel, Vipulkumar K.;Potvain, Florent;Rich, Sharna J.;Sang, Yingxia;Somers, Don O.;Trottet, Lionel;Wan, Zehong;Zhang, Xiaomin. And the article was included in Journal of Medicinal Chemistry in 2016.Computed Properties of C14H17NO3 This article mentions the following:

Lp-PLA₂ has been explored as a target for a number of inflammation associated diseases, including cardiovascular disease and dementia. This article describes the discovery of a new fragment derived chemotype that interacts with the active site of Lp-PLA₂. The starting fragment hit was discovered through an x-ray fragment screen and showed no activity in the bioassay (IC₅₀ > 1 mM). The fragment hit was optimized using a variety of structure-based drug design techniques, including virtual screening, fragment merging, and improvement of shape complementarity. A novel series of Lp-PLA₂ inhibitors was generated with low lipophilicity and a promising pharmacokinetic profile. In the experiment, the researchers used many compounds, for example, Benzyl 4-formylpiperidine-1-carboxylate (cas: 138163-08-3Computed Properties of C14H17NO3).

Benzyl 4-formylpiperidine-1-carboxylate (cas: 138163-08-3) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Computed Properties of C14H17NO3

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Three-Component Coupling of Aldehydes, 2-Aminopyridines, and Diazo Esters via Rhodium(III)-Catalyzed Imidoyl C-H Activation: Synthesis of Pyrido[1,2-a]pyrimidin-4-ones was written by Hoang, Gia L.;Zoll, Adam J.;Ellman, Jonathan A.. And the article was included in Organic Letters in 2019.Formula: C14H17NO3 This article mentions the following:

Imines formed in situ from 2-aminopyridines and aldehydes undergo Rh(III)-catalyzed imidoyl C-H activation and coupling with diazo esters to give pyrido[1,2-a]pyrimidin-4-ones. Aromatic and enolizable aliphatic aldehydes were both effective substrates, and a broad range of functional groups were incorporated at different sites on the heterocyclic products. In addition, methoxy and dimethylamino functionalities could be directly installed on the pyrimidine ring by employing tri-Me orthoformate or N,N-dimethylformamide di-Me acetal in place of the aldehyde, resp. In the experiment, the researchers used many compounds, for example, Benzyl 4-formylpiperidine-1-carboxylate (cas: 138163-08-3Formula: C14H17NO3).

Benzyl 4-formylpiperidine-1-carboxylate (cas: 138163-08-3) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Formula: C14H17NO3

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA₂) was written by Woolford, Alison J.-A.;Day, Philip J.;Beneton, Veronique;Berdini, Valerio;Coyle, Joseph E.;Dudit, Yann;Grondin, Pascal;Huet, Pascal;Lee, Lydia Y. W.;Manas, Eric S.;McMenamin, Rachel L.;Murray, Christopher W.;Page, Lee W.;Patel, Vipulkumar K.;Potvain, Florent;Rich, Sharna J.;Sang, Yingxia;Somers, Don O.;Trottet, Lionel;Wan, Zehong;Zhang, Xiaomin. And the article was included in Journal of Medicinal Chemistry in 2016.Computed Properties of C14H17NO3 This article mentions the following:

Lp-PLA₂ has been explored as a target for a number of inflammation associated diseases, including cardiovascular disease and dementia. This article describes the discovery of a new fragment derived chemotype that interacts with the active site of Lp-PLA₂. The starting fragment hit was discovered through an x-ray fragment screen and showed no activity in the bioassay (IC₅₀ > 1 mM). The fragment hit was optimized using a variety of structure-based drug design techniques, including virtual screening, fragment merging, and improvement of shape complementarity. A novel series of Lp-PLA₂ inhibitors was generated with low lipophilicity and a promising pharmacokinetic profile. In the experiment, the researchers used many compounds, for example, Benzyl 4-formylpiperidine-1-carboxylate (cas: 138163-08-3Computed Properties of C14H17NO3).

Benzyl 4-formylpiperidine-1-carboxylate (cas: 138163-08-3) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Computed Properties of C14H17NO3

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Three-Component Coupling of Aldehydes, 2-Aminopyridines, and Diazo Esters via Rhodium(III)-Catalyzed Imidoyl C-H Activation: Synthesis of Pyrido[1,2-a]pyrimidin-4-ones was written by Hoang, Gia L.;Zoll, Adam J.;Ellman, Jonathan A.. And the article was included in Organic Letters in 2019.Formula: C14H17NO3 This article mentions the following:

Imines formed in situ from 2-aminopyridines and aldehydes undergo Rh(III)-catalyzed imidoyl C-H activation and coupling with diazo esters to give pyrido[1,2-a]pyrimidin-4-ones. Aromatic and enolizable aliphatic aldehydes were both effective substrates, and a broad range of functional groups were incorporated at different sites on the heterocyclic products. In addition, methoxy and dimethylamino functionalities could be directly installed on the pyrimidine ring by employing tri-Me orthoformate or N,N-dimethylformamide di-Me acetal in place of the aldehyde, resp. In the experiment, the researchers used many compounds, for example, Benzyl 4-formylpiperidine-1-carboxylate (cas: 138163-08-3Formula: C14H17NO3).

Benzyl 4-formylpiperidine-1-carboxylate (cas: 138163-08-3) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Formula: C14H17NO3

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Fragment-Based Approach to the Development of an Orally Bioavailable Lactam Inhibitor of Lipoprotein-Associated Phospholipase A2 (Lp-PLA₂) was written by Woolford, Alison J.-A.;Day, Philip J.;Beneton, Veronique;Berdini, Valerio;Coyle, Joseph E.;Dudit, Yann;Grondin, Pascal;Huet, Pascal;Lee, Lydia Y. W.;Manas, Eric S.;McMenamin, Rachel L.;Murray, Christopher W.;Page, Lee W.;Patel, Vipulkumar K.;Potvain, Florent;Rich, Sharna J.;Sang, Yingxia;Somers, Don O.;Trottet, Lionel;Wan, Zehong;Zhang, Xiaomin. And the article was included in Journal of Medicinal Chemistry in 2016.Computed Properties of C14H17NO3 This article mentions the following:

Lp-PLA₂ has been explored as a target for a number of inflammation associated diseases, including cardiovascular disease and dementia. This article describes the discovery of a new fragment derived chemotype that interacts with the active site of Lp-PLA₂. The starting fragment hit was discovered through an x-ray fragment screen and showed no activity in the bioassay (IC₅₀ > 1 mM). The fragment hit was optimized using a variety of structure-based drug design techniques, including virtual screening, fragment merging, and improvement of shape complementarity. A novel series of Lp-PLA₂ inhibitors was generated with low lipophilicity and a promising pharmacokinetic profile. In the experiment, the researchers used many compounds, for example, Benzyl 4-formylpiperidine-1-carboxylate (cas: 138163-08-3Computed Properties of C14H17NO3).

Benzyl 4-formylpiperidine-1-carboxylate (cas: 138163-08-3) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Computed Properties of C14H17NO3

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem