With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.24666-56-6,3-Aminopiperidine-2,6-dione hydrochloride,as a common compound, the synthetic route is as follows.
Methyl-4-bromo-2-(bromomethyl) benzoate (100 g, 324.70 mmol), 3-Aminopiperidine-2,6-dione.hydrochloride (53.2 g, 324.70 mmol), triethylamine (113.29 mL, 811.75 mmol), and dry dimethylformamide (400 mL) were combined and stirred at room temperature under inert atmosphere for 18 hours. The reaction was cooled to 5C and diluted with water (400 mL), acetic acid (115 mL), diethylether (300 mL) with continued stirring at room temperature for 2 hours. The resultant solid was filtered, washed with ether (100 mL) and further dried under high vacuum to give 3-(5-Bromo-1-oxoisoindolin-2-yl)piperidine-2,6-dione (46 g, 142.35 mmol, 43.8 % yield) as a light blue solid. MS(ESI) m/z 325.0 [M+1].
24666-56-6 3-Aminopiperidine-2,6-dione hydrochloride 134548, apiperidines compound, is more and more widely used in various.
Reference£º
Patent; CELGENE CORPORATION; ALEXANDER, Matthew, D.; CORREA, Matthew, D.; HANSEN, Joshua; RAHEJA, Raj, Kumar; SAPIENZA, John; (128 pag.)WO2017/120422; (2017); A1;,
Piperidine – Wikipedia
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