Tag: 236406-39-6

236406-39-6, 8-Boc-2,8-Diazaspiro[4.5]decane is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To a solution of intermediate I-i 3a (445 mg, 1 .25 mmol) in anhydrous DCM(50 mL) was added R-29a: tert-butyl 2,8-diazaspiro[4.5]decane-8-carboxylate(200 mg, 0.833 mmol), Cu(OAc)2 (181 mg, 1.0 mmol), DMAP (22 mg, 0.167 mmol), Et3N (337 mg, 3.332 mmol) and 4A MS (0.8 g), then the mixture was stirred at room temperature for 3 hrs under 02 atmosphere. After LC-MS showed the starting material was consumed completely, then added water,filtered, the mixture was extracted with DCM, the organic layer was washed with brine, dried over anhydrous Na2504, concentrated to give the crude compound which was purified by Prep-TLC ( PE/ EtOAc = 1 .5:1 ) to give the pure intermediate I-131a (60 mg, 13% yield) as a yellow solid. ESI-MS (Mi-i):551 calc. for C30H42N604: 550.3., 236406-39-6

As the paragraph descriping shows that 236406-39-6 is playing an increasingly important role.

Reference£º
Patent; FUNDACION PARA LA INVESTIGACION MEDICA APLICADA; CUADRADO TEJEDOR, Maria Del Mar; FRANCO FERNANDEZ, Rafael; GARCIA OSTA, Ana Maria; OYARZABAL SANTAMARINA, Julen; RABAL GRACIA, Maria Obdulia; WO2014/131855; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.236406-39-6,8-Boc-2,8-Diazaspiro[4.5]decane,as a common compound, the synthetic route is as follows.

At room temperature,To a solution of tert-butyl 2,8-azaspiro[4,5]decane-8-carboxylate (192 mg, 0.88 mmol) in EtOAc (15 mL)And potassium carbonate (276 mg, 2 mmol),Stir at room temperature for 2 hours.Distilled water (30 mL) was added to the reaction mixture, and ethyl acetate (20 mL¡Á3).The layers were combined, dried over anhydrous magnesium sulfate, and concentrated, then purified by silica gel column (DCM: MeOH_NH3H2O=200:10:0.2)A pale yellow oil (260 mg).

The synthetic route of 236406-39-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Zhejiang Sitaili Pharmaceutical Co., Ltd.; Chinese Academy Of Medical Sciences Pharmaceutical Bio-technology Institute; Liu Mingliang; Guo Huiyuan; Lv Kai; Wang Apeng; Chai Yun; Huang Guocheng; Tao Zeyu; Li Xiaoning; Chen Shihong; (23 pag.)CN108484601; (2018); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

236406-39-6, 8-Boc-2,8-Diazaspiro[4.5]decane is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 50 tert-butyl 2-[4-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)phenyl]-2,8-diazaspiro[4.5]decane-8-carboxylate Under an argon atmosphere, an anhydrous toluene (1 mL) solution of trisdibenzylideneacetone dipalladium (21 mg), biphenyl-2-yl(dicyclohexyl)phosphine (32 mg) and tert-butoxy potassium (306 mg) was stirred at room temperature for one hour. To this solution, an anhydrous toluene (2 mL) solution of the compound (714 mg) obtained in Example 49 and tert-butyl 2,8-diazaspiro[4.5]decane-8-carboxylate (594 mg) was added. The reaction solution was stirred at 100C for one hour. The reaction solution was cooled to room temperature, and then water (10 mL) was added. The aqueous layer was filtered through Celite (trade name). The aqueous layer was extracted with ethyl acetate. The combined organic layer was washed with saturated brine and then dried over anhydrous magnesium sulfate. After removing the anhydrous magnesium sulfate by filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography (n-hexane:ethyl acetate=98:2?77:23) to obtain the title compound (683 mg) having the following physical properties. TLC: Rf 0.24(n-hexane:ethyl acetate=19:1); NMR(CDCl3):delta 7.07 (d, J=8.4Hz, 2H), 6.48 (d, J=8.4Hz, 2H), 3.73 (t, J=6.9Hz, 2H), 3.49 (m, 2H), 3.36 (m, 4H), 3.14 (s, 2H), 2.73 (t, J=6.9Hz, 2H), 1.87 (t, J=6.9Hz, 2H), 1.56 (m, 4H), 1.46 (s, 9H), 0.89 (s, 9H), -0.03 (s, 6H).

As the paragraph descriping shows that 236406-39-6 is playing an increasingly important role.

Reference£º
Patent; ONO PHARMACEUTICAL CO., LTD.; EP1961744; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.236406-39-6,8-Boc-2,8-Diazaspiro[4.5]decane,as a common compound, the synthetic route is as follows.

A 250-mL round-bottom flask was charged with 5-chloro-2-(trifluoromethyl)benzaldehyde (0.860 g, 4.12 mmol, 1.00 equiv), tert-butyl 2,8-diazaspiro[4.5]decane-8-carboxylate (1.00 g, 4.16 mmol, 1.00 equiv), and 1,2-dichloroethane (50 mL). The mixture was stirred for 2 hours at room temperature prior to addition of sodium triacetoxyborohydride (3.90 g, 18.4 mmol, 2.00 equiv). The resulting solution was stirred overnight at room temperature and quenched with water (50 mL). The mixture was extracted with dichloromethane (3*50 mL) and the organic layers were combined, washed with water (3*50 mL), dried over anhydrous sodium sulfate, filtered, and concentrated under reduced pressure. The residue was chromatographed on a silica gel column to provide 1.50 g (84% yield) of tert-butyl 2-(5-chloro-2-(trifluoromethyl)benzyl)-2,8-diazaspiro[4.5]decane-8-carboxylate as a white oil. LCMS (ESI, m/z): 433 [M+H]+.

As the paragraph descriping shows that 236406-39-6 is playing an increasingly important role.

Reference£º
Patent; ABIDE THERAPEUTICS, INC.; GRICE, Cheryl A.; CISAR, Justin S.; DUNCAN, Katharine K.; FENG, Yu; WIENER, John J.M.; WEBER, Olivia D.; (79 pag.)US2018/256566; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.236406-39-6,8-Boc-2,8-Diazaspiro[4.5]decane,as a common compound, the synthetic route is as follows.

General procedure: A mixture of compound 8 (0.3 mmol) and corresponding ketones (0.4 mmol) in Ti(OPr)4 was stirred at 70 C for 8 h and cooled to room temperature. MeOH (5 mL) and NaCNBH3 (1.6 mmol) wasadded to the mixture, and stirred for 5 h at 40 C. The mixture was quenched by 1 N NaOH (10 mL), filtered by Celite, and washed by MeOH. The MeOH was evaporated under vacuo. The residue wasdiluted by H2O, and extracted by Et2O. The combined organic layer was washed by brine, dried over anhydrous MgSO4, filtered, andconcentrated. The residue was purified over silica gel column(DCM: MeOH = 30 : 1) to yield oils 11c-g (yield, 40-70%).

236406-39-6 8-Boc-2,8-Diazaspiro[4.5]decane 23282900, apiperidines compound, is more and more widely used in various.

Reference£º
Article; Lv, Kai; Wang, Apeng; Tao, Zeyu; Fu, Lei; Liu, Hongtao; Wang, Bin; Ma, Chao; Wang, Hongjian; Ma, Xican; Han, Bing; Wang, Auyu; Zhang, Kai; Liu, Mingliang; Lu, Yu; European Journal of Medicinal Chemistry; vol. 179; (2019); p. 208 – 217;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem