Tag: 220.2246

Incredible colorimetric sensing behavior of pyrazole-based imine chemosensor towards copper (II) ion detection: synthesis, characterization and theoretical investigations was written by Nelson, Malini;Muniyasamy, Harikrishnan;Ongi, Pavithra;Balakrishnan, Sankar;Sepperumal, Murugesan;Ayyanar, Siva;Jegathalaprathaban, Rajesh. And the article was included in Results in Chemistry in 2022.SDS of cas: 38560-30-4 This article mentions the following:

More conjugated compounds like substituted fluorene, anthracene and pyrene based pyrazole derivatives with good yield was synthesized. All the compounds were thoroughly characterized by various spectral techniques such as NMR and mass anal. Further, the photophys. behavior of pyrazole derivatives (hybrids) upon the addition of analytes was studied using UV-visible spectroscopic techniques. All the hybrid compounds were good colorimetric sensor for copper(II) ion. AS1, AS2 and AS3 hybrid compounds possess the limit of detections as 0.62 μM, 0.47 μM and 4.4 μM resp. The binding constant of the hybrid compounds AS1, AS2 and AS3 were 3.1 x 10^-2 M, 3.9 x 10^-2 M and 2.3 x 10^-2 M resp. The detection limit and binding constant of anthracene based hybrid AS2 was superior when compared to AS1 and AS3. Further, ligand to the metal charge transition of the probe with analytes were confirmed by d. function theory (DFT) through Gaussian 09 Software. In the experiment, the researchers used many compounds, for example, 1-(4-Nitrophenyl)piperidin-2-one (cas: 38560-30-4SDS of cas: 38560-30-4).

1-(4-Nitrophenyl)piperidin-2-one (cas: 38560-30-4) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.SDS of cas: 38560-30-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Powder X-ray diffraction of 1-(4-Nitrophenyl)-2-piperidinone, C₁₁H₁₂N₂O₃ was written by Wang, Qing;Xiong, Xin Nuo;He, Jia Wei;Tang, Pei Xiao;Li, Hui. And the article was included in Powder Diffraction in 2015.Name: 1-(4-Nitrophenyl)piperidin-2-one This article mentions the following:

X-ray powder diffraction data for 1-(4-Nitrophenyl)-2-piperidinone, C₁₁H₁₂N₂O₃, are reported [a = 9.514(3) Å, b = 12.308(6) Å, c = 9.175(1) Å, α = 90°, β = 91.811(2)°, γ = 90°, V = 1073.94 ų, Z = 4, ρ _cal = 1.362 g cm^-3 and space group P2₁/n]. All measured lines were indexed and are consistent with the P2₁/n space group. No detectable impurities were observed In the experiment, the researchers used many compounds, for example, 1-(4-Nitrophenyl)piperidin-2-one (cas: 38560-30-4Name: 1-(4-Nitrophenyl)piperidin-2-one).

1-(4-Nitrophenyl)piperidin-2-one (cas: 38560-30-4) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Name: 1-(4-Nitrophenyl)piperidin-2-one

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Synthesis of apixaban was written by He, Chao;Hou, Yunlei;Zhu, Yan;Ma, Longsheng;Zhao, Yanfang. And the article was included in Zhongguo Yiyao Gongye Zazhi in 2014.Quality Control of 1-(4-Nitrophenyl)piperidin-2-one This article mentions the following:

The key intermediate 3-(4-morpholinyl)-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one (5) was obtained via amidation, cyclization, dichlorination and elimination with 4-nitroaniline as the starting material. While another intermediate Et 2-chloro-2-[2-(4-methoxyphenyl)hydrazono]acetate (6) was prepared from 4-anisidine by diazotization and Japp-Klingemann reaction with Et 2-chloro-3-oxobutanoate. Apixaban, a factor Xa direct inhibitor, was synthesized from 5 and 6 by 1,3-dipolar cycloaddition, olefination, reduction, amidation, cyclization and aminolysis with an overall yield of 25% (based on 4-nitroaniline) and a HPLC purity of 99%. The improved process had several advantages over those reported procedures, such as mild conditions and simple operations, which is more suitable for industrial production In the experiment, the researchers used many compounds, for example, 1-(4-Nitrophenyl)piperidin-2-one (cas: 38560-30-4Quality Control of 1-(4-Nitrophenyl)piperidin-2-one).

1-(4-Nitrophenyl)piperidin-2-one (cas: 38560-30-4) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Quality Control of 1-(4-Nitrophenyl)piperidin-2-one

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem