Tag: 213.2966

CuI/N4 ligand/TEMPO derivatives: a mild and highly efficient system for aerobic oxidation of primary alcohols was written by Zhang, Shufang;Miao, Chengxia;Xu, Daqian;Sun, Wei;Xia, Chungu. And the article was included in Cuihua Xuebao in 2014.Quality Control of 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl This article mentions the following:

A new system consisting of a copper(I) complex generated in situ from a tetradentate nitrogen ligand and CuI in combination with 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) derivatives was successfully developed. The system was suitable for efficient and selective aerobic oxidation of primary benzyl and allyl alcs. with a wide range of functional groups to the corresponding aldehydes at room temperature The best result was obtained with N,N’-dimethyl-N,N’-bis(2-pyridylmethyl)ethane-1,2-diamine as the ligand and 4-OH-TEMPO as a catalyst in MeCN. In addition, high-resolution mass spectrometry, UV-visible spectroscopy, and electrochem. experiments were used to provide evidence of intermediates. In the experiment, the researchers used many compounds, for example, 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl (cas: 14691-89-5Quality Control of 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl).

4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl (cas: 14691-89-5) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Quality Control of 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Synergism of the action of some stabilisers against the destruction of polymer materials was written by Zhukova, Irina;Flik, Evgeniya;Shubina, Elena;Mishurov, Vladimir;Kashparov, Ivan. And the article was included in E3S Web of Conferences in 2021.Category: piperidines This article mentions the following:

The process of thermal-oxidative degradation of polymer materials has been studied on the example of polyethylene in the presence of quinones and/or nitroxyl radicals. The synergistic effect of the pos. action of a mixture of stabilizers from a number of quinones and nitroxyl radicals on the destructive process of polyethylene has been established. It has been shown that the rate of degradation has significantly slowed down when an equimol. mixture of 4-acetylamino-2,2,6,6-tetramethylhexahydropyridine-1-oxyl and 2,6-di-tert-amyl-1,4-cyclohexadienone inhibitors has been introduced into the polymer. The kinetics of the initiated thermo-destructive process of polyethylene oxidation in the presence and absence of stabilizers has been studied. A mechanism of joint action of stabilizers based on their interaction with radicals and the breakage of radical chains, as well as a mechanism for the regeneration of stabilizers, has been proposed. In the experiment, the researchers used many compounds, for example, 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl (cas: 14691-89-5Category: piperidines).

4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl (cas: 14691-89-5) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Thermo-sensitive and swelling properties of cellouronic acid sodium/poly (acrylamide-co-diallyldimethylammonium chloride) semi-IPN was written by Zhang, Heng;Gao, Xin;Chen, Keli;Li, Hui;Peng, Lincai. And the article was included in Carbohydrate Polymers in 2018.Category: piperidines This article mentions the following:

In current study, celluronic acid sodium (CAS), obtained from bagasse pith, has been introduced into poly(acrylamide-co-diallyldimethylammonium chloride) (poly(AM-co-DAC)) network to form novel thermo-sensitive semi-IPNs. The structure and morphol. of the hydrogels were proved by Fourier transformation IR spectroscopy (FT-IR), XPS and SEM (SEM). The effects of CAS content, initiator charge, cross-linker dosage and swelling-medium property on the thermo-responsive water absorptivity were investigated in detail. The results elucidated that the prepared gels exhibited a thermo-sensibility with an upper critical solution temperature (UCST) and a high water-absorbency. And the values of UCST and equilibrium swelling ratio largely depended on the inner structure of the semi-IPNs and the external solvent property. It was also revealed that the swelling process conformed to the Schott’s pseudo second order model and diffusion type was non-Fickian diffusion. The value of activation energy for this polyelectrolyte was found to be 8.74 kJ/mol. In the experiment, the researchers used many compounds, for example, 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl (cas: 14691-89-5Category: piperidines).

4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl (cas: 14691-89-5) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Radical Charge Population and Energy: Critical Role in Redox Potential and Cycling Life of Piperidine Nitroxyl Radical Cathodes in Aqueous Zinc Hybrid Flow Batteries was written by Fan, Hao;Zhang, Jiahui;Ravivarma, Mahalingam;Li, Hongbin;Hu, Bo;Lei, Jiafeng;Feng, Yangyang;Xiong, Shizhao;He, Cheng;Gong, Jianying;Gao, Tieyu;Song, Jiangxuan. And the article was included in ACS Applied Materials & Interfaces in 2020.COA of Formula: C11H21N2O2 This article mentions the following:

Redox-active 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) derivatives have recently been investigated to expand the choice of catholyte for aqueous flow batteries (AFBs). However, the effects of substituent R in 4-position on redox potential and corresponding capacity fading mechanism are still unclear. Here, we conduct comparative studies of four R-TEMPO with R = -OH, -NH₂, -COOH, and -NHCOCH₃ in zinc hybrid AFBs. Exptl. and theor. analyses reveal that low-radical head charge population sum and radical energy, depending on R in 4-position, play a critical role in enhancing redox potential and cycling life of R-TEMPO. The electronic effect brought along by N-acetyl could redistribute the charge and lower systematic energy, making the ring-opening joint sturdy and therefore suppress the side reactions. Accordingly, the 4-NHCOCH₃-TEMPO/Zn battery achieves a high capacity retention of >99.65%/day and an open-circuit voltage of 1.71 V. Our findings on the effects of substituent are greatly anticipated to boost the high-energy d., long-life, and eco-friendly TEMPO-based AFBs. In the experiment, the researchers used many compounds, for example, 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl (cas: 14691-89-5COA of Formula: C11H21N2O2).

4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl (cas: 14691-89-5) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.COA of Formula: C11H21N2O2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Molecular Orientation and Dynamics of a Derivative of 2,2,6,6-Tetramethyl-1-Piperidinyloxyl Radical with a Large Substituent Group Dispersed in 1D-Nanochannels of 2,4,6-Tris(4-Chlorophenoxy)-1,3,5-Triazine Crystal was written by Kobayashi, Hirokazu;Odanaka, Yuki. And the article was included in Applied Magnetic Resonance in 2020.Reference of 14691-89-5 This article mentions the following:

The mol. orientation and dynamics were examined for 4-acetamido-2,2,6,6-tetramethyl-1-piperidinyloxyl (4-acetamido-TEMPO) radicals, which have a larger substituent group than many other TEMPO radicals, dispersed in the one-dimensional (1D) nanochannel of 2,4,6-tris(4-chlorophenoxy)-1,3,5-triazine (CLPOT) with 4-substituted-2,2,6,6-tetramethylpiperidine (R-TEMP; R=OH or H). When TEMPOH (R=OH) was used as a spacer for dispersion in the CLPOT nanochannels, the mol. orientation of 4-acetamido-TEMPO in the CLPOT nanochannels was similar to that of other previously reported 4-substituted-TEMPO (4-X-TEMPO; X=OH, =O or OCH₃) radicals. However, the activation energy for the rotational diffusion of 4-acetamido-TEMPO in the CLPOT nanochannels, estimated to be 11 kJ mol^-1, was larger than that of other 4-X-TEMPO mols. (6-8 kJ mol^-1). These results indicate that the mol. dynamics of 4-X-TEMPO in the CLPOT nanochannels can be controlled by the selection of a larger substituent X at the 4-position in 4-X-TEMPO (in this study, X=NHCOCH₃), and also suggest an important concept for the design of new organic magnets. In the experiment, the researchers used many compounds, for example, 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl (cas: 14691-89-5Reference of 14691-89-5).

4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl (cas: 14691-89-5) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Reference of 14691-89-5

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Ionic Liquid Stabilized 2,2,6,6-Tetramethylpiperidine 1-Oxyl Catalysis for Alcohol Oxidation was written by Li, Min;Klunder, Kevin;Blumenthal, Emmy;Prater, Matthew B.;Lee, Jack;Matthiesen, John E.;Minteer, Shelley D.. And the article was included in ACS Sustainable Chemistry & Engineering in 2020.Application of 14691-89-5 This article mentions the following:

N-Oxyl reagents, particularly 2,2,6,6-tetramethylpiperidine 1-oxyl (TEMPO), have been extensively used for alc. oxidations While TEMPO-mediated oxidations are kinetically and thermodynamically favorable in high-pH electrolytes, base-induced degradation often results in significant loss of catalytic activity. Herein, we demonstrate enhanced alk. stability of a TEMPO derivative in ionic liquids (ILs). By incorporating TEMPO in an imidazole-anchored IL, no loss of current was observed at pH 10.0 after 2.0 h during the oxidation of butanol and glycerol, while TEMPO in polycaprolactone (PCL), a patternable binder material, degraded 58.5% and 67.1%, resp. The stability enhancement was further demonstrated by analyzing the conversion of glycerol in an 800μL electrochem. cell using bulk chem. anal. techniques. Successive cycles of glycerol oxidation indicated 14-fold stability enhancement by applying IL in a TEMPO electrode composite in comparison to PCL. The strategy demonstrated here provides an opportunity to prepare catalytic systems with enhanced stability. Further, this method provides the ability to convert what are typically homogeneous catalysts to heterogeneous systems. To improve the stability of TEMPO, used to mediate oxidations for biorenewables, an ionic liquid based catalyst was developed. In the experiment, the researchers used many compounds, for example, 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl (cas: 14691-89-5Application of 14691-89-5).

4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl (cas: 14691-89-5) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Application of 14691-89-5

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Cellulose dissolution in aqueous NaOH-ZnO: effect of pulp pretreatment at macro and molecular levels was written by Vaisanen, Saija;Kosonen, Harri;Ristolainen, Matti;Vuorinen, Tapani. And the article was included in Cellulose (Dordrecht, Netherlands) in 2021.Synthetic Route of C11H21N2O2 This article mentions the following:

This paper discusses the effect of hydrolytic pretreatments on pulp dissolution in the aqueous NaOH-ZnO solvent system. Eight samples were studied. They consisted of a never-dried softwood kraft pulp that was hydrolyzed under seven different conditions as well as the pulp without hydrolysis as a reference The dissolution of the pulps was evaluated both at the macro level as well as at the mol. level based on their reactivity with 4-acetamido-2,2,6,6-tetramethylpiperidine-1-oxo-piperidium (4-AcNH-TEMPO+). The fiber properties (i.e. the extent of fibrillation, amount of fines and fiber width, coarseness, and length) as well as the chem. composition (hemicellulose and cellulose contents) and the viscosity of the pulps was investigated. The results show that hydrolysis at medium consistency (10%) was successful in increasing the solubility of cellulose. Hydrolysis at high consistency (50%), on the other hand, increased the solubility only to some extent. With extended treatment time the fibers formed aggregates and their dissolution became poor. This phenomenon could be overcome by mech. refining the fibers after the hydrolysis. Moreover, comparison of the viscosity of the pulp over the degree of oxidation revealed that the viscosity needed to decrease below ca. 400 mL/g in order for the outer layers of the fibers to dissolve. Finally, when pulps with similar viscosities where compared against each other, the ones with the higher glucomannan contents formed gels over time. In the experiment, the researchers used many compounds, for example, 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl (cas: 14691-89-5Synthetic Route of C11H21N2O2).

4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl (cas: 14691-89-5) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Synthetic Route of C11H21N2O2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Stabilities, Regeneration Pathways, and Electrocatalytic Properties of Nitroxyl Radicals for the Electrochemical Oxidation of 5-Hydroxymethylfurfural was written by Cardiel, Allison C.;Taitt, Brandon J.;Choi, Kyoung-Shin. And the article was included in ACS Sustainable Chemistry & Engineering in 2019.Recommanded Product: 14691-89-5 This article mentions the following:

2,5-Furandicarboxylic acid (FDCA) is a near-market monomer that has been identified as a viable biomass-derived replacement for petroleum-derived terephthalic acid in the synthesis of polyethylene terephthalate (PET). FDCA can be produced from the oxidation of 5-hydroxymethylfurfural (HMF), which is a versatile biomass intermediate produced from the dehydration of C-6 monosaccharides obtained from cellulosic biomass. In this study, we comparatively investigated the use of 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and 4-acetamido-TEMPO (ACT) for electrochem. HMF oxidation to FDCA. The distinct advantage of TEMPO- and ACT-mediated electrochem. oxidation of HMF is that they can efficiently achieve HMF oxidation in mildly basic conditions (pH 9-10), while other heterogeneous catalysts typically require the use of more basic media. Since HMF oxidation in a strongly basic condition increases the chance to form humins, which are difficult to sep. from FDCA and decrease the com. viability of FDCA and FDCA-derived products, TEMPO- and ACT-mediated HMF oxidation may offer a critical advantage for producing com.-grade FDCA. In this study, the stabilities, electrochem. properties, and electrocatalytic performances of TEMPO and ACT, which has been identified as a less expensive alternative to TEMPO, were comparatively examined for electrochem. HMF oxidation Through investigating the effect of pH, applied potential, and ratio of nitroxyl radical to HMF in solution on HMF oxidation, two different regeneration pathways of TEMPO and ACT in the catalytic cycle and the factors that affect their regeneration pathways were identified. The stability and catalytic activity of TEMPO and ACT for electrochem. HMF oxidation at an elevated temperature were also studied. On the basis of this investigation, optimal electrochem. conditions to efficiently oxidize a concentrated HMF solution (100 mM), which is relevant to large-scale electrochem. FDCA production, were identified. In the experiment, the researchers used many compounds, for example, 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl (cas: 14691-89-5Recommanded Product: 14691-89-5).

4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl (cas: 14691-89-5) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Recommanded Product: 14691-89-5

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Research on enhancing of the regioselective oxidation of cellulose from bagasse pith by ultrasonic pretreatments was written by Gao, Xin;Zhang, Heng;Chen, Keli;Liu, Qixing;Zhu, Zhengliang. And the article was included in Cailiao Daobao in 2014.Application of 14691-89-5 This article mentions the following:

Cellulose from bagasse pith was pretreated by ultrasonic wave. The influence of ultrasound treatment on regioselective oxidation by 4-acetamide-2,2,6,6-tetramethylpiperidine-1-oxyl (4-AcNH-TEMPO)/NaClO/NaClO₂ systems was discussed. The results were shown that the regioselective oxidation reactivity of cellulose was significantly improved by the ultrasound treatment. And the ultrasound power and time were the most important factors on the properties of oxidized cellulose. Furthermore, the oxidized products obtained from this reactive system were comprised of water-soluble and insoluble samples. The structure and morphol. of native cellulose, pretreated samples and the two kinds of oxidized products were characterized by means of FT-IR, SEM and XRD. In the experiment, the researchers used many compounds, for example, 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl (cas: 14691-89-5Application of 14691-89-5).

4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl (cas: 14691-89-5) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Application of 14691-89-5

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

CuI/N4 ligand/TEMPO derivatives: a mild and highly efficient system for aerobic oxidation of primary alcohols was written by Zhang, Shufang;Miao, Chengxia;Xu, Daqian;Sun, Wei;Xia, Chungu. And the article was included in Cuihua Xuebao in 2014.Quality Control of 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl This article mentions the following:

A new system consisting of a copper(I) complex generated in situ from a tetradentate nitrogen ligand and CuI in combination with 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) derivatives was successfully developed. The system was suitable for efficient and selective aerobic oxidation of primary benzyl and allyl alcs. with a wide range of functional groups to the corresponding aldehydes at room temperature The best result was obtained with N,N’-dimethyl-N,N’-bis(2-pyridylmethyl)ethane-1,2-diamine as the ligand and 4-OH-TEMPO as a catalyst in MeCN. In addition, high-resolution mass spectrometry, UV-visible spectroscopy, and electrochem. experiments were used to provide evidence of intermediates. In the experiment, the researchers used many compounds, for example, 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl (cas: 14691-89-5Quality Control of 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl).

4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl (cas: 14691-89-5) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Quality Control of 4-Acetamido-2,2,6,6-tetramethylpiperidine 1-oxyl

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem