Tag: 200-300

Rafiq, Kiran; Saify, Zafar Saied; Vaid, Faiyaz; Navaid, Farzana; Kamil, Arfa; Kausar, Rana; Ghous, Asghari published an article in 2013, the title of the article was Synthesis of 4-(4′-chlorophenyl)-4-hydroxy piperidine analogues having promising compatibility with alpha amylase enzyme.Product Details of 39512-49-7 And the article contains the following content:

A new series of 4-(4′-Chlorophenyl)-4-hydroxy piperidine derivatives I·HX [R = adamantan-1-acyl, 6-methyluracil, 3-phenoxy-1-Pr, 3-phenyl-1-propyl] were synthesized with different phenacyl halide. All synthesized compounds were screened for their in vitro antiamylatic activity by semiquant. agar plate method. The parent compound 4-(4′-Chlorophenyl)-4-hydroxy piperidine showed moderate while I·HX [R = adamantan-1-acyl, 3-phenoxy-1-Pr, 3-phenyl-1-propyl] showed good antiamylatic activity. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Product Details of 39512-49-7

The Article related to chlorophenyl hydroxy piperidine preparation antiamylase, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Product Details of 39512-49-7

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Guo, Yi-An; Lee, Wonchul; Krische, Michael J. published an article in 2017, the title of the article was Enantioselective Synthesis of Oxetanes Bearing All-Carbon Quaternary Stereocenters via Iridium-Catalyzed C-C Bond-Forming Transfer Hydrogenation.Related Products of 39512-49-7 And the article contains the following content:

Oxetanes bearing all-carbon quaternary stereocenters are readily prepared through the iridium-catalyzed anti-diastereo- and enantioselective C-C coupling of primary alcs. and isoprene oxide. Based on this methodol., an oxetane containing analog of haloperidol was prepared A related azetidine formation is also described. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Related Products of 39512-49-7

The Article related to enantioselective synthesis oxetane, iridium catalyst coupling primary alc isoprene oxide, enantioselectivity, iridium, oxetane, quaternary center, transfer hydrogenation, Heterocyclic Compounds (One Hetero Atom): 4-Membered Rings and other aspects.Related Products of 39512-49-7

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Gitto, Rosaria; De Luca, Laura; Mancuso, Francesca; Del Prete, Sonia; Vullo, Daniela; Supuran, Claudiu T.; Capasso, Clemente published an article in 2019, the title of the article was Seeking new approach for therapeutic treatment of cholera disease via inhibition of bacterial carbonic anhydrases: experimental and theoretical studies for sixteen benzenesulfonamide derivatives.Recommanded Product: 4-(4-Chlorophenyl)piperidin-4-ol And the article contains the following content:

A series of sixteen benzenesulfonamide derivatives has been synthesized and tested as inhibitors of Vibrio cholerae carbonic anhydrase (CA) enzymes, belonging to α-CA, β-CA, and γ-CA classes (VchCAα, VchCAβ, and VchCAγ). The determined Ki values were compared to those of selected human CA isoforms (hCA I and hCA II). Structure-affinity relationship anal. highlighted that all tested compounds proved to be active inhibitors of VchCAα at nanomolar concentration The VchCAβ activity was lower to respect inhibitory efficacy toward VchCAα, whereas, these benzenesulfonamide derivatives failed to inhibit VchCAγ. Interestingly, compound combined the best activity toward VchCAα and VchCAβ. In order to obtain a model for binding mode of our inhibitors toward bacterial CAs, we carried out docking simulations by using the available crystal structures of VchCAβ. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Recommanded Product: 4-(4-Chlorophenyl)piperidin-4-ol

The Article related to benzene sulfonamide derivative preparation carbonic anhydrase inhibitor cholera, carbonic anhydrase inhibitors (cais), benzenesulfonamides, molecular docking, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Recommanded Product: 4-(4-Chlorophenyl)piperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On August 31, 2014, Shimakami, Natsumi; Yabutani, Tomoki; Takayanagi, Toshio published an article.Name: 4-(4-Chlorophenyl)piperidin-4-ol The title of the article was Analysis of acid dissociation of photo-degradable haloperidol through the measurement of electrophoretic mobility by capillary zone electrophoresis. And the article contained the following:

The acid dissociation constants (Ka) of Haloperidol and its degraded product were determined by capillary zone electrophoresis (CZE). Haloperidol is degraded by UV-light irradiation, and 4-(p-chlorophenyl)-4-hydroxypiperidine (CPHP) is generated from Haloperidol. When the irradiated solution was analyzed by CZE, residual Haloperidol and two degraded products were detected. The acid dissociation constant of Haloperidol was determined through the electrophoretic mobility of the residual Haloperidol, and the pKa value determined was similar to that measured under no degradation conditions, as well as literature values. It was also confirmed that one of the degraded products was assigned to CPHP based on the migration time, the electrophoretic mobility, and its acid dissociation constant analyzed. It was demonstrated in this study that the acid dissociation constants are accurately determined by using CZE, even under degraded conditions of the analyte. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Name: 4-(4-Chlorophenyl)piperidin-4-ol

The Article related to haloperidol photodegradation acid dissociation constant capillary zone electrophoresis, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Name: 4-(4-Chlorophenyl)piperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Ronson, Thomas O.; Renders, Evelien; Van Steijvoort, Ben F.; Wang, Xubin; Wybon, Clarence C. D.; Prokopcova, Hana; Meerpoel, Lieven; Maes, Bert U. W. published an article in 2019, the title of the article was Ruthenium-Catalyzed Reductive Arylation of N-(2-Pyridinyl)amides with Isopropanol and Arylboronate Esters.Quality Control of 4-(4-Chlorophenyl)piperidin-4-ol And the article contains the following content:

A new three-component reductive arylation of amides with stable reactants (iPrOH and arylboronate esters), making use of a 2-pyridinyl (Py) directing group, is described. The N-Py-amide substrates are readily prepared from carboxylic acids and PyNH2, and the resulting N-Py-1-arylalkanamine reaction products are easily transformed into the corresponding chlorides by substitution of the HN-Py group with HCl. The 1-aryl-1-chloroalkane products allow substitution and cross-coupling reactions. Therefore, a general protocol for the transformation of carboxylic acids into a variety of functionalities is obtained. The Py-NH2 byproduct can be recycled. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Quality Control of 4-(4-Chlorophenyl)piperidin-4-ol

The Article related to multicomponent reductive arylation amide arylboronate ester pyridinyl directing group, amides, amines, arylation, multicomponent reactions, ruthenium, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Quality Control of 4-(4-Chlorophenyl)piperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On April 26, 2012, Connolly, Peter J.; Bian, Haiyan; Li, Xun; Liu, Li; Macielag, Mark J.; McDonnell, Mark E. published a patent.Application of 1251006-64-0 The title of the patent was Azetidinylpiperidine derivatives as monoacylglycerol lipase inhibitors and their preparation and use for the treatment of inflammatory pain. And the patent contained the following:

The invention relates to azetidinylpiperidine of formula I, which are monoacylglycerol lipase (MGL) inhibitors and which are useful in the treatment of inflammatory pain. Compounds of formula I wherein Y and Z are independently (un)substituted C6-10 aryl, (un)substituted thiazolyl, (un)substituted isothiazolyl, etc.; R is H and OH; with provisions; and enantiomers, diastereoisomers and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their MGL inhibitory activity. From the assay, it was determined that compound II exhibited an IC50 value of 0.006 μM. The experimental process involved the reaction of tert-Butyl 3-(piperidin-4-yl)azetidine-1-carboxylate(cas: 1251006-64-0).Application of 1251006-64-0

The Article related to azetidinyl piperidine preparation monoacylglycerol lipase inhibitor treatment inflammatory pain, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application of 1251006-64-0

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Guo, Yi-An; Lee, Wonchul; Krische, Michael J. published an article in 2017, the title of the article was Enantioselective Synthesis of Oxetanes Bearing All-Carbon Quaternary Stereocenters via Iridium-Catalyzed C-C Bond-Forming Transfer Hydrogenation.Related Products of 39512-49-7 And the article contains the following content:

Oxetanes bearing all-carbon quaternary stereocenters are readily prepared through the iridium-catalyzed anti-diastereo- and enantioselective C-C coupling of primary alcs. and isoprene oxide. Based on this methodol., an oxetane containing analog of haloperidol was prepared A related azetidine formation is also described. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Related Products of 39512-49-7

The Article related to enantioselective synthesis oxetane, iridium catalyst coupling primary alc isoprene oxide, enantioselectivity, iridium, oxetane, quaternary center, transfer hydrogenation, Heterocyclic Compounds (One Hetero Atom): 4-Membered Rings and other aspects.Related Products of 39512-49-7

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Gitto, Rosaria; De Luca, Laura; Mancuso, Francesca; Del Prete, Sonia; Vullo, Daniela; Supuran, Claudiu T.; Capasso, Clemente published an article in 2019, the title of the article was Seeking new approach for therapeutic treatment of cholera disease via inhibition of bacterial carbonic anhydrases: experimental and theoretical studies for sixteen benzenesulfonamide derivatives.Recommanded Product: 4-(4-Chlorophenyl)piperidin-4-ol And the article contains the following content:

A series of sixteen benzenesulfonamide derivatives has been synthesized and tested as inhibitors of Vibrio cholerae carbonic anhydrase (CA) enzymes, belonging to α-CA, β-CA, and γ-CA classes (VchCAα, VchCAβ, and VchCAγ). The determined Ki values were compared to those of selected human CA isoforms (hCA I and hCA II). Structure-affinity relationship anal. highlighted that all tested compounds proved to be active inhibitors of VchCAα at nanomolar concentration The VchCAβ activity was lower to respect inhibitory efficacy toward VchCAα, whereas, these benzenesulfonamide derivatives failed to inhibit VchCAγ. Interestingly, compound combined the best activity toward VchCAα and VchCAβ. In order to obtain a model for binding mode of our inhibitors toward bacterial CAs, we carried out docking simulations by using the available crystal structures of VchCAβ. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Recommanded Product: 4-(4-Chlorophenyl)piperidin-4-ol

The Article related to benzene sulfonamide derivative preparation carbonic anhydrase inhibitor cholera, carbonic anhydrase inhibitors (cais), benzenesulfonamides, molecular docking, Pharmacology: Effects Of Antimicrobials and Parasiticides and other aspects.Recommanded Product: 4-(4-Chlorophenyl)piperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

On August 31, 2014, Shimakami, Natsumi; Yabutani, Tomoki; Takayanagi, Toshio published an article.Name: 4-(4-Chlorophenyl)piperidin-4-ol The title of the article was Analysis of acid dissociation of photo-degradable haloperidol through the measurement of electrophoretic mobility by capillary zone electrophoresis. And the article contained the following:

The acid dissociation constants (Ka) of Haloperidol and its degraded product were determined by capillary zone electrophoresis (CZE). Haloperidol is degraded by UV-light irradiation, and 4-(p-chlorophenyl)-4-hydroxypiperidine (CPHP) is generated from Haloperidol. When the irradiated solution was analyzed by CZE, residual Haloperidol and two degraded products were detected. The acid dissociation constant of Haloperidol was determined through the electrophoretic mobility of the residual Haloperidol, and the pKa value determined was similar to that measured under no degradation conditions, as well as literature values. It was also confirmed that one of the degraded products was assigned to CPHP based on the migration time, the electrophoretic mobility, and its acid dissociation constant analyzed. It was demonstrated in this study that the acid dissociation constants are accurately determined by using CZE, even under degraded conditions of the analyte. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Name: 4-(4-Chlorophenyl)piperidin-4-ol

The Article related to haloperidol photodegradation acid dissociation constant capillary zone electrophoresis, Pharmaceutical Analysis: Synthetic Organic Compounds and other aspects.Name: 4-(4-Chlorophenyl)piperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Ronson, Thomas O.; Renders, Evelien; Van Steijvoort, Ben F.; Wang, Xubin; Wybon, Clarence C. D.; Prokopcova, Hana; Meerpoel, Lieven; Maes, Bert U. W. published an article in 2019, the title of the article was Ruthenium-Catalyzed Reductive Arylation of N-(2-Pyridinyl)amides with Isopropanol and Arylboronate Esters.Quality Control of 4-(4-Chlorophenyl)piperidin-4-ol And the article contains the following content:

A new three-component reductive arylation of amides with stable reactants (iPrOH and arylboronate esters), making use of a 2-pyridinyl (Py) directing group, is described. The N-Py-amide substrates are readily prepared from carboxylic acids and PyNH2, and the resulting N-Py-1-arylalkanamine reaction products are easily transformed into the corresponding chlorides by substitution of the HN-Py group with HCl. The 1-aryl-1-chloroalkane products allow substitution and cross-coupling reactions. Therefore, a general protocol for the transformation of carboxylic acids into a variety of functionalities is obtained. The Py-NH2 byproduct can be recycled. The experimental process involved the reaction of 4-(4-Chlorophenyl)piperidin-4-ol(cas: 39512-49-7).Quality Control of 4-(4-Chlorophenyl)piperidin-4-ol

The Article related to multicomponent reductive arylation amide arylboronate ester pyridinyl directing group, amides, amines, arylation, multicomponent reactions, ruthenium, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Quality Control of 4-(4-Chlorophenyl)piperidin-4-ol

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem