Tag: 198.13

Wagner, Gabor et al. published their research in Archiv der Pharmazie (Weinheim, Germany) | CAS: 5472-49-1

1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Name: 1-(3-Chloropropyl)piperidine hydrochloride

SAR exploration of the non-imidazole histamine H3 receptor ligand ZEL-H16 reveals potent inverse agonism was written by Wagner, Gabor;Mocking, Tamara A. M.;Ma, Xiaoyuan;Slynko, Inna;Da Costa Pereira, Daniel;Breeuwer, Robin;Rood, Niek J. N.;van der Horst, Cas;Vischer, Henry F.;de Graaf, Chris;de Esch, Iwan J. P.;Wijtmans, Maikel;Leurs, Rob. And the article was included in Archiv der Pharmazie (Weinheim, Germany).Name: 1-(3-Chloropropyl)piperidine hydrochloride This article mentions the following:

Histamine H3 receptor (H3R) agonists without an imidazole moiety remain very scarce. Of these, ZEL-H16 (1) has been reported previously as a high-affinity non-imidazole H3R (partial) agonist. Our structure-activity relationship anal. using derivatives of 1 identified both basic moieties as key interaction motifs and the distance of these from the central core as a determinant for H3R affinity. However, in spite of the reported H3R (partial) agonism, in our hands, 1 acts as an inverse agonist for G伪i signaling in a CRE-luciferase reporter gene assay and using an H3R conformational sensor. Inverse agonism was also observed for all of the synthesized derivatives of 1. Docking studies and mol. dynamics simulations suggest ionic interactions/hydrogen bonds to H3R residues D1143.32 and E2065.46 as essential interaction points. In the experiment, the researchers used many compounds, for example, 1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1Name: 1-(3-Chloropropyl)piperidine hydrochloride).

1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Name: 1-(3-Chloropropyl)piperidine hydrochloride

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Kossakowski, Jerzy et al. published their research in Acta Poloniae Pharmaceutica in 2005 | CAS: 5472-49-1

1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Application of 5472-49-1

Synthesis of N-substituted aminoalkyl derivatives of some epoxyisoindoles as potential pharmacological agents was written by Kossakowski, Jerzy;Raszkiewicz, Aldona. And the article was included in Acta Poloniae Pharmaceutica in 2005.Application of 5472-49-1 This article mentions the following:

Title compounds I and II (n = 2, R = NMe2, NEt2, piperidino, morpholino; n = 3, R = NMe2, piperidino) were prepared by aminoalkylation of the N-unsubstituted epoxyisoindolediones with Cl(CH2)nR. I and II (n = 2, 3; R = NMe2) showed no activity against 3 cancer cell lines; 8 of the products were tested for anti-HIV activity but showed none. In the experiment, the researchers used many compounds, for example, 1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1Application of 5472-49-1).

1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Application of 5472-49-1

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Eissa, Nermin et al. published their research in International Journal of Molecular Sciences in 2021 | CAS: 5472-49-1

1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Safety of 1-(3-Chloropropyl)piperidine hydrochloride

The multi-targeting ligand ST-2223 with histamine H3 receptor and dopamine D2/D3 receptor antagonist properties mitigates autism-like repetitive behaviors and brain oxidative stress in mice was written by Eissa, Nermin;Venkatachalam, Karthikkumar;Jayaprakash, Petrilla;Falkenstein, Markus;Dubiel, Mariam;Frank, Annika;Reiner-Link, David;Stark, Holger;Sadek, Bassem. And the article was included in International Journal of Molecular Sciences in 2021.Safety of 1-(3-Chloropropyl)piperidine hydrochloride This article mentions the following:

Autism spectrum disorder (ASD) is a complex heterogeneous neurodevelopmental disorder characterized by social and communicative impairments, as well as repetitive and restricted behaviors (RRBs). With the limited effectiveness of current pharmacotherapies in treating repetitive behaviors, the present study determined the effects of acute systemic treatment of the novel multi-targeting ligand ST-2223, with incorporated histamine H3 receptor (H3R) and dopamine D2/D3 receptor affinity properties, on ASD-related RRBs in a male Black and Tan BRachyury (BTBR) mouse model of ASD. ST-2223 (2.5, 5, and 10 mg/kg, i.p.) significantly mitigated the increase in marble burying and self-grooming, and improved reduced spontaneous alternation in BTBR mice (all p < 0.05). Similarly, reference drugs memantine (MEM, 5 mg/kg, i.p.) and aripiprazole (ARP, 1 mg/kg, i.p.), reversed abnormally high levels of several RRBs in BTBR (p < 0.05). Moreover, ST-2223 palliated the disturbed anxiety levels observed in an open field test (all p < 0.05), but did not restore the hyperactivity parameters, whereas MEM failed to restore mouse anxiety and hyperactivity. In addition, ST-2223 (5 mg/kg, i.p.) mitigated oxidative stress status by decreasing the elevated levels of malondialdehyde (MDA), and increasing the levels of decreased glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) in different brain parts of treated BTBR mice (all p < 0.05). These preliminary in vivo findings demonstrate the ameliorative effects of ST-2223 on RRBs in a mouse model of ASD, suggesting its pharmacol. prospective to rescue core ASD-related behaviors. Further confirmatory investigations on its effects on various brain neurotransmitters, e.g., dopamine and histamine, in different brain regions are still warranted to corroborate and expand these initial data. In the experiment, the researchers used many compounds, for example, 1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1Safety of 1-(3-Chloropropyl)piperidine hydrochloride).

1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Safety of 1-(3-Chloropropyl)piperidine hydrochloride

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Nardi, D. et al. published their research in Arzneimittel-Forschung in 1993 | CAS: 5472-49-1

1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine derivatives bearing a masked aldehyde function in the 蔚-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Application In Synthesis of 1-(3-Chloropropyl)piperidine hydrochloride

New basic esters of 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid endowed with spasmolytic properties: synthesis and pharmacological-pharmacokinetic evaluation was written by Nardi, D.;Leonardi, A.;Pennini, R.;Tajana, A.;Cazzulani, P.;Testa, R.. And the article was included in Arzneimittel-Forschung in 1993.Application In Synthesis of 1-(3-Chloropropyl)piperidine hydrochloride This article mentions the following:

Basic esters of 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid (I) were prepared as flavoxate analogs. The activity of I esters as spasmolytics was tested and compared to flavoxate. Terflavoxate hydrochloride (II) showed affinity for muscarinic receptors but was devoid of functional antimuscarinic properties. In the experiment, the researchers used many compounds, for example, 1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1Application In Synthesis of 1-(3-Chloropropyl)piperidine hydrochloride).

1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine derivatives bearing a masked aldehyde function in the 蔚-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Application In Synthesis of 1-(3-Chloropropyl)piperidine hydrochloride

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Kossakowski, Jerzy et al. published their research in Acta Poloniae Pharmaceutica in 2005 | CAS: 5472-49-1

1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Application of 5472-49-1

Synthesis of N-substituted aminoalkyl derivatives of some epoxyisoindoles as potential pharmacological agents was written by Kossakowski, Jerzy;Raszkiewicz, Aldona. And the article was included in Acta Poloniae Pharmaceutica in 2005.Application of 5472-49-1 This article mentions the following:

Title compounds I and II (n = 2, R = NMe2, NEt2, piperidino, morpholino; n = 3, R = NMe2, piperidino) were prepared by aminoalkylation of the N-unsubstituted epoxyisoindolediones with Cl(CH2)nR. I and II (n = 2, 3; R = NMe2) showed no activity against 3 cancer cell lines; 8 of the products were tested for anti-HIV activity but showed none. In the experiment, the researchers used many compounds, for example, 1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1Application of 5472-49-1).

1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Application of 5472-49-1

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Eissa, Nermin et al. published their research in International Journal of Molecular Sciences in 2021 | CAS: 5472-49-1

1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Safety of 1-(3-Chloropropyl)piperidine hydrochloride

The multi-targeting ligand ST-2223 with histamine H3 receptor and dopamine D2/D3 receptor antagonist properties mitigates autism-like repetitive behaviors and brain oxidative stress in mice was written by Eissa, Nermin;Venkatachalam, Karthikkumar;Jayaprakash, Petrilla;Falkenstein, Markus;Dubiel, Mariam;Frank, Annika;Reiner-Link, David;Stark, Holger;Sadek, Bassem. And the article was included in International Journal of Molecular Sciences in 2021.Safety of 1-(3-Chloropropyl)piperidine hydrochloride This article mentions the following:

Autism spectrum disorder (ASD) is a complex heterogeneous neurodevelopmental disorder characterized by social and communicative impairments, as well as repetitive and restricted behaviors (RRBs). With the limited effectiveness of current pharmacotherapies in treating repetitive behaviors, the present study determined the effects of acute systemic treatment of the novel multi-targeting ligand ST-2223, with incorporated histamine H3 receptor (H3R) and dopamine D2/D3 receptor affinity properties, on ASD-related RRBs in a male Black and Tan BRachyury (BTBR) mouse model of ASD. ST-2223 (2.5, 5, and 10 mg/kg, i.p.) significantly mitigated the increase in marble burying and self-grooming, and improved reduced spontaneous alternation in BTBR mice (all p < 0.05). Similarly, reference drugs memantine (MEM, 5 mg/kg, i.p.) and aripiprazole (ARP, 1 mg/kg, i.p.), reversed abnormally high levels of several RRBs in BTBR (p < 0.05). Moreover, ST-2223 palliated the disturbed anxiety levels observed in an open field test (all p < 0.05), but did not restore the hyperactivity parameters, whereas MEM failed to restore mouse anxiety and hyperactivity. In addition, ST-2223 (5 mg/kg, i.p.) mitigated oxidative stress status by decreasing the elevated levels of malondialdehyde (MDA), and increasing the levels of decreased glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) in different brain parts of treated BTBR mice (all p < 0.05). These preliminary in vivo findings demonstrate the ameliorative effects of ST-2223 on RRBs in a mouse model of ASD, suggesting its pharmacol. prospective to rescue core ASD-related behaviors. Further confirmatory investigations on its effects on various brain neurotransmitters, e.g., dopamine and histamine, in different brain regions are still warranted to corroborate and expand these initial data. In the experiment, the researchers used many compounds, for example, 1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1Safety of 1-(3-Chloropropyl)piperidine hydrochloride).

1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Safety of 1-(3-Chloropropyl)piperidine hydrochloride

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Nardi, D. et al. published their research in Arzneimittel-Forschung in 1993 | CAS: 5472-49-1

1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Application In Synthesis of 1-(3-Chloropropyl)piperidine hydrochloride

New basic esters of 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid endowed with spasmolytic properties: synthesis and pharmacological-pharmacokinetic evaluation was written by Nardi, D.;Leonardi, A.;Pennini, R.;Tajana, A.;Cazzulani, P.;Testa, R.. And the article was included in Arzneimittel-Forschung in 1993.Application In Synthesis of 1-(3-Chloropropyl)piperidine hydrochloride This article mentions the following:

Basic esters of 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid (I) were prepared as flavoxate analogs. The activity of I esters as spasmolytics was tested and compared to flavoxate. Terflavoxate hydrochloride (II) showed affinity for muscarinic receptors but was devoid of functional antimuscarinic properties. In the experiment, the researchers used many compounds, for example, 1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1Application In Synthesis of 1-(3-Chloropropyl)piperidine hydrochloride).

1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Application In Synthesis of 1-(3-Chloropropyl)piperidine hydrochloride

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Kossakowski, Jerzy et al. published their research in Acta Poloniae Pharmaceutica in 2005 | CAS: 5472-49-1

1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Application of 5472-49-1

Synthesis of N-substituted aminoalkyl derivatives of some epoxyisoindoles as potential pharmacological agents was written by Kossakowski, Jerzy;Raszkiewicz, Aldona. And the article was included in Acta Poloniae Pharmaceutica in 2005.Application of 5472-49-1 This article mentions the following:

Title compounds I and II (n = 2, R = NMe2, NEt2, piperidino, morpholino; n = 3, R = NMe2, piperidino) were prepared by aminoalkylation of the N-unsubstituted epoxyisoindolediones with Cl(CH2)nR. I and II (n = 2, 3; R = NMe2) showed no activity against 3 cancer cell lines; 8 of the products were tested for anti-HIV activity but showed none. In the experiment, the researchers used many compounds, for example, 1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1Application of 5472-49-1).

1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Application of 5472-49-1

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Eissa, Nermin et al. published their research in International Journal of Molecular Sciences in 2021 | CAS: 5472-49-1

1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Safety of 1-(3-Chloropropyl)piperidine hydrochloride

The multi-targeting ligand ST-2223 with histamine H3 receptor and dopamine D2/D3 receptor antagonist properties mitigates autism-like repetitive behaviors and brain oxidative stress in mice was written by Eissa, Nermin;Venkatachalam, Karthikkumar;Jayaprakash, Petrilla;Falkenstein, Markus;Dubiel, Mariam;Frank, Annika;Reiner-Link, David;Stark, Holger;Sadek, Bassem. And the article was included in International Journal of Molecular Sciences in 2021.Safety of 1-(3-Chloropropyl)piperidine hydrochloride This article mentions the following:

Autism spectrum disorder (ASD) is a complex heterogeneous neurodevelopmental disorder characterized by social and communicative impairments, as well as repetitive and restricted behaviors (RRBs). With the limited effectiveness of current pharmacotherapies in treating repetitive behaviors, the present study determined the effects of acute systemic treatment of the novel multi-targeting ligand ST-2223, with incorporated histamine H3 receptor (H3R) and dopamine D2/D3 receptor affinity properties, on ASD-related RRBs in a male Black and Tan BRachyury (BTBR) mouse model of ASD. ST-2223 (2.5, 5, and 10 mg/kg, i.p.) significantly mitigated the increase in marble burying and self-grooming, and improved reduced spontaneous alternation in BTBR mice (all p < 0.05). Similarly, reference drugs memantine (MEM, 5 mg/kg, i.p.) and aripiprazole (ARP, 1 mg/kg, i.p.), reversed abnormally high levels of several RRBs in BTBR (p < 0.05). Moreover, ST-2223 palliated the disturbed anxiety levels observed in an open field test (all p < 0.05), but did not restore the hyperactivity parameters, whereas MEM failed to restore mouse anxiety and hyperactivity. In addition, ST-2223 (5 mg/kg, i.p.) mitigated oxidative stress status by decreasing the elevated levels of malondialdehyde (MDA), and increasing the levels of decreased glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT) in different brain parts of treated BTBR mice (all p < 0.05). These preliminary in vivo findings demonstrate the ameliorative effects of ST-2223 on RRBs in a mouse model of ASD, suggesting its pharmacol. prospective to rescue core ASD-related behaviors. Further confirmatory investigations on its effects on various brain neurotransmitters, e.g., dopamine and histamine, in different brain regions are still warranted to corroborate and expand these initial data. In the experiment, the researchers used many compounds, for example, 1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1Safety of 1-(3-Chloropropyl)piperidine hydrochloride).

1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Safety of 1-(3-Chloropropyl)piperidine hydrochloride

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Nardi, D. et al. published their research in Arzneimittel-Forschung in 1993 | CAS: 5472-49-1

1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Application In Synthesis of 1-(3-Chloropropyl)piperidine hydrochloride

New basic esters of 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid endowed with spasmolytic properties: synthesis and pharmacological-pharmacokinetic evaluation was written by Nardi, D.;Leonardi, A.;Pennini, R.;Tajana, A.;Cazzulani, P.;Testa, R.. And the article was included in Arzneimittel-Forschung in 1993.Application In Synthesis of 1-(3-Chloropropyl)piperidine hydrochloride This article mentions the following:

Basic esters of 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid (I) were prepared as flavoxate analogs. The activity of I esters as spasmolytics was tested and compared to flavoxate. Terflavoxate hydrochloride (II) showed affinity for muscarinic receptors but was devoid of functional antimuscarinic properties. In the experiment, the researchers used many compounds, for example, 1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1Application In Synthesis of 1-(3-Chloropropyl)piperidine hydrochloride).

1-(3-Chloropropyl)piperidine hydrochloride (cas: 5472-49-1) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Application In Synthesis of 1-(3-Chloropropyl)piperidine hydrochloride

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem