Tag: 195.2334

Optimization of piperidyl-ureas as inhibitors of soluble epoxide hydrolase was written by Eldrup, Anne B.;Soleymanzadeh, Fariba;Farrow, Neil A.;Kukulka, Alison;De Lombaert, Stephane. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Synthetic Route of C11H14FNO This article mentions the following:

Inhibition of sEH is hypothesized to lead to an increase in epoxyeicosatrienoic acids resulting in the potentiation of their anti-inflammatory and vasodilatory effects. In an effort to explore sEH inhibition as an avenue for the development of vasodilatory and cardio- or renal-protective agents, a lead identified through high-throughput screening was optimized, guided by the determination of a solid state co-structure with sEH. Replacement of potential toxicophores was followed by optimization of cell-based potency and ADME properties to provide a new class of functionally potent sEH inhibitors with attractive in vitro metabolic profiles and high and sustained plasma exposures after oral administration in the rat. In the experiment, the researchers used many compounds, for example, 4-(4-Fluorophenoxy)piperidine (cas: 3413-28-3Synthetic Route of C11H14FNO).

4-(4-Fluorophenoxy)piperidine (cas: 3413-28-3) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Synthetic Route of C11H14FNO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Identification of a novel series of selective 5-HT₇ receptor antagonists was written by Forbes, Ian T.;Cooper, David G.;Dodds, Emma K.;Douglas, Sara E.;Gribble, Andrew D.;Ife, Robert J.;Lightfoot, Andrew P.;Meeson, Malcolm;Campbell, Lorraine P.;Coleman, Tanya;Riley, Graham J.;Thomas, David R.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2003.Application In Synthesis of 4-(4-Fluorophenoxy)piperidine This article mentions the following:

Novel 5-HT₇ receptor antagonists containing the benzocycloheptanone core were identified from high throughput screening. Mol. modeling and SAR studies have converted these intractable hits into a more potent, selective and tractable series, exemplified by compound I, SB-691673. In the experiment, the researchers used many compounds, for example, 4-(4-Fluorophenoxy)piperidine (cas: 3413-28-3Application In Synthesis of 4-(4-Fluorophenoxy)piperidine).

4-(4-Fluorophenoxy)piperidine (cas: 3413-28-3) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Application In Synthesis of 4-(4-Fluorophenoxy)piperidine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Optimization of piperidyl-ureas as inhibitors of soluble epoxide hydrolase was written by Eldrup, Anne B.;Soleymanzadeh, Fariba;Farrow, Neil A.;Kukulka, Alison;De Lombaert, Stephane. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Synthetic Route of C11H14FNO This article mentions the following:

Inhibition of sEH is hypothesized to lead to an increase in epoxyeicosatrienoic acids resulting in the potentiation of their anti-inflammatory and vasodilatory effects. In an effort to explore sEH inhibition as an avenue for the development of vasodilatory and cardio- or renal-protective agents, a lead identified through high-throughput screening was optimized, guided by the determination of a solid state co-structure with sEH. Replacement of potential toxicophores was followed by optimization of cell-based potency and ADME properties to provide a new class of functionally potent sEH inhibitors with attractive in vitro metabolic profiles and high and sustained plasma exposures after oral administration in the rat. In the experiment, the researchers used many compounds, for example, 4-(4-Fluorophenoxy)piperidine (cas: 3413-28-3Synthetic Route of C11H14FNO).

4-(4-Fluorophenoxy)piperidine (cas: 3413-28-3) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Synthetic Route of C11H14FNO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Identification of a novel series of selective 5-HT₇ receptor antagonists was written by Forbes, Ian T.;Cooper, David G.;Dodds, Emma K.;Douglas, Sara E.;Gribble, Andrew D.;Ife, Robert J.;Lightfoot, Andrew P.;Meeson, Malcolm;Campbell, Lorraine P.;Coleman, Tanya;Riley, Graham J.;Thomas, David R.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2003.Application In Synthesis of 4-(4-Fluorophenoxy)piperidine This article mentions the following:

Novel 5-HT₇ receptor antagonists containing the benzocycloheptanone core were identified from high throughput screening. Mol. modeling and SAR studies have converted these intractable hits into a more potent, selective and tractable series, exemplified by compound I, SB-691673. In the experiment, the researchers used many compounds, for example, 4-(4-Fluorophenoxy)piperidine (cas: 3413-28-3Application In Synthesis of 4-(4-Fluorophenoxy)piperidine).

4-(4-Fluorophenoxy)piperidine (cas: 3413-28-3) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Application In Synthesis of 4-(4-Fluorophenoxy)piperidine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Optimization of piperidyl-ureas as inhibitors of soluble epoxide hydrolase was written by Eldrup, Anne B.;Soleymanzadeh, Fariba;Farrow, Neil A.;Kukulka, Alison;De Lombaert, Stephane. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Synthetic Route of C11H14FNO This article mentions the following:

Inhibition of sEH is hypothesized to lead to an increase in epoxyeicosatrienoic acids resulting in the potentiation of their anti-inflammatory and vasodilatory effects. In an effort to explore sEH inhibition as an avenue for the development of vasodilatory and cardio- or renal-protective agents, a lead identified through high-throughput screening was optimized, guided by the determination of a solid state co-structure with sEH. Replacement of potential toxicophores was followed by optimization of cell-based potency and ADME properties to provide a new class of functionally potent sEH inhibitors with attractive in vitro metabolic profiles and high and sustained plasma exposures after oral administration in the rat. In the experiment, the researchers used many compounds, for example, 4-(4-Fluorophenoxy)piperidine (cas: 3413-28-3Synthetic Route of C11H14FNO).

4-(4-Fluorophenoxy)piperidine (cas: 3413-28-3) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Synthetic Route of C11H14FNO

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Identification of a novel series of selective 5-HT₇ receptor antagonists was written by Forbes, Ian T.;Cooper, David G.;Dodds, Emma K.;Douglas, Sara E.;Gribble, Andrew D.;Ife, Robert J.;Lightfoot, Andrew P.;Meeson, Malcolm;Campbell, Lorraine P.;Coleman, Tanya;Riley, Graham J.;Thomas, David R.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2003.Application In Synthesis of 4-(4-Fluorophenoxy)piperidine This article mentions the following:

Novel 5-HT₇ receptor antagonists containing the benzocycloheptanone core were identified from high throughput screening. Mol. modeling and SAR studies have converted these intractable hits into a more potent, selective and tractable series, exemplified by compound I, SB-691673. In the experiment, the researchers used many compounds, for example, 4-(4-Fluorophenoxy)piperidine (cas: 3413-28-3Application In Synthesis of 4-(4-Fluorophenoxy)piperidine).

4-(4-Fluorophenoxy)piperidine (cas: 3413-28-3) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Application In Synthesis of 4-(4-Fluorophenoxy)piperidine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem