With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.189442-92-0,1-Boc-4-Formyl-4-methylpiperidine,as a common compound, the synthetic route is as follows.
To a suspension of sodium hydride (60% in mineral oil, 793 mg 19.83 mmol, 1.5 eq) in THF (50 mL) ethyl (diethoxyphosphoryl)acetate (3.77g, 16.83 mmol, 1.3 eq) dropwise at 0C and the mixture was allowed to stir at the same temperature for 30 minutes. To this mixture was added a solution of tert-butyl 4-formyl-4-methylpiperidine- 1 -carboxylate (3 g, 13.22 mmol, 1.0 eq) in THF (5 mL) and the resulting mixture was allowed to stir at room temperature for 1 h.Progress of reaction was monitored by TLC. After completion, reaction mixture was diluted with saturated aq. NH4C1 (100 mL) and extracted with ethyl acetate (3 x 50 mL). Combined organic layer was washed with brine, dried over anhydrous Na2SO4 and evaporated to dryness under vacuum to afford crude which was purified by Combi-Flash using ethyl acetate-hexane system as eluent to afford tert-butyl 4- [( 1E)-3 -ethoxy-3 -oxoprop- 1-en-i -yl] -4-methylpiperidine- 1-carboxylate (1.4 g, 36 %).LCMS: 298 [M+i]
The synthetic route of 189442-92-0 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; AURANSA INC.; PROTTER, Andrew, Asher; GREEN, Michael, John; CHANG, Hak, Jin; PHAM, Son, Minh; CHAKRAVARTY, Sarvajit; LUEDTKE, Gregory, R.; (254 pag.)WO2019/103897; (2019); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem