Tag: 170.2288

Polyamine-Conjugated Nitroxides Are Efficacious Inhibitors of Oxidative Reactions Catalyzed by Endothelial-Localized Myeloperoxidase was written by Maiocchi, Sophie;Ku, Jacqueline;Hawtrey, Tom;De Silvestro, Irene;Malle, Ernst;Rees, Martin;Thomas, Shane R.;Morris, Jonathan C.. And the article was included in Chemical Research in Toxicology in 2021.Recommanded Product: 2896-70-0 This article mentions the following:

The heme enzyme myeloperoxidase (MPO) is a key mediator of endothelial dysfunction and a therapeutic target in cardiovascular disease. During inflammation, MPO released by circulating leukocytes is internalized by endothelial cells and transcytosed into the subendothelial extracellular matrix of diseased vessels. At this site, MPO mediates endothelial dysfunction by catalytically consuming nitric oxide (NO) and producing reactive oxidants, hypochlorous acid (HOCl) and the nitrogen dioxide radical (^•NO₂). Accordingly, there is interest in developing MPO inhibitors that effectively target endothelial-localized MPO. Here the authors studied a series of piperidine nitroxides conjugated to polyamine moieties as novel endothelial-targeted MPO inhibitors. ESR anal. of cell lysates showed that polyamine conjugated nitroxides were efficiently internalized into endothelial cells in a heparan sulfate dependent manner. Nitroxides effectively inhibited the consumption of MPO’s substrate hydrogen peroxide (H₂O₂) and formation of HOCl catalyzed by endothelial-localized MPO, with their efficacy dependent on both nitroxide and conjugated-polyamine structure. Nitroxides also differentially inhibited protein nitration catalyzed by both purified and endothelial-localized MPO, which was dependent on ^•NO₂ scavenging rather than MPO inhibition. Finally, nitroxides uniformly inhibited the catalytic consumption of NO by MPO in human plasma. Nitroxides effectively inhibit local oxidative reactions catalyzed by endothelial-localized MPO. Novel polyamine-conjugated nitroxides, ethylenediamine-TEMPO and putrescine-TEMPO, emerged as efficacious nitroxides uniquely exhibiting high endothelial cell uptake and efficient inhibition of MPO-catalyzed HOCl production, protein nitration, and NO oxidation Polyamine-conjugated nitroxides represent a versatile class of antioxidant drugs capable of targeting endothelial-localized MPO during vascular inflammation. In the experiment, the researchers used many compounds, for example, 4-Oxo-tempo (cas: 2896-70-0Recommanded Product: 2896-70-0).

4-Oxo-tempo (cas: 2896-70-0) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Recommanded Product: 2896-70-0

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Copper oxide functionalized chitosan hybrid hydrogels for highly efficient photocatalytic-reforming of biomass-based monosaccharides to lactic acid was written by Li, Yancong;Ma, Jiliang;Jin, Dongnv;Jiao, Gaojie;Yang, Xiaopan;Liu, Kangning;Zhou, Jinghui;Sun, Runcang. And the article was included in Applied Catalysis, B: Environmental in 2021.Reference of 2896-70-0 This article mentions the following:

Much attention has been focused on the photocatalytic-reforming of biomass to produce high-value chems. due to their unique merits. In this study, we report a freezing-thawing strategy for the preparation of an alk. CuO-chitosan hybrid hydrogel (CuO@CS-H). The synergism between CuO and alk. chitosan hydrogel led to a highly efficient photocatalytic-reforming of xylose to lactic acid under a weak alk. system, and the highest lactic acid yield is 81.6%. The retained lactic acid yield was about 91.2% after being used nine times. The reaction system is universal for the production of lactic acid from biomass-derived pentoses and hexoses, and ^·O^–₂ plays a major role in the synthesis of lactic acid. Industrial production of lactic acid via the as-proposed system was shown to be feasible according to a two-thousand-fold scale-up experiment This work initiates a novel strategy of photocatalytic synthesis of lactic acid from biomass-based monosaccharides. In the experiment, the researchers used many compounds, for example, 4-Oxo-tempo (cas: 2896-70-0Reference of 2896-70-0).

4-Oxo-tempo (cas: 2896-70-0) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Some chemotherapeutic agents have piperidine moiety within their structure, foremost among them, vinblastine and raloxifene.Reference of 2896-70-0

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

To investigate whether hematocrit affects thromboelastography parameters was written by Zhang, Min;He, Keyu;Ye, Dong;Zhang, Qiang;Zhang, Zhengkang. And the article was included in Contrast Media & Molecular Imaging in 2022.Electric Literature of C9H16NO2 This article mentions the following:

Background. Thromboelastogram (TEG) is an experiment to detect coagulation function with whole blood. Red blood cell (RBC) is the most abundant component of blood. Whether RBC has an impact on the results of thromboelastogram? Study Design and Methods. The correlation between hematocrit (HCT) and TEG was analyzed. 17 samples were reconstituted with different HCT. They were tested sep. Correction tests were performed on 17 samples from patients with anemia. HCT was corrected to 0.40 in female and 0.45 in males. The correction formula was determined according to the exptl. correction. Results. HCT was neg. correlated with TEG parameters. As HCT increased, CI and angle decreased (P < 0.05, P < 0.001) and K increased (P < 0.001) in reconstituted samples. In the correction test, the angle measured value was 69.48 ± 4.98 and corrected value was 62.48 ± 6.25, MA measured value was 61.44 ± 7.10 and corrected value was 55.94 ± 7.12, K measured value was 1.45 ± 0.48 and corrected value was 2.11 ± 0.79, and CI measured value was 1.07 ± 1.67 and corrected value was -0.45 ± 1.64. There was a significant difference. The correction formulas of anemia were derived from the exptl. correction results. KCorrection value = (0.7903*A2 – 2.1803A + 2.8268)*KMeasured value; Tan angleCorrection value = Tan angleMeasured value/(0.6596*A2 – 1.7478A + 2.4608); MACorrection value = MAMeasured value/(0.1853ln (A) + 1.0197); CICorrection value = -0.6516RMeasured value – 0.3772KCorrection value + 0.1224MACorrection value + 0.0759angleCorrection value – 7.7922. Conclusion. HCT has a neg. impact on TEG parameters. Coagulation state of anemia patients is overestimated by TEG. The test results of anemia patients need to be corrected whether through the exptl. correction or the formula correction. In the experiment, the researchers used many compounds, for example, 4-Oxo-tempo (cas: 2896-70-0Electric Literature of C9H16NO2).

4-Oxo-tempo (cas: 2896-70-0) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Electric Literature of C9H16NO2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Influence of NH₃ and NH₄⁺ on anaerobic digestion and microbial population structure at increasing total ammonia nitrogen concentrations was written by Mlinar, Stanislava;Weig, Alfons R.;Freitag, Ruth. And the article was included in Bioresource Technology in 2022.Quality Control of 4-Oxo-tempo This article mentions the following:

Despite the extensive research dedicated to ammonia inhibition, the effect of NH₃ and NH₄⁺ on each anaerobic digestion stage and the associated microorganisms is still not completely understood. In the past, the focus was mainly on methanogenesis and either on NH₃ or total ammonia nitrogen (TAN). Here, anaerobic digestion of two defined substrates, namely starch/NH₄Cl and casein, was investigated particularly regarding the effects of different NH₃/NH₄⁺ ratios on the involved microorganisms. TAN affected bacteria, primarily gram-pos. ones, whereas archaea responded largely to the NH₃ concentration These sensitivity differences are attributed to differences in the corresponding cell-membrane structures. A TAN decrease via stripping performed in two full-scale agricultural biogas plants resulted in increased bacterial diversity, with a pronounced increase in the propionate acetogens′ abundance. Based on these data, it is suggested that inhibition can be avoided and processes stabilized in biogas plants by adjusting the NH₃/NH₄⁺ ratio, when feeding nitrogen-rich substrates. In the experiment, the researchers used many compounds, for example, 4-Oxo-tempo (cas: 2896-70-0Quality Control of 4-Oxo-tempo).

4-Oxo-tempo (cas: 2896-70-0) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Quality Control of 4-Oxo-tempo

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Porous protoporphyrin IX-embedded cellulose diacetate electrospun microfibers in antimicrobial photodynamic inactivation was written by Wang, Tingting;Ke, Huizhen;Chen, Shiping;Wang, Jian;Yang, Wushi;Cao, Xiuming;Liu, Jingyan;Wei, Qufu;Ghiladi, Reza A.;Wang, Qingqing. And the article was included in Materials Science & Engineering, C: Materials for Biological Applications in 2021.Electric Literature of C9H16NO2 This article mentions the following:

Motivated by the need for self-disinfecting materials that can be used to reduce the surface transmission of harmful microbes to healthy hosts, here we prepared a photodynamic antimicrobial membrane comprised of electrospun cellulose diacetate (CA) microfibers into which the photosensitizer protoporphyrin IX (PpIX) was in situ embedded. The resultant porous PpIX-embedded CA (PpIX/CA) microfibrous membranes were prepared with two different photosensitizer loadings: 5 and 10 wt% PpIX with respect to CA (85 and 170 nmol PpIX/mg membrane, resp.). The singlet oxygen (¹O₂) generated by the embedded photosensitizer was confirmed by ESR spectroscopic studies through generation of the TEMPO radical, and its photooxidation efficiency was further investigated using potassium iodide as a model substrate. Antibacterial photodynamic inactivation studies showed that the PpIX/CA membrane achieved a 99.8% reduction in Gram-pos. S. aureus after illumination (Xe lamp, 65 ± 5 mW/cm², λ ≥ 420 nm; 30 min), with a lower level of reduction (86.6%) for Gram-neg. E. coli. Potentiation with potassium iodide was found to be an effective way to further enhance the antimicrobial efficacy of the PpIX/CA microfibrous membrane, achieving 99.9999% (6 log units) inactivation of both S. aureus and E. coli in the presence of 25 and 100 mM KI, resp. These findings indicate that the electrospun CA microfibrous membrane is an ideal matrix for a photosensitizer such as PpIX to be embedded and effectively sensitized upon visible light illumination, and its antimicrobial photodynamic inactivation efficiency could be strongly enhanced with the increased KI addition, showing a promising future for its use in pathogen transmission defensive materials. In the experiment, the researchers used many compounds, for example, 4-Oxo-tempo (cas: 2896-70-0Electric Literature of C9H16NO2).

4-Oxo-tempo (cas: 2896-70-0) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Electric Literature of C9H16NO2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Search for ABO₃ Type Ferroelectric Perovskites with Targeted Multi-Properties by Machine Learning Strategies was written by Xu, Pengcheng;Chang, Dongping;Lu, Tian;Li, Long;Li, Minjie;Lu, Wencong. And the article was included in Journal of Chemical Information and Modeling in 2022.Category: piperidines This article mentions the following:

Ferroelec. perovskites are one of the most promising functional materials due to the pyroelec. and piezoelec. effect. In the practical applications of ferroelec. perovskites, it is often necessary to meet the requirements of multiple properties. In this work, a multiproperties machine learning strategy was proposed to accelerate the discovery and design of new ferroelec. ABO₃-type perovskites. First, a classification model was constructed with data collected from publications to distinguish ferroelec. and nonferroelec. perovskites. The classification accuracies of LOOCV and the test set are 87.29% and 86.21%, resp. Then, two machine learning strategies, Machine-Learning Workflow and SISSO, were used to construct the regression models to predict the sp. surface area (SSA), band gap (E_g), Curie temperature (T_c), and dielec. loss (tan δ) of ABO₃-type perovskites. The correlation coefficients of LOOCV in the optimal models for SSA, E_g, and T_c are 0.935, 0.891, and 0.971, resp., while the correlation coefficient of the predicted and exptl. values of the SISSO model for tan δ prediction could reach 0.913. On the basis of the models, 20 ABO₃ ferroelec. perovskites with three different application prospects were screened out with the required properties, which could be explained by the patterns between the important descriptors and the properties by using SHAP. Furthermore, the constructed models were developed into web servers for the researchers to accelerate the rational design and discovery of ABO₃ ferroelec. perovskites with desired multiple properties. In the experiment, the researchers used many compounds, for example, 4-Oxo-tempo (cas: 2896-70-0Category: piperidines).

4-Oxo-tempo (cas: 2896-70-0) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

TEMPO-mediated late stage photochemical hydroxylation of biaryl sulfonium salts was written by Zhao, Yue;Yu, Congjun;Liang, Wenjing;Atodiresei, Iuliana L.;Patureau, Frederic W.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Recommanded Product: 4-Oxo-tempo This article mentions the following:

The late stage photochem. hydroxylation of biaryl sulfonium salts was enabled with a TEMPO derivative as a simple oxygen source, in metal free conditions. The scope and mechanism of this exceptionally simple synthetic method, which constructs important arylated phenols from aromatic C-H bonds, are herein discussed. In the experiment, the researchers used many compounds, for example, 4-Oxo-tempo (cas: 2896-70-0Recommanded Product: 4-Oxo-tempo).

4-Oxo-tempo (cas: 2896-70-0) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Recommanded Product: 4-Oxo-tempo

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Ultrasound Treatment Enhanced Semidry-Milled Rice Flour Properties and Gluten-Free Rice Bread Quality was written by Qin, Wanyu;Xi, Huihan;Wang, Aixia;Gong, Xue;Chen, Zhiying;He, Yue;Wang, Lili;Liu, Liya;Wang, Fengzhong;Tong, Litao. And the article was included in Molecules in 2022.Application In Synthesis of 4-Oxo-tempo This article mentions the following:

The structural and functional properties of phys. modified rice flour, including ultrasound treated rice flour (US), microwave treated rice flour (MW) and hydrothermal treated rice flour (HT) were investigated with wet-milled rice flour (WF) used as a pos. control. The results showed the presence of small dents and pores on the rice flour granules of US and MW while more fragments and cracks were showed in HT. XRD and FTIR revealed that moderate ultrasonic treatment promoted the orderly arrangement of starch while hydrothermal treatment destroyed the crystalline structure of rice flour. In addition, the significant decrease of gelatinization enthalpy and the narrowing gelatinization temperature were observed in US. Compared to that of SF, adding phys. modified rice flour led to a batter with higher viscoelasticity and lower tan δ. However, the batter added HT exhibited highest G ‘ and G” values and lowest tan δ, which led to a harder texture of bread. Texture anal. demonstrated that phys. modified rice flour (except HT) reduced the hardness, cohesion, and gumminess of rice bread. Especially, the sp. volume of bread with US increased by 15.6% and the hardness decreased by 17.6%. This study suggested that ultrasound treatment of rice flour could improve texture properties and appearance of rice bread. In the experiment, the researchers used many compounds, for example, 4-Oxo-tempo (cas: 2896-70-0Application In Synthesis of 4-Oxo-tempo).

4-Oxo-tempo (cas: 2896-70-0) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Application In Synthesis of 4-Oxo-tempo

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Ultrasound Treatment Enhanced Semidry-Milled Rice Flour Properties and Gluten-Free Rice Bread Quality was written by Qin, Wanyu;Xi, Huihan;Wang, Aixia;Gong, Xue;Chen, Zhiying;He, Yue;Wang, Lili;Liu, Liya;Wang, Fengzhong;Tong, Litao. And the article was included in Molecules in 2022.Application In Synthesis of 4-Oxo-tempo This article mentions the following:

The structural and functional properties of phys. modified rice flour, including ultrasound treated rice flour (US), microwave treated rice flour (MW) and hydrothermal treated rice flour (HT) were investigated with wet-milled rice flour (WF) used as a pos. control. The results showed the presence of small dents and pores on the rice flour granules of US and MW while more fragments and cracks were showed in HT. XRD and FTIR revealed that moderate ultrasonic treatment promoted the orderly arrangement of starch while hydrothermal treatment destroyed the crystalline structure of rice flour. In addition, the significant decrease of gelatinization enthalpy and the narrowing gelatinization temperature were observed in US. Compared to that of SF, adding phys. modified rice flour led to a batter with higher viscoelasticity and lower tan δ. However, the batter added HT exhibited highest G ‘ and G” values and lowest tan δ, which led to a harder texture of bread. Texture anal. demonstrated that phys. modified rice flour (except HT) reduced the hardness, cohesion, and gumminess of rice bread. Especially, the sp. volume of bread with US increased by 15.6% and the hardness decreased by 17.6%. This study suggested that ultrasound treatment of rice flour could improve texture properties and appearance of rice bread. In the experiment, the researchers used many compounds, for example, 4-Oxo-tempo (cas: 2896-70-0Application In Synthesis of 4-Oxo-tempo).

4-Oxo-tempo (cas: 2896-70-0) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Application In Synthesis of 4-Oxo-tempo

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem