169750-96-3, tert-Butyl (3-methylpiperidin-3-yl)carbamate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 4-[4-(2-tert-butyl-4-pyridyl)-2-thienyl]-3-chloro-benzoic acid (300 mg, 0.8086 mmol) in DMF (10 mL), was added DIPEA (418 mg, 3.2344 mmol), followed by the addition of HATU (615 mg, 1.6172 mmol). The reaction mixture was stirred for 30 min at RT. tert-Butyl N-(3-methyl-3-piperidyl)carbamate (433 mg, 2.022 mmol) was added and the reaction mixture stirred for 16 h at RT. The reaction was monitored by TLC and LCMS. On completion, the reaction mixture was diluted with water (50 mL) and extracted with EtOAc (2*100 mL). The combined organic layer was washed with water (2*50 mL) and brine (2*50 mL) and dried over anhydrous sodium sulfate to obtain 500 mg of crude product. The crude compound was purified by reverse phase combi-flash to afford tert-butyl N-[1-[4-[4-(2-tert-butyl-4-pyridyl)-2-thienyl]-3-chloro-benzoyl]-3-methyl-3-piperidyl]carbamate (300 mg) as a white solid.
As the paragraph descriping shows that 169750-96-3 is playing an increasingly important role.
Reference£º
Patent; Medivation Technologies LLC; Pujala, Brahmam; Jangir, Ramniwas; Guguloth, Rambabu; Shinde, Bharat Uttam; Rai, Roopa; Pham, Son Minh; Bernales, Sebastian; Lindquist, Jeffrey; Guha, Mausumee; Kallem, Satyanarayana; Bhatt, Bhawana; Bhagwat, Vikas Ramdas; (162 pag.)US2018/51013; (2018); A1;,
Piperidine – Wikipedia
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