Tag: 168.2792

Crystal Structures of Three Organically Modified Metal Halides was written by Zhao, Jin-Jing;Wang, Yan-Ning;Jia, Hong-Li;Yu, Jie-Hui;Xu, Ji-Qing. And the article was included in Journal of Cluster Science in 2014.SDS of cas: 15336-72-8 This article mentions the following:

Under the hydro(solvo)thermal conditions, the reactions of metal halides with organic N-heterocyclic mols. produced three new organically modified metal halides [tmbp][Cu₂Br₄] (1) (tmbp²⁺ = N,N,N’,N’-tetramethyl-4,4′-bipiperidinium), [H₂(dmbpp)][Pb₂I₆] (2) (dmbpp = dimethyl-1,3-bis(4-piperidyl)propane) and [PbI₂(bpp)] (3) (bpp = 1,3-bis(4-pyridyl)propane). It is noteworthy that tmbp²⁺ in compound 1 originated from the in situ alkylation of 4,4′-bipiperidine with CH₃OH. The mechanism study indicates that H⁺ and Br^– play a key role in the alkylation reaction. X-ray single-crystal diffraction anal. revealed that (i) compounds 1 and 2 are the organically templated halometallates. Both possess the 1D chain structures. The 1D chain of compound 1 can be regarded as a linear arrangement of CuBr₄ tetrahedra by sharing the edges, whereas that of compound 2 can be considered as an endless extension of PbI₆ octahedra by sharing the faces; (ii) compound 3 is the 1:1 adduct of PbI₂ and bpp. The PbI₂ chain shows a linear shape. Bpp serves as the connector, propagating the PbI₂ chains into a 2D layer network of compound 3. In the experiment, the researchers used many compounds, for example, 4,4′-Bipiperidine (cas: 15336-72-8SDS of cas: 15336-72-8).

4,4′-Bipiperidine (cas: 15336-72-8) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.SDS of cas: 15336-72-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Diphenidol-related diamines as novel muscarinic M₄ receptor antagonists was written by Varoli, Lucilla;Andreani, Aldo;Burnelli, Silvia;Granaiola, Massimiliano;Leoni, Alberto;Locatelli, Alessandra;Morigi, Rita;Rambaldi, Mirella;Bedini, Andrea;Fazio, Nicola;Spampinato, Santi. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.COA of Formula: C10H20N2 This article mentions the following:

A series of hydrochloride derivatives and quaternary ammonium derivatives of diphenidol have been synthesized and characterized in receptor binding and cellular functional assays vs. human muscarinic M₁-M₅ receptors expressed in CHO cells. A methiodide derivative (I) with a bipiperidinyl moiety and a second diphenidol framework, showed a potent and selective M₄ activity as competitive antagonist. Moreover I, acting as an allosteric modulator, was able to retard the dissociation rate of [³H]-N-methylscopolamine from CHO-M₄ cell membranes exposed to atropine. Taken together, these data suggest that I might open new avenues to the discovery of novel multivalent antagonists for the muscarinic receptors. In the experiment, the researchers used many compounds, for example, 4,4′-Bipiperidine (cas: 15336-72-8COA of Formula: C10H20N2).

4,4′-Bipiperidine (cas: 15336-72-8) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.COA of Formula: C10H20N2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Design, synthesis and structure of new dendritic melamines. First use of a tandem C-2-substituted serinol-O,O-masked 4-piperidone as a peripheral unit in iterative synthesis was written by Popa, Flavia;Lameiras, Pedro;Moldovan, Oana;Tomoaia-Cotisel, Maria;Henon, Eric;Martinez, Agathe;Sacalis, Carmen;Mocanu, Aurora;Ramondenc, Yvan;Darabantu, Mircea. And the article was included in Tetrahedron in 2012.Application In Synthesis of 4,4′-Bipiperidine This article mentions the following:

The iterative chemoselective amination of cyanuric chloride to dimers of new G-2 dendritic N-substituted-2,4,6-triamino-s-triazines (melamines) having C-2-substituted 2-aminopropane-1,3-diols (‘serinols’) in tandem with the ethylene ketal of 4-piperidone as peripheral units is reported. The structure as a function of increasing mol. size was studied by NMR spectroscopy, DFT calculation and AFM imaging. A concise nomenclature defining the restricted rotational phenomena about the newly created C(s-triazine)-N(exocyclic) partial double bonds, seen as axes of (pro)diastereomerism, is used. We propose a new form of frontier rotamerism for the dendrimer surface, which operates over a long range. In the experiment, the researchers used many compounds, for example, 4,4′-Bipiperidine (cas: 15336-72-8Application In Synthesis of 4,4′-Bipiperidine).

4,4′-Bipiperidine (cas: 15336-72-8) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Application In Synthesis of 4,4′-Bipiperidine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Evidence for multiple alkali metal cation complexation in membrane-spanning ion transporters was written by Shabany, Hossein;Murray, Clare L.;Gokel, George W.;Gloeckner, Charles A.;Grayson, Michael A.;Gross, Michael L.. And the article was included in Chemical Communications (Cambridge) in 2000.Application of 15336-72-8 This article mentions the following:

The polynitrogen-containing cation transporters 1-4 are shown by electrospray mass spectrometry to form multi-cationic species. In the absence of Na⁺, protonated species dominate but increasing the sodium concentration leads to all binding sites being occupied. In the experiment, the researchers used many compounds, for example, 4,4′-Bipiperidine (cas: 15336-72-8Application of 15336-72-8).

4,4′-Bipiperidine (cas: 15336-72-8) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.Application of 15336-72-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Neutral Molecule Receptor Systems Using Ferrocene’s “Atomic Ball Bearing” Character as the Flexible Element was written by Li, Chensheng;Medina, Julio C.;Maguire, Glenn E. M.;Abel, Ernesto;Atwood, Jerry L.;Gokel, George W.. And the article was included in Journal of the American Chemical Society in 1997.Application of 15336-72-8 This article mentions the following:

Fourteen novel ferrocene derivatives were designed to serve as receptors for low mol. weight diamines. The compounds that were prepared and fully characterized possess two ferrocenedicarboxylic acid residues bridged by amide formation in their resp. 1′-positions by 4,4′-benzidinyl (15), 3,3′-dimethoxy-4,4′-benzidinyl (16), 2,7-fluorenyl (17), 3-methoxy-2,7-fluorenyl (18), 4-N-piperazinoanilinyl (19), N,N’-4,4′-bipiperdinyl (20; shown as I), and 4,13-diaza-18-crown-6 (21). In two cases, ferrocenecarboxylic acid was bridged by spacers attached using 1-methylene groups. The bridges in these cases were 4,13-diaza-18-crown-6 (22) and 1,5-diaminoanthraquinone (24). In a single case, ferrocenecarboxylic acid was bridged by 1,5-dicarbonylnaphthalene (25). In one addnl. case, the bridge was created by formation of an imine followed by hydrogenation, but both compounds proved to be relatively unstable. Attempts to increase solubility afforded the N-ethylated derivative of 15 and the derivative 27 having carboxamides in the 1′-positions. A solid state structure of the di-Et ester of 20 confirms the design criteria. Complexation constants were determined in THF-d₈ or CDCl₃ for combinations of receptors 18, 19, and 20 with 4-aminopyridine, N,N,N’,N’-tetramethylethylenediamine, N,N,N’,N’-tetramethylpropylenediamine, DABCO, 3-propyladenine, and benzimidazole and were in the range 10²-10⁴. The anticipated complexation mechanism for 20 with N,N,N’,N’-tetramethylpropylenediamine was confirmed by observation of an NOE between host and guest. In the experiment, the researchers used many compounds, for example, 4,4′-Bipiperidine (cas: 15336-72-8Application of 15336-72-8).

4,4′-Bipiperidine (cas: 15336-72-8) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising 伪-glucosidase inhibitors. The former are analogs of DNJ with an improved 伪-glucosidase inhibitory profile than that of DNJ. Boisson et al.Application of 15336-72-8

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem