Tag: 157.2102

Trachsel, Lucca et al. published their research in Biomacromolecules in 2019 | CAS: 1126-09-6

Ethyl piperidine-4-carboxylate (cas: 1126-09-6) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Piperidine derivatives bearing a masked aldehyde function in the 蔚-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Formula: C8H15NO2

Double-Network Hydrogels Including Enzymatically Crosslinked Poly-(2-alkyl-2-oxazoline)s for 3D Bioprinting of Cartilage-Engineering Constructs was written by Trachsel, Lucca;Johnbosco, Castro;Lang, Thamar;Benetti, Edmondo M.;Zenobi-Wong, Marcy. And the article was included in Biomacromolecules in 2019.Formula: C8H15NO2 This article mentions the following:

Double-network (DN) hydrogels are fabricated from poly(2-ethyl-2-oxazoline) (PEOXA)-peptide conjugates, which can be enzymically crosslinked in the presence of Sortase A (SA), and phys. networks of alginate (Alg), yielding matrixes with improved mech. properties with respect to the corresponding PEOXA and Alg single networks and excellent cell viability of encapsulated human auricular chondrocytes (hACs). The addition of a low content of cellulose nanofibrils (CNFs) within DN hydrogel formulations provides the rheol. properties needed for extrusion-based three-dimensional (3D) printing, generating constructs with a good shape fidelity. In the presence of hACs, PEOXA-Alg-CNF prehydrogel mixtures can be bioprinted, finally generating 3D-structured DN hydrogel supports showing a cell viability of more than 90%. Expanding the application of poly(2-alkyl-2-oxazoline)-based formulations in the design of tissue-engineering constructs, this study further demonstrates how SA-mediated enzymic crosslinking represents a suitable and fully orthogonal method to generate biocompatible hydrogels with fast kinetics. In the experiment, the researchers used many compounds, for example, Ethyl piperidine-4-carboxylate (cas: 1126-09-6Formula: C8H15NO2).

Ethyl piperidine-4-carboxylate (cas: 1126-09-6) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Piperidine derivatives bearing a masked aldehyde function in the 蔚-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Formula: C8H15NO2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Bashir, Bushra et al. published their research in Bioorganic Chemistry in 2021 | CAS: 1126-09-6

Ethyl piperidine-4-carboxylate (cas: 1126-09-6) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Application of 1126-09-6

Identification of phenylcarbamoylazinane-1,3,4-oxadiazole amides as lipoxygenase inhibitors with expression analysis and in silico studies was written by Bashir, Bushra;Shahid, Wardah;Ashraf, Muhammad;Saleem, Muhammad;Aziz-ur-Rehman;Muzaffar, Saima;Imran, Muhammad;Amjad, Hira;Bhattarai, Keshab;Riaz, Naheed. And the article was included in Bioorganic Chemistry in 2021.Application of 1126-09-6 This article mentions the following:

In search for new anti-inflammatory agents that inhibit the enzymes of arachidonic acid pathway as the drug targets, the present article describes the screening of 1,3,4-oxadiazole analogs against lipoxygenase (LOX) enzyme. The work is based on the synthesis of new N-alkyl/aralky/aryl derivatives (6a-o) of 2-(4-phenyl-5-(1-phenylcarbamoylpiperidine)-4H-1,3,4-oxadiazol-3-ylthio)acetamide which were obtained by the reaction of 1,3,4-oxadiazole (3) with various electrophiles (5a-o), in KOH. The synthesized analogs showed potent to moderate inhibitory activity against the soybean 15-LOX enzyme; especially 6g, 6b, 6a and 6l displayed the potent inhibitory potential with IC50 values 7.15 卤 0.26, 9.32 卤 0.42, 15.83 卤 0.45 & 18.37 卤 0.53渭M, resp., while excellent to moderate inhibitory profiles with IC50 values in the range of 26.13-98.21渭M were observed from the compounds 6k, 6m, 6j, 6o, 6h, 6f, 6n and 6c. Most of the active compounds exhibited considerable cell viability against blood mononuclear cells (MNCs) at 0.25 mM by MTT assay except 6f, 6h, 6k and 6m which showed around 50% cell viability. Flow cytometry studies of the selected compounds 6a, 6j and 6n revealed that these caused 79.5-88.51% early apoptotic changes in MNCs compared with 4.26% for control quercetin at their resp. IC50 values. The relative expression of 5-LOX gene was monitored in MNCs after treatment with these three mols. and all down-regulated the enzyme activity. In silico ADME and mol. docking studies further supported these studies of oxadiazole derivatives and considered it as potential ‘lead’ compounds in drug discovery and development. In the experiment, the researchers used many compounds, for example, Ethyl piperidine-4-carboxylate (cas: 1126-09-6Application of 1126-09-6).

Ethyl piperidine-4-carboxylate (cas: 1126-09-6) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Application of 1126-09-6

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Moi, Davide et al. published their research in Molecules in 2022 | CAS: 1126-09-6

Ethyl piperidine-4-carboxylate (cas: 1126-09-6) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Recommanded Product: 1126-09-6

Synthesis of Sulfonamides Incorporating Piperidinyl-Hydrazidoureido and Piperidinyl-Hydrazidothioureido Moieties and Their Carbonic Anhydrase I, II, IX and XII Inhibitory Activity was written by Moi, Davide;Deplano, Alessandro;Angeli, Andrea;Balboni, Gianfranco;Supuran, Claudiu T.;Onnis, Valentina. And the article was included in Molecules in 2022.Recommanded Product: 1126-09-6 This article mentions the following:

Here, we report a small library of hydrazinocarbonyl-ureido and -thioureido benzenesulfonamide derivatives, I [R = Ph, C6H11, PhCH2, etc., X = O, S], that were designed and synthesized as potent and selective human carbonic anhydrase inhibitors (hCAIs). The synthesized compounds were ev=aluated against isoforms hCA I, II, IX and XII using acetazolamide (AAZ) as standard inhibitor. Several urea and thiourea derivatives showed inhibitory activity at low nanomolar levels with selectivity against the cytosolic hCA II isoform, as well as the transmembrane, tumor-associated enzymes hCA IX and XII. The thiourea derivatives showed enhanced potency as compared to urea analogs. Addnl., eight compounds, I [R = 3-FC6H4, 2,6-Me2C6H3, 2-MeOC6H4, 4-MeOC6H4, X = O, S], were selected for docking anal. on isoform I, II, IX, XII to illustrate the potential interaction with the enzyme to better understand the activity against the different isoforms. In the experiment, the researchers used many compounds, for example, Ethyl piperidine-4-carboxylate (cas: 1126-09-6Recommanded Product: 1126-09-6).

Ethyl piperidine-4-carboxylate (cas: 1126-09-6) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Recommanded Product: 1126-09-6

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Hahn, Lukas et al. published their research in Macromolecular Chemistry and Physics in 2021 | CAS: 1126-09-6

Ethyl piperidine-4-carboxylate (cas: 1126-09-6) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Related Products of 1126-09-6

ABA Type Amphiphiles with Poly(2-benzhydryl-2-oxazine) Moieties: Synthesis, Characterization and Inverse Thermogelation was written by Hahn, Lukas;Kessler, Larissa;Polzin, Lando;Fritze, Lars;Forster, Stefan;Helten, Holger;Luxenhofer, Robert. And the article was included in Macromolecular Chemistry and Physics in 2021.Related Products of 1126-09-6 This article mentions the following:

Thermoresponsive polymers are frequently involved in the development of materials for various applications. Here, polymers containing poly(2- benzhydryl-2-oxazine) (pBhOzi) repeating units are described for the first time. The homopolymer pBhOzi and an ABA type amphiphile comprising two flanking hydrophilic A blocks of poly(2-methyl-2-oxazoline) (pMeOx) and the hydrophobic aromatic pBhOzi central B block (pMeOx-b-pBhOzi-b-pMeOx) are synthesized and the latter is shown to exhibit inverse thermogelling properties at concentrations of 20 weight% in water. This behavior stands in contrast to a homolog ABA amphiphile consisting of a central poly(2-benzhydryl-2-oxazoline) block (pMeOx-b-pBhOx-b-pMeOx). No inverse thermogelling is observed with this polymer even at 25 weight%. For 25 weight% pMeOx-b-pBhOzi-b-pMeOx, a surprisingly high storage modulus of 鈮?2 kPa and high values for the yield and flow points of 480 Pa and 1.3 kPa are obtained. Exceeding the yield point, pronounced shear thinning is observed Interestingly, only little difference between self-assemblies of pMeOx-b-pBhOzi-b-pMeOx and pMeOx-b-pBhOx-b-pMeOx is observed by dynamic light scattering while transmission electron microscopy images suggest that the micelles of pMeOx-b-pBhOzi-b-pMeOx interact through their hydrophilic coronas, which is probably decisive for the gel formation. Overall, this study introduces new building blocks for poly(2-oxazoline) and poly(2-oxazine)-based self-assemblies, but addnl. studies will be needed to unravel the exact mechanism. In the experiment, the researchers used many compounds, for example, Ethyl piperidine-4-carboxylate (cas: 1126-09-6Related Products of 1126-09-6).

Ethyl piperidine-4-carboxylate (cas: 1126-09-6) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Related Products of 1126-09-6

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Li, Yingxiu et al. published their research in Bioorganic Chemistry in 2020 | CAS: 1126-09-6

Ethyl piperidine-4-carboxylate (cas: 1126-09-6) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Computed Properties of C8H15NO2

Discovery and rational design of 2-aminopyrimidine-based derivatives targeting Janus kinase 2 (JAK2) and FMS-like tyrosine kinase 3 (FLT3) was written by Li, Yingxiu;Wang, Peng;Chen, Cong;Ye, Tianyu;Han, Yufei;Hou, Yunlei;Liu, Yajing;Gong, Ping;Qin, Mingze;Zhao, Yanfang. And the article was included in Bioorganic Chemistry in 2020.Computed Properties of C8H15NO2 This article mentions the following:

Herein, with the help of computer-aided drug design (CADD), the structure-based rational drug design, structure-activity relationships, and synthesis of a series of 2-aminopyrimidine derivatives that inhibit both JAK2 and FLT3 kinases was described. These screening cascades revealed that compound I [R1 = 5-Cl] demonstrated the most inhibitory activity with IC50 values of 1.8 and 0.68 nM against JAK2 and FLT3 resp. Compound I [R1 = 5-Cl] also showed potent anti-proliferative activities against HEL (IC50 = 0.84渭M) and Molm-13 (IC50 = 0.019渭M) cell lines, but relatively weak cytotoxicity against K562 and PC-3 cell lines, which proved that it might have high target specificity. In-vitro metabolism assay, I [R1 = 5-Cl] exhibited moderate stability in RLM (Rat Liver Microsomes) with a half-life time of 31 min. In the cellular context of Molm-13, I [R1 = 5-Cl] induced cell cycle arrest in G1/S phase and enhanced apoptosis in a dose-dependent manner. These results indicated that I [R1 = 5-Cl] s a promising dual JAK2/FLT3 inhibitor and worthy of further development. In the experiment, the researchers used many compounds, for example, Ethyl piperidine-4-carboxylate (cas: 1126-09-6Computed Properties of C8H15NO2).

Ethyl piperidine-4-carboxylate (cas: 1126-09-6) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Computed Properties of C8H15NO2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Shi, Da-Hua et al. published their research in Journal of Chemical Research in 2021 | CAS: 1126-09-6

Ethyl piperidine-4-carboxylate (cas: 1126-09-6) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.HPLC of Formula: 1126-09-6

Synthesis, characterization, crystal structures, and the biological evaluation of 2-phenylthiazole derivatives as cholinesterase inhibitors was written by Shi, Da-Hua;Song, Meng-qiu;Ma, Xiao-Dong;Su, Jia-Bin;Wang, Jing;Wang, Xiu-Jun;Liu, Yu-Wei;Liu, Wei-Wei;Si, Xin-Xin. And the article was included in Journal of Chemical Research in 2021.HPLC of Formula: 1126-09-6 This article mentions the following:

Four 2-phenylthiazole derivatives I [R = 4-methylpiperazin-1-yl, 2-morpholin-4-yl-Et, 3,5-dimethylpiperidin-1-yl, etc.] were synthesized, characterized and evaluated as cholinesterase inhibitors. The structures of the 2-phenylthiazole derivatives were confirmed by 1H and 13C NMR spectroscopy, single-crystal X-ray diffraction studies, and Hirshfeld surfaces anal. Hirshfeld surface anal. of the prepared compounds showed C-H路路路O intermol. interactions. The cholinesterase inhibition activities of the synthesized compounds were tested by Ellman’s method. Compound I [R = 3,5-dimethylpiperidin-1-yl] showed the best acetylcholinesterase inhibition activity with an IC50 value of 8.86渭M and the best butyrylcholinesterase inhibition activity with an IC50 value of 1.03渭M. A docking study demonstrated that the same compound interacted with the catalytic anionic site and peripheral anionic site of acetylcholinesterase and the catalytic anionic site of butyrylcholinesterase. In the experiment, the researchers used many compounds, for example, Ethyl piperidine-4-carboxylate (cas: 1126-09-6HPLC of Formula: 1126-09-6).

Ethyl piperidine-4-carboxylate (cas: 1126-09-6) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.HPLC of Formula: 1126-09-6

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Nicholson, William I. et al. published their research in Angewandte Chemie, International Edition in 2021 | CAS: 1126-09-6

Ethyl piperidine-4-carboxylate (cas: 1126-09-6) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Recommanded Product: 1126-09-6

Direct Amidation of Esters by Ball Milling was written by Nicholson, William I.;Barreteau, Fabien;Leitch, Jamie A.;Payne, Riley;Priestley, Ian;Godineau, Edouard;Battilocchio, Claudio;Browne, Duncan L.. And the article was included in Angewandte Chemie, International Edition in 2021.Recommanded Product: 1126-09-6 This article mentions the following:

The direct mechanochem. amidation of esters RC(O)OR1 (R = Cy, Ph, pyridin-2-yl, etc.; R1 = Me, Et) by ball milling is described. The operationally simple procedure requires an ester, amines R2NHR3 (R2 = H, Me, Et; R3 = i-Pr, Ph, 2,4,6-trimethylphenyl, etc.; R2R3 = -(CH2)2O(CH2)2-, -(CH2)5-, -(CH2)6-, etc.) and 1,2,3,4-tetrahydroquinoline, and substoichiometric KOtBu, and was used to prepare a large and diverse library of 78 amide structures RC(O)N(R2)R3 and (3,4-dihydroquinolin-1(2H)-yl)(phenyl)methanone with modest to excellent efficiency. Heteroaromatic and heterocyclic components are specifically shown to be amenable to this mechanochem. protocol. This direct synthesis platform has been applied to the synthesis of active pharmaceutical ingredients (APIs) and agrochems. as well as the gram-scale synthesis of an active pharmaceutical, all in the absence of a reaction solvent. In the experiment, the researchers used many compounds, for example, Ethyl piperidine-4-carboxylate (cas: 1126-09-6Recommanded Product: 1126-09-6).

Ethyl piperidine-4-carboxylate (cas: 1126-09-6) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Recommanded Product: 1126-09-6

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Meng, Haiwen et al. published their research in European Journal of Organic Chemistry in 2021 | CAS: 1126-09-6

Ethyl piperidine-4-carboxylate (cas: 1126-09-6) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising 伪-glucosidase inhibitors. The former are analogs of DNJ with an improved 伪-glucosidase inhibitory profile than that of DNJ. Boisson et al.Application of 1126-09-6

P(III)-Assisted Electrochemical Access to Ureas via in situ Generation of Isocyanates from Hydroxamic Acids was written by Meng, Haiwen;Sun, Kunhui;Xu, Zhimin;Tian, Lifang;Wang, Yahui. And the article was included in European Journal of Organic Chemistry in 2021.Application of 1126-09-6 This article mentions the following:

An external oxidant-free protocol for the generation of isocyanates from hydroxamic acids assisted by trivalent phosphine under mild electrochem. conditions was reported. The process started with the anodic oxidation of hydroxamic acids, followed by reacting with phosphine to form corresponding alkoxyphosphoniums and subsequent rearrangement with the release of tri-substituted phosphine oxide as the driving force to give isocyanates, which were trapped by N-based nucleophiles to produce various ureas. This method provides a broadly applicable procedure to access isocyanate intermediates under mild electrochem. conditions. In the experiment, the researchers used many compounds, for example, Ethyl piperidine-4-carboxylate (cas: 1126-09-6Application of 1126-09-6).

Ethyl piperidine-4-carboxylate (cas: 1126-09-6) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising 伪-glucosidase inhibitors. The former are analogs of DNJ with an improved 伪-glucosidase inhibitory profile than that of DNJ. Boisson et al.Application of 1126-09-6

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Li, Yingxiu et al. published their research in Bioorganic Chemistry in 2020 | CAS: 1126-09-6

Ethyl piperidine-4-carboxylate (cas: 1126-09-6) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Computed Properties of C8H15NO2

Discovery and rational design of 2-aminopyrimidine-based derivatives targeting Janus kinase 2 (JAK2) and FMS-like tyrosine kinase 3 (FLT3) was written by Li, Yingxiu;Wang, Peng;Chen, Cong;Ye, Tianyu;Han, Yufei;Hou, Yunlei;Liu, Yajing;Gong, Ping;Qin, Mingze;Zhao, Yanfang. And the article was included in Bioorganic Chemistry in 2020.Computed Properties of C8H15NO2 This article mentions the following:

Herein, with the help of computer-aided drug design (CADD), the structure-based rational drug design, structure-activity relationships, and synthesis of a series of 2-aminopyrimidine derivatives that inhibit both JAK2 and FLT3 kinases was described. These screening cascades revealed that compound I [R1 = 5-Cl] demonstrated the most inhibitory activity with IC50 values of 1.8 and 0.68 nM against JAK2 and FLT3 resp. Compound I [R1 = 5-Cl] also showed potent anti-proliferative activities against HEL (IC50 = 0.84μM) and Molm-13 (IC50 = 0.019μM) cell lines, but relatively weak cytotoxicity against K562 and PC-3 cell lines, which proved that it might have high target specificity. In-vitro metabolism assay, I [R1 = 5-Cl] exhibited moderate stability in RLM (Rat Liver Microsomes) with a half-life time of 31 min. In the cellular context of Molm-13, I [R1 = 5-Cl] induced cell cycle arrest in G1/S phase and enhanced apoptosis in a dose-dependent manner. These results indicated that I [R1 = 5-Cl] s a promising dual JAK2/FLT3 inhibitor and worthy of further development. In the experiment, the researchers used many compounds, for example, Ethyl piperidine-4-carboxylate (cas: 1126-09-6Computed Properties of C8H15NO2).

Ethyl piperidine-4-carboxylate (cas: 1126-09-6) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Computed Properties of C8H15NO2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Hahn, Lukas et al. published their research in Macromolecular Chemistry and Physics in 2021 | CAS: 1126-09-6

Ethyl piperidine-4-carboxylate (cas: 1126-09-6) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Related Products of 1126-09-6

ABA Type Amphiphiles with Poly(2-benzhydryl-2-oxazine) Moieties: Synthesis, Characterization and Inverse Thermogelation was written by Hahn, Lukas;Kessler, Larissa;Polzin, Lando;Fritze, Lars;Forster, Stefan;Helten, Holger;Luxenhofer, Robert. And the article was included in Macromolecular Chemistry and Physics in 2021.Related Products of 1126-09-6 This article mentions the following:

Thermoresponsive polymers are frequently involved in the development of materials for various applications. Here, polymers containing poly(2- benzhydryl-2-oxazine) (pBhOzi) repeating units are described for the first time. The homopolymer pBhOzi and an ABA type amphiphile comprising two flanking hydrophilic A blocks of poly(2-methyl-2-oxazoline) (pMeOx) and the hydrophobic aromatic pBhOzi central B block (pMeOx-b-pBhOzi-b-pMeOx) are synthesized and the latter is shown to exhibit inverse thermogelling properties at concentrations of 20 weight% in water. This behavior stands in contrast to a homolog ABA amphiphile consisting of a central poly(2-benzhydryl-2-oxazoline) block (pMeOx-b-pBhOx-b-pMeOx). No inverse thermogelling is observed with this polymer even at 25 weight%. For 25 weight% pMeOx-b-pBhOzi-b-pMeOx, a surprisingly high storage modulus of ≈22 kPa and high values for the yield and flow points of 480 Pa and 1.3 kPa are obtained. Exceeding the yield point, pronounced shear thinning is observed Interestingly, only little difference between self-assemblies of pMeOx-b-pBhOzi-b-pMeOx and pMeOx-b-pBhOx-b-pMeOx is observed by dynamic light scattering while transmission electron microscopy images suggest that the micelles of pMeOx-b-pBhOzi-b-pMeOx interact through their hydrophilic coronas, which is probably decisive for the gel formation. Overall, this study introduces new building blocks for poly(2-oxazoline) and poly(2-oxazine)-based self-assemblies, but addnl. studies will be needed to unravel the exact mechanism. In the experiment, the researchers used many compounds, for example, Ethyl piperidine-4-carboxylate (cas: 1126-09-6Related Products of 1126-09-6).

Ethyl piperidine-4-carboxylate (cas: 1126-09-6) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Related Products of 1126-09-6

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem