Tag: 156.2685

Design, synthesis, anticancer activity and mechanism studies of novel 2-amino-4-aryl-pyrimidine derivatives of ursolic acid was written by Wang, Wen-Yan;Yang, Zi-Hui;Li, A-Liang;Liu, Qing-Song;Sun, Yue;Gu, Wen. And the article was included in New Journal of Chemistry in 2022.Category: piperidines This article mentions the following:

A series of novel 2-amino-4-aryl-pyrimidine derivatives of ursolic acid were designed, synthesized, and evaluated for their anticancer activities against four cancer cell lines (MCF-7, HeLa, HepG2, and A549) and a human hepatocyte cell line (LO2) via MTT assay. Among these derivatives, compound 7b exhibited potent cytotoxic activity against MCF-7 and HeLa cells with IC50 values of 0.48 ± 0.11 and 0.74 ± 0.13 μM, resp., and substantially lower cytotoxicity to LO2 cells. Further cellular mechanism studies in MCF-7 cells elucidated that compound 7b could inhibit cell migration, induce cell cycle arrest at S phase and trigger mitochondrial-related apoptosis by increasing the generation of intracellular ROS and decreasing the mitochondrial membrane potential (MMP), which was associated with upregulation of the protein expression level of Bax and downregulation the level of Bcl-2 and the activation of caspase cascade. Western blot analyses also revealed that compound 7b could simultaneously suppress RAS/Raf/MEK/ERK and PI3K/AKT/mTOR signaling pathways, which could be responsible for the induction of apoptosis. Mol. docking study revealed that MEK1 kinase could be one of the possible targets of the title compounds These results offered a promising scaffold for the investigation of novel targeted anticancer agents. In the experiment, the researchers used many compounds, for example, 3-(2-Methylpiperidin-1-yl)propan-1-amine (cas: 25560-00-3Category: piperidines).

3-(2-Methylpiperidin-1-yl)propan-1-amine (cas: 25560-00-3) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Structure-biodegradability correlations among xenobiotic industrial amines was written by Rothkopf, G. S.;Bartha, R.. And the article was included in JAOCS, J. Am. Oil Chem. Soc. in 1984.Application In Synthesis of 3-(2-Methylpiperidin-1-yl)propan-1-amine This article mentions the following:

Using acclimated sewage sludge enrichment cultures, 60 amines with potential uses in industrial processes were evaluated for their biodegradability. Biodegradation was measured as cell protein yield with 0.05% amine serving as the sole source of C, N, and energy in a mineral solution Inhibitory properties of the amines, measured by their ability to decrease protein yield on a glucose medium, were unrelated to biodegradability. Under the specified test conditions, all amines that contained tertiary C atoms were recalcitrant. Ring N-substituted heterocyclics were readily degraded, but ring C-substituted piperidines, with the exception of pipecolinic acid  [535-75-1] were not. When amines lacked other functional groups, tertiary amino groups hindered degradation Amines with alkyldiamine moieties shorter than Pr did not serve as growth substrates. Predictive generalizations of this type about biodegradability serve as an aid in selecting environmentally safe compounds for industrial processes. In the experiment, the researchers used many compounds, for example, 3-(2-Methylpiperidin-1-yl)propan-1-amine (cas: 25560-00-3Application In Synthesis of 3-(2-Methylpiperidin-1-yl)propan-1-amine).

3-(2-Methylpiperidin-1-yl)propan-1-amine (cas: 25560-00-3) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Application In Synthesis of 3-(2-Methylpiperidin-1-yl)propan-1-amine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Ruthenium half-sandwich complexes as protein kinase inhibitors: An N-succinimidyl ester for rapid derivatizations of the cyclopentadienyl moiety was written by Bregman, Howard;Meggers, Eric. And the article was included in Organic Letters in 2006.Quality Control of 3-(2-Methylpiperidin-1-yl)propan-1-amine This article mentions the following:

Racemic and metal-chiral ruthenium half-sandwich pyrido[2,3-a]carbazole complexes I bearing carboxamide substituents in the cyclopentadienyl ring were prepared and tested for Pim-1 and GSK-3α protein kinase inhibition. Reaction of cyclopentadienylcarboxylic ester complex, [(MeCN)₂(CO)Ru(η⁵-C₅H₄CO₂CH₂CH₂TMS)] with 6-R-pyrido[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H,12H)-dione (HL¹, R = TBS) afforded ruthenium half-sandwich [(L¹-N¹,N¹²)(CO)Ru(η⁵-C₅H₄CO₂CH₂CH₂TMS)] (10a), which after deprotection yields the carboxylic acid [(L-N¹,N¹²)(CO)Ru(η⁵-C₅H₄CO₂H)] [11; L = pyrido[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H,12H)-dione anion]; esterification with N-hydroxysuccinimide gave the active ester, [(L-N¹,N¹²)(CO)Ru(η⁵-C₅H₄CO₂R¹)] (4, R¹ = 2,5-dioxopyrrolidin-1-yl). Amidation of 4 with a library of amines RNH₂ afforded the amides, [(L-N¹,N¹²)(CO)Ru(η⁵-C₅H₄CONHR)] (2, 3, 12–24). The obtained amides were tested for their pharmacol. properties, by inhibition assay of Pim-1 and GSK-3α protein kinases. The organometallic Pim-1 and GSK-3 inhibitors with improved potencies and kinase selectivities were identified. In the experiment, the researchers used many compounds, for example, 3-(2-Methylpiperidin-1-yl)propan-1-amine (cas: 25560-00-3Quality Control of 3-(2-Methylpiperidin-1-yl)propan-1-amine).

3-(2-Methylpiperidin-1-yl)propan-1-amine (cas: 25560-00-3) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Quality Control of 3-(2-Methylpiperidin-1-yl)propan-1-amine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Solid-phase synthesis of 3-aminohydantoin, dihydrouracil, thiohydantoin and dihydrothiouracil derivatives was written by Wu, Shengde;Janusz, John M.. And the article was included in Tetrahedron Letters in 2000.Product Details of 25560-00-3 This article mentions the following:

An efficient and convenient route to 3-aminohydantoins and dihydrouracils using solid-phase chem. has been developed. This methodol. has the advantage of generality and diversity over solution-phase chem. for the preparation of 3-aminohydantoins and dihydrouracils. In the experiment, the researchers used many compounds, for example, 3-(2-Methylpiperidin-1-yl)propan-1-amine (cas: 25560-00-3Product Details of 25560-00-3).

3-(2-Methylpiperidin-1-yl)propan-1-amine (cas: 25560-00-3) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Product Details of 25560-00-3

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Studies on the structure-activity relationship of the basic amine of phenylpiperazines as melanocortin-4 receptor antagonists was written by Tran, Joe A.;Arellano, Melissa;Fleck, Beth A.;Pontillo, Joseph;Marinkovic, Dragan;Tucci, Fabio C.;Wen, Jenny;Saunders, John;Chen, Chen. And the article was included in Medicinal Chemistry in 2008.HPLC of Formula: 25560-00-3 This article mentions the following:

A series of piperazinephenethylamines were synthesized to study the contribution of a basic amine to binding affinity at the melanocortin-4 receptor. Several potent compounds from this series possessed subnanomolar K_i values in a competition binding assay. In the experiment, the researchers used many compounds, for example, 3-(2-Methylpiperidin-1-yl)propan-1-amine (cas: 25560-00-3HPLC of Formula: 25560-00-3).

3-(2-Methylpiperidin-1-yl)propan-1-amine (cas: 25560-00-3) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.HPLC of Formula: 25560-00-3

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Design, synthesis, anticancer activity and mechanism studies of novel 2-amino-4-aryl-pyrimidine derivatives of ursolic acid was written by Wang, Wen-Yan;Yang, Zi-Hui;Li, A-Liang;Liu, Qing-Song;Sun, Yue;Gu, Wen. And the article was included in New Journal of Chemistry in 2022.Category: piperidines This article mentions the following:

A series of novel 2-amino-4-aryl-pyrimidine derivatives of ursolic acid were designed, synthesized, and evaluated for their anticancer activities against four cancer cell lines (MCF-7, HeLa, HepG2, and A549) and a human hepatocyte cell line (LO2) via MTT assay. Among these derivatives, compound 7b exhibited potent cytotoxic activity against MCF-7 and HeLa cells with IC50 values of 0.48 ± 0.11 and 0.74 ± 0.13 μM, resp., and substantially lower cytotoxicity to LO2 cells. Further cellular mechanism studies in MCF-7 cells elucidated that compound 7b could inhibit cell migration, induce cell cycle arrest at S phase and trigger mitochondrial-related apoptosis by increasing the generation of intracellular ROS and decreasing the mitochondrial membrane potential (MMP), which was associated with upregulation of the protein expression level of Bax and downregulation the level of Bcl-2 and the activation of caspase cascade. Western blot analyses also revealed that compound 7b could simultaneously suppress RAS/Raf/MEK/ERK and PI3K/AKT/mTOR signaling pathways, which could be responsible for the induction of apoptosis. Mol. docking study revealed that MEK1 kinase could be one of the possible targets of the title compounds These results offered a promising scaffold for the investigation of novel targeted anticancer agents. In the experiment, the researchers used many compounds, for example, 3-(2-Methylpiperidin-1-yl)propan-1-amine (cas: 25560-00-3Category: piperidines).

3-(2-Methylpiperidin-1-yl)propan-1-amine (cas: 25560-00-3) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine derivatives bearing a masked aldehyde function in the ε-position are easily transformed into quinolizidine compounds through intramolecular reductive amination.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Structure-biodegradability correlations among xenobiotic industrial amines was written by Rothkopf, G. S.;Bartha, R.. And the article was included in JAOCS, J. Am. Oil Chem. Soc. in 1984.Application In Synthesis of 3-(2-Methylpiperidin-1-yl)propan-1-amine This article mentions the following:

Using acclimated sewage sludge enrichment cultures, 60 amines with potential uses in industrial processes were evaluated for their biodegradability. Biodegradation was measured as cell protein yield with 0.05% amine serving as the sole source of C, N, and energy in a mineral solution Inhibitory properties of the amines, measured by their ability to decrease protein yield on a glucose medium, were unrelated to biodegradability. Under the specified test conditions, all amines that contained tertiary C atoms were recalcitrant. Ring N-substituted heterocyclics were readily degraded, but ring C-substituted piperidines, with the exception of pipecolinic acid  [535-75-1] were not. When amines lacked other functional groups, tertiary amino groups hindered degradation Amines with alkyldiamine moieties shorter than Pr did not serve as growth substrates. Predictive generalizations of this type about biodegradability serve as an aid in selecting environmentally safe compounds for industrial processes. In the experiment, the researchers used many compounds, for example, 3-(2-Methylpiperidin-1-yl)propan-1-amine (cas: 25560-00-3Application In Synthesis of 3-(2-Methylpiperidin-1-yl)propan-1-amine).

3-(2-Methylpiperidin-1-yl)propan-1-amine (cas: 25560-00-3) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Application In Synthesis of 3-(2-Methylpiperidin-1-yl)propan-1-amine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Ruthenium half-sandwich complexes as protein kinase inhibitors: An N-succinimidyl ester for rapid derivatizations of the cyclopentadienyl moiety was written by Bregman, Howard;Meggers, Eric. And the article was included in Organic Letters in 2006.Quality Control of 3-(2-Methylpiperidin-1-yl)propan-1-amine This article mentions the following:

Racemic and metal-chiral ruthenium half-sandwich pyrido[2,3-a]carbazole complexes I bearing carboxamide substituents in the cyclopentadienyl ring were prepared and tested for Pim-1 and GSK-3α protein kinase inhibition. Reaction of cyclopentadienylcarboxylic ester complex, [(MeCN)₂(CO)Ru(η⁵-C₅H₄CO₂CH₂CH₂TMS)] with 6-R-pyrido[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H,12H)-dione (HL¹, R = TBS) afforded ruthenium half-sandwich [(L¹-N¹,N¹²)(CO)Ru(η⁵-C₅H₄CO₂CH₂CH₂TMS)] (10a), which after deprotection yields the carboxylic acid [(L-N¹,N¹²)(CO)Ru(η⁵-C₅H₄CO₂H)] [11; L = pyrido[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H,12H)-dione anion]; esterification with N-hydroxysuccinimide gave the active ester, [(L-N¹,N¹²)(CO)Ru(η⁵-C₅H₄CO₂R¹)] (4, R¹ = 2,5-dioxopyrrolidin-1-yl). Amidation of 4 with a library of amines RNH₂ afforded the amides, [(L-N¹,N¹²)(CO)Ru(η⁵-C₅H₄CONHR)] (2, 3, 12–24). The obtained amides were tested for their pharmacol. properties, by inhibition assay of Pim-1 and GSK-3α protein kinases. The organometallic Pim-1 and GSK-3 inhibitors with improved potencies and kinase selectivities were identified. In the experiment, the researchers used many compounds, for example, 3-(2-Methylpiperidin-1-yl)propan-1-amine (cas: 25560-00-3Quality Control of 3-(2-Methylpiperidin-1-yl)propan-1-amine).

3-(2-Methylpiperidin-1-yl)propan-1-amine (cas: 25560-00-3) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Quality Control of 3-(2-Methylpiperidin-1-yl)propan-1-amine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Solid-phase synthesis of 3-aminohydantoin, dihydrouracil, thiohydantoin and dihydrothiouracil derivatives was written by Wu, Shengde;Janusz, John M.. And the article was included in Tetrahedron Letters in 2000.Product Details of 25560-00-3 This article mentions the following:

An efficient and convenient route to 3-aminohydantoins and dihydrouracils using solid-phase chem. has been developed. This methodol. has the advantage of generality and diversity over solution-phase chem. for the preparation of 3-aminohydantoins and dihydrouracils. In the experiment, the researchers used many compounds, for example, 3-(2-Methylpiperidin-1-yl)propan-1-amine (cas: 25560-00-3Product Details of 25560-00-3).

3-(2-Methylpiperidin-1-yl)propan-1-amine (cas: 25560-00-3) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Product Details of 25560-00-3

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Solid-phase synthesis of 3-aminohydantoin, dihydrouracil, thiohydantoin and dihydrothiouracil derivatives was written by Wu, Shengde;Janusz, John M.. And the article was included in Tetrahedron Letters in 2000.Product Details of 25560-00-3 This article mentions the following:

An efficient and convenient route to 3-aminohydantoins and dihydrouracils using solid-phase chem. has been developed. This methodol. has the advantage of generality and diversity over solution-phase chem. for the preparation of 3-aminohydantoins and dihydrouracils. In the experiment, the researchers used many compounds, for example, 3-(2-Methylpiperidin-1-yl)propan-1-amine (cas: 25560-00-3Product Details of 25560-00-3).

3-(2-Methylpiperidin-1-yl)propan-1-amine (cas: 25560-00-3) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Product Details of 25560-00-3

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem