Tag: 155.2804

Metal-Free Catalytic Hydrogenolysis of Silyl Triflates and Halides into Hydrosilanes was written by Durin, Gabriel;Fontaine, Albane;Berthet, Jean-Claude;Nicolas, Emmanuel;Thuery, Pierre;Cantat, Thibault. And the article was included in Angewandte Chemie, International Edition in 2022.Application of 79-55-0 This article mentions the following:

The metal-free catalytic hydrogenolysis of silyl triflates and halides (I, Br) to hydrosilanes is unlocked by using arylborane Lewis acids as catalysts. In the presence of a nitrogen base, the catalyst acts as a Frustrated Lewis Pair (FLP) able to split H₂ and generate a boron hydride intermediate capable of reducing (pseudo)halosilanes. This metal-free organocatalytic system is competitive with metal-based catalysts and enables the formation of a variety of hydrosilanes at room temperature in high yields (>85%) under a low pressure of H₂ (鈮?0 bar). In the experiment, the researchers used many compounds, for example, 1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0Application of 79-55-0).

1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.Application of 79-55-0

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Frustrated Lewis Acid/Bronsted Base Catalysts for Direct Enantioselective 伪-Amination of Carbonyl Compounds was written by Shang, Ming;Wang, Xiaoxu;Koo, Seung Moh;Youn, Jennifer;Chan, Jessica Z.;Yao, Wenzhi;Hastings, Brian T.;Wasa, Masayuki. And the article was included in Journal of the American Chemical Society in 2017.HPLC of Formula: 79-55-0 This article mentions the following:

A method for enantioselective direct 伪-amination reaction catalyzed by a sterically “frustrated” Lewis acid/Bronsted base complex is disclosed. Cooperative functioning of the Lewis acid and Bronsted base components gives rise to in situ enolate generation from monocarbonyl compounds Subsequent reaction with hydrogen-bond activated dialkyl azodicarboxylates delivers 伪-aminocarbonyl compounds in high enantiomeric purity. In the experiment, the researchers used many compounds, for example, 1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0HPLC of Formula: 79-55-0).

1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.HPLC of Formula: 79-55-0

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Development of a new bicyclic imidazole nucleophilic organocatalyst for direct enantioselective C-acylation was written by Zhou, Muxing;He, Ende;Zhang, Lu;Chen, Jianzhong;Zhang, Zhenfeng;Liu, Yangang;Zhang, Wanbin. And the article was included in Organic Chemistry Frontiers in 2019.Application In Synthesis of 1,2,2,6,6-Pentamethylpiperidine This article mentions the following:

A novel chiral nucleophilic organocatalyst I easily synthesized from simple starting materials bearing a 5,6,7,8-tetrahydroimidazo[1,2-a]pyridine skeleton has been developed and successfully applied in the direct enantioselective C-acylation of 3-substituted benzofuranones II (R¹ = Me, Et, Pr; R² = H; R³ = H, Me, Et, i-Pr, t-Bu, MeO, Ph; R⁴ = H, Me, Et, i-Pr, t-Bu, MeO, Ph; R⁵ = H, Me, Et, t-Bu, i-Pr; R²R³ = CH=CH-CH=CH; R⁴R⁵ = CH=CH-CH=CH). Its catalytic efficiency was shown to be comparable to that of the previously reported chiral 6,7-dihydro-5H-pyrrolo[1,2-a]imidazole catalyst. A wide range of 3,3-disubstituted benzofuranones (S)-III possessing a quaternary stereocenter, were synthesized with high yields and enantioselectivities. In the experiment, the researchers used many compounds, for example, 1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0Application In Synthesis of 1,2,2,6,6-Pentamethylpiperidine).

1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.Application In Synthesis of 1,2,2,6,6-Pentamethylpiperidine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Sequential Conia-ene-type cyclization and Negishi coupling by cooperative functions of B(C₆F₅)₃, ZnI₂, Pd(PPh₃)₄ and an amine was written by Cao, Min;Yesilcimen, Ahmet;Prasad, Soumil;Genova, Jason;Myers, Tanner;Wasa, Masayuki. And the article was included in Organic & Biomolecular Chemistry in 2020.Application In Synthesis of 1,2,2,6,6-Pentamethylpiperidine This article mentions the following:

Authors disclose a method for sequential Conia-ene-type cyclization/Negishi coupling for the union of alkynyl ketones and aryl iodides. This process is promoted through cooperative actions of Lewis acidic B(C₆F₅)₃, ZnI₂, Pd-based complex, and a Bronsted basic amine. The three Lewis acid catalysts with potential overlapping functions play their independent roles as activators of carbonyl group, alkyne moiety, and alkenyl zinc intermediate, resp. A variety of 1,2,3-substituted cyclopentenes I (R¹ = n-Bu, Ph, 2-MeOC₆H₄, 2-furyl, 2-naphthyl; R² = Me, Et, n-Pr, n-Bu; Ar = Ph, 2-thienyl, 1-naphthyl, etc.) can be synthesized with high efficiency. In the experiment, the researchers used many compounds, for example, 1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0Application In Synthesis of 1,2,2,6,6-Pentamethylpiperidine).

1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. The piperidine and polyhydroxylated indolizidine derivatives have shown to be promising 伪-glucosidase inhibitors. The former are analogs of DNJ with an improved 伪-glucosidase inhibitory profile than that of DNJ. Boisson et al.Application In Synthesis of 1,2,2,6,6-Pentamethylpiperidine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Azaphosphatranes as hydrogen-bonding organocatalysts for the activation of carbonyl groups: investigation of lactide ring-opening polymerization was written by Zhang, Dawei;Jardel, Damien;Peruch, Frederic;Calin, Nathalie;Dufaud, Veronique;Dutasta, Jean-Pierre;Martinez, Alexandre;Bibal, Brigitte. And the article was included in European Journal of Organic Chemistry in 2016.Computed Properties of C10H21N This article mentions the following:

Azaphosphatranes [N(CH₂CH₂NR)₃PH]X (R = Me, ⁱPr, 4-CH₂C₆H₄OMe; X = NTf₂^–, BAr^F₄^–) were prepared as hydrogen-bond donors and organocatalysts for ring-opening polymerization of lactide. The hydrogen-bonding activation of C:O bonds by azaphosphatranes was explored in a model reaction, i.e., the ring-opening polymerization of lactide. The polymerization process was controlled, and allowed the preparation of polylactides with narrow dispersity under mild conditions (20 掳C, 24 h, 10 mol-% catalyst loading). Interestingly, the steric hindrance of azaphosphatranes, as globular rigid structures, prevents any undesired interaction with the tertiary amine cocatalysts, as shown by x-ray anal. and semi-empirical calculations In contrast to their organocatalytic activity in the CO₂/epoxide reaction, all of the phosphonium derivatives tested were found to be efficient catalysts in this ROP benchmark reaction. In the experiment, the researchers used many compounds, for example, 1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0Computed Properties of C10H21N).

1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Computed Properties of C10H21N

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

UiO-type metal-organic frameworks with NHC or metal-NHC functionalities for N-methylation using CO₂ as the carbon source was written by Zhang, Xu;Jiang, Yilin;Fei, Honghan. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.COA of Formula: C10H21N This article mentions the following:

The first metal-organic framework (MOF) catalyzed N-methylation of amines using 1 atm CO₂ and phenylsilane under ambient conditions was reported. Compared with its homogeneous analog, the incorporation of N-heterocyclic carbene (NHC) into the MOF provided more efficient catalysis with improved reaction kinetics, turnover numbers and recyclability. Moreover, the metalated NHC functionalized MOF achieved direct N-methylation of amines bearing carboxylate moieties, which were common building blocks in pharmaceutical chem. In the experiment, the researchers used many compounds, for example, 1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0COA of Formula: C10H21N).

1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.COA of Formula: C10H21N

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Metal-Free Catalytic Hydrogenolysis of Silyl Triflates and Halides into Hydrosilanes was written by Durin, Gabriel;Fontaine, Albane;Berthet, Jean-Claude;Nicolas, Emmanuel;Thuery, Pierre;Cantat, Thibault. And the article was included in Angewandte Chemie, International Edition in 2022.Application of 79-55-0 This article mentions the following:

The metal-free catalytic hydrogenolysis of silyl triflates and halides (I, Br) to hydrosilanes is unlocked by using arylborane Lewis acids as catalysts. In the presence of a nitrogen base, the catalyst acts as a Frustrated Lewis Pair (FLP) able to split H₂ and generate a boron hydride intermediate capable of reducing (pseudo)halosilanes. This metal-free organocatalytic system is competitive with metal-based catalysts and enables the formation of a variety of hydrosilanes at room temperature in high yields (>85%) under a low pressure of H₂ (≤10 bar). In the experiment, the researchers used many compounds, for example, 1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0Application of 79-55-0).

1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0) belongs to piperidine derivatives. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Application of 79-55-0

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Frustrated Lewis Acid/Bronsted Base Catalysts for Direct Enantioselective α-Amination of Carbonyl Compounds was written by Shang, Ming;Wang, Xiaoxu;Koo, Seung Moh;Youn, Jennifer;Chan, Jessica Z.;Yao, Wenzhi;Hastings, Brian T.;Wasa, Masayuki. And the article was included in Journal of the American Chemical Society in 2017.HPLC of Formula: 79-55-0 This article mentions the following:

A method for enantioselective direct α-amination reaction catalyzed by a sterically “frustrated” Lewis acid/Bronsted base complex is disclosed. Cooperative functioning of the Lewis acid and Bronsted base components gives rise to in situ enolate generation from monocarbonyl compounds Subsequent reaction with hydrogen-bond activated dialkyl azodicarboxylates delivers α-aminocarbonyl compounds in high enantiomeric purity. In the experiment, the researchers used many compounds, for example, 1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0HPLC of Formula: 79-55-0).

1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0) belongs to piperidine derivatives. Piperidine and its derivatives have become increasingly popular in many synthetic schemes. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.HPLC of Formula: 79-55-0

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

Development of a new bicyclic imidazole nucleophilic organocatalyst for direct enantioselective C-acylation was written by Zhou, Muxing;He, Ende;Zhang, Lu;Chen, Jianzhong;Zhang, Zhenfeng;Liu, Yangang;Zhang, Wanbin. And the article was included in Organic Chemistry Frontiers in 2019.Application In Synthesis of 1,2,2,6,6-Pentamethylpiperidine This article mentions the following:

A novel chiral nucleophilic organocatalyst I easily synthesized from simple starting materials bearing a 5,6,7,8-tetrahydroimidazo[1,2-a]pyridine skeleton has been developed and successfully applied in the direct enantioselective C-acylation of 3-substituted benzofuranones II (R¹ = Me, Et, Pr; R² = H; R³ = H, Me, Et, i-Pr, t-Bu, MeO, Ph; R⁴ = H, Me, Et, i-Pr, t-Bu, MeO, Ph; R⁵ = H, Me, Et, t-Bu, i-Pr; R²R³ = CH=CH-CH=CH; R⁴R⁵ = CH=CH-CH=CH). Its catalytic efficiency was shown to be comparable to that of the previously reported chiral 6,7-dihydro-5H-pyrrolo[1,2-a]imidazole catalyst. A wide range of 3,3-disubstituted benzofuranones (S)-III possessing a quaternary stereocenter, were synthesized with high yields and enantioselectivities. In the experiment, the researchers used many compounds, for example, 1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0Application In Synthesis of 1,2,2,6,6-Pentamethylpiperidine).

1,2,2,6,6-Pentamethylpiperidine (cas: 79-55-0) belongs to piperidine derivatives. Piperidine is a saturated organic heteromonocyclic parent, an azacycloalkane, a secondary amine and a member of piperidines. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Application In Synthesis of 1,2,2,6,6-Pentamethylpiperidine

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem