Tag: 149353-75-3

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.149353-75-3,4-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid,as a common compound, the synthetic route is as follows.

1- (N-t-Butoxycarbonylamino)-2-aminobenzene (Method 17,3. 1 g, 14.7 mmol) was added to a stirred solution of 4- (l-t-butoxycarbonylpiperidin-4-yl) benzoic acid (4.1 g, 13.4 mmol) in DMF (50 ml) and the mixture stirred at ambient temperature for 10 minutes. 4- (4, 6- dimethoxy-1, 3,5-triazinyl-2-yl)-4-methylmorpholinium chloride (Method 18,4. 45 g, 16.1 mmol) was added and the mixture stirred at ambient temperature for 24 hours. The solvent was evaporated and the residue was dissolved in ethyl acetate (100 ml) and washed with water. The organics were dried over magnesium sulfate, filtered and evaporated. The resultant gum was purified by flash chromatography using 1% methanol/dichloromethane to give the title compound as a foam (5.44 g, 82%) ; NMR Spectrum : (DMSO-ds) 1.41 (s, 9H), 1.43 (s, 9H), 1.54 (m, 2H), 1.77 (m, 2H), 2.79 (m, 3H), 4. 08 (m, 2H), 7.15 (m, 2H), 7.40 (d, 2H), 7.52 (m, 2H), 7. 87 (d, 2H), 8.60 (br, 1H), 9.74 (br, 1H), Mass Spectrum: (M+E-Boc) 396.

149353-75-3, The synthetic route of 149353-75-3 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2003/87057; (2003); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

149353-75-3, 4-(1-(tert-Butoxycarbonyl)piperidin-4-yl)benzoic acid is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 229 59.1 tert-butyl 4-[4-(cyclopropylmethylcarbamoyl)-phenyl]-piperidine-1-carboxylate 500 mg tert-butyl 4-(4-carboxyphenyl)-piperidine-1-carboxylate are placed in 28 ml dimethylformamide, then 1.14 ml diisopropylethylamine and 747 mg HATU are added. The reaction mixture is stirred for 15 min at ambient temperature, then 194 mg cyclopropylmethylamin hydrochloride are added. The reaction mixture is stirred overnight at ambient temperature. Then the product is purified by preparative HPLC (method A). 480 mg product are obtained as an oil. Analytical HPLC-MS (method B): RT=1.64 min.

As the paragraph descriping shows that 149353-75-3 is playing an increasingly important role.

Reference£º
Patent; BOEHRINGER INGELHEIM INTERNATIONAL GMBH; US2011/21501; (2011); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem