Tag: 143.18

Long, Bohua et al. published their research in Organic & Biomolecular Chemistry in 2020 | CAS: 41447-17-0

(R)-1-Methylpiperidine-2-carboxylic acid (cas: 41447-17-0) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Electric Literature of C7H13NO2

Total synthesis of tubulysin U and N14-desacetoxytubulysin H was written by Long, Bohua;Tao, Cheng;Li, Yinghong;Zeng, Xiaobin;Cao, Meiqun;Wu, Zhengzhi. And the article was included in Organic & Biomolecular Chemistry in 2020.Electric Literature of C7H13NO2 This article mentions the following:

A concise and efficient procedure for the total synthesis of tubulysin U and N14-desacetoxytubulysin H has been developed with high stereoselectivity on a gram scale. This synthesis features an elegant cascade one-pot process to install the challenging thiazole moiety and the employment of stereoselective reductions and a series of high-yield mild reactions to ensure the requisite stereochem., reaction scale, and yield and to avoid the vexing epimerization occurring during peptide formation. In the experiment, the researchers used many compounds, for example, (R)-1-Methylpiperidine-2-carboxylic acid (cas: 41447-17-0Electric Literature of C7H13NO2).

(R)-1-Methylpiperidine-2-carboxylic acid (cas: 41447-17-0) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Electric Literature of C7H13NO2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Long, Bohua et al. published their research in Organic & Biomolecular Chemistry in 2020 | CAS: 41447-17-0

(R)-1-Methylpiperidine-2-carboxylic acid (cas: 41447-17-0) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Electric Literature of C7H13NO2

Total synthesis of tubulysin U and N14-desacetoxytubulysin H was written by Long, Bohua;Tao, Cheng;Li, Yinghong;Zeng, Xiaobin;Cao, Meiqun;Wu, Zhengzhi. And the article was included in Organic & Biomolecular Chemistry in 2020.Electric Literature of C7H13NO2 This article mentions the following:

A concise and efficient procedure for the total synthesis of tubulysin U and N14-desacetoxytubulysin H has been developed with high stereoselectivity on a gram scale. This synthesis features an elegant cascade one-pot process to install the challenging thiazole moiety and the employment of stereoselective reductions and a series of high-yield mild reactions to ensure the requisite stereochem., reaction scale, and yield and to avoid the vexing epimerization occurring during peptide formation. In the experiment, the researchers used many compounds, for example, (R)-1-Methylpiperidine-2-carboxylic acid (cas: 41447-17-0Electric Literature of C7H13NO2).

(R)-1-Methylpiperidine-2-carboxylic acid (cas: 41447-17-0) belongs to piperidine derivatives. Piperidine is a metabolite of cadaverine, a polyamine found in the human intestine. Piperidine derivatives are being utilized in different ways as anticancer, antiviral, antimalarial, antimicrobial, antifungal, antihypertension, analgesic, anti-inflammatory, anti-Alzheimer, antipsychotic and/or anticoagulant agents.Electric Literature of C7H13NO2

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Toader, Dorin et al. published their research in Journal of Medicinal Chemistry in 2016 | CAS: 41447-17-0

(R)-1-Methylpiperidine-2-carboxylic acid (cas: 41447-17-0) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.HPLC of Formula: 41447-17-0

Structure-Cytotoxicity Relationships of Analogues of N14-Desacetoxytubulysin H was written by Toader, Dorin;Wang, Fengjiang;Gingipalli, Lakshmaiah;Vasbinder, Melissa;Roth, Mark;Mao, Shenlan;Block, Michael;Harper, Jay;Thota, Sambaiah;Su, Mei;Ma, Jianquo;Bedian, Vahe;Kamal, Adeela. And the article was included in Journal of Medicinal Chemistry in 2016.HPLC of Formula: 41447-17-0 This article mentions the following:

Herein the authors report structure-cytotoxicity relationships for analogs of N14-Desacetoxytubulyisn H (1). A novel synthetic approach towards 1 enabled the discovery of compounds with a range of activity. Calculated basicity of the N-terminus of tubulysins was shown to be a good predictor of cytotoxicity. The impact of structural modifications at the C-terminus of 1 upon cytotoxicity is also described. These findings will facilitate the development of new tubulysin analogs for the treatment of cancer. In the experiment, the researchers used many compounds, for example, (R)-1-Methylpiperidine-2-carboxylic acid (cas: 41447-17-0HPLC of Formula: 41447-17-0).

(R)-1-Methylpiperidine-2-carboxylic acid (cas: 41447-17-0) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.HPLC of Formula: 41447-17-0

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Toader, Dorin et al. published their research in Journal of Medicinal Chemistry in 2016 | CAS: 41447-17-0

(R)-1-Methylpiperidine-2-carboxylic acid (cas: 41447-17-0) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.HPLC of Formula: 41447-17-0

Structure-Cytotoxicity Relationships of Analogues of N14-Desacetoxytubulysin H was written by Toader, Dorin;Wang, Fengjiang;Gingipalli, Lakshmaiah;Vasbinder, Melissa;Roth, Mark;Mao, Shenlan;Block, Michael;Harper, Jay;Thota, Sambaiah;Su, Mei;Ma, Jianquo;Bedian, Vahe;Kamal, Adeela. And the article was included in Journal of Medicinal Chemistry in 2016.HPLC of Formula: 41447-17-0 This article mentions the following:

Herein the authors report structure-cytotoxicity relationships for analogs of N14-Desacetoxytubulyisn H (1). A novel synthetic approach towards 1 enabled the discovery of compounds with a range of activity. Calculated basicity of the N-terminus of tubulysins was shown to be a good predictor of cytotoxicity. The impact of structural modifications at the C-terminus of 1 upon cytotoxicity is also described. These findings will facilitate the development of new tubulysin analogs for the treatment of cancer. In the experiment, the researchers used many compounds, for example, (R)-1-Methylpiperidine-2-carboxylic acid (cas: 41447-17-0HPLC of Formula: 41447-17-0).

(R)-1-Methylpiperidine-2-carboxylic acid (cas: 41447-17-0) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.HPLC of Formula: 41447-17-0

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Toader, Dorin et al. published their research in Journal of Medicinal Chemistry in 2016 | CAS: 41447-17-0

(R)-1-Methylpiperidine-2-carboxylic acid (cas: 41447-17-0) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.HPLC of Formula: 41447-17-0

Structure-Cytotoxicity Relationships of Analogues of N14-Desacetoxytubulysin H was written by Toader, Dorin;Wang, Fengjiang;Gingipalli, Lakshmaiah;Vasbinder, Melissa;Roth, Mark;Mao, Shenlan;Block, Michael;Harper, Jay;Thota, Sambaiah;Su, Mei;Ma, Jianquo;Bedian, Vahe;Kamal, Adeela. And the article was included in Journal of Medicinal Chemistry in 2016.HPLC of Formula: 41447-17-0 This article mentions the following:

Herein the authors report structure-cytotoxicity relationships for analogs of N14-Desacetoxytubulyisn H (1). A novel synthetic approach towards 1 enabled the discovery of compounds with a range of activity. Calculated basicity of the N-terminus of tubulysins was shown to be a good predictor of cytotoxicity. The impact of structural modifications at the C-terminus of 1 upon cytotoxicity is also described. These findings will facilitate the development of new tubulysin analogs for the treatment of cancer. In the experiment, the researchers used many compounds, for example, (R)-1-Methylpiperidine-2-carboxylic acid (cas: 41447-17-0HPLC of Formula: 41447-17-0).

(R)-1-Methylpiperidine-2-carboxylic acid (cas: 41447-17-0) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.HPLC of Formula: 41447-17-0

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem