Tag: 142374-19-4

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.142374-19-4,tert-Butyl 4-(2-oxoethyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

142374-19-4, To a solution of tert-butyl 4-(oxoethyl)piperidine-l-carboxylate as obtained in step 1 in dichloromethane (50 mL) was added DAST (1.2 g, 7.8 mmol) at 0 0C. The reaction mixture was warmed to room temperature and stirred for 17 h. A 5% aqueous solution of sodium bicarbonate was added and the layers were separated. The organic layer was washed with saturated sodium bicarbonate, and brine, dried over sodium sulfate, filtered and concentrated to provide tert-butyl 4-(2,2-difluoroethyl)piperidine-l-carboxylate that was used directly without further purification.

As the paragraph descriping shows that 142374-19-4 is playing an increasingly important role.

Reference£º
Patent; EXELIXIS, INC.; AAY, Naing; ARCALAS, Arlyn; BOWLES, Owen, Joseph; BUSSENIUS, Joerg; CURTIS, Jeffry, Kimo; DEFINA, Steven, Charles; DUBENKO, Larisa; HARRIS, Jason, R.; JACKSON-UGUETO, Eileen, E.; MANALO, Jean-Claire, Limun; KIM, Angie, Inyoung; PACK, Michael; PETO, Csaba, J.; RICE, Kenneth, D.; TSANG, Tsze, H.; WO2010/138487; (2010); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.142374-19-4,tert-Butyl 4-(2-oxoethyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of methyl 2- (bis (2, 2, 2-trifluoroethoxy) phosphoryl) acetate (1.9 g, 6 mmol) and 18-crown-6 (3.96 g, 15 mmol) in dry THF (70 mL) at -78 was dropwise added KHMDS (15 mL, 7.5 mmol, 0.5 M in toluene) . After stirring at -78 for 0.5h, tert-butyl 4- (2-oxoethyl) piperidine-1-carboxylate (1.14 g, 5 mmol) in dry THF (5 mL) was added to the mixture at -78 and the resulting mixture stirred at rt for 0.5h. The reaction was quenched with saturated aqueous NH4Cl (100 mL) and extracted with DCM (100 mL¡Á3) . The combined organic layers was washed with brine (50 mL) , dried over anhydrous Na2SO4 and concentrated. The residue was purified by chromatography (silica gel: 300-400 mesh, PE/EtOAc 40/1 to 20/1) to afford (Z) -tert-butyl 4- (4-methoxy-4-oxobut-2-enyl) piperidine-1-carboxylate (1.1 g, 78) . LRMS m/z (M-100) 184.1 found, 184.1 required

142374-19-4 tert-Butyl 4-(2-oxoethyl)piperidine-1-carboxylate 10353694, apiperidines compound, is more and more widely used in various.

Reference£º
Patent; MERCK SHARP & DOHME CORP.; RUDD, Michael T.; MENG, Zhaoyang; WAI, Jenny; BENNETT, David Jonathan; BRNARDIC, Edward J.; LIVERTON, Nigel J.; STACHEL, Shawn J.; HAN, Yongxin; TEMPEST, Paul; ZHU, Jiuxiang; XU, Xuewang; (182 pag.)WO2018/68297; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem