Tag: 141.1677

Subramani, Muthuraman et al. published their research in European Journal of Organic Chemistry in 2019 | CAS: 3326-13-4

1-Acetylpiperidin-2-one (cas: 3326-13-4) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Related Products of 3326-13-4

Mild, Metal-Free and Protection-Free Transamidation of N-Acyl-2-piperidones to Amino Acids, Amino Alcohols and Aliphatic Amines and Esterification of N-Acyl-2-piperidones was written by Subramani, Muthuraman;Rajendran, Saravana Kumar. And the article was included in European Journal of Organic Chemistry in 2019.Related Products of 3326-13-4 This article mentions the following:

Amides are indispensable building blocks of biol. systems, pharmaceuticals, and materials. We report a highly selective method for the synthesis of amides via transamidation process. Transamidation of N-acyl-2-piperidones with a broad range of amines is demonstrated under exceedingly mild and metal-free reaction condition that relies on the amide bond twist to weaken the amidic resonance. Transamidation proceeds under the neat condition at room temperature, in short reaction times (30-90 min) with good yields. Considerable variation is tolerated with both amine and imide substrates. Of note, amines bearing carboxylic acids (glycine and serine) and hydroxyl groups (dopamine, tyramine, etc.) are well tolerated which are otherwise problematic under the metal-catalyzed protocol. The current method is applicable for transamidation of both alkyl and aryl-N-acyl-2-piperidones. The practical value of the method is highlighted by the synthesis of four natural product amide alkaloids in high yields under mild reaction conditions. In the absence of nucleophilic amines, N-acyl-2-piperidones undergoes esterification with EtOH at elevated temperature Single crystal X-ray anal. of an N-acyl-2-piperidone shows amide bond twist, 蟿 = -20.39掳 and pyramidalization, 蠂N = -11.73掳. This weakens the amidic conjugation and might be the factor controlling the reactivity and selectivity of these imides. The N-acyl-2-piperidone scaffold could be useful in the synthesis of pharmaceuticals and materials. In the experiment, the researchers used many compounds, for example, 1-Acetylpiperidin-2-one (cas: 3326-13-4Related Products of 3326-13-4).

1-Acetylpiperidin-2-one (cas: 3326-13-4) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Related Products of 3326-13-4

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Konomi, Tuyoshi et al. published their research in Journal of Polymer Science, Part A-1: Polymer Chemistry in 1971 | CAS: 3326-13-4

1-Acetylpiperidin-2-one (cas: 3326-13-4) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Name: 1-Acetylpiperidin-2-one

Problems in low-temperature polymerization of lactams with alkali metal aluminum lactamate as catalysts was written by Konomi, Tuyoshi;Tani, Hisaya. And the article was included in Journal of Polymer Science, Part A-1: Polymer Chemistry in 1971.Name: 1-Acetylpiperidin-2-one This article mentions the following:

In the alkali metal aluminum tetracaprolactamate-catalyzed polymerization of 蔚-caprolactam, at lower catalyst concentrations (0.125-0.50 mole %), polymerization occurred only at >140-150.deg. because of the poor initiator activity of aluminum caprolactamate [17831-77-5], while at higher concentrations (2.0 mole %) the initiation temperature required decreased to .sim.100.deg.. In the presence of Na caprolactamate [2123-24-2] no polymerization occurred even after long polymerization times. Since the alk. polymerization of 蔚-caprolactam initiated by N-acetylcaprolactam gives a polymer both at 75.deg. and 100.deg., the formation of N-acylcaprolactam by the interaction of the lactam anion and the initiator depends both on the nature of the initiator, i.e. the electron-withdrawing power of the N-substituent in 蔚-caprolactam, and on the temperature-dependent ionic character of the alkali metal caprolactamate. In the prolonged polymerization of lactams with potassium diethylaluminum dilactamate, in the absence of initiator, the initiator activity decreased in the order 伪-pyrrolidinone > 蔚-caprolactam > 伪-piperidone. The reactivity of NaAlEt4 or KAlEt4 towards N-acetyllactam was lower than that towards lactam at a given temperature, indicating that no consumption of N-acetyllactam by the reaction with alkali metal ethylaluminum lactamates occurs in the course of low-temperature polymerization of lactams. In the experiment, the researchers used many compounds, for example, 1-Acetylpiperidin-2-one (cas: 3326-13-4Name: 1-Acetylpiperidin-2-one).

1-Acetylpiperidin-2-one (cas: 3326-13-4) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Name: 1-Acetylpiperidin-2-one

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Korte, Friedhelm et al. published their research in Journal of Chromatography in 1962 | CAS: 3326-13-4

1-Acetylpiperidin-2-one (cas: 3326-13-4) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Quality Control of 1-Acetylpiperidin-2-one

Thin-layer chromatography of lactones, lactams, and thiolactones was written by Korte, Friedhelm;Vogel, Juergen. And the article was included in Journal of Chromatography in 1962.Quality Control of 1-Acetylpiperidin-2-one This article mentions the following:

These compounds are separated on thin layers of silica gel G with iso-Pr2O, 80:20 iso-Pr2O:EtOAc or 20:80 or 60:40 iso-Pr2O:isooctane as solvent systems. Lactones were detected by conversion to their hydroxamates, which were sprayed with HOAc and 10% aqueous FeCl3 to give brown spots. Lactams were detected with Dragendorff reagent; thiolactones were split with NaOH, and the resulting SH groups colored with Na nitroprusside. Rf values are tabulated for numerous compounds of these classes with 3 solvent systems. In the experiment, the researchers used many compounds, for example, 1-Acetylpiperidin-2-one (cas: 3326-13-4Quality Control of 1-Acetylpiperidin-2-one).

1-Acetylpiperidin-2-one (cas: 3326-13-4) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Quality Control of 1-Acetylpiperidin-2-one

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Konomi, Tuyoshi et al. published their research in Journal of Polymer Science, Part A-1: Polymer Chemistry in 1971 | CAS: 3326-13-4

1-Acetylpiperidin-2-one (cas: 3326-13-4) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Name: 1-Acetylpiperidin-2-one

Problems in low-temperature polymerization of lactams with alkali metal aluminum lactamate as catalysts was written by Konomi, Tuyoshi;Tani, Hisaya. And the article was included in Journal of Polymer Science, Part A-1: Polymer Chemistry in 1971.Name: 1-Acetylpiperidin-2-one This article mentions the following:

In the alkali metal aluminum tetracaprolactamate-catalyzed polymerization of ε-caprolactam, at lower catalyst concentrations (0.125-0.50 mole %), polymerization occurred only at >140-150.deg. because of the poor initiator activity of aluminum caprolactamate [17831-77-5], while at higher concentrations (2.0 mole %) the initiation temperature required decreased to .sim.100.deg.. In the presence of Na caprolactamate [2123-24-2] no polymerization occurred even after long polymerization times. Since the alk. polymerization of ε-caprolactam initiated by N-acetylcaprolactam gives a polymer both at 75.deg. and 100.deg., the formation of N-acylcaprolactam by the interaction of the lactam anion and the initiator depends both on the nature of the initiator, i.e. the electron-withdrawing power of the N-substituent in ε-caprolactam, and on the temperature-dependent ionic character of the alkali metal caprolactamate. In the prolonged polymerization of lactams with potassium diethylaluminum dilactamate, in the absence of initiator, the initiator activity decreased in the order α-pyrrolidinone > ε-caprolactam > α-piperidone. The reactivity of NaAlEt4 or KAlEt4 towards N-acetyllactam was lower than that towards lactam at a given temperature, indicating that no consumption of N-acetyllactam by the reaction with alkali metal ethylaluminum lactamates occurs in the course of low-temperature polymerization of lactams. In the experiment, the researchers used many compounds, for example, 1-Acetylpiperidin-2-one (cas: 3326-13-4Name: 1-Acetylpiperidin-2-one).

1-Acetylpiperidin-2-one (cas: 3326-13-4) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Name: 1-Acetylpiperidin-2-one

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Korte, Friedhelm et al. published their research in Journal of Chromatography in 1962 | CAS: 3326-13-4

1-Acetylpiperidin-2-one (cas: 3326-13-4) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Quality Control of 1-Acetylpiperidin-2-one

Thin-layer chromatography of lactones, lactams, and thiolactones was written by Korte, Friedhelm;Vogel, Juergen. And the article was included in Journal of Chromatography in 1962.Quality Control of 1-Acetylpiperidin-2-one This article mentions the following:

These compounds are separated on thin layers of silica gel G with iso-Pr2O, 80:20 iso-Pr2O:EtOAc or 20:80 or 60:40 iso-Pr2O:isooctane as solvent systems. Lactones were detected by conversion to their hydroxamates, which were sprayed with HOAc and 10% aqueous FeCl3 to give brown spots. Lactams were detected with Dragendorff reagent; thiolactones were split with NaOH, and the resulting SH groups colored with Na nitroprusside. Rf values are tabulated for numerous compounds of these classes with 3 solvent systems. In the experiment, the researchers used many compounds, for example, 1-Acetylpiperidin-2-one (cas: 3326-13-4Quality Control of 1-Acetylpiperidin-2-one).

1-Acetylpiperidin-2-one (cas: 3326-13-4) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Quality Control of 1-Acetylpiperidin-2-one

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Konomi, Tuyoshi et al. published their research in Journal of Polymer Science, Part A-1: Polymer Chemistry in 1971 | CAS: 3326-13-4

1-Acetylpiperidin-2-one (cas: 3326-13-4) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Name: 1-Acetylpiperidin-2-one

Problems in low-temperature polymerization of lactams with alkali metal aluminum lactamate as catalysts was written by Konomi, Tuyoshi;Tani, Hisaya. And the article was included in Journal of Polymer Science, Part A-1: Polymer Chemistry in 1971.Name: 1-Acetylpiperidin-2-one This article mentions the following:

In the alkali metal aluminum tetracaprolactamate-catalyzed polymerization of ε-caprolactam, at lower catalyst concentrations (0.125-0.50 mole %), polymerization occurred only at >140-150.deg. because of the poor initiator activity of aluminum caprolactamate [17831-77-5], while at higher concentrations (2.0 mole %) the initiation temperature required decreased to .sim.100.deg.. In the presence of Na caprolactamate [2123-24-2] no polymerization occurred even after long polymerization times. Since the alk. polymerization of ε-caprolactam initiated by N-acetylcaprolactam gives a polymer both at 75.deg. and 100.deg., the formation of N-acylcaprolactam by the interaction of the lactam anion and the initiator depends both on the nature of the initiator, i.e. the electron-withdrawing power of the N-substituent in ε-caprolactam, and on the temperature-dependent ionic character of the alkali metal caprolactamate. In the prolonged polymerization of lactams with potassium diethylaluminum dilactamate, in the absence of initiator, the initiator activity decreased in the order α-pyrrolidinone > ε-caprolactam > α-piperidone. The reactivity of NaAlEt4 or KAlEt4 towards N-acetyllactam was lower than that towards lactam at a given temperature, indicating that no consumption of N-acetyllactam by the reaction with alkali metal ethylaluminum lactamates occurs in the course of low-temperature polymerization of lactams. In the experiment, the researchers used many compounds, for example, 1-Acetylpiperidin-2-one (cas: 3326-13-4Name: 1-Acetylpiperidin-2-one).

1-Acetylpiperidin-2-one (cas: 3326-13-4) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Fluorinated piperidines are also the subject of continued interest in medicinal chemistry, for example in the synthesis of selective dipeptidyl peptidase II (DPP II) inhibitors. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions.Name: 1-Acetylpiperidin-2-one

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Korte, Friedhelm et al. published their research in Journal of Chromatography in 1962 | CAS: 3326-13-4

1-Acetylpiperidin-2-one (cas: 3326-13-4) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Quality Control of 1-Acetylpiperidin-2-one

Thin-layer chromatography of lactones, lactams, and thiolactones was written by Korte, Friedhelm;Vogel, Juergen. And the article was included in Journal of Chromatography in 1962.Quality Control of 1-Acetylpiperidin-2-one This article mentions the following:

These compounds are separated on thin layers of silica gel G with iso-Pr2O, 80:20 iso-Pr2O:EtOAc or 20:80 or 60:40 iso-Pr2O:isooctane as solvent systems. Lactones were detected by conversion to their hydroxamates, which were sprayed with HOAc and 10% aqueous FeCl3 to give brown spots. Lactams were detected with Dragendorff reagent; thiolactones were split with NaOH, and the resulting SH groups colored with Na nitroprusside. Rf values are tabulated for numerous compounds of these classes with 3 solvent systems. In the experiment, the researchers used many compounds, for example, 1-Acetylpiperidin-2-one (cas: 3326-13-4Quality Control of 1-Acetylpiperidin-2-one).

1-Acetylpiperidin-2-one (cas: 3326-13-4) belongs to piperidine derivatives. The piperidine moiety constitutes an important building block for the synthesis of a variety of bioactive natural products, alkaloids and other drugs. Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol.Quality Control of 1-Acetylpiperidin-2-one

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem