Tag: 129.2

Lavey, C. Flader et al. published their research in Journal of Labelled Compounds and Radiopharmaceuticals in 2011 | CAS: 103639-57-2

(S)-2-(Piperidin-2-yl)ethanol (cas: 103639-57-2) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Category: piperidines

Synthesis of 3H-, 13C3-, and 14C-labeled Sch 727965 was written by Lavey, C. Flader;Hesk, D.;Koharski, D.;Truong, V.;McNamara, P.. And the article was included in Journal of Labelled Compounds and Radiopharmaceuticals in 2011.Category: piperidines This article mentions the following:

The preparation of [3H]Sch 727965 ([3H]I) from unlabeled compound and tritiated water was base catalyzed. Di-Et [13C3]malonate was used to prepare [13C3]Sch 727965 in five steps in 21.8% overall yield. In a similar manner, [14C]Sch 727965 was prepared in five steps from di-Et [2-14C]malonate in 11.1% radiochem. yield. Copyright 漏 2010 John Wiley & Sons, Ltd. In the experiment, the researchers used many compounds, for example, (S)-2-(Piperidin-2-yl)ethanol (cas: 103639-57-2Category: piperidines).

(S)-2-(Piperidin-2-yl)ethanol (cas: 103639-57-2) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Lavey, C. Flader et al. published their research in Journal of Labelled Compounds and Radiopharmaceuticals in 2011 | CAS: 103639-57-2

(S)-2-(Piperidin-2-yl)ethanol (cas: 103639-57-2) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Category: piperidines

Synthesis of 3H-, 13C3-, and 14C-labeled Sch 727965 was written by Lavey, C. Flader;Hesk, D.;Koharski, D.;Truong, V.;McNamara, P.. And the article was included in Journal of Labelled Compounds and Radiopharmaceuticals in 2011.Category: piperidines This article mentions the following:

The preparation of [3H]Sch 727965 ([3H]I) from unlabeled compound and tritiated water was base catalyzed. Di-Et [13C3]malonate was used to prepare [13C3]Sch 727965 in five steps in 21.8% overall yield. In a similar manner, [14C]Sch 727965 was prepared in five steps from di-Et [2-14C]malonate in 11.1% radiochem. yield. Copyright © 2010 John Wiley & Sons, Ltd. In the experiment, the researchers used many compounds, for example, (S)-2-(Piperidin-2-yl)ethanol (cas: 103639-57-2Category: piperidines).

(S)-2-(Piperidin-2-yl)ethanol (cas: 103639-57-2) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Young, J. R. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2000 | CAS: 103639-57-2

(S)-2-(Piperidin-2-yl)ethanol (cas: 103639-57-2) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.Category: piperidines

Quinolones as gonadotropin releasing hormone (GnRH) antagonists: simultaneous optimization of the C(3)-aryl and C(6)-substituents was written by Young, J. R.;Huang, S. X.;Chen, I.;Walsh, T. F.;DeVita, R. J.;Wyvratt, M. J.;Goulet, M. T.;Ren, N.;Lo, J.;Yang, Y. T.;Yudkovitz, J. B.;Cheng, K.;Smith, R. G.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2000.Category: piperidines This article mentions the following:

A series of 3-arylquinolones was prepared and evaluated for their ability to act as gonadotropin releasing hormone (GnRH) antagonists. A variety of substitution patterns of the 3-aryl substituent are described. The 3,4,5-trimethylphenyl substituent (I) was found to be optimal. In the experiment, the researchers used many compounds, for example, (S)-2-(Piperidin-2-yl)ethanol (cas: 103639-57-2Category: piperidines).

(S)-2-(Piperidin-2-yl)ethanol (cas: 103639-57-2) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N鈥揌 bond in an axial position, and the other in an equatorial position.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Snider, Barry B. et al. published their research in Journal of Organic Chemistry in 2007 | CAS: 103639-57-2

(S)-2-(Piperidin-2-yl)ethanol (cas: 103639-57-2) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Category: piperidines

Total Synthesis of (-)-Senepodine G and (-)-Cermizine C was written by Snider, Barry B.;Grabowski, James F.. And the article was included in Journal of Organic Chemistry in 2007.Category: piperidines This article mentions the following:

An efficient, stereospecific synthesis of the alkaloids senepodine G chloride(I) and cermizine C (II) has been completed using the BF3路Et2O-promoted stereospecific addition of Me2CuLi to an 伪,尾-unsaturated lactam, the addition of MeMgBr followed by HCl to give senepodine G (six steps, 40% overall yield), and the stereospecific NaBH4 reduction of I to give cermizine C (seven steps, 40% overall yield). In the experiment, the researchers used many compounds, for example, (S)-2-(Piperidin-2-yl)ethanol (cas: 103639-57-2Category: piperidines).

(S)-2-(Piperidin-2-yl)ethanol (cas: 103639-57-2) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Young, J. R. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2000 | CAS: 103639-57-2

(S)-2-(Piperidin-2-yl)ethanol (cas: 103639-57-2) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Category: piperidines

Quinolones as gonadotropin releasing hormone (GnRH) antagonists: simultaneous optimization of the C(3)-aryl and C(6)-substituents was written by Young, J. R.;Huang, S. X.;Chen, I.;Walsh, T. F.;DeVita, R. J.;Wyvratt, M. J.;Goulet, M. T.;Ren, N.;Lo, J.;Yang, Y. T.;Yudkovitz, J. B.;Cheng, K.;Smith, R. G.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2000.Category: piperidines This article mentions the following:

A series of 3-arylquinolones was prepared and evaluated for their ability to act as gonadotropin releasing hormone (GnRH) antagonists. A variety of substitution patterns of the 3-aryl substituent are described. The 3,4,5-trimethylphenyl substituent (I) was found to be optimal. In the experiment, the researchers used many compounds, for example, (S)-2-(Piperidin-2-yl)ethanol (cas: 103639-57-2Category: piperidines).

(S)-2-(Piperidin-2-yl)ethanol (cas: 103639-57-2) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Snider, Barry B. et al. published their research in Journal of Organic Chemistry in 2007 | CAS: 103639-57-2

(S)-2-(Piperidin-2-yl)ethanol (cas: 103639-57-2) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Category: piperidines

Total Synthesis of (-)-Senepodine G and (-)-Cermizine C was written by Snider, Barry B.;Grabowski, James F.. And the article was included in Journal of Organic Chemistry in 2007.Category: piperidines This article mentions the following:

An efficient, stereospecific synthesis of the alkaloids senepodine G chloride(I) and cermizine C (II) has been completed using the BF3·Et2O-promoted stereospecific addition of Me2CuLi to an α,β-unsaturated lactam, the addition of MeMgBr followed by HCl to give senepodine G (six steps, 40% overall yield), and the stereospecific NaBH4 reduction of I to give cermizine C (seven steps, 40% overall yield). In the experiment, the researchers used many compounds, for example, (S)-2-(Piperidin-2-yl)ethanol (cas: 103639-57-2Category: piperidines).

(S)-2-(Piperidin-2-yl)ethanol (cas: 103639-57-2) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Young, J. R. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2000 | CAS: 103639-57-2

(S)-2-(Piperidin-2-yl)ethanol (cas: 103639-57-2) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Category: piperidines

Quinolones as gonadotropin releasing hormone (GnRH) antagonists: simultaneous optimization of the C(3)-aryl and C(6)-substituents was written by Young, J. R.;Huang, S. X.;Chen, I.;Walsh, T. F.;DeVita, R. J.;Wyvratt, M. J.;Goulet, M. T.;Ren, N.;Lo, J.;Yang, Y. T.;Yudkovitz, J. B.;Cheng, K.;Smith, R. G.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2000.Category: piperidines This article mentions the following:

A series of 3-arylquinolones was prepared and evaluated for their ability to act as gonadotropin releasing hormone (GnRH) antagonists. A variety of substitution patterns of the 3-aryl substituent are described. The 3,4,5-trimethylphenyl substituent (I) was found to be optimal. In the experiment, the researchers used many compounds, for example, (S)-2-(Piperidin-2-yl)ethanol (cas: 103639-57-2Category: piperidines).

(S)-2-(Piperidin-2-yl)ethanol (cas: 103639-57-2) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem

 

Snider, Barry B. et al. published their research in Journal of Organic Chemistry in 2007 | CAS: 103639-57-2

(S)-2-(Piperidin-2-yl)ethanol (cas: 103639-57-2) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Category: piperidines

Total Synthesis of (-)-Senepodine G and (-)-Cermizine C was written by Snider, Barry B.;Grabowski, James F.. And the article was included in Journal of Organic Chemistry in 2007.Category: piperidines This article mentions the following:

An efficient, stereospecific synthesis of the alkaloids senepodine G chloride(I) and cermizine C (II) has been completed using the BF3·Et2O-promoted stereospecific addition of Me2CuLi to an α,β-unsaturated lactam, the addition of MeMgBr followed by HCl to give senepodine G (six steps, 40% overall yield), and the stereospecific NaBH4 reduction of I to give cermizine C (seven steps, 40% overall yield). In the experiment, the researchers used many compounds, for example, (S)-2-(Piperidin-2-yl)ethanol (cas: 103639-57-2Category: piperidines).

(S)-2-(Piperidin-2-yl)ethanol (cas: 103639-57-2) belongs to piperidine derivatives.Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Category: piperidines

Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem