123855-51-6, tert-Butyl 4-(hydroxymethyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: Boc-piperidinemethanol (27) or Boc-piperidineethanol (28) (23 mmol) dissolved in pyridine (50 mL) and cooled down under nitrogen. Then a tosyl chloride (27,87 mmol) was added portionwise. The was carried out for 3 h on bath-ice, then warm to room temperature and stirred for additional 10 h. The reaction mixture was extracted with CH2Cl2 (150 mL) and the organic phase was washed with 1 M KHSO4 (4 ¡Á 50 mL), water, brine and dried over Na2SO4. The tosyl derivatives (29, 30) were separated by column chromatography using SiO2 and CH2Cl2 followed by CH2Cl2/MeOH = 9/0.1. Next tosyl derivatives (2.44 mmol) were reacted with 4-chlorophenylpiperazine (2 mmol) by heating them in the presence of TEA (21.5 mmol) the boiling mixture of THF/toluene (5 mL/10 mL) for 20 h. After solvent evaporation the crude product was purified on silica gel column chromatography (CH2Cl2/MeOH 9/0.5, v/v) to yield Boc-protected piperidine 31 and 32. For the next stage the products were converted into their TFA salts and were isolated as white foams.
123855-51-6 tert-Butyl 4-(hydroxymethyl)piperidine-1-carboxylate 2764081, apiperidines compound, is more and more widely used in various.
Reference£º
Article; Zajdel, Pawe?; Marciniec, Krzysztof; Ma?lankiewicz, Andrzej; Sata?a, Grzegorz; Duszy?ska, Beata; Bojarski, Andrzej J.; Partyka, Anna; Jastrzbska-Wisek, Magdalena; Wrobel, Dagmara; Weso?owska, Anna; Paw?owski, MacIej; Bioorganic and Medicinal Chemistry; vol. 20; 4; (2012); p. 1545 – 1556;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem