1209780-71-1, tert-Butyl 3,3-difluoro-4-hydroxypiperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
[To asuspension of NaH (60%, 3.44g, 86.1 mmol) in THF (250 mL) was added tert-butyl 3, 3-difluoro-4-hydroxypiperidine-1-carboxylate (16.8 g, 70.7 mmol) at 0 under N 2. The mixture was stirred at 0 for 30 min. Then to the mixture was added 5-fluoro-7-methoxy-3- ( (2- (trimethylsilyl) ethoxy) methyl) quinazolin-4 (3H) -one (20.0 g, 61.5 mmol) at 0 . The reaction mixture was stirred for 4 h. LCMS showed the reaction was complete. The reaction mixture was quenched with ice water and extracted with EtOAc (200 mL x2) . The combined organic layer was dried over anhydrous Na 2SO 4, filtered and concentrated to give a residue. The residue was purified by silica gel chromatography (PE/EtOAc = 2/1) to give the product (30.0 g, 90%yield) as a white solid. MS (ESI) m/z: 542.3 (M+H) +.
The synthetic route of 1209780-71-1 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; SUZHOU ZANRONG PHARMA LIMITED; ZHOU, Ding; CHENG, Ziqiang; (0 pag.)WO2020/57511; (2020); A1;,
Piperidine – Wikipedia
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